Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LYPD4 Gene

Aliases for LYPD4 Gene

  • LY6/PLAUR Domain Containing 4 2 3 5
  • Ly6/PLAUR Domain-Containing Protein 4 3
  • Testicular Tissue Protein Li 159 3
  • Sperm Membrane Receptor 3
  • SMR 3

External Ids for LYPD4 Gene

Previous GeneCards Identifiers for LYPD4 Gene

  • GC19M047033
  • GC19M042341
  • GC19M038774

Summaries for LYPD4 Gene

GeneCards Summary for LYPD4 Gene

LYPD4 (LY6/PLAUR Domain Containing 4) is a Protein Coding gene. Diseases associated with LYPD4 include Retinitis Pigmentosa 4. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is CD177.

Additional gene information for LYPD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYPD4 Gene

Genomics for LYPD4 Gene

GeneHancer (GH) Regulatory Elements for LYPD4 Gene

Promoters and enhancers for LYPD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041845 Promoter 0.8 EPDnew 650.7 +0.2 159 0.1 KLF1 L3MBTL2 GABPB1 SP2 ZBTB33 MGA ZNF395 LYPD4 DMRTC2 PIR52767 GC19M041840
GH19J041844 Promoter 0.8 EPDnew 650.7 +0.3 272 0.1 KLF1 L3MBTL2 ZBTB33 ZNF395 LYPD4 DMRTC2 PIR52767 GC19M041840
GH19J041846 Promoter 0.7 EPDnew 650.7 -0.2 -161 0.1 L3MBTL2 GABPB1 ZBTB33 DMRTC2 LYPD4 RPS19
GH19J041843 Enhancer 0.5 Ensembl 650.7 +1.8 1761 0.2 ZNF766 ZNF362 ZSCAN4 ZNF384 LYPD4 DMRTC2 PIR52767 GC19M041840
GH19J042267 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.8 -426.0 -426026 6.9 MLX FEZF1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC CIC PIR59110 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PRR19 PAFAH1B3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LYPD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LYPD4 gene promoter:

Genomic Locations for LYPD4 Gene

Genomic Locations for LYPD4 Gene
11,177 bases
Minus strand

Genomic View for LYPD4 Gene

Genes around LYPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYPD4 Gene

Proteins for LYPD4 Gene

  • Protein details for LYPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ly6/PLAUR domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8IYW0

    Protein attributes for LYPD4 Gene

    246 amino acids
    Molecular mass:
    26763 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LYPD4 Gene


neXtProt entry for LYPD4 Gene

Post-translational modifications for LYPD4 Gene

  • Glycosylation at posLast=117117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LYPD4 Gene

Domains & Families for LYPD4 Gene

Gene Families for LYPD4 Gene

Protein Domains for LYPD4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LYPD4: view

No data available for UniProtKB/Swiss-Prot for LYPD4 Gene

Function for LYPD4 Gene

genes like me logo Genes that share phenotypes with LYPD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LYPD4

CRISPR Products

miRNA for LYPD4 Gene

miRTarBase miRNAs that target LYPD4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPD4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LYPD4 Gene

Localization for LYPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYPD4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYPD4 gene
Compartment Confidence
extracellular 5
plasma membrane 4
lysosome 1

Gene Ontology (GO) - Cellular Components for LYPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LYPD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LYPD4 Gene

Pathways & Interactions for LYPD4 Gene

genes like me logo Genes that share pathways with LYPD4: view

Interacting Proteins for LYPD4 Gene

Gene Ontology (GO) - Biological Process for LYPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with LYPD4: view

No data available for SIGNOR curated interactions for LYPD4 Gene

Drugs & Compounds for LYPD4 Gene

No Compound Related Data Available

Transcripts for LYPD4 Gene

mRNA/cDNA for LYPD4 Gene

Unigene Clusters for LYPD4 Gene

LY6/PLAUR domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYPD4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYPD4 Gene

No ASD Table

Relevant External Links for LYPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LYPD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LYPD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYPD4 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for LYPD4 Gene

This gene is overexpressed in Monocytes (54.6) and Testis (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LYPD4 Gene

Protein tissue co-expression partners for LYPD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LYPD4 Gene:


SOURCE GeneReport for Unigene cluster for LYPD4 Gene:

genes like me logo Genes that share expression patterns with LYPD4: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LYPD4 Gene

Orthologs for LYPD4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LYPD4 33
  • 88.41 (n)
(Canis familiaris)
Mammalia LYPD4 33
  • 83.33 (n)
(Bos Taurus)
Mammalia LYPD4 33
  • 79.59 (n)
(Mus musculus)
Mammalia Lypd4 16 33
  • 77.64 (n)
Species where no ortholog for LYPD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYPD4 Gene

Gene Tree for LYPD4 (if available)
Gene Tree for LYPD4 (if available)
Evolutionary constrained regions (ECRs) for LYPD4: view image

Paralogs for LYPD4 Gene

Paralogs for LYPD4 Gene

(1) SIMAP similar genes for LYPD4 Gene using alignment to 2 proteins:

  • A8K8E0_HUMAN
genes like me logo Genes that share paralogs with LYPD4: view

Variants for LYPD4 Gene

Sequence variations from dbSNP and Humsavar for LYPD4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000084791 -- 41,838,926(-) T/G coding_sequence_variant, intron_variant, missense_variant
rs1000371697 -- 41,835,132(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000381957 -- 41,841,204(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000560049 -- 41,845,743(-) C/G upstream_transcript_variant
rs1000579438 -- 41,839,738(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LYPD4 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV gain 19592680

Variation tolerance for LYPD4 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYPD4 Gene

Disorders for LYPD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LYPD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 4
  • rp4
- elite association - COSMIC cancer census association via MalaCards
Search LYPD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LYPD4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LYPD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LYPD4 Gene

Publications for LYPD4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3 58
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58

Products for LYPD4 Gene

Sources for LYPD4 Gene

Loading form....