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Aliases for LYPLA1 Gene

Aliases for LYPLA1 Gene

  • Lysophospholipase I 2 3 4 5
  • Acyl-Protein Thioesterase 1 2 3
  • LysoPLA I 3 4
  • APT-1 3 4
  • LPL-I 3 4
  • HAPT1 3 4
  • APT1 3 4
  • LPL1 3 4
  • Lysophospholipid-Specific Lysophospholipase 3
  • Lysophospholipase 1 4
  • EC 3.1.2.- 4

External Ids for LYPLA1 Gene

Previous GeneCards Identifiers for LYPLA1 Gene

  • GC08M054231
  • GC08M054898
  • GC08M054682
  • GC08M055008
  • GC08M055121
  • GC08M050427

Summaries for LYPLA1 Gene

Entrez Gene Summary for LYPLA1 Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

GeneCards Summary for LYPLA1 Gene

LYPLA1 (Lysophospholipase I) is a Protein Coding gene. Among its related pathways are Metabolism and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is LYPLA2.

UniProtKB/Swiss-Prot for LYPLA1 Gene

  • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.

Gene Wiki entry for LYPLA1 Gene

Additional gene information for LYPLA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPLA1 Gene

Genomics for LYPLA1 Gene

GeneHancer (GH) Regulatory Elements for LYPLA1 Gene

Promoters and enhancers for LYPLA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J054100 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 585 2.7 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF766 GLIS2 ELK1 LYPLA1 TCEA1 MRPL15 TDGF1P5
GH08J054616 Promoter 0.5 EPDnew 4.7 -514.1 -514060 0.1 RP1 LYPLA1 GC08P054612 LOC100131013
GH08J054883 Enhancer 0.3 ENCODE 5 -780.3 -780299 0.2 CREB1 LYPLA1 LOC105375842 GC08P055061
GH08J054105 Enhancer 1 FANTOM5 ENCODE 0.7 -4.5 -4501 1.7 HDAC1 PKNOX1 FOS NCOA1 ZEB2 ZNF592 ZNF217 ATF4 HMBOX1 MGA PIR33175 MRPL15 TCEA1 RGS20 ATP6V1H LYPLA1
GH08J054098 Enhancer 0.4 ENCODE 0.7 +3.7 3741 0.2 ZNF3 NCOR1 CBFA2T3 MRPL15 TCEA1 LYPLA1 TDGF1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYPLA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYPLA1 gene promoter:
  • POU2F1a
  • POU2F1
  • NRSF form 2
  • NRSF form 1
  • STAT1beta
  • STAT1alpha
  • STAT1
  • Nkx2-5
  • GATA-1
  • NRF-2

Genomic Locations for LYPLA1 Gene

Genomic Locations for LYPLA1 Gene
chr8:54,046,367-54,102,017
(GRCh38/hg38)
Size:
55,651 bases
Orientation:
Minus strand
chr8:54,958,938-55,014,577
(GRCh37/hg19)
Size:
55,640 bases
Orientation:
Minus strand

Genomic View for LYPLA1 Gene

Genes around LYPLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPLA1 Gene

Proteins for LYPLA1 Gene

  • Protein details for LYPLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75608-LYPA1_HUMAN
    Recommended name:
    Acyl-protein thioesterase 1
    Protein Accession:
    O75608
    Secondary Accessions:
    • O43202
    • Q9UQF9

    Protein attributes for LYPLA1 Gene

    Size:
    230 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB88180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYPLA1 Gene

    Alternative splice isoforms for LYPLA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYPLA1 Gene

Post-translational modifications for LYPLA1 Gene

  • Ubiquitination at isoforms=2105
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LYPLA1 Gene

Domains & Families for LYPLA1 Gene

Gene Families for LYPLA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LYPLA1 Gene

Graphical View of Domain Structure for InterPro Entry

O75608

UniProtKB/Swiss-Prot:

LYPA1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
genes like me logo Genes that share domains with LYPLA1: view

Function for LYPLA1 Gene

Molecular function for LYPLA1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-protein + H(2)O = palmitate + protein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by palmostatin-B, leading to impair depalmitoylating of Ras.

Enzyme Numbers (IUBMB) for LYPLA1 Gene

Phenotypes From GWAS Catalog for LYPLA1 Gene

Gene Ontology (GO) - Molecular Function for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 10064899
GO:0005515 protein binding IPI --
GO:0008474 palmitoyl-(protein) hydrolase activity TAS --
GO:0016298 lipase activity IDA 24682756
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with LYPLA1: view
genes like me logo Genes that share phenotypes with LYPLA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPLA1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLA1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPLA1 Gene

Localization for LYPLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPLA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPLA1 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LYPLA1: view

Pathways & Interactions for LYPLA1 Gene

genes like me logo Genes that share pathways with LYPLA1: view

Pathways by source for LYPLA1 Gene

Gene Ontology (GO) - Biological Process for LYPLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IBA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0042997 negative regulation of Golgi to plasma membrane protein transport IEA --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with LYPLA1: view

No data available for SIGNOR curated interactions for LYPLA1 Gene

Drugs & Compounds for LYPLA1 Gene

(3) Drugs for LYPLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0

(34) Additional Compounds for LYPLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0/0:0)
  • 1-C14:0-Lysophosphatidylcholine betaine
  • 1-Myristoyl-glycero-3-phosphocholine
  • 1-Myristoyl-sn-glycero-3-phosphocholine betaine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine
  • 1-Tetradecanoyl-sn-glycero-3-phosphocholine betaine
20559-16-4
LysoPC(14:1(9Z))
  • 1-(9Z-Tetradecenoyl)-sn-glycero-3-phosphocholine
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC 14:1(9Z)/0:0
  • LPC(14:1(9Z)/0:0)
  • LysoPC 14:1(9Z)/0:0
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • (2R)-2-Hydroxy-3-(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
  • 1-16:0-LysoPC
  • 1-16:0-Lysophosphatidylcholine
  • 1-Hexadecanoyl-2-lysophosphatidylcholine
  • 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
genes like me logo Genes that share compounds with LYPLA1: view

Transcripts for LYPLA1 Gene

Unigene Clusters for LYPLA1 Gene

Lysophospholipase I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPLA1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPLA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: -

Relevant External Links for LYPLA1 Gene

GeneLoc Exon Structure for
LYPLA1
ECgene alternative splicing isoforms for
LYPLA1

Expression for LYPLA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPLA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LYPLA1 Gene

This gene is overexpressed in Bone (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYPLA1 Gene



Protein tissue co-expression partners for LYPLA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPLA1 Gene:

LYPLA1

SOURCE GeneReport for Unigene cluster for LYPLA1 Gene:

Hs.744046

Evidence on tissue expression from TISSUES for LYPLA1 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with LYPLA1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPLA1 Gene

Orthologs for LYPLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LYPLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYPLA1 33
  • 99.13 (n)
oppossum
(Monodelphis domestica)
Mammalia LYPLA1 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LYPLA1 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lypla1 33
  • 88.99 (n)
mouse
(Mus musculus)
Mammalia Lypla1 16 34 33
  • 88.55 (n)
cow
(Bos Taurus)
Mammalia LYPLA1 34 33
  • 87.25 (n)
OneToMany
-- 34
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LYPLA1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770321 33
  • 78.6 (n)
LYPLA1 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYPLA1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lypla1 33
  • 74.35 (n)
Str.355 33
zebrafish
(Danio rerio)
Actinopterygii lypla1 34 33
  • 74.02 (n)
OneToOne
Dr.15000 33
fruit fly
(Drosophila melanogaster)
Insecta CG18815 34 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ath-1 34 33
  • 56.09 (n)
OneToMany
K04G2.5 35
  • 49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17908g 33
  • 48.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR118C 33
  • 46.76 (n)
-- 34
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22305 33
  • 49.16 (n)
rice
(Oryza sativa)
Liliopsida Os04g0669500 33
  • 47.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2523 34
  • 47 (a)
OneToMany
Species where no ortholog for LYPLA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LYPLA1 Gene

ENSEMBL:
Gene Tree for LYPLA1 (if available)
TreeFam:
Gene Tree for LYPLA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYPLA1: view image

Paralogs for LYPLA1 Gene

Paralogs for LYPLA1 Gene

(1) SIMAP similar genes for LYPLA1 Gene using alignment to 6 proteins:

  • LYPA1_HUMAN
  • E5RFT6_HUMAN
  • E5RGR0_HUMAN
  • E5RI35_HUMAN
  • E5RJ48_HUMAN
  • Q6IAQ1_HUMAN

Pseudogenes.org Pseudogenes for LYPLA1 Gene

genes like me logo Genes that share paralogs with LYPLA1: view

Variants for LYPLA1 Gene

Sequence variations from dbSNP and Humsavar for LYPLA1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000059847 -- 54,072,875(-) G/T intron_variant
rs1000111910 -- 54,073,104(-) T/A intron_variant
rs1000124359 -- 54,066,152(-) T/C intron_variant
rs1000139836 -- 54,046,336(-) G/A downstream_transcript_variant
rs1000177438 -- 54,066,398(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LYPLA1 Gene

Variant ID Type Subtype PubMed ID
esv2349042 CNV deletion 18987734
esv2667256 CNV deletion 23128226
esv2737007 CNV deletion 23290073
esv2759617 CNV gain 17122850
esv3543508 CNV deletion 23714750
esv3576573 CNV gain 25503493
esv4675 CNV loss 18987735
esv6149 CNV loss 19470904
nsv1026869 CNV gain 25217958
nsv1077043 CNV deletion 25765185
nsv1119178 CNV deletion 24896259
nsv1137366 CNV deletion 24896259
nsv1152591 CNV deletion 26484159
nsv956051 CNV deletion 24416366
nsv967590 CNV duplication 23825009
nsv971309 CNV duplication 23825009

Variation tolerance for LYPLA1 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYPLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPLA1 Gene

Disorders for LYPLA1 Gene

Additional Disease Information for LYPLA1

No disorders were found for LYPLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LYPLA1 Gene

Publications for LYPLA1 Gene

  1. Small-molecule inhibition of APT1 affects Ras localization and signaling. (PMID: 20418879) Dekker FJ … Waldmann H (Nature chemical biology 2010) 3 4 22 58
  2. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. (PMID: 10064899) Wang A … Dennis EA (Biochimica et biophysica acta 1999) 2 3 22 58
  3. Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. (PMID: 19439193) Hirano T … Izumi T (Biochimica et biophysica acta 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for LYPLA1 Gene

Sources for LYPLA1 Gene

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