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Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
LYZL2 (Lysozyme Like 2) is a Protein Coding gene. Diseases associated with LYZL2 include Dental Caries. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZL1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J030630 | Enhancer | 0.8 | FANTOM5 Ensembl ENCODE | 750.6 | -1.0 | -1039 | 1.6 | MAFK ZNF316 EMSY | LYZL2 lnc-MAP3K8-2 MAP3K8 ZNF438 HSALNG0077050 | |
GH10J030629 | Promoter | 0.3 | EPDnew | 750.6 | +0.0 | 14 | 0.1 | LYZL2 lnc-MAP3K8-2 | ||
GH10J030605 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas | 0.3 | +24.0 | 23961 | 2.4 | MLX NR2F6 MIXL1 NFYC RERE ELF3 SP1 CEBPG TFE3 PPARG | HSALNG0077046 lnc-MAP3K8-12 LYZL2 | |
GH10J030638 | Enhancer | 0.9 | FANTOM5 ENCODE | 0.4 | -8.5 | -8505 | 0.2 | PRDM1 FOSL2 CREB1 JUN JUND SP1 SCRT2 ZSCAN5C OSR2 SAP130 | MAP3K8 ZNF438 HSALNG0077050 LYZL2 | |
GH10J030611 | Enhancer | 0.9 | ENCODE | 0.4 | +17.1 | 17111 | 1.5 | LCORL MLX RBPJ NR2F6 ATF1 MIXL1 ELF3 SP1 MAFK CEBPG | lnc-MAP3K8-12 HSALNG0077046 LYZL2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003796 | lysozyme activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008152 | metabolic process | IEA | -- |
GO:0050829 | defense response to Gram-negative bacterium | IBA | 21873635 |
GO:0050830 | defense response to Gram-positive bacterium | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LYZL2 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | LYZL1 33 |
|
OneToMany | |
dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
mouse (Mus musculus) |
Mammalia | Lyzl1 33 |
|
OneToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | lyz 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG11159 33 32 |
|
ManyToMany | |
LysB 33 |
|
ManyToMany | |||
LysD 33 |
|
ManyToMany | |||
LysC 33 |
|
ManyToMany | |||
LysS 33 |
|
ManyToMany | |||
LysP 33 |
|
ManyToMany | |||
LysE 33 |
|
ManyToMany | |||
LysX 33 |
|
ManyToMany | |||
CG7798 33 |
|
ManyToMany | |||
CG16756 33 |
|
ManyToMany | |||
CG30062 33 |
|
ManyToMany | |||
CG16799 33 |
|
ManyToMany | |||
CG8492 33 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | LYSC4 32 |
|
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000006710 | -- | 30,627,276(-) | C/G | intron_variant | |
rs1000052806 | -- | 30,605,915(-) | A/T | downstream_transcript_variant | |
rs1000117739 | -- | 30,621,557(-) | TGTTGTT/TGTT | genic_downstream_transcript_variant, intron_variant | |
rs1000171916 | -- | 30,624,714(-) | G/A/T | intron_variant | |
rs1000272050 | -- | 30,621,249(-) | T/C | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1962669 | CNV | deletion | 18987734 |
nsv1129323 | OTHER | inversion | 24896259 |
nsv1161936 | CNV | duplication | 26073780 |
nsv831822 | CNV | gain | 17160897 |
nsv947811 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dental caries |
|
|