Aliases for LYN Gene
Aliases for LYN Gene
External Ids for LYN Gene
- HGNC: 6735
- Entrez Gene: 4067
- Ensembl: ENSG00000254087
- OMIM: 165120
- UniProtKB: P07948
Previous GeneCards Identifiers for LYN Gene
- GC08P055975
- GC08P056731
- GC08P056515
- GC08P056842
- GC08P056954
- GC08P056792
- GC08P052260
Summaries for LYN Gene
-
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for LYN Gene
LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LYN include Sarcoma and Hantavirus Pulmonary Syndrome. Among its related pathways are Immune response Fc epsilon RI pathway and CD209 (DC-SIGN) signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HCK.
UniProtKB/Swiss-Prot for LYN Gene
-
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on Tyr-72. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
-
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.
Additional gene information for LYN Gene
- Monarch Initiative
- Search for LYN at DataMed
- Search for LYN at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYN Gene
Genomics for LYN Gene
GeneHancer (GH) Regulatory Elements for LYN Gene
Promoters and enhancers for LYN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LYN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LYN gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for LYN Gene
Genomic Locations for LYN Gene
- chr8:55,878,463-56,014,168
- (GRCh38/hg38)
- Size:
- 135,706 bases
- Orientation:
- Plus strand
- chr8:56,792,372-56,923,940
- (GRCh37/hg19)
- Size:
- 131,569 bases
- Orientation:
- Plus strand
Genomic View for LYN Gene
Genes around LYN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q12.1 by Entrez Gene
- 8q12.1 by HGNC
- 8q12.1 by Ensembl
LYN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LYN Gene
Proteins for LYN Gene
-
Protein details for LYN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07948-LYN_HUMAN
- Recommended name:
- Tyrosine-protein kinase Lyn
- Protein Accession:
- P07948
- A0AVQ5
Protein attributes for LYN Gene
- Size:
- 512 amino acids
- Molecular mass:
- 58574 Da
- Quaternary structure:
-
- Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1. Interacts with Epstein-Barr virus LMP2A. Interacts with Herpes virus saimiri tyrosine kinase interacting protein (Tip). Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation. Interacts with CD36. Interacts with LYN (By similarity).
Three dimensional structures from OCA and Proteopedia for LYN Gene
Protein Expression for LYN Gene
Post-translational modifications for LYN Gene
- Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent.
- Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for LYN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LYN (Lyn)
-
Custom Antibody ServicesOriGene Antibodies for LYN
- Novus Biologicals Antibodies for LYN
-
Abcam antibodies for LYN
- Invitrogen Antibodies for LYN (AFLGC-LYN)
- antibodies-online: Search results for 237 available LYN Antibodies ranked by validation data
- Compare Top LYN Antibodies
-
Recommended
- 187 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 90 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 119 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- GeneTex LYN Antibody for LYN
-
Santa Cruz Biotechnology (SCBT) Antibodies for LYN
Protein Products
- R&D Systems Proteins and Enzymes for LYN (Lyn B)
-
OriGene Purified Proteins for LYN
- Search Origene for MassSpec and Protein Over-expression Lysates for LYN
- Origene Custom Protein Services for LYN
- Sino Biological Recombinant Proteins for LYN
- Sino Biological Cell Lysates for LYN
- ProSpec Recombinant Proteins for LYN
- GeneTex Proteins for LYN
-
Abcam proteins for LYN
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for LYN (Lyn)
No data available for DME Specific Peptides for LYN Gene
Domains & Families for LYN Gene
Gene Families for LYN Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for LYN Gene
Suggested Antigen Peptide Sequences for LYN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07948UniProtKB/Swiss-Prot:
LYN_HUMAN :- The protein kinase domain plays an important role in its localization in the cell membrane.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
- Domain:
-
- The protein kinase domain plays an important role in its localization in the cell membrane.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Function for LYN Gene
Molecular function for LYN Gene
- UniProtKB/Swiss-Prot Function:
- Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on Tyr-72. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656.
- GENATLAS Biochemistry:
- Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous system,physically linked to AMPA receptor and activated following stimulation of the receptor,then activating the MAP Kinase pathway
Enzyme Numbers (IUBMB) for LYN Gene
Phenotypes From GWAS Catalog for LYN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | TAS,IBA | -- |
| GO:0004716 | obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity | TAS | -- |
| GO:0005102 | signaling receptor binding | IBA | -- |
Phenotypes for LYN Gene
- MGI mutant phenotypes for LYN:
- inferred from 12 alleles
- GenomeRNAi human phenotypes for LYN:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased viability with TRAIL
- Decreased viability in HMC1.1 cells
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Increased cell migration
- Decreased cell migration
- Decreased viability
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LYN
-
CRISPR Products
-
OriGene CRISPR knockouts for LYN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYN
- genomics-online: gRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- Applied Biological Materials CRISPR for LYN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYN
- GenScript: Design CRISPR guide RNA sequences for LYN
miRNA for LYN Gene
- miRTarBase miRNAs that target LYN
-
- hsa-mir-222-3p (MIRT046575)
- hsa-mir-32-3p (MIRT322915)
- hsa-mir-4731-3p (MIRT322916)
- hsa-mir-4801 (MIRT322917)
- hsa-mir-548c-3p (MIRT322922)
- hsa-mir-205-5p (MIRT440300)
- hsa-mir-6513-5p (MIRT473926)
- hsa-mir-3913-5p (MIRT473927)
- hsa-mir-3122 (MIRT473928)
- hsa-mir-450a-1-3p (MIRT473929)
- hsa-mir-4278 (MIRT473930)
- hsa-mir-625-5p (MIRT473931)
- hsa-mir-3148 (MIRT473932)
- hsa-mir-4668-5p (MIRT473933)
- hsa-mir-98-5p (MIRT473934)
- hsa-mir-4500 (MIRT473935)
- hsa-mir-4458 (MIRT473936)
- hsa-let-7i-5p (MIRT473937)
- hsa-let-7g-5p (MIRT473938)
- hsa-let-7f-5p (MIRT473939)
- hsa-let-7e-5p (MIRT473940)
- hsa-let-7d-5p (MIRT473941)
- hsa-let-7c-5p (MIRT473942)
- hsa-let-7b-5p (MIRT473943)
- hsa-let-7a-5p (MIRT473944)
- hsa-mir-4330 (MIRT473945)
- hsa-mir-10b-3p (MIRT473946)
- hsa-mir-6732-5p (MIRT473947)
- hsa-mir-6805-5p (MIRT473948)
- hsa-mir-6794-5p (MIRT473949)
- hsa-mir-4716-3p (MIRT473950)
- hsa-mir-628-5p (MIRT570808)
- hsa-mir-466 (MIRT570809)
- hsa-mir-221-3p (MIRT570810)
- hsa-mir-548v (MIRT570811)
- hsa-mir-187-5p (MIRT570812)
- hsa-mir-4643 (MIRT570813)
- hsa-mir-4789-3p (MIRT570814)
- hsa-mir-122-5p (MIRT761335)
- hsa-mir-1304-3p (MIRT762418)
- hsa-mir-143-5p (MIRT762686)
- hsa-mir-3135b (MIRT764932)
- hsa-mir-3652 (MIRT766291)
- hsa-mir-4430 (MIRT768926)
- hsa-mir-4639-3p (MIRT770545)
- hsa-mir-504-3p (MIRT773055)
- hsa-mir-564 (MIRT774921)
- hsa-mir-5693 (MIRT775037)
- hsa-mir-5698 (MIRT775151)
- hsa-mir-6499-3p (MIRT776300)
- hsa-mir-6794-3p (MIRT779333)
- hsa-mir-891a-3p (MIRT782619)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYN
- Browse OriGene Inhibitory RNA Products For LYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYN
- genomics-online: shRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
Clone Products
- Sino Biological Human cDNA Clone for LYN
- Addgene plasmids for LYN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYN
- Applied Biological Materials Clones for LYN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LYN
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYN Gene
Localization for LYN Gene
Subcellular locations from UniProtKB/Swiss-Prot for LYN Gene
- Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane; Lipid-anchor. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| mitochondrion | 3 |
| lysosome | 3 |
| cytoskeleton | 2 |
| endosome | 1 |
- Golgi apparatus (3)
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005758 | mitochondrial intermembrane space | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | 15173188 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for LYN Gene
Pathways by source for LYN Gene
5 Sino Biological pathways for LYN Gene
22 BioSystems pathways for LYN Gene
39 Reactome pathways for LYN Gene
6 GeneGo (Thomson Reuters) pathways for LYN Gene
9 Qiagen pathways for LYN Gene
3 Cell Signaling Technology pathways for LYN Gene
Interacting Proteins for LYN Gene
Selected Interacting proteins:
P07948-LYN_HUMAN
ENSP00000428924
for LYN Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for LYN
SIGNOR curated interactions for LYN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | ISS | -- |
| GO:0001817 | regulation of cytokine production | ISS | -- |
| GO:0001932 | regulation of protein phosphorylation | TAS | 15489917 |
| GO:0001933 | negative regulation of protein phosphorylation | ISS | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IGI | 24217950 |
Drugs & Compounds for LYN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| bosutinib | Approved | Pharma | inhibitor, Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 295 | |
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Nintedanib | Approved | Pharma | Target, inhibitor | VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors | 126 | |
| Ponatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 36 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| PD 166285 dihydrochloride |
|
212391-63-4 |
|
|
(4) Tocris Compounds for LYN Gene
| Compound | Action | Cas Number |
|---|---|---|
| Herbimycin A | Src family kinase inhibitor. Also Hsp90 inhibitor | 70563-58-5 |
| MNS | Selective inhibitor of Src and Syk | 1485-00-3 |
| PD 166285 dihydrochloride | Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 | 212391-63-4 |
| PP 3 | Negative control for PP 2 (Cat. No. 1407) | 5334-30-5 |
Drug Products
Transcripts for LYN Gene
mRNA/cDNA for LYN Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (296) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000420292 561 bps (uc064mya.1)
- ENST00000520050 550 bps (uc064mxz.1)
- ENST00000520220 5808 bps (uc003xsl.5)
- ENST00000519728 2297 bps (uc003xsk.5)
Unigene Clusters for LYN Gene
- V-yes-1 Yamaguchi sarcoma viral related oncogene homolog:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LYN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYN
- genomics-online: gRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- Applied Biological Materials CRISPR for LYN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LYN
- GenScript: Design CRISPR guide RNA sequences for LYN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYN
- Browse OriGene Inhibitory RNA Products For LYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYN
- genomics-online: shRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
Clone Products
- Sino Biological Human cDNA Clone for LYN
- Addgene plasmids for LYN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYN
- Applied Biological Materials Clones for LYN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LYN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Granulocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- Skeletal Muscle (Muscoskeletal System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Heart (Cardiovascular System)
- Eye (Sensory Organs)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for LYN Gene
This gene is overexpressed in Whole Blood (x23.5).
This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Platelet (10.7), and Lymph node (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LYN Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LYN Gene:
LYNSOURCE GeneReport for Unigene cluster for LYN Gene:
Hs.491767mRNA Expression by UniProt/SwissProt for LYN Gene:
P07948-LYN_HUMAN
Tissue specificity:
Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
Evidence on tissue expression from TISSUES for LYN Gene
- Blood(4.6)
- Nervous system(4.3)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for LYN
-
OriGene qPCR primer pairs and template standards for LYN
- genomics-online: primer clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LYN Gene
Orthologs for LYN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LYN 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LYN 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LYN 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LYN 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lyn 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Lyn 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LYN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LYN 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LYN 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lyn 33 |
|
||
| Str.11837 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | lyn-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lyn 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Src64B 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | src-1 35 |
|
|
|
| K09B11.5 35 |
|
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|||
| W02A2.4 35 |
|
|
|||
| F26E4.5 35 |
|
|
|||
| T25B9.5 35 |
|
|
|||
| Y69E1A.3 35 |
|
|
|||
| Y52D5A.2 35 |
|
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|||
| kin-26 35 |
|
|
|||
| W01B6.5 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for LYN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for LYN Gene
- ENSEMBL:
- Gene Tree for LYN (if available)
- TreeFam:
- Gene Tree for LYN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LYN: view image
Paralogs for LYN Gene
(45) SIMAP similar genes for LYN Gene using alignment to 3 proteins:
- LYN_HUMAN
- E5RJ37_HUMAN
- Q6NUK7_HUMAN
- HCK
- BLK
- YES1
- c-fgr
- FYN
- FGR
- SRC
- FRK
- EPHA2
- LCK
- NCK1
- NCK2
- EPHA6
- PTK6
- TXK
- EPHA4
- EPHA3
- BTK kinase deficient isoform 2
- BMX
- BCR/ABL fusion
- EPHA5
- BTK
- TEC
- EPHB4
- EPHB3
- ITK
- GRAPL
- GRAP2
- SRMS
- SLA2
- EPHB2 variant protein
- EPHB2
- EPHB1
- PRKAA1
- SLA
- CSK
- ABL1
- lsk
- FER
- DKFZp434L0319
- MATK
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- GRB2
- urf-ret
Variants for LYN Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041737 | A breast pleomorphic lobular carcinoma sample | p.Asp385Tyr | |||
| rs1000009575 | -- | 55,996,118(+) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000031811 | -- | 55,904,488(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000053078 | -- | 55,920,944(+) | G/A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000054242 | -- | 55,898,147(+) | C/CC | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12173n54 | CNV | gain | 21841781 |
| dgv459n21 | CNV | gain | 19592680 |
| dgv7228n100 | CNV | gain | 25217958 |
| dgv889n27 | CNV | gain | 19166990 |
| esv1236863 | CNV | insertion | 17803354 |
| esv1459437 | CNV | deletion | 17803354 |
| esv2752257 | CNV | gain | 17911159 |
| esv3617283 | CNV | gain | 21293372 |
| esv3617285 | CNV | gain | 21293372 |
| esv3617287 | CNV | gain | 21293372 |
| esv3891398 | CNV | gain | 25118596 |
| nsv1077747 | CNV | insertion | 25765185 |
| nsv1142531 | CNV | tandem duplication | 24896259 |
| nsv507467 | OTHER | sequence alteration | 20534489 |
| nsv522326 | CNV | gain | 19592680 |
| nsv524526 | CNV | loss | 19592680 |
| nsv527033 | CNV | loss | 19592680 |
| nsv527341 | CNV | gain | 19592680 |
| nsv611393 | CNV | gain | 21841781 |
| nsv831319 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.45;
9.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LYN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYN Gene
Disorders for LYN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma |
|
|
| hantavirus pulmonary syndrome |
|
|
| spherocytosis, type 1 |
|
|
| leukemia, chronic myeloid |
|
|
| megakaryocytic leukemia |
|
|
Search LYN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LYN_HUMAN- Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein. Abnormally elevated expression levels or activation of LYN signaling may play a role in survival and proliferation of some types of cancer cells.
Additional Disease Information for LYN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for LYN Gene
Publications for LYN Gene
- Genetic associations of LYN with systemic lupus erythematosus. (PMID: 19369946) Lu R … Guthridge JM (Genes and immunity 2009) 3 22 44 58
- Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. (PMID: 18817770) Ikeda K … Yamaguchi N (Experimental cell research 2008) 3 4 22 58
- Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. (PMID: 18577747) Wu J … Donato NJ (Journal of the National Cancer Institute 2008) 3 4 22 58
- Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. (PMID: 18235045) Wu J … Donato NJ (Blood 2008) 3 4 22 58
- Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PMID: 18070987) Tauzin S … Hoessli DC (Blood 2008) 3 4 22 58
Products for LYN Gene
- R&D Systems Antibodies for LYN (Lyn)
- R&D Systems Proteins and Enzymes for LYN (Lyn B)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for LYN (Lyn)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for LYN
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for LYN
- Search Origene for MassSpec and Protein Over-expression Lysates for LYN
- Origene Custom Protein Services for LYN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LYN
- Browse OriGene Inhibitory RNA Products For LYN
- OriGene qPCR primer pairs for LYN
- OriGene qPCR primer pairs and template standards for LYN
- OriGene CRISPR knockouts for LYN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LYN
- GenScript: Next-day shipping of latest version cDNA ORF clones for LYN in any vector
- GenScript Custom Purified and Recombinant Proteins Services for LYN
- GenScript Custom Assay Services for LYN
- GenScript Custom overexpressing Cell Line Services for LYN
- GenScript: Design CRISPR guide RNA sequences for LYN
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LYN
- Sino Biological Human cDNA Clone for LYN
- Sino Biological Recombinant Proteins for LYN
- Sino Biological Cell Lysates for LYN
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LYN
- Novus Biologicals proteins and lysates for LYN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for LYN
- Abcam proteins for LYN
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for LYN
- Invitrogen Antibodies for LYN (AFLGC-LYN)
- Cyagen custom Knockout/knockin (KOKI) mouse models for LYN
- Addgene plasmids for LYN
- antibodies-online: Search results for 237 available LYN Antibodies ranked by validation data
- Compare Top LYN Antibodies
- Recommended
- 187 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 90 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 119 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Search results for 12 available LYN Elisa Kits ranked by validation data
- Compare Top LYN Elisa Kits
- antibodies-online: Search results for 21 available LYN Proteins ranked by validation data
- Compare Top LYN Proteins
- GeneTex LYN Antibody for LYN
- GeneTex Proteins for LYN
- Santa Cruz Biotechnology (SCBT) Antibodies for LYN
- Search Santa Cruz Biotechnology (SCBT) for LYN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LYN
- Horizon Cell Lines for LYN
- genomics-online: cdna clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- orf clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- genomics-online: gRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- genomics-online: primer clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- genomics-online: shRNA clones - Search results for 139 available LYN gene related products
- Overview of 139 available LYN gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LYN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LYN
- GeneCopoeia miRNA 3'UTR Target clone products for LYN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYN
Sources for LYN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt