Aliases for LY96 Gene
Aliases for LY96 Gene
External Ids for LY96 Gene
- HGNC: 17156
- Entrez Gene: 23643
- Ensembl: ENSG00000154589
- OMIM: 605243
- UniProtKB: Q9Y6Y9
Previous GeneCards Identifiers for LY96 Gene
- GC08P074844
- GC08P074626
- GC08P074953
- GC08P075066
- GC08P070394
Summaries for LY96 Gene
-
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
GeneCards Summary for LY96 Gene
LY96 (Lymphocyte Antigen 96) is a Protein Coding gene. Diseases associated with LY96 include Intestinal Botulism and Wound Botulism. Among its related pathways are MIF Action Through Endocytic Pathway and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include coreceptor activity and lipopolysaccharide receptor activity.
UniProtKB/Swiss-Prot for LY96 Gene
-
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Additional gene information for LY96 Gene
- Monarch Initiative
- Search for LY96 at DataMed
- Search for LY96 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY96 Gene
Genomics for LY96 Gene
GeneHancer (GH) Regulatory Elements for LY96 Gene
Promoters and enhancers for LY96 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J073990 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 650.7 | +0.5 | 450 | 2.4 | HDAC1 ELF3 FOXA2 ZBTB40 RARA ZNF121 ATF7 ETV6 IKZF2 RUNX3 | LY96 TMEM70 GC08M074003 | |
| GH08J073967 | Enhancer | 0.6 | ENCODE | 10.6 | -24.8 | -24848 | 0.2 | HLF CEBPB CEBPG IRF9 CEBPA IKZF1 NFE2 FOS PRDM1 | GC08P073966 LY96 UBE2W TMEM70 ELOC GC08M073941 | |
| GH08J073966 | Enhancer | 0.3 | Ensembl | 10.6 | -24.4 | -24428 | 0.2 | CEBPB | GC08P073966 LY96 UBE2W GC08M073941 ELOC | |
| GH08J074032 | Enhancer | 0.2 | ENCODE | 11 | +41.9 | 41938 | 0.9 | TMEM70 LY96 ELOC GC08M074003 RNU6-1300P | ||
| GH08J074033 | Enhancer | 0.2 | ENCODE | 11 | +41.3 | 41292 | 0.2 | LY96 TMEM70 ELOC GDAP1 GC08M074003 RNU6-1300P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LY96 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LY96 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- IRF-1
- Msx-1
- MRF-2
- TBP
- MZF-1
- STAT1
- STAT1alpha
Regulatory Element Products
Genomic Locations for LY96 Gene
Genomic Locations for LY96 Gene
- chr8:73,991,329-74,032,562
- (GRCh38/hg38)
- Size:
- 41,234 bases
- Orientation:
- Plus strand
- chr8:74,903,564-74,941,322
- (GRCh37/hg19)
- Size:
- 37,759 bases
- Orientation:
- Plus strand
Genomic View for LY96 Gene
Genes around LY96 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.11 by Entrez Gene
- 8q21.11 by HGNC
- 8q21.11 by Ensembl
LY96 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LY96 Gene
Proteins for LY96 Gene
-
Protein details for LY96 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6Y9-LY96_HUMAN
- Recommended name:
- Lymphocyte antigen 96
- Protein Accession:
- Q9Y6Y9
- B3Y6A5
- E5RJJ7
Protein attributes for LY96 Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18546 Da
- Quaternary structure:
-
- Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.
Three dimensional structures from OCA and Proteopedia for LY96 Gene
Protein Expression for LY96 Gene
Post-translational modifications for LY96 Gene
- N-glycosylated; high-mannose.
- Glycosylation at posLast=114114 and isoforms=226
- Modification sites at PhosphoSitePlus
Other Protein References for LY96 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LY96 (MD2)
-
Custom Antibody ServicesOriGene Antibodies for LY96
- Novus Biologicals Antibodies for LY96
-
Abcam antibodies for LY96
- Invitrogen Antibodies for LY96
- GeneTex LY96 Antibody for LY96
-
Custom Antibody ServicesProSci Antibodies for LY96
-
Santa Cruz Biotechnology (SCBT) Antibodies for LY96
Protein Products
- R&D Systems Proteins and Enzymes for LY96 (MD2)
-
OriGene Purified Proteins for LY96
- Search Origene for MassSpec and Protein Over-expression Lysates for LY96
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- Sino Biological Cell Lysates for LY96
- Sino Biological Recombinant Proteins for LY96
- Search GeneTex for Proteins for LY96
-
ProSci Proteins for LY96
-
Abcam proteins for LY96
Assay Products
No data available for DME Specific Peptides for LY96 Gene
Domains & Families for LY96 Gene
Gene Families for LY96 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for LY96 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LY96 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LY96 Gene
Function for LY96 Gene
Molecular function for LY96 Gene
- UniProtKB/Swiss-Prot Function:
- Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Phenotypes From GWAS Catalog for LY96 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001875 | lipopolysaccharide receptor activity | IDA | 19252480 |
| GO:0005515 | protein binding | IPI | 17803912 |
| GO:0015026 | coreceptor activity | TAS | 10359581 |
Phenotypes for LY96 Gene
- MGI mutant phenotypes for LY96:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LY96:
Animal Models for LY96 Gene
- MGI Knock Outs for LY96:
-
- Ly96 Ly96<tm1Kmiy>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LY96
-
CRISPR Products
-
OriGene CRISPR knockouts for LY96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY96
- genomics-online: gRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- Applied Biological Materials CRISPR for LY96
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LY96
- GenScript: Design CRISPR guide RNA sequences for LY96
miRNA for LY96 Gene
- miRTarBase miRNAs that target LY96
-
- mmu-mir-1198-5p (MIRT591223)
- mmu-mir-511-3p (MIRT591224)
- mmu-mir-466e-5p (MIRT591225)
- mmu-mir-466a-5p (MIRT591226)
- mmu-mir-1187 (MIRT591227)
- mmu-mir-466p-5p (MIRT591228)
- mmu-mir-466d-5p (MIRT591229)
- mmu-mir-466l-5p (MIRT591230)
- mmu-mir-466i-5p (MIRT591231)
- mmu-mir-466k (MIRT591232)
- mmu-mir-871-5p (MIRT591233)
- mmu-mir-669f-3p (MIRT592229)
- mmu-mir-466n-3p (MIRT592230)
- mmu-mir-669m-3p (MIRT592231)
- mmu-mir-466e-3p (MIRT592232)
- mmu-mir-466a-3p (MIRT592233)
- mmu-mir-466d-3p (MIRT592234)
- mmu-mir-467g (MIRT592235)
- mmu-mir-297b-3p (MIRT592236)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY96
- Browse OriGene Inhibitory RNA Products For LY96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
- genomics-online: shRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LY96
- VectorBuilder custom plasmid, inducible vectors for LY96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LY96
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LY96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY96
- Applied Biological Materials Clones for LY96
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LY96
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LY96 Gene
Localization for LY96 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LY96 Gene
- Secreted, extracellular space. Secreted. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). {ECO:0000269 PubMed:10359581, ECO:0000269 PubMed:11593030}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 5 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0031226 | intrinsic component of plasma membrane | IDA | 11274165 |
Pathways & Interactions for LY96 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | Development Slit-Robo signaling | ||
Pathways by source for LY96 Gene
1 Sino Biological pathway for LY96 Gene
1 GeneTex pathway for LY96 Gene
3 BioSystems pathways for LY96 Gene
35 Reactome pathways for LY96 Gene
5 KEGG pathways for LY96 Gene
8 GeneGo (Thomson Reuters) pathways for LY96 Gene
2 R&D Systems pathways for LY96 Gene
Interacting Proteins for LY96 Gene
Selected Interacting proteins:
ENSP00000284818
Q9Y6Y9-LY96_HUMAN
for LY96 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for LY96
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
| GO:0006954 | inflammatory response | IEA | -- |
No data available for SIGNOR curated interactions for LY96 Gene
Drugs & Compounds for LY96 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| lauric acid | Approved, Experimental | Pharma | Agonist, Target | 0 | ||
| Methadone | Approved | Pharma | Target | 341 | ||
| Morphine | Approved, Investigational | Pharma | Full agonist, Agonist, Partial agonist, Target | 1100 | ||
| Kadian | Approved July 1996 | Pharma | 0 | |||
| UltraJect | Approved August 1996 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for LY96 Gene
mRNA/cDNA for LY96 Gene
- (5) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000284818 607 bps (uc003yad.4)
- ENST00000518893 430 bps (uc022awb.2)
Unigene Clusters for LY96 Gene
- Lymphocyte antigen 96:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LY96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY96
- genomics-online: gRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- Applied Biological Materials CRISPR for LY96
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LY96
- GenScript: Design CRISPR guide RNA sequences for LY96
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY96
- Browse OriGene Inhibitory RNA Products For LY96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
- genomics-online: shRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LY96
- VectorBuilder custom plasmid, inducible vectors for LY96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LY96
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LY96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY96
- Applied Biological Materials Clones for LY96
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LY96 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LY96 Gene
This gene is overexpressed in Whole Blood (x10.3) and Spleen (x5.0).
This gene is overexpressed in Gallbladder (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LY96 Gene
NURSA nuclear receptor signaling pathways regulating expression of LY96 Gene:
LY96SOURCE GeneReport for Unigene cluster for LY96 Gene:
Hs.726603Evidence on tissue expression from TISSUES for LY96 Gene
- Liver(4.4)
- Blood(3.1)
- Spleen(2.8)
- Intestine(2.5)
- Lymph node(2.5)
- Lung(2.3)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for LY96
-
OriGene qPCR primer pairs for LY96
- genomics-online: primer clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY96 Gene
Orthologs for LY96 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LY96 33 |
|
||
| MD2 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LY96 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LY96 33 |
|
||
| MD2 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ly96 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ly96 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LY96 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LY96 34 |
|
OneToOne |
- Species where no ortholog for LY96 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for LY96 Gene
- ENSEMBL:
- Gene Tree for LY96 (if available)
- TreeFam:
- Gene Tree for LY96 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LY96: view image
Paralogs for LY96 Gene
No data available for Paralogs for LY96 Gene
Variants for LY96 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003109 | -- | 74,030,296(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000035964 | -- | 74,024,718(+) | T/C | intron_variant | |
| rs1000057015 | -- | 74,024,286(+) | G/A | intron_variant | |
| rs1000060019 | -- | 74,063,638(+) | A/C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000082970 | -- | 74,036,049(+) | G/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2668168 | CNV | deletion | 23128226 |
| esv3617644 | CNV | loss | 21293372 |
| nsv6259 | CNV | insertion | 18451855 |
| nsv831355 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LY96 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY96 Gene
Disorders for LY96 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intestinal botulism |
|
|
| wound botulism |
|
|
| interstitial emphysema |
|
|
| parametritis |
|
|
| neurotic disorder |
|
|
Search LY96 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LY96
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LY96 Gene
Publications for LY96 Gene
- Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. (PMID: 17569869) Ohto U … Satow Y (Science (New York, N.Y.) 2007) 3 4 22 58
- Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (PMID: 17803912) Kim HM … Lee JO (Cell 2007) 3 4 22 58
- MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components. (PMID: 11160242) Dziarski R … Gupta D (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 22 58
- Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. (PMID: 11274165) da Silva Correia J … Ulevitch RJ (The Journal of biological chemistry 2001) 3 4 22 58
- Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. (PMID: 11466383) Abreu MT … Arditi M (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 22 58
Products for LY96 Gene
- R&D Systems Antibodies for LY96 (MD2)
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- Sino Biological Human cDNA Clone for LY96
- Sino Biological Cell Lysates for LY96
- Sino Biological Recombinant Proteins for LY96
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LY96
- Novus Biologicals lysates and proteins for LY96
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for LY96
- Abcam proteins for LY96
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for LY96
- VectorBuilder custom plasmid, inducible vectors for LY96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LY96
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LY96
- antibodies-online: Search results for 106 available LY96 Antibodies ranked by validation data
- Compare Top LY96 Antibodies
- antibodies-online: Search results for 18 available LY96 Elisa Kits ranked by validation data
- Compare Top LY96 Elisa Kits
- antibodies-online: Search results for 13 available LY96 Proteins ranked by validation data
- Compare Top LY96 Proteins
- GeneTex LY96 Antibody for LY96
- Search GeneTex for Proteins for LY96
- Santa Cruz Biotechnology (SCBT) Antibodies for LY96
- Search Santa Cruz Biotechnology (SCBT) for LY96 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LY96
- Custom Antibody ServicesProSci Antibodies for LY96
- ProSci Proteins for LY96
- Horizon Cell Lines for LY96
- genomics-online: cdna clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- orf clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- genomics-online: gRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- genomics-online: primer clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- genomics-online: shRNA clones - Search results for 122 available LY96 gene related products
- Overview of 122 available LY96 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY96
- GeneCopoeia miRNA 3'UTR Target clone products for LY96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY96
Sources for LY96 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt