LYZL2 Gene (Protein Coding)

Lysozyme Like 2

GC10M030922
GIFtS:
31
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009] See more...

Aliases for LYZL2 Gene

Aliases for LYZL2 Gene

  • Lysozyme Like 2 2 3 5
  • Lysozyme-Like Protein 2 3 4
  • Lysozyme-2 3 4
  • Lysozyme-Like 2 2
  • Lysozyme D2 3
  • EC 3.2.1.17 4
  • LYZD2 3
  • LYZL2 5

External Ids for LYZL2 Gene

Previous GeneCards Identifiers for LYZL2 Gene

  • GC10M030905
  • GC10M030940
  • GC10M030619
  • GC10M030648
  • GC10M030726

Summaries for LYZL2 Gene

Entrez Gene Summary for LYZL2 Gene

  • Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

GeneCards Summary for LYZL2 Gene

LYZL2 (Lysozyme Like 2) is a Protein Coding gene. Diseases associated with LYZL2 include Dental Caries and Van Maldergem Syndrome 2. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZL1.

Additional gene information for LYZL2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYZL2 Gene

Genomics for LYZL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LYZL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J030630 Enhancer 0.8 FANTOM5 Ensembl ENCODE 250.7 -1.0 -1039 1.6 ZNF316 MAFK CEBPB EMSY LYZL2 lnc-MAP3K8-2 MAP3K8 ZNF438 HSALNG0077050
GH10J030629 Promoter 0.3 EPDnew 250.7 +0.0 14 0.1 LYZL2 lnc-MAP3K8-2 MAP3K8
GH10J030638 Enhancer 0.9 FANTOM5 ENCODE 0.4 -8.5 -8505 0.2 JUND HOMEZ FOXA2 SMAD4 SAP130 RARA TEAD3 FOSL2 SOX5 ZNF792 MAP3K8 ZNF438 HSALNG0077050 LYZL2
GH10J030642 Enhancer 1 ENCODE dbSUPER 0.4 -14.9 -14934 2.7 ZNF600 ZNF580 ATF2 FEZF1 ZNF639 ZEB1 ZNF843 ZNF146 KLF16 PRDM6 MAP3K8 HSALNG0077050 RF00017-571 LYZL2 ZNF438
GH10J030587 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.3 +41.6 41561 3.6 BCLAF1 IKZF1 ZMYM3 BCL11A TRIM22 HOMEZ KMT2B RXRA SMAD4 SAP130 ENSG00000285630 LOC105376479 lnc-LYZL2-7 MAP3K8 MTPAP ZNF438 piR-38352-044 LYZL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYZL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYZL2

Top Transcription factor binding sites by QIAGEN in the LYZL2 gene promoter:
  • c-Myb
  • CUTL1
  • En-1
  • FOXJ2 (long isoform)
  • HFH-1
  • Ik-3
  • RORalpha1
  • SRY
  • XBP-1

Genomic Locations for LYZL2 Gene

Latest Assembly
chr10:30,606,222-30,629,762
(GRCh38/hg38)
Size:
23,541 bases
Orientation:
Minus strand

Previous Assembly
chr10:30,900,708-30,918,682
(GRCh37/hg19 by Entrez Gene)
Size:
17,975 bases
Orientation:
Minus strand

chr10:30,900,718-30,918,691
(GRCh37/hg19 by Ensembl)
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for LYZL2 Gene

Genes around LYZL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LYZL2 Gene

Proteins for LYZL2 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for LYZL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4W2-LYZL2_HUMAN
    Recommended name:
    Lysozyme-like protein 2
    Protein Accession:
    Q7Z4W2
    Secondary Accessions:
    • Q6NZ69

    Protein attributes for LYZL2 Gene

    Size:
    148 amino acids
    Molecular mass:
    16656 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for LYZL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYZL2 Gene

Post-translational modifications for LYZL2 Gene

  • Glycosylation at Asn58
  • Modification sites at PhosphoSitePlus

Other Protein References for LYZL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LYZL2 Gene

Domains & Families for LYZL2 Gene

Gene Families for LYZL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for LYZL2 Gene

InterPro:
Blocks:
  • Lysozyme signature

Suggested Antigen Peptide Sequences for LYZL2 Gene

GenScript: Design optimal peptide antigens:
  • Lysozyme-like protein 2 (LYZL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4W2

UniProtKB/Swiss-Prot:

LYZL2_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL2: view

Function for LYZL2 Gene

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  1. Animal Models for research
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  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for LYZL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.

Enzyme Numbers (IUBMB) for LYZL2 Gene

Phenotypes From GWAS Catalog for LYZL2 Gene

Gene Ontology (GO) - Molecular Function for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with LYZL2: view
genes like me logo Genes that share phenotypes with LYZL2: view

Animal Models for research

miRNA for LYZL2 Gene

miRTarBase miRNAs that target LYZL2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYZL2 Gene

Localization for LYZL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL2 gene
Compartment Confidence
extracellular 3
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LYZL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYZL2 Gene

Pathways & Interactions for LYZL2 Gene

PathCards logo

SuperPathways for LYZL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with LYZL2: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL2 Gene

Drugs & Compounds for LYZL2 Gene

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  1. Drug products for research

(1) Drugs for LYZL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with LYZL2: view

Transcripts for LYZL2 Gene

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mRNA/cDNA for LYZL2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL2

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL2 Gene

No ASD Table

Relevant External Links for LYZL2 Gene

GeneLoc Exon Structure for
LYZL2

Expression for LYZL2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYZL2 Gene

mRNA expression in normal human tissues for LYZL2 Gene
mRNA expression by GTEx for LYZL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for LYZL2 Gene

This gene is overexpressed in Testis (x52.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYZL2

SOURCE GeneReport for Unigene cluster for LYZL2 Gene:

Hs.522610

mRNA Expression by UniProt/SwissProt for LYZL2 Gene:

Q7Z4W2-LYZL2_HUMAN
Tissue specificity: Expressed in testis, epididymis and placenta.
genes like me logo Genes that share expression patterns with LYZL2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZL2 Gene

Orthologs for LYZL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LYZL2 29 30
  • 98.63 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 30
  • 84 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia LYZL1 30
  • 84 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Lyzl1 30
  • 74 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 52 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 43 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii lyz 29
  • 57 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11159 29 30
  • 51.41 (n)
 ManyToMany
LysB 30
  • 36 (a)
 ManyToMany
LysD 30
  • 36 (a)
 ManyToMany
LysC 30
  • 36 (a)
 ManyToMany
LysS 30
  • 36 (a)
 ManyToMany
LysP 30
  • 35 (a)
 ManyToMany
LysE 30
  • 35 (a)
 ManyToMany
LysX 30
  • 35 (a)
 ManyToMany
CG7798 30
  • 32 (a)
 ManyToMany
CG16756 30
  • 28 (a)
 ManyToMany
CG30062 30
  • 27 (a)
 ManyToMany
CG16799 30
  • 27 (a)
 ManyToMany
CG8492 30
  • 4 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta LYSC4 29
  • 46.57 (n)
Species where no ortholog for LYZL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LYZL2 Gene

ENSEMBL:
Gene Tree for LYZL2 (if available)
TreeFam:
Gene Tree for LYZL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYZL2: view image
Alliance of Genome Resources:
Additional Orthologs for LYZL2

Paralogs for LYZL2 Gene

Paralogs for LYZL2 Gene

(8) SIMAP similar genes for LYZL2 Gene using alignment to 1 proteins:

  • LYZL2_HUMAN
genes like me logo Genes that share paralogs with LYZL2: view

Variants for LYZL2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYZL2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1054570 -- p.Asp144Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LYZL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LYZL2 Gene

Variant ID Type Subtype PubMed ID
esv1962669 CNV deletion 18987734
nsv1129323 OTHER inversion 24896259
nsv1161936 CNV duplication 26073780
nsv831822 CNV gain 17160897
nsv947811 CNV duplication 23825009

Variation tolerance for LYZL2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYZL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYZL2
Leiden Open Variation Database (LOVD)
LYZL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL2 Gene

Disorders for LYZL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LYZL2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
van maldergem syndrome 2
  • vmlds2
- elite association - COSMIC cancer census association via MalaCards
Search LYZL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYZL2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LYZL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYZL2 Gene

Publications for LYZL2 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K … Yu L (Biology of reproduction 2005) 3 4 22
  2. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PMID: 18984674) Argyropoulos G … Rankinen T (Physiological genomics 2009) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for LYZL2 gene in Mastermind

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