Aliases for LYPLA1 Gene
External Ids for LYPLA1 Gene
Previous GeneCards Identifiers for LYPLA1 Gene
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
GeneCards Summary for LYPLA1 Gene
LYPLA1 (Lysophospholipase 1) is a Protein Coding gene. Diseases associated with LYPLA1 include Triple-Receptor Negative Breast Cancer. Among its related pathways are Phospholipase D signaling pathway and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is LYPLA2.
UniProtKB/Swiss-Prot Summary for LYPLA1 Gene
Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Has depalmitoylating activity toward KCNMA1 (PubMed:22399288). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252).