Aliases for LYPD6B Gene
External Ids for LYPD6B Gene
Previous GeneCards Identifiers for LYPD6B Gene
GeneCards Summary for LYPD6B Gene
LYPD6B (LY6/PLAUR Domain Containing 6B) is a Protein Coding gene. Diseases associated with LYPD6B include Tobacco Addiction. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is LYPD6.
UniProtKB/Swiss-Prot for LYPD6B Gene
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.