Aliases for LY6E Gene
External Ids for LY6E Gene
Previous GeneCards Identifiers for LY6E Gene
GeneCards Summary for LY6E Gene
LY6E (Lymphocyte Antigen 6 Family Member E) is a Protein Coding gene. Diseases associated with LY6E include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Acute Promyelocytic Leukemia. Among its related pathways are Metabolism of proteins and Ectoderm Differentiation. An important paralog of this gene is GPIHBP1.
UniProtKB/Swiss-Prot Summary for LY6E Gene
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation.
(Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477).