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Aliases for LY6G6C Gene

Aliases for LY6G6C Gene

  • Lymphocyte Antigen 6 Family Member G6C 2 3 5
  • Lymphocyte Antigen 6 Complex, Locus G6C 2 3
  • C6orf24 3 4
  • NG24 3 4
  • G6c 3 4
  • Lymphocyte Antigen 6 Complex Locus Protein G6c 3
  • Chromosome 6 Open Reading Frame 24 2
  • Lymphocyte Antigen-6 G6C 3

External Ids for LY6G6C Gene

Previous HGNC Symbols for LY6G6C Gene

  • C6orf24

Previous GeneCards Identifiers for LY6G6C Gene

  • GC06M031749
  • GC06M031457
  • GC06M031790
  • GC06M031794
  • GC06M031691
  • GC06M031692
  • GC06M031472
  • GC06M031699
  • GC06M031719
  • GC06M031729
  • GC06M031795
  • GC06M031833
  • GC06M031862
  • GC06M031896

Summaries for LY6G6C Gene

Entrez Gene Summary for LY6G6C Gene

  • LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LY6G6C Gene

LY6G6C (Lymphocyte Antigen 6 Family Member G6C) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

Additional gene information for LY6G6C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6G6C Gene

Genomics for LY6G6C Gene

GeneHancer (GH) Regulatory Elements for LY6G6C Gene

Promoters and enhancers for LY6G6C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031723 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 -1.7 -1695 0.5 ZBTB48 IKZF1 CBFA2T3 ID3 ZBTB33 LY6G6C MPIG6B DDAH2
GH06I031721 Promoter 0.5 EPDnew 550.8 +0.1 79 0.1 LY6G6C MPIG6B
GH06I031720 Enhancer 0.4 ENCODE 550.8 +1.4 1446 0.2 CTBP1 KLF4 LY6G6C MPIG6B LY6G5C PSORS1C3
GH06I031813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.7 -104.0 -104031 25.6 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 C6orf48 HSPA1B HSPA1A HSPA1L GC06P032039 ATF6B DDX39B LY6G5B LSM2 BAG6
GH06I031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.1 -15.6 -15610 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 DDX39B LY6G5B ATF6B LSM2 CSNK2B SKIV2L GPANK1 BAG6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LY6G6C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LY6G6C gene promoter:

Genomic Locations for LY6G6C Gene

Genomic Locations for LY6G6C Gene
3,198 bases
Minus strand

Genomic View for LY6G6C Gene

Genes around LY6G6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6G6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6G6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for LY6G6C Gene

  • Protein details for LY6G6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte antigen 6 complex locus protein G6c
    Protein Accession:
    Secondary Accessions:
    • Q5SRS8
    • Q8IY94

    Protein attributes for LY6G6C Gene

    125 amino acids
    Molecular mass:
    13821 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LY6G6C Gene

Post-translational modifications for LY6G6C Gene

Other Protein References for LY6G6C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY6G6C Gene

Domains & Families for LY6G6C Gene

Gene Families for LY6G6C Gene

Protein Domains for LY6G6C Gene


Suggested Antigen Peptide Sequences for LY6G6C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY6G6C: view

No data available for UniProtKB/Swiss-Prot for LY6G6C Gene

Function for LY6G6C Gene

Phenotypes From GWAS Catalog for LY6G6C Gene

Gene Ontology (GO) - Molecular Function for LY6G6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA,IDA 17008713
genes like me logo Genes that share ontologies with LY6G6C: view
genes like me logo Genes that share phenotypes with LY6G6C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G6C Gene

Localization for LY6G6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6G6C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY6G6C gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for LY6G6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 colocalizes_with external side of plasma membrane IEA,IDA 17008713
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LY6G6C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LY6G6C Gene

Pathways & Interactions for LY6G6C Gene

genes like me logo Genes that share pathways with LY6G6C: view

Interacting Proteins for LY6G6C Gene

Selected Interacting proteins: O95867-LY66C_HUMAN for LY6G6C Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LY6G6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0051260 protein homooligomerization IDA,IEA 17008713
genes like me logo Genes that share ontologies with LY6G6C: view

No data available for SIGNOR curated interactions for LY6G6C Gene

Drugs & Compounds for LY6G6C Gene

No Compound Related Data Available

Transcripts for LY6G6C Gene

mRNA/cDNA for LY6G6C Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LY6G6C Gene

Lymphocyte antigen 6 complex, locus G6C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY6G6C Gene

No ASD Table

Relevant External Links for LY6G6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LY6G6C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LY6G6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LY6G6C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.0) and Skin - Not Sun Exposed (Suprapubic) (x21.9).

Protein differential expression in normal tissues from HIPED for LY6G6C Gene

This gene is overexpressed in Cervix (62.9) and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY6G6C Gene

Protein tissue co-expression partners for LY6G6C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LY6G6C Gene:


SOURCE GeneReport for Unigene cluster for LY6G6C Gene:


mRNA Expression by UniProt/SwissProt for LY6G6C Gene:

Tissue specificity: Highly expressed at the leading edges of cells, on filopodia.

Evidence on tissue expression from TISSUES for LY6G6C Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with LY6G6C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6G6C Gene

Orthologs for LY6G6C Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY6G6C Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LY6G6C 33 34
  • 89.07 (n)
(Bos Taurus)
Mammalia LY6G6C 33 34
  • 86.93 (n)
(Rattus norvegicus)
Mammalia Ly6g6c 33
  • 85.42 (n)
(Mus musculus)
Mammalia Ly6g6c 33 16 34
  • 85.12 (n)
(Monodelphis domestica)
Mammalia LY6G6C 34
  • 57 (a)
Species where no ortholog for LY6G6C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6G6C Gene

Gene Tree for LY6G6C (if available)
Gene Tree for LY6G6C (if available)

Paralogs for LY6G6C Gene

No data available for Paralogs for LY6G6C Gene

Variants for LY6G6C Gene

Sequence variations from dbSNP and Humsavar for LY6G6C Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001126146 -- 31,722,750(-) G/A upstream_transcript_variant
rs1001157311 -- 31,723,065(-) C/T upstream_transcript_variant
rs1001185679 -- 31,720,088(-) G/A intron_variant
rs1001215235 -- 31,719,657(-) C/T intron_variant
rs1002799794 -- 31,720,944(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LY6G6C Gene

Variant ID Type Subtype PubMed ID
nsv1126749 CNV deletion 24896259
nsv1112900 CNV deletion 24896259
nsv1073969 CNV deletion 25765185
dgv10404n54 CNV loss 21841781
dgv10403n54 CNV loss 21841781

Variation tolerance for LY6G6C Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LY6G6C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G6C Gene

Disorders for LY6G6C Gene

Additional Disease Information for LY6G6C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LY6G6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6G6C Gene

Publications for LY6G6C Gene

  1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (PMID: 12079290) Mallya M … Aguado B (Genomics 2002) 2 3 4 58
  2. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PMID: 10384126) Ribas G … Campbell RD (Journal of immunology (Baltimore, Md. : 1950) 1999) 2 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. (PMID: 17008713) Mallya M … Aguado B (Protein science : a publication of the Protein Society 2006) 3 4 58

Products for LY6G6C Gene

Sources for LY6G6C Gene

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