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Aliases for LYRM9 Gene

Aliases for LYRM9 Gene

  • LYR Motif Containing 9 2 3 5
  • C17orf108 3 4
  • Chromosome 17 Open Reading Frame 108 2
  • LYR Motif-Containing Protein 9 3
  • UPF0631 Protein C17orf108 3
  • HSD24 3

External Ids for LYRM9 Gene

Previous HGNC Symbols for LYRM9 Gene

  • C17orf108

Previous GeneCards Identifiers for LYRM9 Gene

  • GC17M026206

Summaries for LYRM9 Gene

GeneCards Summary for LYRM9 Gene

LYRM9 (LYR Motif Containing 9) is a Protein Coding gene. An important paralog of this gene is ENSG00000266202.

Additional gene information for LYRM9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYRM9 Gene

Genomics for LYRM9 Gene

GeneHancer (GH) Regulatory Elements for LYRM9 Gene

Promoters and enhancers for LYRM9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I027892 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.4 1364 2 PKNOX1 SMAD1 ATF1 SIN3A ZNF143 KLF7 ATF7 REST ZNF592 KAT8 ENSG00000266202 GC17M027891 LYRM9 NOS2
GH17I027884 Promoter 0.5 EPDnew 550.4 +10.4 10373 0.1 GC17P027886 LYRM9 NOS2 ENSG00000266202 ENSG00000266527
GH17I027984 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.4 -91.5 -91450 3.4 PKNOX1 SMAD1 ARNT ZNF766 E2F8 REST ZNF592 MEF2D SMARCA4 NBN LYRM9 NLK ENSG00000251818 ENSG00000202389 LINC01992 GC17M027891
GH17I027809 Enhancer 1 FANTOM5 ENCODE 16.6 +83.5 83465 2.9 ZNF146 IRF2 BACH1 EBF1 BATF IRF4 POLR2A STAT2 ATF7 ETV6 LYRM9 NOS2 LGALS9 ENSG00000266527 ENSG00000266202
GH17I027807 Enhancer 1.1 FANTOM5 Ensembl ENCODE 14.8 +86.3 86320 1.9 HDAC1 IRF2 ZMYM3 EBF1 ZBTB40 IRF4 RELA CTBP1 POLR2A RUNX3 LYRM9 NOS2 ENSG00000266527 ENSG00000266202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LYRM9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LYRM9 Gene

Genomic Locations for LYRM9 Gene
chr17:27,878,314-27,894,752
(GRCh38/hg38)
Size:
16,439 bases
Orientation:
Minus strand
chr17:26,205,340-26,221,778
(GRCh37/hg19)

Genomic View for LYRM9 Gene

Genes around LYRM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYRM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYRM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYRM9 Gene

Proteins for LYRM9 Gene

  • Protein details for LYRM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MSI8-LYRM9_HUMAN
    Recommended name:
    LYR motif-containing protein 9
    Protein Accession:
    A8MSI8
    Secondary Accessions:
    • A6NJT7
    • Q6X7B8

    Protein attributes for LYRM9 Gene

    Size:
    78 amino acids
    Molecular mass:
    9374 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP20058.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW51051.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LYRM9 Gene

Post-translational modifications for LYRM9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LYRM9 Gene

Domains & Families for LYRM9 Gene

Gene Families for LYRM9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYRM9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LYRM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MSI8

UniProtKB/Swiss-Prot:

LYRM9_HUMAN :
  • Belongs to the complex I LYR family. LYRM9 subfamily.
Family:
  • Belongs to the complex I LYR family. LYRM9 subfamily.
genes like me logo Genes that share domains with LYRM9: view

Function for LYRM9 Gene

Phenotypes From GWAS Catalog for LYRM9 Gene

Phenotypes for LYRM9 Gene

genes like me logo Genes that share phenotypes with LYRM9: view

Animal Models for LYRM9 Gene

MGI Knock Outs for LYRM9:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYRM9 Gene

Localization for LYRM9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYRM9 gene
Compartment Confidence
mitochondrion 3
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LYRM9 Gene

Pathways & Interactions for LYRM9 Gene

SuperPathways for LYRM9 Gene

No Data Available

Interacting Proteins for LYRM9 Gene

Gene Ontology (GO) - Biological Process for LYRM9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LYRM9 Gene

Drugs & Compounds for LYRM9 Gene

No Compound Related Data Available

Transcripts for LYRM9 Gene

Unigene Clusters for LYRM9 Gene

LYR motif containing 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYRM9 Gene

No ASD Table

Relevant External Links for LYRM9 Gene

GeneLoc Exon Structure for
LYRM9
ECgene alternative splicing isoforms for
LYRM9

Expression for LYRM9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYRM9 Gene

Protein differential expression in normal tissues from HIPED for LYRM9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.1) and Frontal cortex (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYRM9 Gene



NURSA nuclear receptor signaling pathways regulating expression of LYRM9 Gene:

LYRM9

SOURCE GeneReport for Unigene cluster for LYRM9 Gene:

Hs.687951
genes like me logo Genes that share expression patterns with LYRM9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYRM9 Gene

Orthologs for LYRM9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LYRM9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYRM9 33
  • 99.15 (n)
-- 34
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
LYRM9 33
  • 94.44 (n)
cow
(Bos Taurus)
Mammalia LYRM9 33 34
  • 90.6 (n)
mouse
(Mus musculus)
Mammalia Lyrm9 33 16 34
  • 89.74 (n)
rat
(Rattus norvegicus)
Mammalia Lyrm9 33
  • 86.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves LYRM9 33
  • 75.76 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lyrm9 33
  • 72.65 (n)
zebrafish
(Danio rerio)
Actinopterygii lyrm9 33 34
  • 66.23 (n)
Species where no ortholog for LYRM9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LYRM9 Gene

ENSEMBL:
Gene Tree for LYRM9 (if available)
TreeFam:
Gene Tree for LYRM9 (if available)

Paralogs for LYRM9 Gene

Paralogs for LYRM9 Gene

Pseudogenes.org Pseudogenes for LYRM9 Gene

genes like me logo Genes that share paralogs with LYRM9: view

Variants for LYRM9 Gene

Sequence variations from dbSNP and Humsavar for LYRM9 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000209203 -- 27,893,882(-) A/C upstream_transcript_variant
rs1000915502 -- 27,892,997(-) GAG/GAGAG genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001070737 -- 27,886,291(-) A/G intron_variant
rs1001167294 -- 27,881,084(-) A/G intron_variant
rs1001537660 -- 27,890,585(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LYRM9 Gene

Variant ID Type Subtype PubMed ID
esv1008106 CNV deletion 20482838
nsv2015 CNV deletion 18451855

Variation tolerance for LYRM9 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYRM9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYRM9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYRM9 Gene

Disorders for LYRM9 Gene

Additional Disease Information for LYRM9

No disorders were found for LYRM9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYRM9 Gene

Publications for LYRM9 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk RJ … EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (The Journal of allergy and clinical immunology 2014) 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for LYRM9 Gene

Sources for LYRM9 Gene

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