Aliases for LYST Gene
External Ids for LYST Gene
Previous HGNC Symbols for LYST Gene
Previous GeneCards Identifiers for LYST Gene
This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
GeneCards Summary for LYST Gene
LYST (Lysosomal Trafficking Regulator) is a Protein Coding gene. Diseases associated with LYST include Chediak-Higashi Syndrome and Attenuated Chédiak-Higashi Syndrome. Gene Ontology (GO) annotations related to this gene include binding and phospholipid binding. An important paralog of this gene is NBEAL2.
UniProtKB/Swiss-Prot for LYST Gene
May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.