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The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008] See more...
Aliases for LY6G6F Gene
Aliases for LY6G6F Gene
External Ids for LY6G6F Gene
- HGNC: 13933
- Entrez Gene: 259215
- Ensembl: ENSG00000204424
- OMIM: 611404
- UniProtKB: Q5SQ64
Previous HGNC Symbols for LY6G6F Gene
- LY6G6D
- C6orf21
Previous GeneCards Identifiers for LY6G6F Gene
- GC06P031784
- GC06P031674
- GC06P031460
Summaries for LY6G6F Gene
-
The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]
GeneCards Summary for LY6G6F Gene
LY6G6F (Lymphocyte Antigen 6 Family Member G6F) is a Protein Coding gene. Diseases associated with LY6G6F include Dependent Personality Disorder and Histrionic Personality Disorder. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is LY6G6F-LY6G6D.
UniProtKB/Swiss-Prot Summary for LY6G6F Gene
-
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Additional gene information for LY6G6F Gene
- HGNC(13933)
- Entrez Gene(259215)
- Ensembl(ENSG00000204424)
- OMIM(611404)
- UniProtKB(Q5SQ64)
- Open Targets Platform(ENSG00000204424)
- Search for LY6G6F at DataMed
- Search for LY6G6F at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LY6G6F Gene
Genomics for LY6G6F Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LY6G6F Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LY6G6F on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LY6G6F
- Top Transcription factor binding sites by QIAGEN in the LY6G6F gene promoter:
-
- ITF-2
- MRF-2
- NF-kappaB1
- PPAR-gamma1
- PPAR-gamma2
- RFX1
- Sp1
- Tal-1beta
Genomic Locations for LY6G6F Gene
Genomic Locations for LY6G6F Gene
- chr6:31,706,866-31,710,679
- (GRCh38/hg38)
- Size:
- 3,814 bases
- Orientation:
- Plus strand
- chr6:31,674,640-31,685,581
- (GRCh37/hg19)
- Size:
- 10,942 bases
- Orientation:
- Plus strand
Genomic View for LY6G6F Gene
Genes around LY6G6F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
LY6G6F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LY6G6F Gene
Proteins for LY6G6F Gene
-
Protein details for LY6G6F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5SQ64-LY66F_HUMAN
- Recommended name:
- Lymphocyte antigen 6 complex locus protein G6f
- Protein Accession:
- Q5SQ64
- B0UXB7
- O95869
- Q7Z5H2
- Q96QC7
- Q9NZJ1
Protein attributes for LY6G6F Gene
- Size:
- 297 amino acids
- Molecular mass:
- 32465 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.
- SequenceCaution:
-
- Sequence=AAD18078.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB63382.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for LY6G6F Gene
Post-translational modifications for LY6G6F Gene
- N-glycosylated.
-
Glycosylation at Asn88
- NX_Q5SQ64 (NX_Q5SQ64-1)
- Modification sites at PhosphoSitePlus
Other Protein References for LY6G6F Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for LY6G6F
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Protein Products
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Signalway Proteins for LY6G6F
-
Abcam proteins for LY6G6F
Assay Products
- antibodies-online: Show 6 available LY6G6F Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for LY6G6F Gene
Domains & Families for LY6G6F Gene
Gene Families for LY6G6F Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for LY6G6F Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LY6G6F Gene
- GenScript: Design optimal peptide antigens:
-
- Lymphocyte antigen 6 complex, locus G6F (B0UXB7_HUMAN)
- Lymphocyte antigen 6 complex locus protein G6f (LY66F_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LY6G6F Gene
Function for LY6G6F Gene
Molecular function for LY6G6F Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Phenotypes From GWAS Catalog for LY6G6F Gene
Phenotypes for LY6G6F Gene
- GenomeRNAi human phenotypes for LY6G6F:
Animal Model Products
-
Taconic Biosciences Mouse Models for LY6G6F
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY6G6F - Select products 50% OFF >
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-
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-
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miRNA for LY6G6F Gene
- miRTarBase miRNAs that target LY6G6F
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY6G6F
Cell Line Products
-
Horizon Cell Lines for LY6G6F
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G6F Gene
Localization for LY6G6F Gene
Subcellular locations from UniProtKB/Swiss-Prot for LY6G6F Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0031092 | platelet alpha granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LY6G6F Gene
Pathways & Interactions for LY6G6F Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for LY6G6F Gene
4 Reactome pathways for LY6G6F Gene
Interacting Proteins for LY6G6F Gene
Selected Interacting proteins:
Q5SQ64-LY66F_HUMAN
ENSP00000364992
for LY6G6F Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for LY6G6F
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
No data available for SIGNOR curated interactions for LY6G6F Gene
Transcripts for LY6G6F Gene
mRNA/cDNA for LY6G6F Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000375832 1023 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY6G6F - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LY6G6F
- Addgene plasmids for LY6G6F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY6G6F
Relevant External Links for LY6G6F Gene
- GeneLoc Exon Structure for
- LY6G6F
Expression for LY6G6F Gene
mRNA differential expression in normal tissues according to GTEx for LY6G6F Gene
This gene is overexpressed in Whole Blood (x45.1).
This gene is overexpressed in Platelet (32.0), Peripheral blood mononuclear cells (23.1), and Serum (12.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY6G6F Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LY6G6F
SOURCE GeneReport for Unigene cluster for LY6G6F Gene:
Hs.591794Evidence on tissue expression from TISSUES for LY6G6F Gene
- Blood(4.4)
Primer Products
-
OriGene qPCR primer pairs for LY6G6F
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6G6F Gene
Orthologs for LY6G6F Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LY6G6F 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | LY6G6F 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | LY6G6F 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ly6g6f 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Ly6g6f 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for LY6G6F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LY6G6F Gene
- ENSEMBL:
- Gene Tree for LY6G6F (if available)
- TreeFam:
- Gene Tree for LY6G6F (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LY6G6F: view image
Paralogs for LY6G6F Gene
Variants for LY6G6F Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LY6G6F Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 780983 | Benign: not provided | 31,707,506(+) | C/A | MISSENSE_VARIANT | |
| rs17200983 | - | p.Pro34Gln | |||
| rs2242653 | - | p.Arg167Lys | |||
| rs805295 | - | p.Pro39Ser | |||
| rs9267547 | - | p.Ala107Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv1161370 | CNV | deletion | 26073780 |
Residual Variation Intolerance Score:
94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.42;
90.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LY6G6F Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G6F Gene
Disorders for LY6G6F Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dependent personality disorder |
|
|
| histrionic personality disorder |
|
|
| retinitis pigmentosa 20 |
|
|
Search LY6G6F in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LY6G6F
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LY6G6F Gene
Publications for LY6G6F Gene
- Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC. (PMID: 12852788) De Vet EC … Campbell RD (The Biochemical journal 2003) 2 3 4 23
- Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 41
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
- Regulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism. (PMID: 18817541) Calvanese V … Aguado B (BMC molecular biology 2008) 23
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay IC … Ouwehand WH (Blood 2007) 3
ExternalLinks
Products for LY6G6F Gene
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- Signalway Proteins for LY6G6F
Sources for LY6G6F Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
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- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (101) ClinicalTrials
- (102) RVIS
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB