Aliases for LYVE1 Gene
External Ids for LYVE1 Gene
Previous HGNC Symbols for LYVE1 Gene
Previous GeneCards Identifiers for LYVE1 Gene
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
GeneCards Summary for LYVE1 Gene
LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) is a Protein Coding gene. Diseases associated with LYVE1 include Complete Androgen Insensitivity Syndrome and Androgen Insensitivity Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Cell adhesion_Cell-matrix glycoconjugates. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is CD44.
UniProtKB/Swiss-Prot Summary for LYVE1 Gene
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.