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Aliases for LYVE1 Gene

Aliases for LYVE1 Gene

  • Lymphatic Vessel Endothelial Hyaluronan Receptor 1 2 3 5
  • Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 3 4
  • Extracellular Link Domain-Containing Protein 1 3 4
  • Hyaluronic Acid Receptor 3 4
  • CRSBP-1 3 4
  • LYVE-1 3 4
  • XLKD1 3 4
  • HAR 3 4
  • Cell Surface Retention Sequence Binding Protein-1 3
  • Cell Surface Retention Sequence-Binding Protein 1 4
  • Extracellular Link Domain-Containing 1 3
  • Extracellular Link Domain Containing 1 2
  • CRSBP1 4

External Ids for LYVE1 Gene

Previous HGNC Symbols for LYVE1 Gene

  • XLKD1

Previous GeneCards Identifiers for LYVE1 Gene

  • GC11M010536
  • GC11M010251
  • GC11M010578
  • GC11M010605
  • GC11M010579
  • GC11M010585
  • GC11M010591
  • GC11M010598

Summaries for LYVE1 Gene

Entrez Gene Summary for LYVE1 Gene

  • This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYVE1 Gene

LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) is a Protein Coding gene. Diseases associated with LYVE1 include Androgen Insensitivity Syndrome and Complete Androgen Insensitivity Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Cell adhesion_Cell-matrix glycoconjugates. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is CD44.

UniProtKB/Swiss-Prot for LYVE1 Gene

  • Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Gene Wiki entry for LYVE1 Gene

Additional gene information for LYVE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYVE1 Gene

Genomics for LYVE1 Gene

GeneHancer (GH) Regulatory Elements for LYVE1 Gene

Promoters and enhancers for LYVE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J010563 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 611.9 +45.1 45071 5.7 CTCF SP1 SMARCA4 ARID2 IKZF1 ZIC2 REST PKNOX1 ZNF316 CEBPB LYVE1 MRVI1-AS1 MRVI1 RNF141 GC11M010611
GH11J010611 Enhancer 1 FANTOM5 ENCODE dbSUPER 600.7 -0.9 -893 1.7 RNF2 RFX1 IKZF1 SMARCA4 POLR2A CBX8 SMARCA5 LYVE1 RNF141 MRVI1-AS1 MRVI1 AMPD3 SBF2 GC11M010667
GH11J010348 Enhancer 1.9 VISTA FANTOM5 ENCODE dbSUPER 13.6 +259.5 259456 7.6 SP1 ELF3 CBFA2T2 CEBPG ZSCAN21 BACH1 TFE3 SP7 PPARG PRDM1 LYVE1 MRVI1 SBF2 ADM EIF4G2 AMPD3 PIR60970 CAND1.11 GC11M010399 RNU6ATAC33P
GH11J010651 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -45.1 -45074 9.9 SP1 ZFX ELF3 CC2D1A CTCF CBFA2T2 CEBPG RERE ZNF687 AHR MRVI1 LYVE1 CTR9 MTRNR2L8 MRVI1-AS1 ADM GC11M010667 GC11M010630
GH11J010454 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 +154.4 154420 6.4 CC2D1A SP1 ZFX CBFA2T2 ZNF148 GTF2F1 ZNF687 CDC5L TRIM24 RELA AMPD3 CTR9 MTRNR2L8 LYVE1 MRVI1 GC11M010466 GC11P010430
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYVE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYVE1 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha
  • HOXA5
  • Lmo2
  • MZF-1
  • Nkx2-5

Genomic Locations for LYVE1 Gene

Genomic Locations for LYVE1 Gene
chr11:10,556,966-10,611,689
(GRCh38/hg38)
Size:
54,724 bases
Orientation:
Minus strand
chr11:10,578,513-10,633,236
(GRCh37/hg19)
Size:
54,724 bases
Orientation:
Minus strand

Genomic View for LYVE1 Gene

Genes around LYVE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYVE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYVE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYVE1 Gene

Proteins for LYVE1 Gene

  • Protein details for LYVE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y7-LYVE1_HUMAN
    Recommended name:
    Lymphatic vessel endothelial hyaluronic acid receptor 1
    Protein Accession:
    Q9Y5Y7
    Secondary Accessions:
    • Q8TC18
    • Q9UNF4

    Protein attributes for LYVE1 Gene

    Size:
    322 amino acids
    Molecular mass:
    35213 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).

neXtProt entry for LYVE1 Gene

Post-translational modifications for LYVE1 Gene

  • O-glycosylated.
  • Glycosylation at isoforms=130 and posLast=5353
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LYVE1_HUMAN (734)

Other Protein References for LYVE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Abcam proteins for LYVE1

No data available for DME Specific Peptides for LYVE1 Gene

Domains & Families for LYVE1 Gene

Gene Families for LYVE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for LYVE1 Gene

Suggested Antigen Peptide Sequences for LYVE1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92817, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA (B2R672_HUMAN)
  • Hyaluronic acid receptor (LYVE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LYVE1: view

No data available for UniProtKB/Swiss-Prot for LYVE1 Gene

Function for LYVE1 Gene

Molecular function for LYVE1 Gene

UniProtKB/Swiss-Prot Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Phenotypes From GWAS Catalog for LYVE1 Gene

Gene Ontology (GO) - Molecular Function for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0005540 hyaluronic acid binding IBA 21873635
GO:0038023 signaling receptor activity TAS 10037799
genes like me logo Genes that share ontologies with LYVE1: view
genes like me logo Genes that share phenotypes with LYVE1: view

Animal Models for LYVE1 Gene

MGI Knock Outs for LYVE1:

Animal Model Products

  • Taconic Biosciences Mouse Models for LYVE1

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for LYVE1 - Now 50% OFF >
  • * LYVE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LYVE1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYVE1 Gene

Localization for LYVE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYVE1 Gene

Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYVE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 10037799
GO:0016020 membrane IEA,TAS 10037799
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with LYVE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYVE1 Gene

Pathways & Interactions for LYVE1 Gene

genes like me logo Genes that share pathways with LYVE1: view

Pathways by source for LYVE1 Gene

Gene Ontology (GO) - Biological Process for LYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006027 glycosaminoglycan catabolic process IEA --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 10037799
GO:0009611 response to wounding TAS 10037799
GO:0009653 anatomical structure morphogenesis TAS 10037799
genes like me logo Genes that share ontologies with LYVE1: view

No data available for SIGNOR curated interactions for LYVE1 Gene

Drugs & Compounds for LYVE1 Gene

(17) Drugs for LYVE1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 659

(17) Additional Compounds for LYVE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LYVE1: view

Transcripts for LYVE1 Gene

mRNA/cDNA for LYVE1 Gene

Unigene Clusters for LYVE1 Gene

Lymphatic vessel endothelial hyaluronan receptor 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for LYVE1 - Now 50% OFF >
  • * LYVE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LYVE1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for LYVE1 Gene

No ASD Table

Relevant External Links for LYVE1 Gene

GeneLoc Exon Structure for
LYVE1
ECgene alternative splicing isoforms for
LYVE1

Expression for LYVE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYVE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYVE1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.4) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for LYVE1 Gene

This gene is overexpressed in Urine (15.0), Serum (12.8), Plasma (11.2), and Synovial fluid (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYVE1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LYVE1 Gene:

LYVE1

SOURCE GeneReport for Unigene cluster for LYVE1 Gene:

Hs.655332

mRNA Expression by UniProt/SwissProt for LYVE1 Gene:

Q9Y5Y7-LYVE1_HUMAN
Tissue specificity: Mainly expressed in endothelial cells lining lymphatic vessels.

Evidence on tissue expression from TISSUES for LYVE1 Gene

  • Liver(4.5)
  • Bone marrow(4.3)
  • Heart(3.6)
  • Spleen(3.1)
  • Lymph node(2.8)
  • Muscle(2.7)
  • Lung(2.5)
  • Blood(2.4)
  • Nervous system(2.4)
  • Intestine(2.2)
  • Kidney(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with LYVE1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYVE1 Gene

Orthologs for LYVE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LYVE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYVE1 35 34
  • 98.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LYVE1 35 34
  • 85.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LYVE1 35 34
  • 80.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lyve1 17 35 34
  • 76.94 (n)
rat
(Rattus norvegicus)
Mammalia Lyve1 34
  • 76.54 (n)
oppossum
(Monodelphis domestica)
Mammalia LYVE1 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves LYVE1 35 34
  • 52.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYVE1 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lyve1 34
  • 49.24 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC560618 34
  • 44.49 (n)
lyve1b 35
  • 21 (a)
OneToMany
LYVE1 (2 of 2) 35
  • 20 (a)
OneToMany
Species where no ortholog for LYVE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYVE1 Gene

ENSEMBL:
Gene Tree for LYVE1 (if available)
TreeFam:
Gene Tree for LYVE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYVE1: view image

Paralogs for LYVE1 Gene

Paralogs for LYVE1 Gene

(1) SIMAP similar genes for LYVE1 Gene using alignment to 3 proteins:

  • LYVE1_HUMAN
  • E7EPC7_HUMAN
  • F2Z296_HUMAN
genes like me logo Genes that share paralogs with LYVE1: view

Variants for LYVE1 Gene

Sequence variations from dbSNP and Humsavar for LYVE1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000007875 -- 10,568,554(-) A/C 5_prime_UTR_variant
rs1000302694 -- 10,570,008(-) C/T upstream_transcript_variant
rs1000716275 -- 10,563,195(-) C/T intron_variant
rs1001447689 -- 10,566,517(-) C/G/T intron_variant
rs1001591093 -- 10,563,715(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LYVE1 Gene

Variant ID Type Subtype PubMed ID
nsv7675 CNV insertion 18451855
nsv819020 CNV loss 19587683

Variation tolerance for LYVE1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYVE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYVE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYVE1 Gene

Disorders for LYVE1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for LYVE1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
androgen insensitivity syndrome
  • ais
complete androgen insensitivity syndrome
  • testicular feminization
bladder sarcoma
  • sarcoma of bladder
capillary lymphangioma
  • cutaneous lymphangioma
androgen insensitivity, partial
  • pais
- elite association - COSMIC cancer census association via MalaCards
Search LYVE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYVE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LYVE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYVE1 Gene

Publications for LYVE1 Gene

  1. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. (PMID: 10037799) Banerji S … Jackson DG (The Journal of cell biology 1999) 2 3 4 23 58
  2. Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers. (PMID: 19908110) Arimoto J … Ueda M (Journal of gastroenterology 2010) 3 23 58
  3. [Expression of lymphatic vessel endothelial hyaluronan receptor-1 in human colorectal cancer and its clinical significance]. (PMID: 19742347) Li ZX … Fan YZ (Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2009) 3 23 58
  4. Candidate gene analysis in primary lymphedema. (PMID: 18564921) Ferrell RE … Finegold DN (Lymphatic research and biology 2008) 3 45 58
  5. Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. (PMID: 18181096) Ishikawa Y … Toho Study Group for Cancer Biological Behavior (Cancer 2008) 3 23 58

Products for LYVE1 Gene

  • Boster Bio Antibodies for LYVE1
  • Boster Bio ELISA Kits for LYVE1

Sources for LYVE1 Gene

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