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The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]
LY6G6F (Lymphocyte Antigen 6 Family Member G6F) is a Protein Coding gene. Diseases associated with LY6G6F include Dependent Personality Disorder and Histrionic Personality Disorder. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is LY6G6F-LY6G6D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0031092 | platelet alpha granule membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002576 | platelet degranulation | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LY6G6F 30 |
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-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | LY6G6F 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | LY6G6F 30 |
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||
Mouse (Mus musculus) |
Mammalia | Ly6g6f 30 17 |
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||
Rat (Rattus norvegicus) |
Mammalia | Ly6g6f 30 |
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||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780983 | Benign: not provided | 31,707,506(+) | C/A | MISSENSE_VARIANT | |
rs17200983 | - | p.Pro34Gln | |||
rs2242653 | - | p.Arg167Lys | |||
rs805295 | - | p.Pro39Ser | |||
rs9267547 | - | p.Ala107Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10403n54 | CNV | loss | 21841781 |
dgv10404n54 | CNV | loss | 21841781 |
nsv1073969 | CNV | deletion | 25765185 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1126749 | CNV | deletion | 24896259 |
nsv1161370 | CNV | deletion | 26073780 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dependent personality disorder |
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|
histrionic personality disorder |
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|
retinitis pigmentosa 20 |
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