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This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding dif... See more...
Aliases for LY96 Gene
Aliases for LY96 Gene
External Ids for LY96 Gene
- HGNC: 17156
- Entrez Gene: 23643
- Ensembl: ENSG00000154589
- OMIM: 605243
- UniProtKB: Q9Y6Y9
Previous GeneCards Identifiers for LY96 Gene
- GC08P074844
- GC08P074626
- GC08P074953
- GC08P075066
- GC08P070394
Summaries for LY96 Gene
-
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
GeneCards Summary for LY96 Gene
LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include Melioidosis and Intestinal Botulism. Among its related pathways are Antigen processing-Cross presentation and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.
UniProtKB/Swiss-Prot Summary for LY96 Gene
-
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Additional gene information for LY96 Gene
- HGNC(17156)
- Entrez Gene(23643)
- Ensembl(ENSG00000154589)
- OMIM(605243)
- UniProtKB(Q9Y6Y9)
- Open Targets Platform(ENSG00000154589)
- Monarch Initiative
- Search for LY96 at DataMed
- Search for LY96 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LY96 Gene
Genomics for LY96 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LY96 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J073990 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 600.7 | +1.2 | 1221 | 3.8 | SP1 GATAD2A TFE3 JUND RELA TCF12 IKZF2 TRIM22 HDAC1 GABPA | LY96 TMEM70 ELOC piR-60140-024 GDAP1 | |
| GH08J073967 | Enhancer | 0.6 | ENCODE | 10.6 | -24.8 | -24794 | 0.2 | IKZF1 PRDM1 RBFOX2 CEBPA CEBPB NFE2 FOS CEBPG ZNF384 IRF9 | LY96 UBE2W TMEM70 ELOC piR-57461-258 | |
| GH08J073965 | Promoter | 0.6 | Ensembl | 10.6 | -25.4 | -25374 | 0.2 | NR3C1 ZNF189 ZNF24 | LY96 UBE2W ELOC piR-57461-258 | |
| GH08J073966 | Promoter | 0.5 | Ensembl | 10.6 | -24.4 | -24374 | 0.2 | RBFOX2 CEBPB | LY96 UBE2W ELOC piR-57461-258 | |
| GH08J074056 | Enhancer | 0.3 | Ensembl | 10.8 | +66.0 | 66026 | 1.4 | ZNF316 MAFK | RPS3AP32 lnc-LY96-5 TMEM70 ELOC LY96 GDAP1 ENSG00000253596 ENSG00000254288 lnc-LY96-4 RF00026-1084 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LY96 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LY96
- Top Transcription factor binding sites by QIAGEN in the LY96 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- IRF-1
- MRF-2
- Msx-1
- MZF-1
- STAT1
- STAT1alpha
- TBP
Genomic Locations for LY96 Gene
Genomic Locations for LY96 Gene
- chr8:73,991,275-74,099,807
- (GRCh38/hg38)
- Size:
- 108,533 bases
- Orientation:
- Plus strand
- chr8:74,903,564-74,941,322
- (GRCh37/hg19)
- Size:
- 37,759 bases
- Orientation:
- Plus strand
Genomic View for LY96 Gene
Genes around LY96 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.11 by HGNC
- 8q21.11 by Entrez Gene
- 8q21.11 by Ensembl
LY96 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LY96 Gene
Proteins for LY96 Gene
-
Protein details for LY96 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6Y9-LY96_HUMAN
- Recommended name:
- Lymphocyte antigen 96
- Protein Accession:
- Q9Y6Y9
- B3Y6A5
- E5RJJ7
Protein attributes for LY96 Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18546 Da
- Quaternary structure:
-
- Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.
Three dimensional structures from OCA and Proteopedia for LY96 Gene
Protein Expression for LY96 Gene
Post-translational modifications for LY96 Gene
- N-glycosylated; high-mannose.
-
Glycosylation at Asn26 and Asn114
- NX_Q9Y6Y9 (NX_Q9Y6Y9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for LY96 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ LY96 Antibody
-
Custom Antibody ServicesOriGene Antibodies for LY96
- Novus Biologicals Antibodies for LY96
-
Abcam antibodies for LY96
- Invitrogen Antibodies for LY96 (AFLGC-LY96)
-
Custom Antibody ServicesProSci Antibodies for LY96
-
Santa Cruz Biotechnology (SCBT) Antibodies for LY96
Protein Products
-
OriGene Purified Proteins for LY96
- Search Origene for MassSpec and Protein Over-expression Lysates for LY96
- Origene Custom Protein Services for LY96
- Sino Biological Recombinant Proteins for LY96
- Sino Biological Cell Lysates for LY96
-
Abcam proteins for LY96
No data available for DME Specific Peptides for LY96 Gene
Domains & Families for LY96 Gene
Gene Families for LY96 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for LY96 Gene
Suggested Antigen Peptide Sequences for LY96 Gene
- GenScript: Design optimal peptide antigens:
-
- MD-2 mimetic protein variant (D0VAW8_HUMAN)
- Protein MD-2 (LY96_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LY96 Gene
Function for LY96 Gene
Molecular function for LY96 Gene
- UniProtKB/Swiss-Prot Function:
- Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Phenotypes From GWAS Catalog for LY96 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IEA | -- |
| GO:0001875 | lipopolysaccharide receptor activity | IBA,IDA | 19252480 |
| GO:0005515 | protein binding | IPI | 15728506 |
| GO:0015026 | coreceptor activity | TAS | 10359581 |
| GO:0035662 | Toll-like receptor 4 binding | IEA | -- |
Phenotypes for LY96 Gene
- MGI mutant phenotypes for LY96:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for LY96:
Animal Models for LY96 Gene
- MGI Knock Outs for LY96:
-
- Ly96 Ly96<tm1Kmiy>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY96 - Select products 50% OFF >
- * LY96 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LY96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY96
-
Santa Cruz Biotechnology (SCBT) CRISPR for LY96
miRNA for LY96 Gene
- miRTarBase miRNAs that target LY96
-
- mmu-miR-1198-5p (MIRT591223)
- mmu-miR-511-3p (MIRT591224)
- mmu-miR-466e-5p (MIRT591225)
- mmu-miR-466a-5p (MIRT591226)
- mmu-miR-1187 (MIRT591227)
- mmu-miR-466p-5p (MIRT591228)
- mmu-miR-466d-5p (MIRT591229)
- mmu-miR-466l-5p (MIRT591230)
- mmu-miR-466i-5p (MIRT591231)
- mmu-miR-466k (MIRT591232)
- mmu-miR-871-5p (MIRT591233)
- mmu-miR-669f-3p (MIRT592229)
- mmu-miR-466n-3p (MIRT592230)
- mmu-miR-669m-3p (MIRT592231)
- mmu-miR-466e-3p (MIRT592232)
- mmu-miR-466a-3p (MIRT592233)
- mmu-miR-466d-3p (MIRT592234)
- mmu-miR-467g (MIRT592235)
- mmu-miR-297b-3p (MIRT592236)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY96
- Browse OriGene Inhibitory RNA Products For LY96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
Clone Products
- Applied Biological Materials (abm): Clones for LY96 - Select products 50% OFF >
- * LY96 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225297
- MG225298
- MR225297
- MR225297L3
- MR225297L4
- MR225298
- MR225298L3
- MR225298L4
- RC204686
- RC204686L1
- RC204686L2
- RC204686L3
- RC204686L4
- RC230968
- RC230968L3
- RC230968L4
- RG204686
- RG230968
- RR204674
- RR204674L3
- RR204674L4
- MR225297L3V
- MR225297L4V
- MR225298L3V
- MR225298L4V
- RC204686L1V
- RC204686L2V
- RC204686L3V
- RC204686L4V
- RC230968L3V
- RC230968L4V
- RR204674L3V
- RR204674L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LY96
- Addgene plasmids for LY96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY96
Cell Line Products
-
Horizon Cell Lines for LY96
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LY96 Gene
Localization for LY96 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LY96 Gene
- Secreted, extracellular space. Secreted. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). {ECO:0000269 PubMed:10359581, ECO:0000269 PubMed:11593030}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0031226 | intrinsic component of plasma membrane | IDA | 11274165 |
Pathways & Interactions for LY96 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
| 5 | Toll-Like receptor Signaling Pathways |
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
Pathways by source for LY96 Gene
1 Sino Biological pathway for LY96 Gene
3 BioSystems pathways for LY96 Gene
35 Reactome pathways for LY96 Gene
5 KEGG pathways for LY96 Gene
8 GeneGo (Thomson Reuters) pathways for LY96 Gene
- Bacterial infections in CF airways
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Immune response Bacterial infections in normal airways
- Immune response MIF in innate immunity response
2 R&D Systems pathways for LY96 Gene
5 Qiagen pathways for LY96 Gene
- MIF Action Through Endocytic Pathway
- MIF Mediated Glucocorticoid Regulation
- MIF Regulation of Innate Immune Cells
- Toll Comparative Pathway
- Toll-Like Receptors Pathway
1 GeneTex pathway for LY96 Gene
Interacting Proteins for LY96 Gene
Selected Interacting proteins:
Q9Y6Y9-LY96_HUMAN
ENSP00000284818
for LY96 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LY96
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
| GO:0006954 | inflammatory response | IEA | -- |
Drugs & Compounds for LY96 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| lauric acid | Approved, Experimental | Pharma | Agonist, Target | 0 | ||
| Morphine | Approved, Investigational | Pharma | Agonist, Full agonist, Partial agonist, Target, activator | 1406 | ||
| (R)-3-hydroxytetradecanoic acid | Experimental | Pharma | Target | 0 | ||
| Myristic acid | Experimental | Pharma | Target | 0 | ||
| Tumor necrosis factor alpha (TNF-alpha) inhibitors | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for LY96 Gene
mRNA/cDNA for LY96 Gene
- 2 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000284818 559 nts (view in UCSC)
- ENST00000518893 430 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY96 - Select products 50% OFF >
- * LY96 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LY96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY96
-
Santa Cruz Biotechnology (SCBT) CRISPR for LY96
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY96
- Browse OriGene Inhibitory RNA Products For LY96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
Clone Products
- Applied Biological Materials (abm): Clones for LY96 - Select products 50% OFF >
- * LY96 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225297
- MG225298
- MR225297
- MR225297L3
- MR225297L4
- MR225298
- MR225298L3
- MR225298L4
- RC204686
- RC204686L1
- RC204686L2
- RC204686L3
- RC204686L4
- RC230968
- RC230968L3
- RC230968L4
- RG204686
- RG230968
- RR204674
- RR204674L3
- RR204674L4
- MR225297L3V
- MR225297L4V
- MR225298L3V
- MR225298L4V
- RC204686L1V
- RC204686L2V
- RC204686L3V
- RC204686L4V
- RC230968L3V
- RC230968L4V
- RR204674L3V
- RR204674L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LY96
- Addgene plasmids for LY96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY96
Relevant External Links for LY96 Gene
- GeneLoc Exon Structure for
- LY96
Expression for LY96 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LY96 Gene
This gene is overexpressed in Whole Blood (x10.3) and Spleen (x5.0).
This gene is overexpressed in Gallbladder (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LY96 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LY96
SOURCE GeneReport for Unigene cluster for LY96 Gene:
Hs.726603Evidence on tissue expression from TISSUES for LY96 Gene
- Liver(4.5)
- Blood(3.6)
- Spleen(3.4)
- Lymph node(3.2)
- Intestine(3.1)
- Heart(3)
- Lung(2.9)
- Nervous system(2.9)
- Kidney(2.7)
- Bone marrow(2.5)
- Skin(2.5)
- Muscle(2.5)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs for LY96
-
OriGene qPCR primer pairs and template standards for LY96
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY96 Gene
Orthologs for LY96 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LY96 30 |
|
||
| MD2 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | LY96 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LY96 30 |
|
||
| MD2 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Ly96 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ly96 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | LY96 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LY96 31 |
|
OneToOne |
- Species where no ortholog for LY96 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LY96 Gene
- ENSEMBL:
- Gene Tree for LY96 (if available)
- TreeFam:
- Gene Tree for LY96 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LY96: view image
Paralogs for LY96 Gene
No data available for Paralogs for LY96 Gene
Variants for LY96 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LY96 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11466004 | - | p.Pro157Ser | |||
| rs6472812 | - | p.Arg56Gly |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2668168 | CNV | deletion | 23128226 |
| esv3617644 | CNV | loss | 21293372 |
| nsv6259 | CNV | insertion | 18451855 |
| nsv831355 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LY96 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY96 Gene
Disorders for LY96 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melioidosis |
|
|
| intestinal botulism |
|
|
| irak4 deficiency |
|
|
| myd88 deficiency |
|
|
| parametritis |
|
|
Search LY96 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LY96
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LY96 Gene
Publications for LY96 Gene
- Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PMID: 19200604) Verstraelen H … Temmerman M (Journal of reproductive immunology 2009) 3 23 41
- Natural selection in the TLR-related genes in the course of primate evolution. (PMID: 18810425) Nakajima T … Kimura A (Immunogenetics 2008) 3 4 23
- Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. (PMID: 17569869) Ohto U … Satow Y (Science (New York, N.Y.) 2007) 3 4 23
- Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (PMID: 17803912) Kim HM … Lee JO (Cell 2007) 3 4 23
- Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. (PMID: 11274165) da Silva Correia J … Ulevitch RJ (The Journal of biological chemistry 2001) 3 4 23
ExternalLinks
Products for LY96 Gene
- Custom Antibody ServicesOriGene Antibodies for LY96
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- antibodies-online: Show 38 available LY96 Antibodies ranked by validation data
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
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