Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008] See more...

Aliases for LYPLA2 Gene

Aliases for LYPLA2 Gene

  • Lysophospholipase 2 2 3 5
  • Acyl-Protein Thioesterase 2 2 3 4
  • Lysophospholipase II 2 3 4
  • LysoPLA II 3 4
  • LPL-II 3 4
  • APT-2 3 4
  • APT2 3 4
  • Testicular Tissue Protein Li 3 3
  • EC 3.1.2.- 4
  • DJ886K2.4 3
  • EC 3.1.2 54

External Ids for LYPLA2 Gene

Previous GeneCards Identifiers for LYPLA2 Gene

  • GC01P023675
  • GC01P023188
  • GC01P023587
  • GC01P023862
  • GC01P023990
  • GC01P024117
  • GC01P022369

Summaries for LYPLA2 Gene

Entrez Gene Summary for LYPLA2 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYPLA2 Gene

LYPLA2 (Lysophospholipase 2) is a Protein Coding gene. Among its related pathways are Developmental Biology and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is LYPLA1.

UniProtKB/Swiss-Prot Summary for LYPLA2 Gene

  • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).

Additional gene information for LYPLA2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYPLA2 Gene

Genomics for LYPLA2 Gene

GeneHancer (GH) Regulatory Elements for LYPLA2 Gene

Promoters and enhancers for LYPLA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J023789 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +1.1 1083 5.4 SIN3A ZBTB40 SIX5 SMARCE1 POLR2A USF2 NR2F6 CREB1 HCFC1 MIXL1 LOC105376860 LYPLA2 LINC01355 SRSF10 FUCA1 SRRM1 MG828730-001
GH01J023824 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +34.5 34515 2.6 ZBTB40 SP1 MLX RBPJ POLR2A USF2 CREB1 HCFC1 RUNX1 ZNF362 HMGCL KDM1A ELOA SRSF10 PITHD1 SRRM1 FUCA1 HNRNPR LINC01355 LYPLA2
GH01J023930 Enhancer 0.7 ENCODE CraniofacialAtlas dbSUPER 11.4 +140.5 140476 1.5 ZNF362 ZNF18 ZBTB33 lnc-PNRC2-4 PNRC2 FUCA1 SRSF10 LYPLA2 piR-36393-009
GH01J023751 Enhancer 0.6 ENCODE 11.6 -39.3 -39309 0.2 CTCF CC2D1A RAD21 PRDM1 REST TRIM22 ZNF143 SCRT2 SCRT1 SMC3 PITHD1 ELOA-AS1 LYPLA2 ELOA piR-41041 MG828730-001
GH01J023756 Enhancer 0.5 Ensembl 11.6 -34.0 -33984 0.8 PRDM1 JUND FOS FOSL1 NRF1 ELOA-AS1 PITHD1 LYPLA2 FUCA1 piR-41041 ELOA MG828730-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYPLA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYPLA2 gene promoter:
  • AML1a
  • E2F-2
  • E2F-3a

Genomic Locations for LYPLA2 Gene

Genomic Locations for LYPLA2 Gene
chr1:23,790,785-23,795,539
(GRCh38/hg38)
Size:
4,755 bases
Orientation:
Plus strand
chr1:24,117,460-24,122,029
(GRCh37/hg19)
Size:
4,570 bases
Orientation:
Plus strand

Genomic View for LYPLA2 Gene

Genes around LYPLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA2 Gene

Proteins for LYPLA2 Gene

  • Protein details for LYPLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95372-LYPA2_HUMAN
    Recommended name:
    Acyl-protein thioesterase 2
    Protein Accession:
    O95372
    Secondary Accessions:
    • Q7Z4Z2

    Protein attributes for LYPLA2 Gene

    Size:
    231 amino acids
    Molecular mass:
    24737 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97210.1; Type=Frameshift; Positions=5, 164, 179; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA2 Gene

neXtProt entry for LYPLA2 Gene

Selected DME Specific Peptides for LYPLA2 Gene

O95372:
  • IVLGGFS
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA2 Gene

  • Ubiquitination at Lys108 and Lys190
  • Modification sites at PhosphoSitePlus

Domains & Families for LYPLA2 Gene

Gene Families for LYPLA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LYPLA2 Gene

Suggested Antigen Peptide Sequences for LYPLA2 Gene

GenScript: Design optimal peptide antigens:
  • Lysophospholipase II (LYPA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95372

UniProtKB/Swiss-Prot:

LYPA2_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA2: view

Function for LYPLA2 Gene

Molecular function for LYPLA2 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; Evidence=. ;.

Enzyme Numbers (IUBMB) for LYPLA2 Gene

Phenotypes From GWAS Catalog for LYPLA2 Gene

Gene Ontology (GO) - Molecular Function for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008474 palmitoyl-(protein) hydrolase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0045296 cadherin binding HDA 25468996
GO:0052689 carboxylic ester hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with LYPLA2: view
genes like me logo Genes that share phenotypes with LYPLA2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA2 Gene

Localization for LYPLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA2 gene
Compartment Confidence
cytosol 4
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 25468996
GO:0005795 Golgi stack IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with LYPLA2: view

Pathways & Interactions for LYPLA2 Gene

genes like me logo Genes that share pathways with LYPLA2: view

Pathways by source for LYPLA2 Gene

3 Reactome pathways for LYPLA2 Gene
1 KEGG pathway for LYPLA2 Gene

Gene Ontology (GO) - Biological Process for LYPLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IDA 28826475
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with LYPLA2: view

No data available for SIGNOR curated interactions for LYPLA2 Gene

Drugs & Compounds for LYPLA2 Gene

(3) Drugs for LYPLA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma Full agonist, Agonist 25
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0

(33) Additional Compounds for LYPLA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z))
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • (2R)-2-Hydroxy-3-(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
  • 1-16:0-LysoPC
  • 1-16:0-Lysophosphatidylcholine
  • 1-Hexadecanoyl-2-lysophosphatidylcholine
  • 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
genes like me logo Genes that share compounds with LYPLA2: view

Transcripts for LYPLA2 Gene

mRNA/cDNA for LYPLA2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for LYPLA2 Gene

GeneLoc Exon Structure for
LYPLA2
ECgene alternative splicing isoforms for
LYPLA2

Expression for LYPLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA2 Gene

This gene is overexpressed in Bone (14.6) and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LYPLA2 Gene



Protein tissue co-expression partners for LYPLA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA2 Gene:

LYPLA2

SOURCE GeneReport for Unigene cluster for LYPLA2 Gene:

Hs.533479

Evidence on tissue expression from TISSUES for LYPLA2 Gene

  • Intestine(4.2)
  • Nervous system(3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with LYPLA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA2 Gene

Orthologs for LYPLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA2 33 32
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LYPLA2 33 32
  • 96.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LYPLA2 33 32
  • 94.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lypla2 17 33 32
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Lypla2 32
  • 92.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA2 33
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA2 33
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LYPLA2 33 32
  • 81.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYPLA2 33
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla2 32
  • 72.01 (n)
MGC75683 32
African clawed frog
(Xenopus laevis)
Amphibia MGC52664 32
zebrafish
(Danio rerio)
Actinopterygii lypla2 33 32
  • 73.3 (n)
OneToOne
zgc73210 32
fruit fly
(Drosophila melanogaster)
Insecta CG18815 33 34 32
  • 59.07 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012126 32
  • 55.61 (n)
worm
(Caenorhabditis elegans)
Secernentea K04G2.5 34
  • 45 (a)
ath-1 33
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
  • 32 (a)
OneToMany
-- 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20060 32
  • 46.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0175000 32
  • 47.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02027 32
  • 56.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8E11.04c 32
  • 47.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 33
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA2 Gene

ENSEMBL:
Gene Tree for LYPLA2 (if available)
TreeFam:
Gene Tree for LYPLA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYPLA2: view image

Paralogs for LYPLA2 Gene

Paralogs for LYPLA2 Gene

(1) SIMAP similar genes for LYPLA2 Gene using alignment to 8 proteins:

  • LYPA2_HUMAN
  • E7EPS4_HUMAN
  • Q5QPN5_HUMAN
  • Q5QPN9_HUMAN
  • Q5QPQ0_HUMAN
  • Q5QPQ1_HUMAN
  • Q5QPQ2_HUMAN
  • Q5QPQ3_HUMAN
genes like me logo Genes that share paralogs with LYPLA2: view

Variants for LYPLA2 Gene

Sequence variations from dbSNP and Humsavar for LYPLA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs535702110 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,622(+) T/A downstream_transcript_variant
rs557214506 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,621(+) TTATT/TTATTATT downstream_transcript_variant
rs576468712 uncertain-significance, UDPglucose-4-epimerase deficiency 23,795,757(+) A/G downstream_transcript_variant
rs1000219306 -- 23,793,275(+) G/C intron_variant
rs1000550545 -- 23,794,865(+) G/C 3_prime_UTR_variant

Variation tolerance for LYPLA2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYPLA2 Gene

Disorders for LYPLA2 Gene

Additional Disease Information for LYPLA2

No disorders were found for LYPLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA2 Gene

Publications for LYPLA2 Gene

  1. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. (PMID: 28826475) Abrami L … van der Goot FG (eLife 2017) 3 4 56
  2. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PMID: 21152083) Tomatis VM … Daniotti JL (PloS one 2010) 3 4 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for LYPLA2 Gene

Sources for LYPLA2 Gene