Aliases for LYZL1 Gene

Aliases for LYZL1 Gene

  • Lysozyme Like 1 2 3 5
  • LYC2 2 3 4
  • Lysozyme-Like Protein 1 3 4
  • Lysozyme-Like 1 2
  • Lysozyme D1 3
  • EC 3.2.1.17 4
  • BA534G20.1 3
  • MGC33408 2
  • KAAG648 3
  • PRO1278 3
  • LYZD1 3
  • LYZL1 5

External Ids for LYZL1 Gene

Previous GeneCards Identifiers for LYZL1 Gene

  • GC10P029583
  • GC10P029618

Summaries for LYZL1 Gene

GeneCards Summary for LYZL1 Gene

LYZL1 (Lysozyme Like 1) is a Protein Coding gene. Diseases associated with LYZL1 include Nail Disorder, Nonsyndromic Congenital, 4 and Eumycotic Mycetoma. Among its related pathways are Salivary secretion. Gene Ontology (GO) annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZL2.

Additional gene information for LYZL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYZL1 Gene

Genomics for LYZL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LYZL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J029289 Promoter 0.3 EPDnew 600.7 +0.0 22 0.1 LYZL1 lnc-SVIL-5 SVIL
GH10J028675 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 -609.5 -609520 7.7 RNF2 ARHGAP35 SP1 HNRNPL ZNF629 PRDM10 LEF1 IKZF1 NFKBIZ KDM1A BAMBI WAC-AS1 RNU6-270P LYZL1 WAC piR-50444-041
GH10J029252 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 12.2 -33.5 -33517 5.6 PRDM10 ZNF629 ZNF512 LEF1 JUND ZIC2 PKNOX1 MTA1 PATZ1 HDAC1 LYZL1 C10orf126 RNU6-270P HSALNG0076961 BAMBI
GH10J029317 Enhancer 1.1 ENCODE CraniofacialAtlas 11.5 +29.8 29773 1.7 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 PRDM1 ZIC2 RBFOX2 RXRB PATZ1 lnc-SVIL-5 LYZL1 lnc-SVIL-4 SVIL
GH10J028734 Enhancer 1.1 Ensembl ENCODE 10.6 -554.0 -553950 1.8 GATAD2A PRDM10 ZNF629 RFX1 LEF1 IKZF1 RCOR2 JUND MTA2 PKNOX1 ENSG00000236716 RNU6-270P LYZL1 HSALNG0076923 piR-43105-049 BAMBI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYZL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYZL1

Top Transcription factor binding sites by QIAGEN in the LYZL1 gene promoter:
  • En-1
  • FOXD1
  • FOXF2
  • FOXL1
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • HSF2
  • POU2F1
  • POU2F1a

Genomic Locations for LYZL1 Gene

Genomic Locations for LYZL1 Gene
chr10:29,289,051-29,318,328
(GRCh38/hg38)
Size:
29,278 bases
Orientation:
Plus strand
chr10:29,577,990-29,607,257
(GRCh37/hg19)
Size:
29,268 bases
Orientation:
Plus strand

Genomic View for LYZL1 Gene

Genes around LYZL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYZL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYZL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZL1 Gene

Proteins for LYZL1 Gene

  • Protein details for LYZL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWQ5-LYZL1_HUMAN
    Recommended name:
    Lysozyme-like protein 1
    Protein Accession:
    Q6UWQ5
    Secondary Accessions:
    • Q5T921
    • Q8WW16

    Protein attributes for LYZL1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16654 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for LYZL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYZL1 Gene

Post-translational modifications for LYZL1 Gene

  • Glycosylation at Asn58
  • Modification sites at PhosphoSitePlus

Other Protein References for LYZL1 Gene

No data available for DME Specific Peptides for LYZL1 Gene

Domains & Families for LYZL1 Gene

Gene Families for LYZL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for LYZL1 Gene

Suggested Antigen Peptide Sequences for LYZL1 Gene

GenScript: Design optimal peptide antigens:
  • Lysozyme-like protein 1 (LYZL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWQ5

UniProtKB/Swiss-Prot:

LYZL1_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZL1: view

Function for LYZL1 Gene

Molecular function for LYZL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.

Enzyme Numbers (IUBMB) for LYZL1 Gene

Phenotypes From GWAS Catalog for LYZL1 Gene

Gene Ontology (GO) - Molecular Function for LYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with LYZL1: view
genes like me logo Genes that share phenotypes with LYZL1: view

Animal Models for LYZL1 Gene

MGI Knock Outs for LYZL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for LYZL1

CRISPR Products

miRNA for LYZL1 Gene

miRTarBase miRNAs that target LYZL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYZL1 Gene

Localization for LYZL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYZL1 gene
Compartment Confidence
extracellular 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LYZL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYZL1 Gene

Pathways & Interactions for LYZL1 Gene

PathCards logo

SuperPathways for LYZL1 Gene

SuperPathway Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with LYZL1: view

Pathways by source for LYZL1 Gene

1 KEGG pathway for LYZL1 Gene

Interacting Proteins for LYZL1 Gene

Gene Ontology (GO) - Biological Process for LYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0050829 defense response to Gram-negative bacterium IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
genes like me logo Genes that share ontologies with LYZL1: view

No data available for SIGNOR curated interactions for LYZL1 Gene

Drugs & Compounds for LYZL1 Gene

(2) Drugs for LYZL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0

(1) Additional Compounds for LYZL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dextrin
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
9004-53-9
genes like me logo Genes that share compounds with LYZL1: view

Transcripts for LYZL1 Gene

mRNA/cDNA for LYZL1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZL1

Alternative Splicing Database (ASD) splice patterns (SP) for LYZL1 Gene

No ASD Table

Relevant External Links for LYZL1 Gene

GeneLoc Exon Structure for
LYZL1

Expression for LYZL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYZL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZL1 Gene

This gene is overexpressed in Testis (x52.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYZL1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYZL1

SOURCE GeneReport for Unigene cluster for LYZL1 Gene:

Hs.558572
genes like me logo Genes that share expression patterns with LYZL1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZL1 Gene

Orthologs for LYZL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LYZL1 30 31
  • 98.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 86 (a)
OneToMany
LYZL1 30
  • 84.91 (n)
Cow
(Bos Taurus)
Mammalia LYZL1 30 31
  • 85.36 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Lyzl1 30 17 31
  • 81.53 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Lyzl1 30
  • 80.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 53 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta LYSC7 30
  • 53.38 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta LysC 31
  • 36 (a)
ManyToMany
LysE 31
  • 36 (a)
ManyToMany
LysS 31
  • 36 (a)
ManyToMany
LysD 31
  • 36 (a)
ManyToMany
LysP 31
  • 35 (a)
ManyToMany
LysB 31
  • 35 (a)
ManyToMany
LysX 31
  • 34 (a)
ManyToMany
CG11159 31
  • 34 (a)
ManyToMany
CG7798 31
  • 31 (a)
ManyToMany
CG16799 31
  • 28 (a)
ManyToMany
CG16756 31
  • 28 (a)
ManyToMany
CG30062 31
  • 27 (a)
ManyToMany
CG8492 31
  • 4 (a)
ManyToMany
Species where no ortholog for LYZL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LYZL1 Gene

ENSEMBL:
Gene Tree for LYZL1 (if available)
TreeFam:
Gene Tree for LYZL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYZL1: view image

Paralogs for LYZL1 Gene

Paralogs for LYZL1 Gene

(8) SIMAP similar genes for LYZL1 Gene using alignment to 2 proteins:

  • LYZL1_HUMAN
  • H0YDZ2_HUMAN
genes like me logo Genes that share paralogs with LYZL1: view

Variants for LYZL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYZL1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
769366 Benign: not provided 29,292,013(+) C/T
769367 Benign: not provided 29,292,015(+) C/A
rs3818551 - p.Gln62Pro

Additional dbSNP identifiers (rs#s) for LYZL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LYZL1 Gene

Variant ID Type Subtype PubMed ID
esv1963029 CNV deletion 18987734
esv2615964 CNV deletion 19546169
esv2734606 CNV deletion 23290073
esv2734905 CNV deletion 23290073
esv3546091 CNV deletion 23714750
esv3622764 CNV gain 21293372
esv3622767 CNV gain 21293372
nsv1047143 CNV gain 25217958
nsv1048531 CNV loss 25217958
nsv508574 CNV deletion 20534489
nsv517926 CNV loss 19592680
nsv526199 CNV loss 19592680
nsv831818 CNV gain 17160897

Variation tolerance for LYZL1 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYZL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYZL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZL1 Gene

Disorders for LYZL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LYZL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nail disorder, nonsyndromic congenital, 4
  • ndnc4
eumycotic mycetoma
  • eumycetoma
fraser syndrome 1
  • frasrs1
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search LYZL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYZL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LYZL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYZL1 Gene

Publications for LYZL1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 41
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for LYZL1 Gene

Sources for LYZL1 Gene