Aliases for LYVE1 Gene
External Ids for LYVE1 Gene
Previous HGNC Symbols for LYVE1 Gene
Previous GeneCards Identifiers for LYVE1 Gene
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
GeneCards Summary for LYVE1 Gene
LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) is a Protein Coding gene. Diseases associated with LYVE1 include Intramuscular Hemangioma and Complete Androgen Insensitivity Syndrome. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is CD44.
UniProtKB/Swiss-Prot Summary for LYVE1 Gene
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.