Aliases for LYRM2 Gene

Aliases for LYRM2 Gene

  • LYR Motif Containing 2 2 3 5
  • LYR Motif-Containing Protein 2 3 4
  • DJ122O8.2 2 3
  • LYRM2 5

External Ids for LYRM2 Gene

Previous GeneCards Identifiers for LYRM2 Gene

  • GC06M090404
  • GC06M090398
  • GC06M090311
  • GC06M087558

Summaries for LYRM2 Gene

GeneCards Summary for LYRM2 Gene

LYRM2 (LYR Motif Containing 2) is a Protein Coding gene. Diseases associated with LYRM2 include Combined Oxidative Phosphorylation Deficiency 19.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYRM2 Gene

Genomics for LYRM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LYRM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYRM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYRM2

Top Transcription factor binding sites by QIAGEN in the LYRM2 gene promoter:
  • aMEF-2
  • ATF
  • CUTL1
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • MEF-2A
  • NF-kappaB
  • TGIF

Genomic Locations for LYRM2 Gene

Latest Assembly
chr6:89,568,144-89,638,749
(GRCh38/hg38)
Size:
70,606 bases
Orientation:
Minus strand

Previous Assembly
chr6:90,341,943-90,348,466
(GRCh37/hg19 by Entrez Gene)
Size:
6,524 bases
Orientation:
Minus strand

chr6:90,277,863-90,348,472
(GRCh37/hg19 by Ensembl)
Size:
70,610 bases
Orientation:
Minus strand

Genomic View for LYRM2 Gene

Genes around LYRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYRM2 Gene

Proteins for LYRM2 Gene

  • Protein details for LYRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU23-LYRM2_HUMAN
    Recommended name:
    LYR motif-containing protein 2
    Protein Accession:
    Q9NU23
    Secondary Accessions:
    • B2R4U2
    • E1P517

    Protein attributes for LYRM2 Gene

    Size:
    88 amino acids
    Molecular mass:
    10449 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LYRM2 Gene

Post-translational modifications for LYRM2 Gene

  • Ubiquitination at Lys14 and Lys81
  • Modification sites at PhosphoSitePlus

Other Protein References for LYRM2 Gene

No data available for DME Specific Peptides for LYRM2 Gene

Domains & Families for LYRM2 Gene

Gene Families for LYRM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYRM2 Gene

InterPro:
Blocks:
  • Complex 1 LYR protein
ProtoNet:

Suggested Antigen Peptide Sequences for LYRM2 Gene

GenScript: Design optimal peptide antigens:
  • LYR motif-containing protein 2 (LYRM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NU23

UniProtKB/Swiss-Prot:

LYRM2_HUMAN :
  • Belongs to the complex I LYR family.
Family:
  • Belongs to the complex I LYR family.
genes like me logo Genes that share domains with LYRM2: view

Function for LYRM2 Gene

Phenotypes From GWAS Catalog for LYRM2 Gene

Gene Ontology (GO) - Molecular Function for LYRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LYRM2: view
genes like me logo Genes that share phenotypes with LYRM2: view

miRNA for LYRM2 Gene

miRTarBase miRNAs that target LYRM2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYRM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYRM2 Gene

Localization for LYRM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYRM2 gene
Compartment Confidence
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LYRM2 Gene

Pathways & Interactions for LYRM2 Gene

PathCards logo

SuperPathways for LYRM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LYRM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LYRM2 Gene

Drugs & Compounds for LYRM2 Gene

No Compound Related Data Available

Transcripts for LYRM2 Gene

mRNA/cDNA for LYRM2 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYRM2

Alternative Splicing Database (ASD) splice patterns (SP) for LYRM2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for LYRM2 Gene

GeneLoc Exon Structure for
LYRM2

Expression for LYRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYRM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYRM2 Gene

This gene is overexpressed in Heart (24.9), Salivary gland (12.3), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYRM2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYRM2

SOURCE GeneReport for Unigene cluster for LYRM2 Gene:

Hs.177275
genes like me logo Genes that share expression patterns with LYRM2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYRM2 Gene

Orthologs for LYRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LYRM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LYRM2 30 31
  • 98.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LYRM2 30 31
  • 92.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LYRM2 30 31
  • 91.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lyrm2 30
  • 84.47 (n)
Mouse
(Mus musculus)
Mammalia Lyrm2 30 17 31
  • 83.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LYRM2 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LYRM2 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LYRM2 30 31
  • 65.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LYRM2 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lyrm2 30
  • 64.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii lyrm2 30 31
  • 63.95 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7067 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG34229 30 31
  • 50.2 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011816 30
  • 49.02 (n)
Species where no ortholog for LYRM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LYRM2 Gene

ENSEMBL:
Gene Tree for LYRM2 (if available)
TreeFam:
Gene Tree for LYRM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYRM2: view image

Paralogs for LYRM2 Gene

Pseudogenes.org Pseudogenes for LYRM2 Gene

genes like me logo Genes that share paralogs with LYRM2: view

No data available for Paralogs for LYRM2 Gene

Variants for LYRM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYRM2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1055889 - p.Thr60Pro
rs11553069 - p.Arg34Trp
rs34012596 - p.Lys46Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LYRM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LYRM2 Gene

Variant ID Type Subtype PubMed ID
dgv6089n100 CNV gain 25217958
esv3609903 CNV gain 21293372
esv3890901 CNV gain 25118596
esv3890903 CNV gain 25118596
nsv604124 CNV loss 21841781
nsv965747 CNV duplication 23825009

Variation tolerance for LYRM2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYRM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYRM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYRM2 Gene

Disorders for LYRM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LYRM2 Gene - From: COP

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 19
  • coxpd19
- elite association - COSMIC cancer census association via MalaCards
Search LYRM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYRM2

genes like me logo Genes that share disorders with LYRM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYRM2 Gene

Publications for LYRM2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3
  5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. (PMID: 31536960) Moutaoufik MT … Babu M (iScience 2019) 3

Products for LYRM2 Gene

Sources for LYRM2 Gene