Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009] See more...

Aliases for LYZL2 Gene

Aliases for LYZL2 Gene

  • Lysozyme Like 2 2 3 5
  • Lysozyme-Like Protein 2 3 4
  • Lysozyme-2 3 4
  • Lysozyme-Like 2 2
  • Lysozyme D2 3
  • EC 3.2.1.17 4
  • LYZD2 3

External Ids for LYZL2 Gene

Previous GeneCards Identifiers for LYZL2 Gene

  • GC10M030905
  • GC10M030940

Summaries for LYZL2 Gene

Entrez Gene Summary for LYZL2 Gene

  • Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]

GeneCards Summary for LYZL2 Gene

LYZL2 (Lysozyme Like 2) is a Protein Coding gene. Diseases associated with LYZL2 include Dental Caries. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZL1.

Additional gene information for LYZL2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYZL2 Gene

Genomics for LYZL2 Gene

GeneHancer (GH) Regulatory Elements for LYZL2 Gene

Promoters and enhancers for LYZL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J030630 Enhancer 0.8 FANTOM5 Ensembl ENCODE 750.6 -1.0 -1039 1.6 MAFK ZNF316 EMSY LYZL2 lnc-MAP3K8-2 MAP3K8 ZNF438 HSALNG0077050
GH10J030629 Promoter 0.3 EPDnew 750.6 +0.0 14 0.1 LYZL2 lnc-MAP3K8-2
GH10J030605 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 0.3 +24.0 23961 2.4 MLX NR2F6 MIXL1 NFYC RERE ELF3 SP1 CEBPG TFE3 PPARG HSALNG0077046 lnc-MAP3K8-12 LYZL2
GH10J030638 Enhancer 0.9 FANTOM5 ENCODE 0.4 -8.5 -8505 0.2 PRDM1 FOSL2 CREB1 JUN JUND SP1 SCRT2 ZSCAN5C OSR2 SAP130 MAP3K8 ZNF438 HSALNG0077050 LYZL2
GH10J030611 Enhancer 0.9 ENCODE 0.4 +17.1 17111 1.5 LCORL MLX RBPJ NR2F6 ATF1 MIXL1 ELF3 SP1 MAFK CEBPG lnc-MAP3K8-12 HSALNG0077046 LYZL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYZL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYZL2 gene promoter:
  • c-Myb
  • CUTL1
  • En-1
  • FOXJ2 (long isoform)
  • HFH-1
  • Ik-3
  • RORalpha1
  • SRY
  • XBP-1

Genomic Locations for LYZL2 Gene

Genomic Locations for LYZL2 Gene
chr10:30,606,232-30,629,762
(GRCh38/hg38)
Size:
23,531 bases
Orientation:
Minus strand
chr10:30,900,708-30,918,691
(GRCh37/hg19)
Size:
17,984 bases
Orientation:
Minus strand

Genomic View for LYZL2 Gene

Genes around LYZL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL2 Gene

Proteins for LYZL2 Gene

  • Protein details for LYZL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4W2-LYZL2_HUMAN
    Recommended name:
    Lysozyme-like protein 2
    Protein Accession:
    Q7Z4W2
    Secondary Accessions:
    • Q6NZ69

    Protein attributes for LYZL2 Gene

    Size:
    148 amino acids
    Molecular mass:
    16656 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for LYZL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYZL2 Gene

Post-translational modifications for LYZL2 Gene

  • Glycosylation at Asn58
  • Modification sites at PhosphoSitePlus

Other Protein References for LYZL2 Gene

No data available for DME Specific Peptides for LYZL2 Gene

Domains & Families for LYZL2 Gene

Gene Families for LYZL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LYZL2 Gene

GenScript: Design optimal peptide antigens:
  • Lysozyme-like protein 2 (LYZL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4W2

UniProtKB/Swiss-Prot:

LYZL2_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL2: view

Function for LYZL2 Gene

Molecular function for LYZL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.

Enzyme Numbers (IUBMB) for LYZL2 Gene

Phenotypes From GWAS Catalog for LYZL2 Gene

Gene Ontology (GO) - Molecular Function for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with LYZL2: view
genes like me logo Genes that share phenotypes with LYZL2: view

Animal Model Products

CRISPR Products

miRNA for LYZL2 Gene

miRTarBase miRNAs that target LYZL2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYZL2 Gene

Localization for LYZL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL2 gene
Compartment Confidence
extracellular 3
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LYZL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYZL2 Gene

Pathways & Interactions for LYZL2 Gene

PathCards logo

SuperPathways for LYZL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0050829 defense response to Gram-negative bacterium IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
genes like me logo Genes that share ontologies with LYZL2: view

No data available for Pathways by source and SIGNOR curated interactions for LYZL2 Gene

Drugs & Compounds for LYZL2 Gene

(1) Drugs for LYZL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with LYZL2: view

Transcripts for LYZL2 Gene

mRNA/cDNA for LYZL2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL2

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL2 Gene

No ASD Table

Relevant External Links for LYZL2 Gene

GeneLoc Exon Structure for
LYZL2
ECgene alternative splicing isoforms for
LYZL2

Expression for LYZL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYZL2 Gene

mRNA differential expression in normal tissues according to GTEx for LYZL2 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of LYZL2 Gene:

LYZL2

SOURCE GeneReport for Unigene cluster for LYZL2 Gene:

Hs.522610

mRNA Expression by UniProt/SwissProt for LYZL2 Gene:

Q7Z4W2-LYZL2_HUMAN
Tissue specificity: Expressed in testis, epididymis and placenta.
genes like me logo Genes that share expression patterns with LYZL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZL2 Gene

Orthologs for LYZL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYZL2 33 32
  • 98.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LYZL1 33
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lyzl1 33
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lyz 32
  • 57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 33 32
  • 51.41 (n)
ManyToMany
LysB 33
  • 36 (a)
ManyToMany
LysD 33
  • 36 (a)
ManyToMany
LysC 33
  • 36 (a)
ManyToMany
LysS 33
  • 36 (a)
ManyToMany
LysP 33
  • 35 (a)
ManyToMany
LysE 33
  • 35 (a)
ManyToMany
LysX 33
  • 35 (a)
ManyToMany
CG7798 33
  • 32 (a)
ManyToMany
CG16756 33
  • 28 (a)
ManyToMany
CG30062 33
  • 27 (a)
ManyToMany
CG16799 33
  • 27 (a)
ManyToMany
CG8492 33
  • 4 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta LYSC4 32
  • 46.57 (n)
Species where no ortholog for LYZL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYZL2 Gene

ENSEMBL:
Gene Tree for LYZL2 (if available)
TreeFam:
Gene Tree for LYZL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYZL2: view image

Paralogs for LYZL2 Gene

Paralogs for LYZL2 Gene

(8) SIMAP similar genes for LYZL2 Gene using alignment to 1 proteins:

  • LYZL2_HUMAN
genes like me logo Genes that share paralogs with LYZL2: view

Variants for LYZL2 Gene

Sequence variations from dbSNP and Humsavar for LYZL2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000006710 -- 30,627,276(-) C/G intron_variant
rs1000052806 -- 30,605,915(-) A/T downstream_transcript_variant
rs1000117739 -- 30,621,557(-) TGTTGTT/TGTT genic_downstream_transcript_variant, intron_variant
rs1000171916 -- 30,624,714(-) G/A/T intron_variant
rs1000272050 -- 30,621,249(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LYZL2 Gene

Variant ID Type Subtype PubMed ID
esv1962669 CNV deletion 18987734
nsv1129323 OTHER inversion 24896259
nsv1161936 CNV duplication 26073780
nsv831822 CNV gain 17160897
nsv947811 CNV duplication 23825009

Variation tolerance for LYZL2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYZL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYZL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL2 Gene

Disorders for LYZL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LYZL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
- elite association - COSMIC cancer census association via MalaCards
Search LYZL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYZL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LYZL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYZL2 Gene

Publications for LYZL2 Gene

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. (PMID: 16014814) Zhang K … Yu L (Biology of reproduction 2005) 3 4 23 56
  2. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PMID: 18984674) Argyropoulos G … Rankinen T (Physiological genomics 2009) 3 43 56
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for LYZL2 Gene

Sources for LYZL2 Gene