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This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include Amyloidosis, Familial Visceral and Al Amyloidosis. Among its related pathways are C-MYB transcription factor network and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003796 | lysozyme activity | IEA,TAS | 2829884 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
GO:0042802 | identical protein binding | IPI | 23353684 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS | 2829884 |
GO:0035578 | azurophil granule lumen | TAS | -- |
GO:0035580 | specific granule lumen | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Salivary secretion | ||
3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
4 | Defensins | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001895 | retina homeostasis | HEP | 23580065 |
GO:0006954 | inflammatory response | TAS | 366724 |
GO:0008152 | metabolic process | IEA | -- |
GO:0019730 | antimicrobial humoral response | TAS | -- |
GO:0019835 | cytolysis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Propyl alcohol | Approved, Experimental | Pharma | Target | 0 | ||
Aspartic acid | Approved | Nutra | Target | 182 | ||
Furan | Approved, Experimental, Investigational | Pharma | Target | 0 | ||
Rose bengal | Approved, Investigational | Pharma | Enzyme, ligand | VGlut and vesicular monoamine transporter (VMAT) inhibitor, Potent VGlut and VMAT inhibitor; cell permeable | 0 | |
N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
egg white lysozyme (19-36) [Gallus gallus] | Dissolution of cell wall |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | |||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LYZ 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LYZ 30 31 |
|
OneToMany | |
LYZ1 31 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
LYSB 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
LYZ3 31 |
|
OneToMany | |||
LYZ2 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | LYZ 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lyz2 30 17 31 |
|
OneToMany | |
Lyz1 17 31 |
|
OneToMany | |||
9530003J23Rik 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Lyz2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | LYZ 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | LYZ 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LYZ 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492798 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | LysE 31 |
|
ManyToMany | |
CG7798 31 |
|
ManyToMany | |||
LysB 31 |
|
ManyToMany | |||
LysD 31 |
|
ManyToMany | |||
LysS 31 |
|
ManyToMany | |||
LysC 31 |
|
ManyToMany | |||
LysP 31 |
|
ManyToMany | |||
LysX 31 |
|
ManyToMany | |||
CG16756 31 |
|
ManyToMany | |||
CG11159 31 |
|
ManyToMany | |||
CG30062 31 |
|
ManyToMany | |||
CG16799 31 |
|
ManyToMany | |||
CG8492 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
722403 | Likely Benign: not provided | 69,353,206(+) | G/A | MISSENSE_VARIANT | |
881352 | Benign: Familial visceral amyloidosis, Ostertag type | 69,353,485(+) | G/A | THREE_PRIME_UTR_VARIANT | |
881353 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,485(+) | G/C | THREE_PRIME_UTR_VARIANT | |
881354 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,519(+) | C/T | THREE_PRIME_UTR_VARIANT | |
881355 | Uncertain Significance: Familial visceral amyloidosis, Ostertag type | 69,353,528(+) | G/A | THREE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
amyloidosis, familial visceral |
|
|
al amyloidosis |
|
|
amyloidosis |
|
|
meningitis |
|
|
microscopic colitis |
|
|