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Aliases for LYPLA2 Gene

Aliases for LYPLA2 Gene

  • Lysophospholipase II 2 3 4 5
  • LysoPLA II 3 4
  • LPL-II 3 4
  • APT-2 3 4
  • APT2 3 4
  • Testicular Tissue Protein Li 3 3
  • Acyl-Protein Thioesterase 2 3
  • EC 3.1.2.- 4
  • DJ886K2.4 3
  • EC 3.1.2 56

External Ids for LYPLA2 Gene

Previous GeneCards Identifiers for LYPLA2 Gene

  • GC01P023675
  • GC01P023188
  • GC01P023587
  • GC01P023862
  • GC01P023990
  • GC01P024117
  • GC01P022369

Summaries for LYPLA2 Gene

Entrez Gene Summary for LYPLA2 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYPLA2 Gene

LYPLA2 (Lysophospholipase II) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is LYPLA1.

UniProtKB/Swiss-Prot for LYPLA2 Gene

  • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).

Additional gene information for LYPLA2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA2 Gene

Genomics for LYPLA2 Gene

GeneHancer (GH) Regulatory Elements for LYPLA2 Gene

Promoters and enhancers for LYPLA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023789 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1083 5.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC105376860 LYPLA2 LINC01355 SRSF10 FUCA1 SRRM1
GH01I023824 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 +34.4 34351 2.3 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 HMGCL FUCA1 LYPLA2 KDM1A GC01P023838 LOC105376861 PIR41142
GH01I023930 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.4 +140.5 140476 1.5 ZNF362 ZBTB33 ZNF18 GC01P023930 PNRC2 FUCA1 SRSF10 LYPLA2 ENSG00000230228
GH01I023751 Enhancer 0.7 ENCODE 11.6 -39.3 -39309 0.2 ELF3 HDGF CTCF ARID4B EBF1 ZNF2 RAD21 CC2D1A ZNF335 SCRT2 ELOA-AS1 PITHD1 LYPLA2 GC01P023754 ELOA
GH01I023750 Enhancer 0.2 ENCODE 11.6 -39.9 -39859 0.2 ELOA-AS1 PITHD1 LYPLA2 GC01P023754 ELOA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LYPLA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYPLA2 gene promoter:

Genomic Locations for LYPLA2 Gene

Genomic Locations for LYPLA2 Gene
chr1:23,790,785-23,795,539
(GRCh38/hg38)
Size:
4,755 bases
Orientation:
Plus strand
chr1:24,117,460-24,122,029
(GRCh37/hg19)

Genomic View for LYPLA2 Gene

Genes around LYPLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA2 Gene

Proteins for LYPLA2 Gene

  • Protein details for LYPLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95372-LYPA2_HUMAN
    Recommended name:
    Acyl-protein thioesterase 2
    Protein Accession:
    O95372
    Secondary Accessions:
    • Q7Z4Z2

    Protein attributes for LYPLA2 Gene

    Size:
    231 amino acids
    Molecular mass:
    24737 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97210.1; Type=Frameshift; Positions=5, 164, 179; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA2 Gene

neXtProt entry for LYPLA2 Gene

Selected DME Specific Peptides for LYPLA2 Gene

O95372:
  • IVLGGFS
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA2 Gene

  • Ubiquitination at posLast=108108 and posLast=190190
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LYPLA2
  • Cloud-Clone Corp. Antibodies for LYPLA2

Domains & Families for LYPLA2 Gene

Gene Families for LYPLA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYPLA2 Gene

Suggested Antigen Peptide Sequences for LYPLA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95372

UniProtKB/Swiss-Prot:

LYPA2_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA2: view

Function for LYPLA2 Gene

Molecular function for LYPLA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).

Enzyme Numbers (IUBMB) for LYPLA2 Gene

Gene Ontology (GO) - Molecular Function for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008474 palmitoyl-(protein) hydrolase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
GO:0045296 cadherin binding IDA 25468996
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with LYPLA2: view
genes like me logo Genes that share phenotypes with LYPLA2: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA2 Gene

Localization for LYPLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA2 gene
Compartment Confidence
extracellular 5
cytosol 5
peroxisome 2
nucleus 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25468996
GO:0005795 Golgi stack IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with LYPLA2: view

Pathways & Interactions for LYPLA2 Gene

genes like me logo Genes that share pathways with LYPLA2: view

Pathways by source for LYPLA2 Gene

3 Reactome pathways for LYPLA2 Gene
1 KEGG pathway for LYPLA2 Gene

Gene Ontology (GO) - Biological Process for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IDA 28826475
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with LYPLA2: view

No data available for SIGNOR curated interactions for LYPLA2 Gene

Drugs & Compounds for LYPLA2 Gene

(3) Drugs for LYPLA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0

(33) Additional Compounds for LYPLA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with LYPLA2: view

Transcripts for LYPLA2 Gene

Unigene Clusters for LYPLA2 Gene

Lysophospholipase II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for LYPLA2 Gene

GeneLoc Exon Structure for
LYPLA2
ECgene alternative splicing isoforms for
LYPLA2

Expression for LYPLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA2 Gene

This gene is overexpressed in Bone (14.6) and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LYPLA2 Gene



Protein tissue co-expression partners for LYPLA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA2 Gene:

LYPLA2

SOURCE GeneReport for Unigene cluster for LYPLA2 Gene:

Hs.533479

Evidence on tissue expression from TISSUES for LYPLA2 Gene

  • Intestine(4.2)
  • Nervous system(3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with LYPLA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA2 Gene

Orthologs for LYPLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA2 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia LYPLA2 33 34
  • 96.25 (n)
cow
(Bos Taurus)
Mammalia LYPLA2 33 34
  • 94.52 (n)
mouse
(Mus musculus)
Mammalia Lypla2 33 16 34
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Lypla2 33
  • 92.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA2 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA2 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYPLA2 33 34
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia LYPLA2 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla2 33
  • 72.01 (n)
MGC75683 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52664 33
zebrafish
(Danio rerio)
Actinopterygii lypla2 33 34
  • 73.3 (n)
zgc73210 33
fruit fly
(Drosophila melanogaster)
Insecta CG18815 35 33 34
  • 59.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012126 33
  • 55.61 (n)
worm
(Caenorhabditis elegans)
Secernentea K04G2.5 35
  • 45 (a)
ath-1 34
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 32 (a)
OneToMany
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20060 33
  • 46.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0175000 33
  • 47.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02027 33
  • 56.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8E11.04c 33
  • 47.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 34
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA2 Gene

ENSEMBL:
Gene Tree for LYPLA2 (if available)
TreeFam:
Gene Tree for LYPLA2 (if available)

Paralogs for LYPLA2 Gene

Paralogs for LYPLA2 Gene

(1) SIMAP similar genes for LYPLA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LYPLA2: view

Variants for LYPLA2 Gene

Sequence variations from dbSNP and Humsavar for LYPLA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs535702110 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,622(+) T/A downstream_transcript_variant
rs557214506 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,621(+) TTATT/TTATTATT downstream_transcript_variant
rs576468712 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,757(+) A/G downstream_transcript_variant
rs1000219306 -- 23,793,275(+) G/C intron_variant
rs1000550545 -- 23,794,865(+) G/C 3_prime_UTR_variant

Variation tolerance for LYPLA2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYPLA2 Gene

Disorders for LYPLA2 Gene

Additional Disease Information for LYPLA2

No disorders were found for LYPLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA2 Gene

Publications for LYPLA2 Gene

  1. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. (PMID: 28826475) Abrami L … van der Goot FG (eLife 2017) 3 4 58
  2. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PMID: 21152083) Tomatis VM … Daniotti JL (PloS one 2010) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LYPLA2 Gene

Sources for LYPLA2 Gene

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