LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in si... See more...

Aliases for LY6G5B Gene

Aliases for LY6G5B Gene

  • Lymphocyte Antigen 6 Family Member G5B 2 3 5
  • Lymphocyte Antigen 6 Complex Locus Protein G5b 3 4
  • Lymphocyte Antigen 6 Complex, Locus G5B 2 3
  • C6orf19 3 4
  • G5b 2 3
  • Lymphocyte Antigen-6 G5B Splicing Isoform 288 3
  • Lymphocyte Antigen-6 G5B Splicing Isoform 452 3
  • Lymphocyte Antigen-6 G5B Splicing Isoform 690 3
  • Lymphocyte Antigen-6 G5B Splicing Isoform 837 3
  • Chromosome 6 Open Reading Frame 19 2
  • LY6G5B 5
  • G5B 4

External Ids for LY6G5B Gene

Previous HGNC Symbols for LY6G5B Gene

  • C6orf19

Previous GeneCards Identifiers for LY6G5B Gene

  • GC06P031701
  • GC06P031408
  • GC06P031742
  • GC06P031746
  • GC06Pf31766
  • GC06P031637
  • GC06P031638
  • GC06P031424
  • GC06P031671
  • GC06P031734
  • GC06P032319
  • GC06P032507
  • GC06P032612
  • GC06P033407
  • GC06P031777
  • GC06P031788
  • GC06P031858
  • GC06P031900
  • GC06P031942
  • GC06P032007
  • GC06P032196
  • GC06P032219

Summaries for LY6G5B Gene

Entrez Gene Summary for LY6G5B Gene

  • LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LY6G5B Gene

LY6G5B (Lymphocyte Antigen 6 Family Member G5B) is a Protein Coding gene. An important paralog of this gene is ENSG00000263020.

Additional gene information for LY6G5B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LY6G5B Gene

Genomics for LY6G5B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LY6G5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LY6G5B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LY6G5B

Top Transcription factor binding sites by QIAGEN in the LY6G5B gene promoter:
  • E47
  • Hand1
  • HNF-4alpha1
  • HNF-4alpha2
  • HTF
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LY6G5B Gene

Genomic Locations for LY6G5B Gene
chr6:31,670,167-31,673,776
(GRCh38/hg38)
Size:
3,610 bases
Orientation:
Plus strand
chr6:31,637,944-31,641,553
(GRCh37/hg19)
Size:
3,610 bases
Orientation:
Plus strand

Genomic View for LY6G5B Gene

Genes around LY6G5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6G5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6G5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for LY6G5B Gene

  • Protein details for LY6G5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDX9-LY65B_HUMAN
    Recommended name:
    Lymphocyte antigen 6 complex locus protein G5b
    Protein Accession:
    Q8NDX9
    Secondary Accessions:
    • B0UXB2
    • B0UZ65
    • B0UZP8
    • B7ZCA3
    • Q5SQ62
    • Q5SST3
    • Q9UKT0
    • Q9UMQ0

    Protein attributes for LY6G5B Gene

    Size:
    201 amino acids
    Molecular mass:
    22572 Da
    Quaternary structure:
    • Forms oligomer.

    Alternative splice isoforms for LY6G5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY6G5B Gene

Post-translational modifications for LY6G5B Gene

Other Protein References for LY6G5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY6G5B Gene

Domains & Families for LY6G5B Gene

Gene Families for LY6G5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LY6G5B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LY6G5B Gene

GenScript: Design optimal peptide antigens:
  • Lymphocyte antigen 6 complex, locus G5B (B0UXB1_HUMAN)
  • Lymphocyte antigen 6 complex, locus G5B (B0UZ64_HUMAN)
  • Lymphocyte antigen 6 complex, locus G5B (B0UZP7_HUMAN)
  • Lymphocyte antigen 6 complex, locus G5B (B1B0L8_HUMAN)
  • Lymphocyte antigen 6 complex locus protein G5b (LY65B_HUMAN)
genes like me logo Genes that share domains with LY6G5B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LY6G5B Gene

Function for LY6G5B Gene

Phenotypes From GWAS Catalog for LY6G5B Gene

Gene Ontology (GO) - Molecular Function for LY6G5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 17008713
genes like me logo Genes that share ontologies with LY6G5B: view
genes like me logo Genes that share phenotypes with LY6G5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LY6G5B

CRISPR Products

miRNA for LY6G5B Gene

miRTarBase miRNAs that target LY6G5B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY6G5B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G5B Gene

Localization for LY6G5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6G5B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY6G5B gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for LY6G5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009897 colocalizes_with external side of plasma membrane IDA 17008713
GO:0032991 protein-containing complex IDA 17008713
genes like me logo Genes that share ontologies with LY6G5B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LY6G5B Gene

Pathways & Interactions for LY6G5B Gene

PathCards logo

SuperPathways for LY6G5B Gene

No Data Available

Interacting Proteins for LY6G5B Gene

Gene Ontology (GO) - Biological Process for LY6G5B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LY6G5B Gene

Drugs & Compounds for LY6G5B Gene

No Compound Related Data Available

Transcripts for LY6G5B Gene

mRNA/cDNA for LY6G5B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY6G5B

Alternative Splicing Database (ASD) splice patterns (SP) for LY6G5B Gene

No ASD Table

Relevant External Links for LY6G5B Gene

GeneLoc Exon Structure for
LY6G5B

Expression for LY6G5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LY6G5B Gene

mRNA expression in normal human tissues for LY6G5B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LY6G5B

SOURCE GeneReport for Unigene cluster for LY6G5B Gene:

Hs.708719

Evidence on tissue expression from TISSUES for LY6G5B Gene

  • Nervous system(4.6)
  • Lung(4.6)
  • Skin(3.7)
  • Liver(3.6)
  • Heart(3.6)
  • Pancreas(3.6)
  • Eye(3.2)
  • Intestine(3.2)
  • Bone(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with LY6G5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6G5B Gene

Orthologs for LY6G5B Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY6G5B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LY6G5B 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LY6G5B 30 31
  • 84.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LY6G5B 30 31
  • 81.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ly6g5b 30
  • 74.48 (n)
Mouse
(Mus musculus)
Mammalia Ly6g5b 30 17 31
  • 74.39 (n)
OneToOne
Species where no ortholog for LY6G5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LY6G5B Gene

ENSEMBL:
Gene Tree for LY6G5B (if available)
TreeFam:
Gene Tree for LY6G5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LY6G5B: view image

Paralogs for LY6G5B Gene

Paralogs for LY6G5B Gene

(2) SIMAP similar genes for LY6G5B Gene using alignment to 5 proteins:

  • LY65B_HUMAN
  • N0E4D1_HUMAN
  • N0E641_HUMAN
  • N0E652_HUMAN
  • N0E6I9_HUMAN
genes like me logo Genes that share paralogs with LY6G5B: view

Variants for LY6G5B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LY6G5B Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
732236 Benign: not provided 31,671,193(+) C/T SYNONYMOUS_VARIANT
rs11758242 - p.Ser131Tyr
rs805267 - p.Asp102Asn
rs9267532 - p.Arg176Cys

Additional dbSNP identifiers (rs#s) for LY6G5B Gene

Structural Variations from Database of Genomic Variants (DGV) for LY6G5B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
esv2663763 CNV deletion 23128226
esv3608567 CNV loss 21293372
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv830627 CNV loss 17160897

Variation tolerance for LY6G5B Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LY6G5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LY6G5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G5B Gene

Disorders for LY6G5B Gene

Additional Disease Information for LY6G5B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LY6G5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6G5B Gene

Publications for LY6G5B Gene

  1. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. (PMID: 17008713) Mallya M … Aguado B (Protein science : a publication of the Protein Society 2006) 2 3 4
  2. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (PMID: 12079290) Mallya M … Aguado B (Genomics 2002) 2 3 4
  3. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). (PMID: 8812450) Albertella MR … Campbell RD (Genomics 1996) 2 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41

Products for LY6G5B Gene

Sources for LY6G5B Gene