This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008] See more...

Aliases for LXN Gene

Aliases for LXN Gene

  • Latexin 2 3 4 5
  • Endogenous Carboxypeptidase Inhibitor 3 4
  • Tissue Carboxypeptidase Inhibitor 3 4
  • ECI 3 4
  • TCI 3 4
  • Protein MUM 4
  • MUM 3

External Ids for LXN Gene

Previous GeneCards Identifiers for LXN Gene

  • GC03M155644
  • GC03M159331
  • GC03M159645
  • GC03M159705
  • GC03M159866
  • GC03M158366
  • GC03M155780

Summaries for LXN Gene

Entrez Gene Summary for LXN Gene

  • This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]

GeneCards Summary for LXN Gene

LXN (Latexin) is a Protein Coding gene. Diseases associated with LXN include Endocervicitis and Oppositional Defiant Disorder. Gene Ontology (GO) annotations related to this gene include heparin binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is RARRES1.

UniProtKB/Swiss-Prot Summary for LXN Gene

  • Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.

Additional gene information for LXN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LXN Gene

Genomics for LXN Gene

GeneHancer (GH) Regulatory Elements for LXN Gene

Promoters and enhancers for LXN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LXN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LXN

Top Transcription factor binding sites by QIAGEN in the LXN gene promoter:
  • AML1a
  • c-Myc
  • FOXO1
  • FOXO1a
  • FOXO4
  • HNF-3beta
  • IRF-2
  • Max1
  • Nkx2-5
  • SEF-1 (1)

Genomic Locations for LXN Gene

Genomic Locations for LXN Gene
chr3:158,645,822-158,672,693
(GRCh38/hg38)
Size:
26,872 bases
Orientation:
Minus strand
chr3:158,363,611-158,390,482
(GRCh37/hg19)
Size:
26,872 bases
Orientation:
Minus strand

Genomic View for LXN Gene

Genes around LXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LXN Gene

Proteins for LXN Gene

  • Protein details for LXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS40-LXN_HUMAN
    Recommended name:
    Latexin
    Protein Accession:
    Q9BS40
    Secondary Accessions:
    • Q96PN2
    • Q9NQS6

    Protein attributes for LXN Gene

    Size:
    222 amino acids
    Molecular mass:
    25750 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LXN Gene

neXtProt entry for LXN Gene

Post-translational modifications for LXN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LXN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LXN Gene

Domains & Families for LXN Gene

Gene Families for LXN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LXN Gene

Blocks:
  • Proteinase inhibitor I47, latexin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LXN Gene

GenScript: Design optimal peptide antigens:
  • Tissue carboxypeptidase inhibitor (LXN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BS40

UniProtKB/Swiss-Prot:

LXN_HUMAN :
  • Belongs to the protease inhibitor I47 (latexin) family.
Family:
  • Belongs to the protease inhibitor I47 (latexin) family.
genes like me logo Genes that share domains with LXN: view

Function for LXN Gene

Molecular function for LXN Gene

UniProtKB/Swiss-Prot Function:
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.

Phenotypes From GWAS Catalog for LXN Gene

Gene Ontology (GO) - Molecular Function for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008191 metalloendopeptidase inhibitor activity IBA 21873635
GO:0008201 heparin binding IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with LXN: view
genes like me logo Genes that share phenotypes with LXN: view

Animal Models for LXN Gene

MGI Knock Outs for LXN:
  • Lxn Lxn<tm1Yari>

Animal Model Products

CRISPR Products

miRNA for LXN Gene

miRTarBase miRNAs that target LXN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LXN Gene

Localization for LXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LXN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LXN gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LXN: view

Pathways & Interactions for LXN Gene

PathCards logo

SuperPathways for LXN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA --
genes like me logo Genes that share ontologies with LXN: view

No data available for Pathways by source and SIGNOR curated interactions for LXN Gene

Drugs & Compounds for LXN Gene

No Compound Related Data Available

Transcripts for LXN Gene

mRNA/cDNA for LXN Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LXN Gene

No ASD Table

Relevant External Links for LXN Gene

GeneLoc Exon Structure for
LXN

Expression for LXN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LXN Gene

mRNA differential expression in normal tissues according to GTEx for LXN Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for LXN Gene

This gene is overexpressed in Salivary gland (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LXN Gene



Protein tissue co-expression partners for LXN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LXN

SOURCE GeneReport for Unigene cluster for LXN Gene:

Hs.478067

mRNA Expression by UniProt/SwissProt for LXN Gene:

Q9BS40-LXN_HUMAN
Tissue specificity: Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.

Evidence on tissue expression from TISSUES for LXN Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Blood(3)
  • Intestine(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with LXN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LXN Gene

Orthologs for LXN Gene

This gene was present in the common ancestor of chordates.

Orthologs for LXN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LXN 31 30
  • 99.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LXN 31 30
  • 90.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LXN 31 30
  • 85.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lxn 30
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Lxn 17 31 30
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LXN 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LXN 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LXN 31 30
  • 65.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LXN 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lxn 30
  • 61.75 (n)
zebrafish
(Danio rerio)
Actinopterygii lxn 31 30
  • 48.22 (n)
OneToMany
Species where no ortholog for LXN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LXN Gene

ENSEMBL:
Gene Tree for LXN (if available)
TreeFam:
Gene Tree for LXN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LXN: view image

Paralogs for LXN Gene

Paralogs for LXN Gene

(1) SIMAP similar genes for LXN Gene using alignment to 2 proteins:

  • LXN_HUMAN
  • H7C5A4_HUMAN

Pseudogenes.org Pseudogenes for LXN Gene

genes like me logo Genes that share paralogs with LXN: view

Variants for LXN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LXN Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
678894 Benign: not provided 158,666,424(-) A/G THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs59718588 - p.Thr134Met
rs8455 - p.His53Arg

Additional dbSNP identifiers (rs#s) for LXN Gene

Structural Variations from Database of Genomic Variants (DGV) for LXN Gene

Variant ID Type Subtype PubMed ID
esv2763312 CNV gain 21179565
nsv1004124 CNV gain 25217958
nsv1014255 CNV gain 25217958

Variation tolerance for LXN Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LXN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LXN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LXN Gene

Disorders for LXN Gene

MalaCards: The human disease database

(10) MalaCards diseases for LXN Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervicitis
oppositional defiant disorder
postsurgical hypothyroidism
  • post-surgical hypothyroidism
amyloidosis, familial visceral
  • amyloidosis viii
listeriosis
  • infection by listeria monocytogenes
- elite association - COSMIC cancer census association via MalaCards
Search LXN in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LXN Gene

Publications for LXN Gene

  1. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PMID: 15738388) Pallarès I … Gomis-Rüth FX (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23 54
  2. Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. (PMID: 11455960) Liu Q … Zhao S (Molecular biology reports 2000) 3 4 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3 54
  5. Latexin and hematopoiesis. (PMID: 29608488) Zhang C … Liang Y (Current opinion in hematology 2018) 3 54

Products for LXN Gene

Sources for LXN Gene