Aliases for LY96 Gene
External Ids for LY96 Gene
Previous GeneCards Identifiers for LY96 Gene
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
GeneCards Summary for LY96 Gene
LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include Melioidosis and Acute Gonococcal Cervicitis. Among its related pathways are Bacterial infections in CF airways and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.
UniProtKB/Swiss-Prot Summary for LY96 Gene
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).