Aliases for LURAP1L Gene

Aliases for LURAP1L Gene

  • Leucine Rich Adaptor Protein 1 Like 2 3 5
  • Leucine Rich Adaptor Protein 1-Like 2 3 4
  • C9orf150 3 4
  • LRAP35b 2 3
  • BA3L8.2 2 3
  • Similar To DNA Segment, Chr 4, Brigham & Womens Genetics 0951 Expressed 2
  • Chromosome 9 Open Reading Frame 150 2
  • Leucine Repeat Adaptor Protein 35b 3
  • HYST0841 3
  • MGC46502 2
  • FLJ38505 2
  • LURAP1L 5

External Ids for LURAP1L Gene

Previous HGNC Symbols for LURAP1L Gene

  • C9orf150

Summaries for LURAP1L Gene

GeneCards Summary for LURAP1L Gene

LURAP1L (Leucine Rich Adaptor Protein 1 Like) is a Protein Coding gene. Diseases associated with LURAP1L include Chromosome 9P Deletion Syndrome. An important paralog of this gene is LURAP1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LURAP1L Gene

Genomics for LURAP1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LURAP1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J012774 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.6 +1.8 1809 4.8 HNRNPL GATAD2A CTCF TEAD4 PRDM10 REST TFE3 SOX13 ZNF7 ZIC2 LURAP1L LURAP1L-AS1 MPDZ
GH09J012811 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 18.6 +40.9 40904 8.4 CEBPG CREB1 GATAD2A CTCF ATF7 PRDM10 REST ZNF629 TFE3 SOX13 LURAP1L-AS1 LURAP1L HSALNG0070015 MPDZ
GH09J012797 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.9 +23.0 23004 2.4 POLR2A SMARCA4 BCL6B EZH2 LURAP1L LURAP1L-AS1 MPDZ
GH09J012722 Enhancer 0.4 Ensembl 19.8 -52.7 -52693 0.6 KLF8 GATA3 ZNF366 FOS LURAP1L lnc-LURAP1L-2 TYRP1 LURAP1L-AS1
GH09J012697 Promoter/Enhancer 1 Ensembl ENCODE 7.5 -78.0 -77993 3.2 ZBTB44 ZXDB CEBPB OSR2 BCL11A ZBTB48 ZBTB17 NR2F2 WT1 KLF8 TYRP1 LURAP1L lnc-LURAP1L-2 LURAP1L-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LURAP1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LURAP1L

Genomic Locations for LURAP1L Gene

Genomic Locations for LURAP1L Gene
chr9:12,774,994-12,823,060
(GRCh38/hg38)
Size:
48,067 bases
Orientation:
Plus strand
chr9:12,775,012-12,823,059
(GRCh37/hg19)
Size:
48,048 bases
Orientation:
Plus strand

Genomic View for LURAP1L Gene

Genes around LURAP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LURAP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LURAP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LURAP1L Gene

Proteins for LURAP1L Gene

  • Protein details for LURAP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV03-LUR1L_HUMAN
    Recommended name:
    Leucine rich adaptor protein 1-like
    Protein Accession:
    Q8IV03
    Secondary Accessions:
    • Q5VZX7
    • Q8N923
    • Q8NCG2

    Protein attributes for LURAP1L Gene

    Size:
    231 amino acids
    Molecular mass:
    24583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK074752; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for LURAP1L Gene

Post-translational modifications for LURAP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LURAP1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LURAP1L Gene

Domains & Families for LURAP1L Gene

Gene Families for LURAP1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LURAP1L Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with LURAP1L: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LURAP1L Gene

Function for LURAP1L Gene

Phenotypes From GWAS Catalog for LURAP1L Gene

genes like me logo Genes that share phenotypes with LURAP1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LURAP1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LURAP1L Gene

Localization for LURAP1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LURAP1L gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LURAP1L Gene

Pathways & Interactions for LURAP1L Gene

PathCards logo

SuperPathways for LURAP1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LURAP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with LURAP1L: view

No data available for Pathways by source and SIGNOR curated interactions for LURAP1L Gene

Drugs & Compounds for LURAP1L Gene

No Compound Related Data Available

Transcripts for LURAP1L Gene

mRNA/cDNA for LURAP1L Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LURAP1L

Alternative Splicing Database (ASD) splice patterns (SP) for LURAP1L Gene

No ASD Table

Relevant External Links for LURAP1L Gene

GeneLoc Exon Structure for
LURAP1L

Expression for LURAP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LURAP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LURAP1L Gene

This gene is overexpressed in Pancreas (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LURAP1L Gene



Protein tissue co-expression partners for LURAP1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LURAP1L

SOURCE GeneReport for Unigene cluster for LURAP1L Gene:

Hs.445356

Evidence on tissue expression from TISSUES for LURAP1L Gene

  • Pancreas(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with LURAP1L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LURAP1L Gene

Orthologs for LURAP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for LURAP1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LURAP1L 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LURAP1L 30 31
  • 88.16 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LURAP1L 30 31
  • 84.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lurap1l 30 17 31
  • 82.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lurap1l 30
  • 82.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia LURAP1L 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LURAP1L 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C9ORF150 30
  • 73.12 (n)
Lizard
(Anolis carolinensis)
Reptilia LURAP1L 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lurap1l 30
  • 63.33 (n)
Species where no ortholog for LURAP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LURAP1L Gene

ENSEMBL:
Gene Tree for LURAP1L (if available)
TreeFam:
Gene Tree for LURAP1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LURAP1L: view image

Paralogs for LURAP1L Gene

Paralogs for LURAP1L Gene

(1) SIMAP similar genes for LURAP1L Gene using alignment to 1 proteins:

  • LUR1L_HUMAN
genes like me logo Genes that share paralogs with LURAP1L: view

Variants for LURAP1L Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LURAP1L Gene

LUR1L_HUMAN-Q8IV03
The poly-Gly region is polymorphic and the number of Gly varies in the population (from 9 to 12).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LURAP1L Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
916565 Likely Pathogenic: Tracheoesophageal fistula 12,821,419(+) C/T MISSENSE_VARIANT
rs3750501 - p.Ser62Gly

Additional dbSNP identifiers (rs#s) for LURAP1L Gene

Structural Variations from Database of Genomic Variants (DGV) for LURAP1L Gene

Variant ID Type Subtype PubMed ID
esv2422212 CNV duplication 17116639
esv2759671 CNV loss 17122850
esv3891612 CNV gain 25118596
nsv1021844 CNV gain 25217958
nsv1030835 CNV gain 25217958
nsv472191 CNV novel sequence insertion 20440878

Variation tolerance for LURAP1L Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LURAP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LURAP1L

Disorders for LURAP1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for LURAP1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 9p deletion syndrome
  • monosomy 9p syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LURAP1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LURAP1L Gene

Publications for LURAP1L Gene

  1. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PMID: 12766061) Tomarev SI … Malyukova I (Investigative ophthalmology & visual science 2003) 2 3

Products for LURAP1L Gene

Sources for LURAP1L Gene