LYN Gene (Protein Coding)

LYN Proto-Oncogene, Src Family Tyrosine Kinase

GC08P055879
GIFtS:
50
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] See more...

Aliases for LYN Gene

Aliases for LYN Gene

  • LYN Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog 2 3 4
  • JTK8 2 3 4
  • Lck/Yes-Related Novel Protein Tyrosine Kinase 3 4
  • Tyrosine-Protein Kinase Lyn 3 4
  • EC 2.7.10.2 4 50
  • P53Lyn 3 4
  • P56Lyn 3 4
  • EC 2.7.10 50
  • LYN 5

External Ids for LYN Gene

Previous GeneCards Identifiers for LYN Gene

  • GC08P055975
  • GC08P056731
  • GC08P056515
  • GC08P056842
  • GC08P056954
  • GC08P056792
  • GC08P052260

Summaries for LYN Gene

Entrez Gene Summary for LYN Gene

  • This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

CIViC Summary for LYN Gene

GeneCards Summary for LYN Gene

LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LYN include Sarcoma and Mastocytosis, Cutaneous. Among its related pathways are RET signaling and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HCK.

UniProtKB/Swiss-Prot Summary for LYN Gene

  • Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).

Tocris Summary for LYN Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for LYN Gene

Additional gene information for LYN Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LYN Gene

Genomics for LYN Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LYN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LYN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LYN

Top Transcription factor binding sites by QIAGEN in the LYN gene promoter:
  • AML1a

Genomic Locations for LYN Gene

Latest Assembly
chr8:55,876,041-56,014,169
(GRCh38/hg38)
Size:
138,129 bases
Orientation:
Plus strand

Previous Assembly
chr8:56,792,394-56,926,728
(GRCh37/hg19 by Entrez Gene)
Size:
134,335 bases
Orientation:
Plus strand

chr8:56,792,372-56,923,940
(GRCh37/hg19 by Ensembl)
Size:
131,569 bases
Orientation:
Plus strand

Genomic View for LYN Gene

Genes around LYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LYN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LYN Gene

Proteins for LYN Gene

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  • Protein details for LYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07948-LYN_HUMAN
    Recommended name:
    Tyrosine-protein kinase Lyn
    Protein Accession:
    P07948
    Secondary Accessions:
    • A0AVQ5

    Protein attributes for LYN Gene

    Size:
    512 amino acids
    Molecular mass:
    58574 Da
    Quaternary structure:
    • Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region) (PubMed:21930792). This interaction facilitates the phosphorylation of SCIMP on 'Tyr-107', which enhances binding of SCIMP to TLR4, and consequently the phosphorylation of TLR4 in response to stimulation by lipopolysaccharide in macrophages (By similarity). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3-domain) with ANKRD54 (via ankyrin repeat region) in an activation-independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1. Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation. Interacts with CD36. Interacts with LYN (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity).
    • (Microbial infection) Interacts with Epstein-Barr virus LMP2A.
    • (Microbial infection) Interacts with Herpes virus saimiri tyrosine kinase interacting protein (Tip).

    Three dimensional structures from OCA and Proteopedia for LYN Gene

    Alternative splice isoforms for LYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYN Gene

Protein Expression for LYN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for LYN Gene

P07948:
  • KTLKPGTM
  • KWTAPEA
  • TATEGQYQ
  • IKSDVWSFGILL
  • FLIRESE
  • FTIKSDVWSFG
  • NYIHRDLR
  • CKIADFGLAR
  • RKDAERQLL
  • GQFGEVW
  • LVRLYAVV
  • KGSLLDFLK
  • LSVRDFD
  • YISPRITFP
  • DNGGYYI
  • LETEEWFFK
  • EPIYIITE
  • DLSFKKG
  • KSDVWSFG
  • DFYTATE
  • KFPIKWTAPE
  • AQIAEGMA
  • DAWEIPR
  • LGAGQFGEV
  • PIYIITE
  • GMAYIER

Post-translational modifications for LYN Gene

  • Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent.
  • Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for LYN

Domains & Families for LYN Gene

Gene Families for LYN Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for LYN Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tyrosine protein kinase, active site
  • SH3 domain signature

Suggested Antigen Peptide Sequences for LYN Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein kinase Lyn (LYN_HUMAN)
  • LYN protein (Q6NUK7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07948

UniProtKB/Swiss-Prot:

LYN_HUMAN :
  • The protein kinase domain plays an important role in its localization in the cell membrane.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The protein kinase domain plays an important role in its localization in the cell membrane.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with LYN: view

Function for LYN Gene

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  1. Animal Models for research
  2. CRISPR products for research
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  6. Cell Lines for research

Molecular function for LYN Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:7682714, ECO:0000269|PubMed:8064233};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656.
GENATLAS Biochemistry:
Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog,highly expressed in the central nervous system,physically linked to AMPA receptor and activated following stimulation of the receptor,then activating the MAP Kinase pathway

Enzyme Numbers (IUBMB) for LYN Gene

Phenotypes From GWAS Catalog for LYN Gene

Gene Ontology (GO) - Molecular Function for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,TAS --
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with LYN: view
genes like me logo Genes that share phenotypes with LYN: view

Animal Models for LYN Gene

MGI Knock Outs for LYN:
  • Lyn Lyn<tm1Sor>
  • Lyn Lyn<tm1Ard>
  • Lyn Lyn<tm1b(EUCOMM)Hmgu>
  • Lyn Lyn<tm1Tya>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYN

Clone products for research

  • Addgene plasmids for LYN

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LYN Gene

Localization for LYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYN Gene

Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane. Lipid-anchor. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LYN gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Plasma membrane (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005794 Golgi apparatus IDA 15173188
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LYN: view

Pathways & Interactions for LYN Gene

genes like me logo Genes that share pathways with LYN: view

Pathways by source for LYN Gene

6 GeneGo (Thomson Reuters) pathways for LYN Gene
  • Development EPO-induced Jak-STAT pathway
  • Development EPO-induced MAPK pathway
  • Immune response BCR pathway
  • Immune response Fc epsilon RI pathway
  • Immune response NFAT in immune response
9 Qiagen pathways for LYN Gene
  • Fc-EpsilonRI Pathway
  • Fc-GammaR Pathway
  • Fc-Gamma-RIIB Signaling in B-Cells
  • Fc-GammaR-Mediated Phagocytosis in Macrophages
  • NFAT in Immune Response
3 Cell Signaling Technology pathways for LYN Gene

SIGNOR curated interactions for LYN Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for LYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0001817 regulation of cytokine production ISS --
GO:0001932 regulation of protein phosphorylation TAS 15489917
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0001934 positive regulation of protein phosphorylation IGI 24217950
genes like me logo Genes that share ontologies with LYN: view

Drugs & Compounds for LYN Gene

Products:

  1. Drug products for research

(44) Drugs for LYN Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 334
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Nintedanib Approved Pharma Target, inhibitor VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors 152
Ponatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 67

(26) Additional Compounds for LYN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
PD 166285 dihydrochloride
212391-63-4

(4) Tocris Compounds for LYN Gene

Compound Action Cas Number
Herbimycin A Src family kinase inhibitor. Also Hsp90 inhibitor 70563-58-5
MNS Selective inhibitor of Src and Syk 1485-00-3
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 212391-63-4
PP 3 Negative control for PP 2 (Cat. No. 1407) 5334-30-5

(3) ApexBio Compounds for LYN Gene

Compound Action Cas Number
Bafetinib (INNO-406) Bcr-Abl/Lyn tyrosine kinase inhibitor 887650-05-7
PP 1 Src family tyrosine kinase inhibitor 172889-26-8
PP 2 (AG 1879) Src-family kinases inhibitor 172889-27-9
genes like me logo Genes that share compounds with LYN: view

Drug products for research

Transcripts for LYN Gene

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mRNA/cDNA for LYN Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LYN

Clone products for research

  • Addgene plasmids for LYN

Alternative Splicing Database (ASD) splice patterns (SP) for LYN Gene

No ASD Table

Relevant External Links for LYN Gene

GeneLoc Exon Structure for
LYN

Expression for LYN Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LYN Gene

mRNA expression in normal human tissues for LYN Gene
mRNA expression by BioGPS for LYN GenemRNA expression by GTEx for LYN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYN Gene

This gene is overexpressed in Whole Blood (x23.5).

Protein differential expression in normal tissues from HIPED for LYN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Platelet (10.7), and Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LYN Gene



Protein tissue co-expression partners for LYN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LYN

SOURCE GeneReport for Unigene cluster for LYN Gene:

Hs.491767

mRNA Expression by UniProt/SwissProt for LYN Gene:

P07948-LYN_HUMAN
Tissue specificity: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.

Evidence on tissue expression from TISSUES for LYN Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Liver(4.4)
  • Heart(2.4)
  • Bone marrow(2.3)
  • Spleen(2.2)
  • Lymph node(2.2)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with LYN: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LYN Gene

Orthologs for LYN Gene

This gene was present in the common ancestor of animals.

Orthologs for LYN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LYN 29 30
  • 99.61 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia LYN 30
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LYN 29 30
  • 91.41 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LYN 29 30
  • 89.97 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Lyn 29 16 30
  • 88.93 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Lyn 29
  • 87.89 (n)
Oppossum
(Monodelphis domestica)
 Mammalia LYN 30
  • 85 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LYN 29 30
  • 80.35 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia LYN 30
  • 86 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia lyn 29
  • 76.5 (n)
Str.11837 29
African clawed frog
(Xenopus laevis)
 Amphibia lyn-A 29
Zebrafish
(Danio rerio)
 Actinopterygii lyn 29 30
  • 71.81 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Src64B 31
  • 48 (a)
Worm
(Caenorhabditis elegans)
 Secernentea src-1 31
  • 43 (a)
K09B11.5 31
  • 35 (a)
W02A2.4 31
  • 35 (a)
T25B9.5 31
  • 34 (a)
F26E4.5 31
  • 34 (a)
Y69E1A.3 31
  • 33 (a)
kin-26 31
  • 32 (a)
Y52D5A.2 31
  • 32 (a)
W01B6.5 31
  • 29 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 53 (a)
 ManyToMany
-- 30
  • 49 (a)
 ManyToMany
-- 30
  • 47 (a)
 ManyToMany
Species where no ortholog for LYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LYN Gene

ENSEMBL:
Gene Tree for LYN (if available)
TreeFam:
Gene Tree for LYN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LYN: view image
Alliance of Genome Resources:
Additional Orthologs for LYN

Paralogs for LYN Gene

Variants for LYN Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LYN Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1007962 Uncertain Significance: not provided 55,941,890(+) A/G
NM_002350.4(LYN):c.31A>G (p.Ser11Gly) 		MISSENSE
rs2227978 Benign: not provided 55,998,369(+) C/T
NM_002350.4(LYN):c.1074C>T (p.Ile358=) 		SYNONYMOUS
rs2227979 Benign: not provided 55,953,956(+) C/T
NM_002350.4(LYN):c.762C>T (p.Gly254=) 		SYNONYMOUS
rs766357723 Likely Benign: not provided 55,947,612(+) CT/C
NM_002350.4(LYN):c.179-3del 		INTRON
VAR_041737 A breast pleomorphic lobular carcinoma sample p.Asp385Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LYN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LYN Gene

Variant ID Type Subtype PubMed ID
dgv12173n54 CNV gain 21841781
dgv459n21 CNV gain 19592680
dgv7228n100 CNV gain 25217958
dgv889n27 CNV gain 19166990
esv1236863 CNV insertion 17803354
esv1459437 CNV deletion 17803354
esv2752257 CNV gain 17911159
esv3617283 CNV gain 21293372
esv3617285 CNV gain 21293372
esv3617287 CNV gain 21293372
esv3891398 CNV gain 25118596
nsv1077747 CNV insertion 25765185
nsv1142531 CNV tandem duplication 24896259
nsv507467 OTHER sequence alteration 20534489
nsv522326 CNV gain 19592680
nsv524526 CNV loss 19592680
nsv527033 CNV loss 19592680
nsv527341 CNV gain 19592680
nsv611393 CNV gain 21841781
nsv831319 CNV gain 17160897

Variation tolerance for LYN Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LYN Gene

Human Gene Mutation Database (HGMD)
LYN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LYN
Leiden Open Variation Database (LOVD)
LYN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LYN Gene

Disorders for LYN Gene

MalaCards: The human disease database

(24) MalaCards diseases for LYN Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
mastocytosis, cutaneous
  • mastc
hantavirus pulmonary syndrome
  • four corners hantavirus
choreoacanthocytosis
  • chac
myeloid leukemia
  • leukaemia myelogenous
- elite association - COSMIC cancer census association via MalaCards
Search LYN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LYN_HUMAN
  • Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein. Abnormally elevated expression levels or activation of LYN signaling may play a role in survival and proliferation of some types of cancer cells.

Additional Disease Information for LYN

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LYN: view

No data available for Genatlas for LYN Gene

Publications for LYN Gene

  1. Genetic associations of LYN with systemic lupus erythematosus. (PMID: 19369946) Lu R … Guthridge JM (Genes and immunity 2009) 3 22 40
  2. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. (PMID: 18577747) Wu J … Donato NJ (Journal of the National Cancer Institute 2008) 3 4 22
  3. Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. (PMID: 18817770) Ikeda K … Yamaguchi N (Experimental cell research 2008) 3 4 22
  4. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. (PMID: 18235045) Wu J … Donato NJ (Blood 2008) 3 4 22
  5. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. (PMID: 18070987) Tauzin S … Hoessli DC (Blood 2008) 3 4 22

ExternalLinks

View latest publications for LYN gene in Mastermind

Products for LYN Gene

  • Addgene plasmids for LYN

Sources for LYN Gene