This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provide... See more...

Aliases for LYPLA1 Gene

Aliases for LYPLA1 Gene

  • Lysophospholipase 1 2 3 4 5
  • Acyl-Protein Thioesterase 1 2 3 4
  • Lysophospholipase I 2 3 4
  • APT-1 2 3 4
  • LPL1 2 3 4
  • LysoPLA I 3 4
  • LPL-I 3 4
  • HAPT1 3 4
  • APT1 3 4
  • Lysophospholipid-Specific Lysophospholipase 3
  • EC 3.1.2.- 4
  • EC 3.1.2 51
  • LYPLA1 5

External Ids for LYPLA1 Gene

Previous GeneCards Identifiers for LYPLA1 Gene

  • GC08M054231
  • GC08M054898
  • GC08M054682
  • GC08M055008
  • GC08M055121
  • GC08M050427

Summaries for LYPLA1 Gene

Entrez Gene Summary for LYPLA1 Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

GeneCards Summary for LYPLA1 Gene

LYPLA1 (Lysophospholipase 1) is a Protein Coding gene. Diseases associated with LYPLA1 include Triple-Receptor Negative Breast Cancer. Among its related pathways are Phospholipase D signaling pathway and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is LYPLA2.

UniProtKB/Swiss-Prot Summary for LYPLA1 Gene

  • Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Has depalmitoylating activity toward KCNMA1 (PubMed:22399288). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252).

Gene Wiki entry for LYPLA1 Gene

Additional gene information for LYPLA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYPLA1 Gene

Genomics for LYPLA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LYPLA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J054100 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 417 3.2 HNRNPL ZNF692 POLR2A BACH1 LARP7 ZNF143 RBFOX2 SMAD5 ZNF740 REST LYPLA1 lnc-TCEA1-1 TCEA1 MRPL15 piR-43107-287 RF00017-7053
GH08J054018 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +81.0 81009 5.7 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 RFX1 SIX5 TCEA1 lnc-RGS20-5 lnc-LYPLA1-2 ENSG00000253667 LYPLA1 piR-41405-112 MN298114-259 RGS20
GH08J054881 Enhancer 0.5 Ensembl ENCODE 5 -780.3 -780284 3 CREB1 YY1 LYPLA1 LOC107986944 LOC105375842 XKR4 RP1
GH08J054616 Promoter 0.3 EPDnew 4.6 -514.1 -514060 0.1 RP1 LYPLA1 piR-55948-114 NONHSAG050254.2 XKR4
GH08J054105 Enhancer 1 FANTOM5 ENCODE 0.7 -4.5 -4501 1.7 DDX20 PKNOX1 ZNF740 HDAC1 EP300 MGA GTF2E2 HMBOX1 ESR1 CTBP1 piR-40176-031 piR-35564-137 piR-35564-138 piR-53063-250 MRPL15 TCEA1 RGS20 ATP6V1H LYPLA1 RF00017-7053
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYPLA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYPLA1

Top Transcription factor binding sites by QIAGEN in the LYPLA1 gene promoter:
  • GATA-1
  • Nkx2-5
  • NRF-2
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for LYPLA1 Gene

Genomic Locations for LYPLA1 Gene
chr8:54,046,367-54,102,017
(GRCh38/hg38)
Size:
55,651 bases
Orientation:
Minus strand
chr8:54,958,938-55,014,577
(GRCh37/hg19)
Size:
55,640 bases
Orientation:
Minus strand

Genomic View for LYPLA1 Gene

Genes around LYPLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA1 Gene

Proteins for LYPLA1 Gene

  • Protein details for LYPLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75608-LYPA1_HUMAN
    Recommended name:
    Acyl-protein thioesterase 1
    Protein Accession:
    O75608
    Secondary Accessions:
    • O43202
    • Q9UQF9

    Protein attributes for LYPLA1 Gene

    Size:
    230 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB88180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA1 Gene

    Alternative splice isoforms for LYPLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYPLA1 Gene

Selected DME Specific Peptides for LYPLA1 Gene

O75608:
  • GMMHSSCQQEMMD
  • HGLGDTGHGWA
  • DPLVPLMFGSLT
  • AAENIKALI
  • ALSCWLPL
  • VIFLHGL
  • KYICPHAP
  • LGGFSQGGALSLYTALT
  • FLHGLGD

Post-translational modifications for LYPLA1 Gene

  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

Domains & Families for LYPLA1 Gene

Gene Families for LYPLA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LYPLA1 Gene

InterPro:
Blocks:
  • Phospholipase/Carboxylesterase
ProtoNet:

Suggested Antigen Peptide Sequences for LYPLA1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52008, highly similar to Acyl-protein thioesterase 1 (EC 3.1.2.-) (B4DP64_HUMAN)
  • Lysophospholipase I (LYPA1_HUMAN)
  • cDNA, FLJ94339, Homo sapiens lysophospholipase I (LYPLA1), mRNA (Q6IAQ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75608

UniProtKB/Swiss-Prot:

LYPA1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA1: view

Function for LYPLA1 Gene

Molecular function for LYPLA1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Has depalmitoylating activity toward KCNMA1 (PubMed:22399288). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; Evidence={ECO:0000269|PubMed:22399288};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000269|PubMed:19439193};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:41720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57875, ChEBI:CHEBI:78421; Evidence={ECO:0000269|PubMed:21393252};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=27.3 uM for lysophosphatidylcholine for lysophospholipase activity {ECO:0000269|PubMed:19439193}; KM=3.49 uM for thioesterase activity {ECO:0000269|PubMed:19439193}; Vmax=1.62 umol/min/mg enzyme toward lysophosphatidylcholine for lysophospholipase activity {ECO:0000269|PubMed:19439193}; Vmax=27.3 umol/min/mg enzyme for thioesterase activity {ECO:0000269|PubMed:19439193}; pH dependence: Optimum pH is 7.4 for the thioesterase activity. {ECO:0000269|PubMed:19439193};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by palmostatin-B, leading to impair depalmitoylating of Ras.

Enzyme Numbers (IUBMB) for LYPLA1 Gene

Phenotypes From GWAS Catalog for LYPLA1 Gene

Gene Ontology (GO) - Molecular Function for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 21393252
GO:0004622 lysophospholipase activity IDA 19439193
GO:0005515 protein binding IPI --
GO:0008474 palmitoyl-(protein) hydrolase activity IBA,IMP 20418879
GO:0016298 lipase activity IDA 24682756
genes like me logo Genes that share ontologies with LYPLA1: view
genes like me logo Genes that share phenotypes with LYPLA1: view

Animal Models for LYPLA1 Gene

MGI Knock Outs for LYPLA1:
  • Lypla1 Lypla1<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPLA1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLA1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYPLA1 Gene

Localization for LYPLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA1 Gene

Cytoplasm. Cell membrane. Nucleus membrane. Endoplasmic reticulum. Note=Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. {ECO:0000269 PubMed:19439193}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 4
mitochondrion 2
peroxisome 2
lysosome 2
golgi apparatus 2
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 19439193
GO:0005783 endoplasmic reticulum IDA 19439193
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 19439193
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LYPLA1: view

Pathways & Interactions for LYPLA1 Gene

genes like me logo Genes that share pathways with LYPLA1: view

Pathways by source for LYPLA1 Gene

Gene Ontology (GO) - Biological Process for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA 21873635
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0042997 negative regulation of Golgi to plasma membrane protein transport IEA --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with LYPLA1: view

No data available for SIGNOR curated interactions for LYPLA1 Gene

Drugs & Compounds for LYPLA1 Gene

(4) Drugs for LYPLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0
sn-glycero-3-phosphoethanolamine Experimental Pharma 0

(33) Additional Compounds for LYPLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z))
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • (2R)-2-Hydroxy-3-(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
  • 1-16:0-LysoPC
  • 1-16:0-Lysophosphatidylcholine
  • 1-Hexadecanoyl-2-lysophosphatidylcholine
  • 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
genes like me logo Genes that share compounds with LYPLA1: view

Transcripts for LYPLA1 Gene

mRNA/cDNA for LYPLA1 Gene

6 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLA1

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for LYPLA1 Gene

GeneLoc Exon Structure for
LYPLA1

Expression for LYPLA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYPLA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA1 Gene

This gene is overexpressed in Bone (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYPLA1 Gene



Protein tissue co-expression partners for LYPLA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYPLA1

SOURCE GeneReport for Unigene cluster for LYPLA1 Gene:

Hs.744046

mRNA Expression by UniProt/SwissProt for LYPLA1 Gene:

O75608-LYPA1_HUMAN
Tissue specificity: Platelets.

Evidence on tissue expression from TISSUES for LYPLA1 Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Bone marrow(4.3)
  • Eye(4.3)
  • Skin(2.5)
  • Kidney(2.5)
  • Liver(2.4)
  • Heart(2.2)
  • Stomach(2.2)
  • Muscle(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with LYPLA1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA1 Gene

Orthologs for LYPLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LYPLA1 30
  • 99.13 (n)
Oppossum
(Monodelphis domestica)
Mammalia LYPLA1 31
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LYPLA1 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lypla1 30
  • 88.99 (n)
Mouse
(Mus musculus)
Mammalia Lypla1 30 17 31
  • 88.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LYPLA1 30 31
  • 87.25 (n)
OneToMany
-- 31
  • 86 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC770321 30
  • 78.6 (n)
LYPLA1 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LYPLA1 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lypla1 30
  • 74.35 (n)
Str.355 30
Zebrafish
(Danio rerio)
Actinopterygii lypla1 30 31
  • 74.02 (n)
OneToOne
Dr.15000 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG18815 31 32
  • 50 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ath-1 30 31
  • 56.09 (n)
OneToMany
K04G2.5 32
  • 49 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17908g 30
  • 48.78 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR118C 30
  • 46.76 (n)
-- 31
  • 35 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G22305 30
  • 49.16 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0669500 30
  • 47.55 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2523 31
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LYPLA1 Gene

ENSEMBL:
Gene Tree for LYPLA1 (if available)
TreeFam:
Gene Tree for LYPLA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYPLA1: view image

Paralogs for LYPLA1 Gene

Paralogs for LYPLA1 Gene

(1) SIMAP similar genes for LYPLA1 Gene using alignment to 6 proteins:

  • LYPA1_HUMAN
  • E5RFT6_HUMAN
  • E5RGR0_HUMAN
  • E5RI35_HUMAN
  • E5RJ48_HUMAN
  • Q6IAQ1_HUMAN

Pseudogenes.org Pseudogenes for LYPLA1 Gene

genes like me logo Genes that share paralogs with LYPLA1: view

Variants for LYPLA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYPLA1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
783525 Benign: not provided 54,052,660(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs11549448 - p.Pro153Ser

Additional dbSNP identifiers (rs#s) for LYPLA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LYPLA1 Gene

Variant ID Type Subtype PubMed ID
esv2349042 CNV deletion 18987734
esv2667256 CNV deletion 23128226
esv2737007 CNV deletion 23290073
esv2759617 CNV gain 17122850
esv3543508 CNV deletion 23714750
esv3576573 CNV gain 25503493
esv4675 CNV loss 18987735
esv6149 CNV loss 19470904
nsv1026869 CNV gain 25217958
nsv1077043 CNV deletion 25765185
nsv1119178 CNV deletion 24896259
nsv1137366 CNV deletion 24896259
nsv1152591 CNV deletion 26484159
nsv956051 CNV deletion 24416366
nsv967590 CNV duplication 23825009
nsv971309 CNV duplication 23825009

Variation tolerance for LYPLA1 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPLA1 Gene

Disorders for LYPLA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LYPLA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LYPLA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYPLA1 Gene

Publications for LYPLA1 Gene

  1. Small-molecule inhibition of APT1 affects Ras localization and signaling. (PMID: 20418879) Dekker FJ … Waldmann H (Nature chemical biology 2010) 3 4 23
  2. Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. (PMID: 19439193) Hirano T … Izumi T (Biochimica et biophysica acta 2009) 3 4 23
  3. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. (PMID: 10064899) Wang A … Dennis EA (Biochimica et biophysica acta 1999) 2 3 23
  4. The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation. (PMID: 21393252) Bolen AL … Tigyi G (Journal of lipid research 2011) 3 4
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