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This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacteri... See more...
Aliases for LYZ Gene
Aliases for LYZ Gene
External Ids for LYZ Gene
- HGNC: 6740
- Entrez Gene: 4069
- Ensembl: ENSG00000090382
- OMIM: 153450
- UniProtKB: P61626
Previous GeneCards Identifiers for LYZ Gene
- GC12M069521
- GC12P069681
- GC12P069458
- GC12P068028
- GC12P066791
Summaries for LYZ Gene
-
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
GeneCards Summary for LYZ Gene
LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include Amyloidosis, Familial Visceral and Al Amyloidosis. Among its related pathways are C-MYB transcription factor network and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA3.
UniProtKB/Swiss-Prot Summary for LYZ Gene
-
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Additional gene information for LYZ Gene
- HGNC(6740)
- Entrez Gene(4069)
- Ensembl(ENSG00000090382)
- OMIM(153450)
- UniProtKB(P61626)
- Open Targets Platform(ENSG00000090382)
- Monarch Initiative
- Search for LYZ at DataMed
- Search for LYZ at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYZ Gene
Genomics for LYZ Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LYZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LYZ on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYZ
- Top Transcription factor binding sites by QIAGEN in the LYZ gene promoter:
-
- AREB6
- C/EBPbeta
- CUTL1
- Evi-1
- FOXO1
- FOXO1a
- p53
- Sp1
- STAT3
Genomic Locations for LYZ Gene
Genomic Locations for LYZ Gene
- chr12:69,348,381-69,354,234
- (GRCh38/hg38)
- Size:
- 5,854 bases
- Orientation:
- Plus strand
- chr12:69,742,121-69,748,014
- (GRCh37/hg19)
- Size:
- 5,894 bases
- Orientation:
- Plus strand
Genomic View for LYZ Gene
Genes around LYZ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q15 by HGNC
- 12q15 by Entrez Gene
- 12q15 by Ensembl
LYZ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LYZ Gene
Proteins for LYZ Gene
-
Protein details for LYZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61626-LYSC_HUMAN
- Recommended name:
- Lysozyme C
- Protein Accession:
- P61626
- P00695
- Q13170
- Q9UCF8
Protein attributes for LYZ Gene
- Size:
- 148 amino acids
- Molecular mass:
- 16537 Da
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=CAA32175.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Protein Expression for LYZ Gene
Selected DME Specific Peptides for LYZ Gene
- P61626:
-
- ALLQDNIADAV
- QINSRYWC
- CAKRVVRDPQG
- GKTPGAVNAC
- GIRAWVAW
- SLANWMCL
- CELARTL
- WCNDGKT
- DYGIFQIN
- LLSVTVQGK
- VQGKVFERCELAR
- AWVAWRN
- CLAKWES
- YNTRATN
- DGYRGISLA
- AVACAKRVV
- LGLVLLSV
Post-translational modifications for LYZ Gene
Other Protein References for LYZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Lysosome (AS1A22) monoclonal antibody and Immunotag™ LYZ Antibody
- NSJ Bioreagents Lysozyme Antibody / LYZ
-
Custom Antibody ServicesOriGene Antibodies for LYZ
- AP08130PU-N
- AP08130PU-S
- AP10434PU-N
- AP26396PU-N
- AP31591PU-N
- AP31591PU-S
- AP32827AF-N
- AP32827BT-N
- AP32827FC-N
- AP32827HR-N
- AP32827SU-N
- AP33372SU-N
- AP33372SU-S
- BM003
- BM5023
- BM584
- CF506191
- CF506192
- CF506197
- R1098
- TA307736
- TA321092
- TA321093
- TA327697
- TA342900
- TA342901
- TA506191
- TA506191S
- TA506192
- TA506192S
- TA506197
- TA506197S
- Novus Biologicals Antibodies for LYZ
-
Abcam antibodies for LYZ
- Invitrogen Antibodies for LYZ (AFLGC-LYZ)
-
Santa Cruz Biotechnology (SCBT) Antibodies for LYZ
Protein Products
- G Biosciences Human Lysozyme C/LYZ, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for LYZ
- Origene Custom Protein Services for LYZ
- antibodies-online: Show 62 available LYZ Proteins ranked by validation data
- Compare Top LYZ Proteins
-
ProSci Proteins for LYZ
-
Abcam proteins for LYZ
Assay Products
- G Biosciences Immunotag™ Human LZMg (Lysozyme G) ELISA and Immunotag™ Lysozyme C ELISA Kit
-
Custom Assay ServicesOriGene ELISA Kits for LYZ
- Novus Biologicals ELISA Kits for LYZ
- antibodies-online: Show 78 available LYZ Elisa Kits ranked by validation data
- Compare Top LYZ Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for LYZ
-
Abcam assays for LYZ
Domains & Families for LYZ Gene
Gene Families for LYZ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for LYZ Gene
- InterPro:
- Blocks:
-
- Lysozyme signature
- ProtoNet:
Suggested Antigen Peptide Sequences for LYZ Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92040, Homo sapiens lysozyme (renal amyloidosis) (LYZ), mRNA (B2R4C5_HUMAN)
- 1,4-beta-N-acetylmuramidase C (LYSC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61626- Family:
-
- Belongs to the glycosyl hydrolase 22 family.
Function for LYZ Gene
Molecular function for LYZ Gene
- UniProtKB/Swiss-Prot Function:
- Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;.
- GENATLAS Biochemistry:
- lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram- bacteria
Enzyme Numbers (IUBMB) for LYZ Gene
Phenotypes From GWAS Catalog for LYZ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003796 | lysozyme activity | IEA,TAS | 2829884 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 23353684 |
Phenotypes for LYZ Gene
- MGI mutant phenotypes for LYZ:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for LYZ:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased the percentage of infected cells
- Increased cell death in HCC-1954 cells
- Decreased melanin production
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LYZ - Select products 50% OFF >
- * LYZ CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LYZ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYZ
miRNA for LYZ Gene
- miRTarBase miRNAs that target LYZ
-
- hsa-miR-26b-5p (MIRT030049)
- bta-miR-15b (MIRT053812)
- bta-miR-16a (MIRT053837)
- bta-miR-223 (MIRT054008)
- hsa-miR-4668-5p (MIRT696206)
- hsa-miR-6720-5p (MIRT696207)
- hsa-miR-7703 (MIRT696208)
- hsa-miR-6512-3p (MIRT696209)
- hsa-miR-6729-5p (MIRT696210)
- hsa-miR-4649-5p (MIRT696211)
- hsa-miR-1273a (MIRT696212)
- hsa-miR-661 (MIRT696213)
- hsa-miR-873-3p (MIRT696214)
- hsa-miR-4486 (MIRT696215)
- hsa-miR-766-3p (MIRT696216)
- hsa-miR-372-5p (MIRT696217)
- hsa-miR-371a-5p (MIRT696218)
- hsa-miR-616-5p (MIRT696219)
- hsa-miR-373-5p (MIRT696220)
- hsa-miR-371b-5p (MIRT696221)
- hsa-miR-939-3p (MIRT696222)
- hsa-miR-6849-3p (MIRT696223)
- hsa-miR-3613-3p (MIRT696224)
- hsa-miR-508-5p (MIRT696225)
- hsa-miR-1247-3p (MIRT761551)
- hsa-miR-1273g-3p (MIRT761957)
- hsa-miR-3689d (MIRT767076)
- hsa-miR-377-5p (MIRT767424)
- hsa-miR-4252 (MIRT768014)
- hsa-miR-4537 (MIRT770171)
- hsa-miR-455-3p (MIRT770360)
- hsa-miR-4793-3p (MIRT772402)
- hsa-miR-5186 (MIRT773502)
- hsa-miR-6086 (MIRT775555)
- hsa-miR-6134 (MIRT775950)
- hsa-miR-6499-3p (MIRT776301)
- hsa-miR-6516-5p (MIRT777157)
- hsa-miR-6799-5p (MIRT779422)
- hsa-miR-6851-5p (MIRT780414)
- hsa-miR-6880-5p (MIRT780837)
- hsa-miR-7847-3p (MIRT782153)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYZ
- Browse OriGene Inhibitory RNA Products For LYZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZ
Clone Products
- Applied Biological Materials (abm): Clones for LYZ - Select products 50% OFF >
- * LYZ as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LYZ
- Addgene plasmids for LYZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYZ
Cell Line Products
-
Horizon Cell Lines for LYZ
No data available for Transcription Factor Targets and HOMER Transcription for LYZ Gene
Localization for LYZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for LYZ Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (3)
- Actin filaments (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS | 2829884 |
| GO:0035578 | azurophil granule lumen | TAS | -- |
| GO:0035580 | specific granule lumen | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for LYZ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Salivary secretion | ||
| 3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 4 | Defensins | ||
| 5 | Metabolism of proteins | ||
Pathways by source for LYZ Gene
1 BioSystems pathway for LYZ Gene
6 Reactome pathways for LYZ Gene
1 KEGG pathway for LYZ Gene
Interacting Proteins for LYZ Gene
Selected Interacting proteins:
P61626-LYSC_HUMAN
ENSP00000261267
for LYZ Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LYZ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001895 | retina homeostasis | HEP | 23580065 |
| GO:0006954 | inflammatory response | TAS | 366724 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0019730 | antimicrobial humoral response | TAS | -- |
| GO:0019835 | cytolysis | IEA | -- |
Drugs & Compounds for LYZ Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Propyl alcohol | Approved, Experimental | Pharma | Target | 0 | ||
| Aspartic acid | Approved | Nutra | Target | 182 | ||
| Furan | Approved, Experimental, Investigational | Pharma | Target | 0 | ||
| Rose bengal | Approved, Investigational | Pharma | Enzyme, ligand | VGlut and vesicular monoamine transporter (VMAT) inhibitor, Potent VGlut and VMAT inhibitor; cell permeable | 0 | |
| N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for LYZ Gene
| Compound | Action | Cas Number |
|---|---|---|
| egg white lysozyme (19-36) [Gallus gallus] | Dissolution of cell wall |
Transcripts for LYZ Gene
mRNA/cDNA for LYZ Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261267 1490 nts (view in UCSC)
- ENST00000548839 558 nts (view in UCSC)
- ENST00000549690 669 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LYZ - Select products 50% OFF >
- * LYZ CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LYZ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYZ
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYZ
- Browse OriGene Inhibitory RNA Products For LYZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZ
Clone Products
- Applied Biological Materials (abm): Clones for LYZ - Select products 50% OFF >
- * LYZ as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LYZ
- Addgene plasmids for LYZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYZ
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | |||||||||||
| SP3: |
Relevant External Links for LYZ Gene
- GeneLoc Exon Structure for
- LYZ
Expression for LYZ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Double Negative 2 Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Double Negative 2 Thymocytes Thymus
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Endothelium (Cardiovascular System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Tonsil (Hematopoietic System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for LYZ Gene
This gene is overexpressed in Whole Blood (x27.8) and Minor Salivary Gland (x14.6).
This gene is overexpressed in Milk (31.8), Neutrophil (11.0), and Saliva (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LYZ Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYZ
SOURCE GeneReport for Unigene cluster for LYZ Gene:
Hs.524579Evidence on tissue expression from TISSUES for LYZ Gene
- Intestine(4.9)
- Eye(4.8)
- Blood(4.5)
- Stomach(4.5)
- Urine(4.4)
- Lung(3.9)
- Bone marrow(3.9)
- Spleen(3.5)
- Lymph node(3.4)
- Skin(3.2)
- Liver(3)
- Kidney(3)
- Heart(2.8)
- Gall bladder(2.8)
- Muscle(2.8)
- Nervous system(2.7)
- Bone(2.4)
- Thyroid gland(2.4)
- Pancreas(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LYZ Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- urinary
Regions:
Head and neck:
- ear
- eye
- head
- mouth
Thorax:
- heart
- lung
Abdomen:
- abdominal wall
- biliary tract
- gallbladder
- kidney
- liver
- pancreas
- spleen
Pelvis:
- ureter
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for LYZ
-
OriGene qPCR primer pairs and template standards for LYZ
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for LYZ Gene
Orthologs for LYZ Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LYZ 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LYZ 30 31 |
|
OneToMany | |
| LYZ1 31 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| LYSB 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| LYZ3 31 |
|
OneToMany | |||
| LYZ2 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | LYZ 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lyz2 30 17 31 |
|
OneToMany | |
| Lyz1 17 31 |
|
OneToMany | |||
| 9530003J23Rik 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Lyz2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LYZ 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | LYZ 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LYZ 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492798 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | LysE 31 |
|
ManyToMany | |
| CG7798 31 |
|
ManyToMany | |||
| LysB 31 |
|
ManyToMany | |||
| LysD 31 |
|
ManyToMany | |||
| LysS 31 |
|
ManyToMany | |||
| LysC 31 |
|
ManyToMany | |||
| LysP 31 |
|
ManyToMany | |||
| LysX 31 |
|
ManyToMany | |||
| CG16756 31 |
|
ManyToMany | |||
| CG11159 31 |
|
ManyToMany | |||
| CG30062 31 |
|
ManyToMany | |||
| CG16799 31 |
|
ManyToMany | |||
| CG8492 31 |
|
ManyToMany |
- Species where no ortholog for LYZ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LYZ Gene
- ENSEMBL:
- Gene Tree for LYZ (if available)
- TreeFam:
- Gene Tree for LYZ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LYZ: view image
Paralogs for LYZ Gene
Variants for LYZ Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYZ Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 722403 | Likely Benign: not provided | 69,353,206(+) | G/A | MISSENSE_VARIANT | |
| 881352 | Benign: Familial visceral amyloidosis, Ostertag type | 69,353,485(+) | G/A | THREE_PRIME_UTR_VARIANT | |
| 881353 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,485(+) | G/C | THREE_PRIME_UTR_VARIANT | |
| 881354 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,519(+) | C/T | THREE_PRIME_UTR_VARIANT | |
| 881355 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,528(+) | G/A | THREE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.23;
40.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LYZ Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYZ Gene
Disorders for LYZ Gene
(12) MalaCards diseases for LYZ Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyloidosis, familial visceral |
|
|
| al amyloidosis |
|
|
| amyloidosis |
|
|
| meningitis |
|
|
| microscopic colitis |
|
|
Search LYZ in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LYSC_HUMAN- Amyloidosis 8 (AMYL8) [MIM:105200]: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. {ECO:0000269 PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LYZ
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LYZ Gene
Publications for LYZ Gene
- Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. (PMID: 18591461) Turner ST … Boerwinkle E (Hypertension (Dallas, Tex. : 1979) 2008) 3 23 41
- Human lysozyme gene mutations cause hereditary systemic amyloidosis. (PMID: 8464497) Pepys MB … Terry CJ (Nature 1993) 2 3 4
- The human lysozyme gene. Sequence organization and chromosomal localization. (PMID: 2546758) Peters CW … Sippel AE (European journal of biochemistry 1989) 2 3 4
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 41
- A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 41
ExternalLinks
Products for LYZ Gene
- Custom Antibody ServicesOriGene Antibodies for LYZ
- AP08130PU-N
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- AP10434PU-N
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- AP32827AF-N
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- AP32827HR-N
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- AP33372SU-N
- AP33372SU-S
- BM003
- BM5023
- BM584
- CF506191
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- R1098
- TA307736
- TA321092
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- TA342900
- TA342901
- TA506191
- TA506191S
- TA506192
- TA506192S
- TA506197
- TA506197S
- Custom Assay ServicesOriGene ELISA Kits for LYZ
- Search Origene for MassSpec and Protein Over-expression Lysates for LYZ
- Origene Custom Protein Services for LYZ
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYZ
- Browse OriGene Inhibitory RNA Products For LYZ
- OriGene qPCR primer pairs for LYZ
- OriGene qPCR primer pairs and template standards for LYZ
- OriGene CRISPR knockouts for LYZ
- OriGene ORF clones in human for LYZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for LYZ
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for LYZ
- Novus Biologicals ELISA Kits for LYZ
- Browse Antibodies
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- Invitrogen Antibodies for LYZ (AFLGC-LYZ)
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- VectorBuilder Custom and pre-made DNA vectors for LYZ (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LYZ (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LYZ (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LYZ CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LYZ
- Addgene plasmids for LYZ
- antibodies-online: Show 103 available LYZ Antibodies ranked by validation data
- Compare Top LYZ Antibodies
- antibodies-online: Show 78 available LYZ Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 62 available LYZ Proteins ranked by validation data
- Compare Top LYZ Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for LYZ
- Search Santa Cruz Biotechnology (SCBT) for LYZ siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LYZ
- Search for LYZ Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for LYZ
- Horizon Cell Lines for LYZ
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYZ
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LYZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYZ
Sources for LYZ Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB