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LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]
LY6G5B (Lymphocyte Antigen 6 Family Member G5B) is a Protein Coding gene. An important paralog of this gene is ENSG00000263020.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042802 | identical protein binding | IDA | 17008713 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0009897 | colocalizes_with external side of plasma membrane | IDA | 17008713 |
GO:0032991 | protein-containing complex | IDA | 17008713 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LY6G5B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LY6G5B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LY6G5B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ly6g5b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ly6g5b 30 17 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
732236 | Benign: not provided | 31,671,193(+) | C/T | SYNONYMOUS_VARIANT | |
rs11758242 | - | p.Ser131Tyr | |||
rs805267 | - | p.Asp102Asn | |||
rs9267532 | - | p.Arg176Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10403n54 | CNV | loss | 21841781 |
dgv10404n54 | CNV | loss | 21841781 |
esv2663763 | CNV | deletion | 23128226 |
esv3608567 | CNV | loss | 21293372 |
nsv1073969 | CNV | deletion | 25765185 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1126749 | CNV | deletion | 24896259 |
nsv1161370 | CNV | deletion | 26073780 |
nsv830627 | CNV | loss | 17160897 |
No disorders were found for LY6G5B Gene.