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The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
LYRM4 (LYR Motif Containing 4) is a Protein Coding gene. Diseases associated with LYRM4 include Combined Oxidative Phosphorylation Deficiency 19 and Combined Oxidative Phosphorylation Deficiency. Among its related pathways are Mitochondrial iron-sulfur cluster biogenesis and Metabolism. An important paralog of this gene is HMGA2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 26342079 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005739 | mitochondrion | IBA | 21873635 |
GO:0005759 | mitochondrial matrix | TAS | -- |
GO:0016604 | nuclear body | IDA | -- |
GO:1990221 | L-cysteine desulfurase complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
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2 | Mitochondrial iron-sulfur cluster biogenesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016226 | iron-sulfur cluster assembly | IBA | 21873635 |
GO:0044281 | small molecule metabolic process | TAS | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LYRM4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lyrm4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC102550385 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LYRM4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LYRM4 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LYRM4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LYRM4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lyrm4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lyrm4 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | bcn92 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISD11 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
676148 | Benign: not provided | 5,216,777(-) | C/T | INTRON_VARIANT | |
676237 | Benign: not provided | 5,261,059(-) | G/A | FIVE_PRIME_UTR_VARIANT | |
676277 | Benign: not provided | 5,261,030(-) | C/T | FIVE_PRIME_UTR_VARIANT | |
676278 | Benign: not provided | 5,260,903(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
680626 | Benign: not provided | 5,261,126(-) | A/G | FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
combined oxidative phosphorylation deficiency 19 |
|
|
combined oxidative phosphorylation deficiency |
|
|
friedreich ataxia |
|
|
chromosome 6pter-p24 deletion syndrome |
|
|
multiple mitochondrial dysfunctions syndrome 3 |
|
|