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LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in si... See more...
Aliases for LY6G5B Gene
Aliases for LY6G5B Gene
External Ids for LY6G5B Gene
- HGNC: 13931
- Entrez Gene: 58496
- Ensembl: ENSG00000240053
- OMIM: 610433
- UniProtKB: Q8NDX9
Previous HGNC Symbols for LY6G5B Gene
- C6orf19
Previous GeneCards Identifiers for LY6G5B Gene
- GC06P031701
- GC06P031408
- GC06P031742
- GC06P031746
- GC06Pf31766
- GC06P031637
- GC06P031638
- GC06P031424
- GC06P031671
- GC06P031734
- GC06P032319
- GC06P032507
- GC06P032612
- GC06P033407
- GC06P031777
- GC06P031788
- GC06P031858
- GC06P031900
- GC06P031942
- GC06P032007
- GC06P032196
- GC06P032219
Summaries for LY6G5B Gene
-
LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]
GeneCards Summary for LY6G5B Gene
LY6G5B (Lymphocyte Antigen 6 Family Member G5B) is a Protein Coding gene. An important paralog of this gene is ENSG00000263020.
Additional gene information for LY6G5B Gene
- HGNC(13931)
- Entrez Gene(58496)
- Ensembl(ENSG00000240053)
- OMIM(610433)
- UniProtKB(Q8NDX9)
- Open Targets Platform(ENSG00000240053)
- Search for LY6G5B at DataMed
- Search for LY6G5B at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LY6G5B Gene
Genomics for LY6G5B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LY6G5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LY6G5B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LY6G5B
- Top Transcription factor binding sites by QIAGEN in the LY6G5B gene promoter:
-
- E47
- Hand1
- HNF-4alpha1
- HNF-4alpha2
- HTF
- Pax-5
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for LY6G5B Gene
Genomic Locations for LY6G5B Gene
- chr6:31,670,167-31,673,776
- (GRCh38/hg38)
- Size:
- 3,610 bases
- Orientation:
- Plus strand
- chr6:31,637,944-31,641,553
- (GRCh37/hg19)
- Size:
- 3,610 bases
- Orientation:
- Plus strand
Genomic View for LY6G5B Gene
Genes around LY6G5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
LY6G5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LY6G5B Gene
Proteins for LY6G5B Gene
-
Protein details for LY6G5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NDX9-LY65B_HUMAN
- Recommended name:
- Lymphocyte antigen 6 complex locus protein G5b
- Protein Accession:
- Q8NDX9
- B0UXB2
- B0UZ65
- B0UZP8
- B7ZCA3
- Q5SQ62
- Q5SST3
- Q9UKT0
- Q9UMQ0
Protein attributes for LY6G5B Gene
- Size:
- 201 amino acids
- Molecular mass:
- 22572 Da
- Quaternary structure:
-
- Forms oligomer.
Post-translational modifications for LY6G5B Gene
- N-glycosylated.
-
Glycosylation at Asn141 and Asn183
- NX_Q8NDX9 (NX_Q8NDX9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for LY6G5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LY6G5B
- Invitrogen Antibodies for LY6G5B (AFLGC-LY6G5B)
- antibodies-online: Show 9 available LY6G5B Antibodies ranked by validation data
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-
Quality Products:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LY6G5B
- Origene Custom Protein Services for LY6G5B
- antibodies-online: Show 3 available LY6G5B Proteins ranked by validation data
- Compare Top LY6G5B Proteins
-
Quality Products:
-
Abcam proteins for LY6G5B
No data available for DME Specific Peptides for LY6G5B Gene
Domains & Families for LY6G5B Gene
Gene Families for LY6G5B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for LY6G5B Gene
- GenScript: Design optimal peptide antigens:
-
- Lymphocyte antigen 6 complex, locus G5B (B0UXB1_HUMAN)
- Lymphocyte antigen 6 complex, locus G5B (B0UZ64_HUMAN)
- Lymphocyte antigen 6 complex, locus G5B (B0UZP7_HUMAN)
- Lymphocyte antigen 6 complex, locus G5B (B1B0L8_HUMAN)
- Lymphocyte antigen 6 complex locus protein G5b (LY65B_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LY6G5B Gene
Function for LY6G5B Gene
Phenotypes From GWAS Catalog for LY6G5B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042802 | identical protein binding | IDA | 17008713 |
Phenotypes for LY6G5B Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for LY6G5B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY6G5B - Select products 50% OFF >
- * LY6G5B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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OriGene CRISPR knockouts for LY6G5B
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-
Santa Cruz Biotechnology (SCBT) CRISPR for LY6G5B
miRNA for LY6G5B Gene
- miRTarBase miRNAs that target LY6G5B
-
- hsa-miR-320b (MIRT036227)
- hsa-miR-92a-3p (MIRT048964)
- hsa-miR-6513-5p (MIRT541876)
- hsa-miR-887-5p (MIRT541877)
- hsa-miR-3913-5p (MIRT541878)
- hsa-miR-3122 (MIRT541879)
- hsa-miR-450a-1-3p (MIRT541880)
- hsa-miR-6779-5p (MIRT541881)
- hsa-miR-6780a-5p (MIRT541882)
- hsa-miR-3689c (MIRT541883)
- hsa-miR-3689b-3p (MIRT541884)
- hsa-miR-3689a-3p (MIRT541885)
- hsa-miR-30b-3p (MIRT541886)
- hsa-miR-6788-5p (MIRT541887)
- hsa-miR-1273h-5p (MIRT541888)
- hsa-miR-30c-2-3p (MIRT541889)
- hsa-miR-30c-1-3p (MIRT541890)
- hsa-miR-4284 (MIRT541891)
- hsa-miR-24-3p (MIRT541892)
- hsa-miR-342-3p (MIRT541893)
- hsa-miR-1228-3p (MIRT541894)
- hsa-miR-665 (MIRT662819)
- hsa-miR-6771-5p (MIRT662820)
- hsa-miR-7977 (MIRT662821)
- hsa-miR-7160-5p (MIRT662822)
- hsa-miR-4722-5p (MIRT662823)
- hsa-miR-6884-5p (MIRT662824)
- hsa-miR-485-5p (MIRT662825)
- hsa-miR-1827 (MIRT662826)
- hsa-miR-4649-3p (MIRT662827)
- hsa-miR-6746-5p (MIRT662828)
- hsa-miR-4768-3p (MIRT662829)
- hsa-miR-5690 (MIRT662830)
- hsa-miR-2114-5p (MIRT662831)
- hsa-miR-5588-3p (MIRT662832)
- hsa-miR-4478 (MIRT662833)
- hsa-miR-4419b (MIRT662834)
- hsa-miR-3929 (MIRT662835)
- hsa-miR-940 (MIRT662836)
- hsa-miR-6893-5p (MIRT662837)
- hsa-miR-6808-5p (MIRT662838)
- hsa-miR-5089-5p (MIRT692369)
- hsa-miR-5589-5p (MIRT692370)
- hsa-miR-4731-5p (MIRT692371)
- hsa-miR-6778-3p (MIRT692372)
- hsa-miR-6506-5p (MIRT692373)
- hsa-miR-619-5p (MIRT692374)
- hsa-miR-150-5p (MIRT692375)
- hsa-miR-7107-5p (MIRT692376)
- hsa-miR-1234-3p (MIRT692377)
- hsa-miR-186-3p (MIRT692378)
- hsa-miR-520h (MIRT692379)
- hsa-miR-520g-3p (MIRT692380)
- hsa-miR-512-3p (MIRT692381)
- hsa-miR-520e (MIRT692382)
- hsa-miR-520d-3p (MIRT692383)
- hsa-miR-520c-3p (MIRT692384)
- hsa-miR-520b (MIRT692385)
- hsa-miR-520a-3p (MIRT692386)
- hsa-miR-373-3p (MIRT692387)
- hsa-miR-372-3p (MIRT692388)
- hsa-miR-302e (MIRT692389)
- hsa-miR-302d-3p (MIRT692390)
- hsa-miR-302c-3p (MIRT692391)
- hsa-miR-302b-3p (MIRT692392)
- hsa-miR-302a-3p (MIRT692393)
- hsa-miR-93-5p (MIRT692394)
- hsa-miR-526b-3p (MIRT692395)
- hsa-miR-519d-3p (MIRT692396)
- hsa-miR-20b-5p (MIRT692397)
- hsa-miR-20a-5p (MIRT692398)
- hsa-miR-17-5p (MIRT692399)
- hsa-miR-106b-5p (MIRT692400)
- hsa-miR-106a-5p (MIRT692401)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY6G5B
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Clone Products
- Applied Biological Materials (abm): Clones for LY6G5B - Select products 50% OFF >
- * LY6G5B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LY6G5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY6G5B
Cell Line Products
-
Horizon Cell Lines for LY6G5B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G5B Gene
Localization for LY6G5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for LY6G5B Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| cytosol | 1 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0009897 | colocalizes_with external side of plasma membrane | IDA | 17008713 |
| GO:0032991 | protein-containing complex | IDA | 17008713 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LY6G5B Gene
Transcripts for LY6G5B Gene
mRNA/cDNA for LY6G5B Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000375864 2654 nts (view in UCSC)
- ENST00000409525 1505 nts (view in UCSC)
- ENST00000471088 677 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LY6G5B - Select products 50% OFF >
- * LY6G5B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LY6G5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LY6G5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for LY6G5B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LY6G5B
- Browse OriGene Inhibitory RNA Products For LY6G5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LY6G5B
Clone Products
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- * LY6G5B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for LY6G5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LY6G5B
Relevant External Links for LY6G5B Gene
- GeneLoc Exon Structure for
- LY6G5B
Expression for LY6G5B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LY6G5B
SOURCE GeneReport for Unigene cluster for LY6G5B Gene:
Hs.708719Evidence on tissue expression from TISSUES for LY6G5B Gene
- Nervous system(4.6)
- Lung(4.6)
- Skin(3.7)
- Liver(3.6)
- Heart(3.6)
- Pancreas(3.6)
- Eye(3.2)
- Intestine(3.2)
- Bone(2.6)
- Kidney(2.5)
- Muscle(2.4)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for LY6G5B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6G5B Gene
Orthologs for LY6G5B Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LY6G5B 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LY6G5B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LY6G5B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ly6g5b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ly6g5b 30 17 31 |
|
OneToOne |
- Species where no ortholog for LY6G5B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LY6G5B Gene
- ENSEMBL:
- Gene Tree for LY6G5B (if available)
- TreeFam:
- Gene Tree for LY6G5B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LY6G5B: view image
Paralogs for LY6G5B Gene
Paralogs for LY6G5B Gene
(2) SIMAP similar genes for LY6G5B Gene using alignment to 5 proteins:
- LY65B_HUMAN
- N0E4D1_HUMAN
- N0E641_HUMAN
- N0E652_HUMAN
- N0E6I9_HUMAN
Variants for LY6G5B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LY6G5B Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 732236 | Benign: not provided | 31,671,193(+) | C/T | SYNONYMOUS_VARIANT | |
| rs11758242 | - | p.Ser131Tyr | |||
| rs805267 | - | p.Asp102Asn | |||
| rs9267532 | - | p.Arg176Cys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| esv2663763 | CNV | deletion | 23128226 |
| esv3608567 | CNV | loss | 21293372 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv1161370 | CNV | deletion | 26073780 |
| nsv830627 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.32;
76.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LY6G5B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LY6G5B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G5B Gene
Disorders for LY6G5B Gene
Additional Disease Information for LY6G5B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for LY6G5B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6G5B Gene
Publications for LY6G5B Gene
- Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. (PMID: 17008713) Mallya M … Aguado B (Protein science : a publication of the Protein Society 2006) 2 3 4
- Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (PMID: 12079290) Mallya M … Aguado B (Genomics 2002) 2 3 4
- Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). (PMID: 8812450) Albertella MR … Campbell RD (Genomics 1996) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41
ExternalLinks
Products for LY6G5B Gene
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- Humanized Mice
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- antibodies-online: Show 9 available LY6G5B Antibodies ranked by validation data
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Sources for LY6G5B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
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