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This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include Melioidosis and Acute Gonococcal Cervicitis. Among its related pathways are Bacterial infections in CF airways and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J073990 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 250.7 | +1.2 | 1221 | 3.8 | SP1 BCL11A GABPA GTF2E2 FOXA2 TRIM22 ELF1 EBF1 ZNF316 ADNP | HSALNG0066214 LY96 TMEM70 ELOC PCBP2P2 piR-60140-024 GDAP1 | |
GH08J073967 | Enhancer | 0.6 | ENCODE | 10.6 | -24.8 | -24794 | 0.2 | CEBPA IKZF1 CEBPB NFE2 IRF9 ZNF384 CEBPG HLF FOS RBFOX2 | LY96 UBE2W TMEM70 ELOC HSALNG0066207 piR-57461-258 | |
GH08J073966 | Promoter | 0.5 | Ensembl | 10.6 | -24.4 | -24374 | 0.2 | CEBPB RBFOX2 | LY96 UBE2W ELOC HSALNG0066207 piR-57461-258 | |
GH08J073965 | Promoter | 0.5 | Ensembl | 10.6 | -25.4 | -25374 | 0.2 | ZNF189 ZNF24 | LY96 UBE2W ELOC HSALNG0066207 piR-57461-258 | |
GH08J074056 | Enhancer | 0.3 | Ensembl | 10.8 | +66.0 | 66026 | 1.4 | ZNF316 MAFK | RPS3AP32 lnc-LY96-5 TMEM70 ELOC LY96 GDAP1 ENSG00000253596 ENSG00000254288 lnc-LY96-4 RF00026-1084 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | IEA | -- |
GO:0001875 | lipopolysaccharide receptor activity | IBA,IDA | 19252480 |
GO:0005515 | protein binding | IPI | 15728506 |
GO:0015026 | coreceptor activity | TAS | 10359581 |
GO:0035662 | Toll-like receptor 4 binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0010008 | endosome membrane | TAS | -- |
GO:0031226 | intrinsic component of plasma membrane | IDA | 11274165 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Diseases associated with the TLR signaling cascade | ||
3 | Toll-like Receptor Signaling Pathway | ||
4 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
5 | Toll-Like receptor Signaling Pathways |
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
GO:0006954 | inflammatory response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
lauric acid | Approved, Experimental | Pharma | Target | 0 | ||
Morphine | Approved, Investigational | Pharma | Target, activator | 1486 | ||
(R)-3-hydroxytetradecanoic acid | Experimental | Pharma | Target | 0 | ||
Myristic acid | Experimental | Pharma | Target | 0 | ||
Tumor necrosis factor alpha (TNF-alpha) inhibitors | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LY96 30 |
|
||
MD2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | LY96 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LY96 30 |
|
||
MD2 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Ly96 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ly96 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | LY96 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LY96 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11466004 | - |
p.Pro157Ser |
|||
rs6472812 | - |
p.Arg56Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2668168 | CNV | deletion | 23128226 |
esv3617644 | CNV | loss | 21293372 |
nsv6259 | CNV | insertion | 18451855 |
nsv831355 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melioidosis |
|
|
acute gonococcal cervicitis |
|
|
acute cervicitis |
|
|
pneumonia |
|
|
cataract 30 |
|
|