This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] See more...

Aliases for LUZP4 Gene

Aliases for LUZP4 Gene

  • Leucine Zipper Protein 4 2 3 4 5
  • Cancer/Testis Antigen 28 2 3 4
  • Tumor Antigen HOM-TES-85 3 4
  • CT-28 3 4
  • CT28 3 4
  • HOM-TES-85 Tumor Antigen 3
  • HOM-TES-85 3
  • CT-8 3

External Ids for LUZP4 Gene

Previous GeneCards Identifiers for LUZP4 Gene

  • GC0XP114347
  • GC0XP114524
  • GC0XP104109

Summaries for LUZP4 Gene

Entrez Gene Summary for LUZP4 Gene

  • This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for LUZP4 Gene

LUZP4 (Leucine Zipper Protein 4) is a Protein Coding gene. Diseases associated with LUZP4 include Parapsoriasis. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm.

UniProtKB/Swiss-Prot Summary for LUZP4 Gene

  • Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).

Additional gene information for LUZP4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LUZP4 Gene

Genomics for LUZP4 Gene

GeneHancer (GH) Regulatory Elements for LUZP4 Gene

Promoters and enhancers for LUZP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ115289 Promoter 0.4 EPDnew 500.7 0.0 -6 0.1 E2F6 LUZP4 hsa-miR-5095-540
GH0XJ115311 Enhancer 0.5 ENCODE 0.4 +22.1 22082 0.5 USF1 MYNN CTCF IKZF1 SIN3A RAD21 BHLHE40 USF2 GATAD2B piR-59558-010 LUZP4
GH0XJ115317 Enhancer 0.3 Ensembl ENCODE 0.3 +28.3 28286 1.6 piR-59558-010 LRCH2 LUZP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LUZP4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LUZP4

Top Transcription factor binding sites by QIAGEN in the LUZP4 gene promoter:
  • AML1a
  • CUTL1
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • Hlf
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for LUZP4 Gene

Genomic Locations for LUZP4 Gene
chrX:115,289,715-115,307,563
(GRCh38/hg38)
Size:
17,849 bases
Orientation:
Plus strand
chrX:114,524,292-114,542,121
(GRCh37/hg19)
Size:
17,830 bases
Orientation:
Plus strand

Genomic View for LUZP4 Gene

Genes around LUZP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUZP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUZP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUZP4 Gene

Proteins for LUZP4 Gene

  • Protein details for LUZP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P127-LUZP4_HUMAN
    Recommended name:
    Leucine zipper protein 4
    Protein Accession:
    Q9P127
    Secondary Accessions:
    • B3KSD6

    Protein attributes for LUZP4 Gene

    Size:
    313 amino acids
    Molecular mass:
    35937 Da
    Quaternary structure:
    • Interacts NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.

    Alternative splice isoforms for LUZP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUZP4 Gene

Post-translational modifications for LUZP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUZP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LUZP4 Gene

Domains & Families for LUZP4 Gene

Gene Families for LUZP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LUZP4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LUZP4 Gene

GenScript: Design optimal peptide antigens:
  • LUZP4 protein (A1A4W3_HUMAN)
  • cDNA FLJ36050 fis, clone TESTI2018060, highly similar to Homo sapiens leucine zipper protein 4 (LUZP4), mRNA (B3KSD6_HUMAN)
  • Tumor antigen HOM-TES-85 (LUZP4_HUMAN)
genes like me logo Genes that share domains with LUZP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LUZP4 Gene

Function for LUZP4 Gene

Molecular function for LUZP4 Gene

UniProtKB/Swiss-Prot Function:
Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).

Phenotypes From GWAS Catalog for LUZP4 Gene

Gene Ontology (GO) - Molecular Function for LUZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LUZP4: view
genes like me logo Genes that share phenotypes with LUZP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUZP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LUZP4 Gene

Localization for LUZP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUZP4 Gene

Nucleus. Cytoplasm. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division. {ECO:0000269 PubMed:12032826, ECO:0000269 PubMed:25662211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUZP4 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LUZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LUZP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LUZP4 Gene

Pathways & Interactions for LUZP4 Gene

genes like me logo Genes that share pathways with LUZP4: view

Gene Ontology (GO) - Biological Process for LUZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with LUZP4: view

No data available for SIGNOR curated interactions for LUZP4 Gene

Drugs & Compounds for LUZP4 Gene

No Compound Related Data Available

Transcripts for LUZP4 Gene

mRNA/cDNA for LUZP4 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUZP4

Alternative Splicing Database (ASD) splice patterns (SP) for LUZP4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for LUZP4 Gene

GeneLoc Exon Structure for
LUZP4

Expression for LUZP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LUZP4 Gene

mRNA differential expression in normal tissues according to GTEx for LUZP4 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for LUZP4 Gene

This gene is overexpressed in Fetal ovary (47.5), Peripheral blood mononuclear cells (14.0), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LUZP4 Gene



Protein tissue co-expression partners for LUZP4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LUZP4

SOURCE GeneReport for Unigene cluster for LUZP4 Gene:

Hs.242183

mRNA Expression by UniProt/SwissProt for LUZP4 Gene:

Q9P127-LUZP4_HUMAN
Tissue specificity: Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.
genes like me logo Genes that share expression patterns with LUZP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUZP4 Gene

Orthologs for LUZP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LUZP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LUZP4 31 30
  • 97.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LUZP4 31 30
  • 75 (n)
OneToOne
Species where no ortholog for LUZP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LUZP4 Gene

ENSEMBL:
Gene Tree for LUZP4 (if available)
TreeFam:
Gene Tree for LUZP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LUZP4: view image

Paralogs for LUZP4 Gene

Pseudogenes.org Pseudogenes for LUZP4 Gene

genes like me logo Genes that share paralogs with LUZP4: view

No data available for Paralogs for LUZP4 Gene

Variants for LUZP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LUZP4 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
777824 Benign: not provided 115,306,318(+) A/G SYNONYMOUS_VARIANT
rs10482480 - p.Pro14Ser
rs35314601 - p.Thr306Ala

Additional dbSNP identifiers (rs#s) for LUZP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for LUZP4 Gene

Variant ID Type Subtype PubMed ID
dgv65n50 CNV loss 21212237
esv2666748 CNV deletion 23128226
esv33994 CNV gain+loss 17666407
esv3577051 CNV gain 25503493
nsv520351 CNV gain 19592680
nsv7046 CNV deletion 18451855
nsv819545 CNV gain 19587683

Variation tolerance for LUZP4 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LUZP4 Gene

Human Gene Mutation Database (HGMD)
LUZP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUZP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUZP4 Gene

Disorders for LUZP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LUZP4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parapsoriasis
  • digitate dermatosis
- elite association - COSMIC cancer census association via MalaCards
Search LUZP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LUZP4

genes like me logo Genes that share disorders with LUZP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LUZP4 Gene

Publications for LUZP4 Gene

  1. A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing. (PMID: 12032826) Türeci O … Pfreundschuh M (Oncogene 2002) 2 3 4 54
  2. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N … Wilson SA (Nucleic acids research 2015) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Expression of cancer testis genes in human brain tumors. (PMID: 11051238) Sahin U … Pfreundschuh M (Clinical cancer research : an official journal of the American Association for Cancer Research 2000) 2 3 54
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 54

Products for LUZP4 Gene

Sources for LUZP4 Gene