Aliases for LYPLAL1 Gene

Aliases for LYPLAL1 Gene

  • Lysophospholipase Like 1 2 3 5
  • Lysophospholipase-Like Protein 1 3 4
  • Q96AV0 2 3
  • Lysophospholipase-Like 1 2
  • EC 3.1.2.- 4
  • LYPLAL1 5

External Ids for LYPLAL1 Gene

Previous GeneCards Identifiers for LYPLAL1 Gene

  • GC01P215190
  • GC01P215894
  • GC01P216403
  • GC01P215735
  • GC01P217413
  • GC01P219347
  • GC01P190016

Summaries for LYPLAL1 Gene

GeneCards Summary for LYPLAL1 Gene

LYPLAL1 (Lysophospholipase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lysophospholipase activity. An important paralog of this gene is LYPLA1.

UniProtKB/Swiss-Prot Summary for LYPLAL1 Gene

  • Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.

Additional gene information for LYPLAL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYPLAL1 Gene

Genomics for LYPLAL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LYPLAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYPLAL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYPLAL1

Top Transcription factor binding sites by QIAGEN in the LYPLAL1 gene promoter:
  • c-Ets-1
  • GATA-1
  • NRF-2
  • POU2F1
  • POU2F1a
  • RP58
  • Tal-1beta
  • TBP
  • USF-1
  • USF1

Genomic Locations for LYPLAL1 Gene

Genomic Locations for LYPLAL1 Gene
chr1:219,173,831-219,445,121
(GRCh38/hg38)
Size:
271,291 bases
Orientation:
Plus strand
chr1:219,347,186-219,386,207
(GRCh37/hg19)
Size:
39,022 bases
Orientation:
Plus strand

Genomic View for LYPLAL1 Gene

Genes around LYPLAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLAL1 Gene

Proteins for LYPLAL1 Gene

  • Protein details for LYPLAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWZ2-LYPL1_HUMAN
    Recommended name:
    Lysophospholipase-like protein 1
    Protein Accession:
    Q5VWZ2
    Secondary Accessions:
    • A8K677
    • Q5VWZ3
    • Q7Z4A3
    • Q96AV0

    Protein attributes for LYPLAL1 Gene

    Size:
    237 amino acids
    Molecular mass:
    26316 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be due to a competing acceptor splice site.

    Three dimensional structures from OCA and Proteopedia for LYPLAL1 Gene

    Alternative splice isoforms for LYPLAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYPLAL1 Gene

Post-translational modifications for LYPLAL1 Gene

  • Ubiquitination at Lys55 and Lys70
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LYPLAL1 Gene

Domains & Families for LYPLAL1 Gene

Gene Families for LYPLAL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYPLAL1 Gene

InterPro:
Blocks:
  • Phospholipase/Carboxylesterase
ProtoNet:

Suggested Antigen Peptide Sequences for LYPLAL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ41634 fis, clone FCBBF4000076, highly similar to Lysophospholipase-like protein 1 (EC 3.1.2.-) (B3KVW3_HUMAN)
  • Lysophospholipase-like protein 1 (LYPL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VWZ2

UniProtKB/Swiss-Prot:

LYPL1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLAL1: view

Function for LYPLAL1 Gene

Molecular function for LYPLAL1 Gene

UniProtKB/Swiss-Prot Function:
Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; Evidence={ECO:0000269|PubMed:22399288};.

Enzyme Numbers (IUBMB) for LYPLAL1 Gene

Phenotypes From GWAS Catalog for LYPLAL1 Gene

Gene Ontology (GO) - Molecular Function for LYPLAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity NAS 12706107
GO:0008474 palmitoyl-(protein) hydrolase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with LYPLAL1: view
genes like me logo Genes that share phenotypes with LYPLAL1: view

Animal Models for LYPLAL1 Gene

MGI Knock Outs for LYPLAL1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLAL1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYPLAL1 Gene

Localization for LYPLAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLAL1 Gene

[Isoform 1]: Cytoplasm, cytosol.
[Isoform 2]: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLAL1 gene
Compartment Confidence
cytosol 4
extracellular 2
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LYPLAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA,IDA --
genes like me logo Genes that share ontologies with LYPLAL1: view

Pathways & Interactions for LYPLAL1 Gene

PathCards logo

SuperPathways for LYPLAL1 Gene

No Data Available

Interacting Proteins for LYPLAL1 Gene

Gene Ontology (GO) - Biological Process for LYPLAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LYPLAL1: view

No data available for Pathways by source and SIGNOR curated interactions for LYPLAL1 Gene

Drugs & Compounds for LYPLAL1 Gene

No Compound Related Data Available

Transcripts for LYPLAL1 Gene

mRNA/cDNA for LYPLAL1 Gene

7 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLAL1

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLAL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - -

ExUns: 10i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for LYPLAL1 Gene

GeneLoc Exon Structure for
LYPLAL1

Expression for LYPLAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYPLAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLAL1 Gene

This gene is overexpressed in Skin (10.0) and Uterus (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LYPLAL1 Gene



Protein tissue co-expression partners for LYPLAL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYPLAL1

SOURCE GeneReport for Unigene cluster for LYPLAL1 Gene:

Hs.657617

Evidence on tissue expression from TISSUES for LYPLAL1 Gene

  • Liver(4.6)
  • Blood(4.4)
  • Bone marrow(4.2)
  • Heart(2.9)
  • Nervous system(2.6)
  • Kidney(2.5)
  • Muscle(2.5)
  • Skin(2.4)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with LYPLAL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLAL1 Gene

Orthologs for LYPLAL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LYPLAL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LYPLAL1 30 31
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LYPLAL1 30 31
  • 91.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LYPLAL1 30 31
  • 90.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lyplal1 30 17 31
  • 80.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lyplal1 30
  • 79.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia LYPLAL1 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LYPLAL1 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LYPLAL1 30 31
  • 74.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LYPLAL1 31
  • 73 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii zgc:110848 30
  • 58.07 (n)
lyplal1 31
  • 57 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6567 30 31
  • 48.85 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004271 30
  • 47.9 (n)
Worm
(Caenorhabditis elegans)
Secernentea ath-1 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 23 (a)
OneToMany
Species where no ortholog for LYPLAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for LYPLAL1 Gene

ENSEMBL:
Gene Tree for LYPLAL1 (if available)
TreeFam:
Gene Tree for LYPLAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYPLAL1: view image

Paralogs for LYPLAL1 Gene

Paralogs for LYPLAL1 Gene

genes like me logo Genes that share paralogs with LYPLAL1: view

Variants for LYPLAL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYPLAL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714102 Benign: not provided 219,211,603(+) C/G MISSENSE_VARIANT
759907 Likely Benign: not provided 219,173,960(+) C/T SYNONYMOUS_VARIANT
rs34201999 - p.Leu197Val
rs940570 - p.Ile131Met

Additional dbSNP identifiers (rs#s) for LYPLAL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LYPLAL1 Gene

Variant ID Type Subtype PubMed ID
dgv25n21 CNV loss 19592680
nsv4620 CNV deletion 18451855

Variation tolerance for LYPLAL1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPLAL1 Gene

Human Gene Mutation Database (HGMD)
LYPLAL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPLAL1 Gene

Disorders for LYPLAL1 Gene

Additional Disease Information for LYPLAL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LYPLAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLAL1 Gene

Publications for LYPLAL1 Gene

  1. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. (PMID: 22052940) Bürger M … Vetter IR (Journal of lipid research 2012) 3 4
  2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 41
  3. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PMID: 20935629) Heid IM … Lindgren CM (Nature genetics 2010) 3 41
  4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PMID: 20724581) den Hoed M … Loos RJ (Diabetes 2010) 3 41
  5. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. (PMID: 19557161) Lindgren CM … Giant Consortium (PLoS genetics 2009) 3 41

Products for LYPLAL1 Gene

Sources for LYPLAL1 Gene