Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
LYN (LYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LYN include Sarcoma and Hantavirus Pulmonary Syndrome. Among its related pathways are B cell receptor signaling pathway (KEGG) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HCK.
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | TAS | -- |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IBA,TAS | -- |
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | 15173188 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Fc epsilon RI pathway |
Immune response BCR pathway
.44
Immune response Fc epsilon RI pathway
.44
|
|
2 | RET signaling | ||
3 | B cell receptor signaling pathway (KEGG) | ||
4 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||
5 | EPH-Ephrin signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001782 | B cell homeostasis | ISS | -- |
GO:0001817 | regulation of cytokine production | ISS | -- |
GO:0001932 | regulation of protein phosphorylation | TAS | 15489917 |
GO:0001933 | negative regulation of protein phosphorylation | ISS | -- |
GO:0001934 | positive regulation of protein phosphorylation | IGI | 24217950 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
bosutinib | Approved | Pharma | Target, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
Dasatinib | Approved, Investigational | Pharma | Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 324 | |
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Nintedanib | Approved | Pharma | Target, inhibitor | VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors | 145 | |
Ponatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 57 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
PD 166285 dihydrochloride |
|
212391-63-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
Herbimycin A | Src family kinase inhibitor. Also Hsp90 inhibitor | 70563-58-5 |
MNS | Selective inhibitor of Src and Syk | 1485-00-3 |
PD 166285 dihydrochloride | Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 | 212391-63-4 |
PP 3 | Negative control for PP 2 (Cat. No. 1407) | 5334-30-5 |
Compound | Action | Cas Number |
---|---|---|
Bafetinib (INNO-406) | Bcr-Abl/Lyn tyrosine kinase inhibitor | 887650-05-7 |
PP 1 | Src family tyrosine kinase inhibitor | 172889-26-8 |
PP 2 (AG 1879) | Src-family kinases inhibitor | 172889-27-9 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LYN 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LYN 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LYN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LYN 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lyn 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lyn 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | LYN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LYN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LYN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lyn 30 |
|
||
Str.11837 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | lyn-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lyn 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Src64B 32 |
|
|
|
Worm (Caenorhabditis elegans) |
Secernentea | src-1 32 |
|
|
|
K09B11.5 32 |
|
|
|||
W02A2.4 32 |
|
|
|||
T25B9.5 32 |
|
|
|||
F26E4.5 32 |
|
|
|||
Y69E1A.3 32 |
|
|
|||
kin-26 32 |
|
|
|||
Y52D5A.2 32 |
|
|
|||
W01B6.5 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783841 | Benign: not provided | 55,998,369(+) | C/T | SYNONYMOUS_VARIANT | |
785251 | Benign: not provided | 55,953,956(+) | C/T | SYNONYMOUS_VARIANT | |
VAR_041737 | A breast pleomorphic lobular carcinoma sample | p.Asp385Tyr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12173n54 | CNV | gain | 21841781 |
dgv459n21 | CNV | gain | 19592680 |
dgv7228n100 | CNV | gain | 25217958 |
dgv889n27 | CNV | gain | 19166990 |
esv1236863 | CNV | insertion | 17803354 |
esv1459437 | CNV | deletion | 17803354 |
esv2752257 | CNV | gain | 17911159 |
esv3617283 | CNV | gain | 21293372 |
esv3617285 | CNV | gain | 21293372 |
esv3617287 | CNV | gain | 21293372 |
esv3891398 | CNV | gain | 25118596 |
nsv1077747 | CNV | insertion | 25765185 |
nsv1142531 | CNV | tandem duplication | 24896259 |
nsv507467 | OTHER | sequence alteration | 20534489 |
nsv522326 | CNV | gain | 19592680 |
nsv524526 | CNV | loss | 19592680 |
nsv527033 | CNV | loss | 19592680 |
nsv527341 | CNV | gain | 19592680 |
nsv611393 | CNV | gain | 21841781 |
nsv831319 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sarcoma |
|
|
hantavirus pulmonary syndrome |
|
|
mastocytosis, cutaneous |
|
|
choreoacanthocytosis |
|
|
myeloid leukemia |
|