Aliases for LURAP1 Gene

Aliases for LURAP1 Gene

  • Leucine Rich Adaptor Protein 1 2 3 4 5
  • Leucine Repeat Adapter Protein 35A 3 4
  • Leucine Repeat Adaptor Protein 35a 2 3
  • C1orf190 3 4
  • LRP35A 3 4
  • Chromosome 1 Open Reading Frame 190 2
  • NF-Kappa-B Activator C1orf190 3
  • LRAP35a 3
  • LRAP35A 4

External Ids for LURAP1 Gene

Previous HGNC Symbols for LURAP1 Gene

  • C1orf190

Previous GeneCards Identifiers for LURAP1 Gene

  • GC01P046671

Summaries for LURAP1 Gene

GeneCards Summary for LURAP1 Gene

LURAP1 (Leucine Rich Adaptor Protein 1) is a Protein Coding gene. An important paralog of this gene is LURAP1L.

UniProtKB/Swiss-Prot Summary for LURAP1 Gene

  • Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

Additional gene information for LURAP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LURAP1 Gene

Genomics for LURAP1 Gene

GeneHancer (GH) Regulatory Elements for LURAP1 Gene

Promoters and enhancers for LURAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046202 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 533.9 +1.4 1405 4.4 HNRNPK ZBTB40 NRF1 ZIC2 ZNF423 GABPA AFF1 ZBTB26 TRIM28 SAP30 LURAP1 NSUN4 RAD54L P3R3URF PIK3R3 TSPAN1 POMGNT1
GH01J046201 Promoter 0.4 Ensembl 500.7 -1.2 -1233 0.6 PRDM2 LURAP1 P3R3URF PIK3R3 TSPAN1 RAD54L lnc-PIK3R3-4 POMGNT1
GH01J046196 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 36.5 -5.1 -5088 2.8 HNRNPK CTCF POLR2G NCOR1 PHF8 ZFX POLR2A ZNF623 AFF1 ZBTB26 POMGNT1 LURAP1 P3R3URF PIK3R3 TSPAN1 RAD54L TOE1 MUTYH ZSWIM5 lnc-PIK3R3-4
GH01J046299 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22.6 +99.9 99853 6.4 RXRA FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G USF1 LRRC41 UQCRH LURAP1 NASP TOE1 MUTYH GPBP1L1 IPP EFCAB14 ZSWIM5
GH01J046178 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 23.1 -20.8 -20849 7 ZNF217 CTCF SIN3A POLR2G BCLAF1 JUND PHB2 FOS ZFX ZNF639 TSPAN1 ENSG00000234329 EFCAB14-AS1 GPBP1L1 LRRC41 LURAP1 TOE1 RPS15AP10 CCDC163 CCDC17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LURAP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LURAP1

Genomic Locations for LURAP1 Gene

Genomic Locations for LURAP1 Gene
chr1:46,203,334-46,221,256
(GRCh38/hg38)
Size:
17,923 bases
Orientation:
Plus strand
chr1:46,669,006-46,686,933
(GRCh37/hg19)
Size:
17,928 bases
Orientation:
Plus strand

Genomic View for LURAP1 Gene

Genes around LURAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LURAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LURAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LURAP1 Gene

Proteins for LURAP1 Gene

  • Protein details for LURAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR2-LURA1_HUMAN
    Recommended name:
    Leucine rich adaptor protein 1
    Protein Accession:
    Q96LR2

    Protein attributes for LURAP1 Gene

    Size:
    239 amino acids
    Molecular mass:
    25806 Da
    Quaternary structure:
    • Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation. Interacts with CDC42BPA and CDC42BPB.

neXtProt entry for LURAP1 Gene

Post-translational modifications for LURAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LURAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LURAP1 Gene

Domains & Families for LURAP1 Gene

Gene Families for LURAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LURAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LURAP1 Gene

GenScript: Design optimal peptide antigens:
  • NF-kappa-B activator C1orf190 (CA190_HUMAN)
genes like me logo Genes that share domains with LURAP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LURAP1 Gene

Function for LURAP1 Gene

Molecular function for LURAP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

Phenotypes From GWAS Catalog for LURAP1 Gene

Gene Ontology (GO) - Molecular Function for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LURAP1: view
genes like me logo Genes that share phenotypes with LURAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LURAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LURAP1 Gene

Localization for LURAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LURAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LURAP1 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21048106
GO:0005829 cytosol IDA --
GO:0042641 actomyosin IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with LURAP1: view

Pathways & Interactions for LURAP1 Gene

PathCards logo

SuperPathways for LURAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 21048106
GO:0016477 cell migration IEA --
GO:0031032 actomyosin structure organization IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 21048106
genes like me logo Genes that share ontologies with LURAP1: view

No data available for Pathways by source and SIGNOR curated interactions for LURAP1 Gene

Drugs & Compounds for LURAP1 Gene

No Compound Related Data Available

Transcripts for LURAP1 Gene

mRNA/cDNA for LURAP1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LURAP1

Alternative Splicing Database (ASD) splice patterns (SP) for LURAP1 Gene

No ASD Table

Relevant External Links for LURAP1 Gene

GeneLoc Exon Structure for
LURAP1

Expression for LURAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LURAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LURAP1 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for LURAP1 Gene

This gene is overexpressed in Frontal cortex (27.6), CD4 Tcells (15.2), Fetal ovary (12.6), and CD8 Tcells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LURAP1 Gene



Protein tissue co-expression partners for LURAP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LURAP1

SOURCE GeneReport for Unigene cluster for LURAP1 Gene:

Hs.568642

Evidence on tissue expression from TISSUES for LURAP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LURAP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LURAP1 Gene

Orthologs for LURAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LURAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LURAP1 31 30
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LURAP1 31 30
  • 89.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LURAP1 31 30
  • 87.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lurap1 30
  • 86.75 (n)
mouse
(Mus musculus)
Mammalia Lurap1 17 31 30
  • 85.91 (n)
oppossum
(Monodelphis domestica)
Mammalia LURAP1 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF190 30
  • 63.95 (n)
LURAP1 31
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LURAP1 31
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lurap1 30
  • 62 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171930 30
  • 58.63 (n)
LURAP1 31
  • 39 (a)
OneToOne
Species where no ortholog for LURAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LURAP1 Gene

ENSEMBL:
Gene Tree for LURAP1 (if available)
TreeFam:
Gene Tree for LURAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LURAP1: view image

Paralogs for LURAP1 Gene

Paralogs for LURAP1 Gene

(1) SIMAP similar genes for LURAP1 Gene using alignment to 1 proteins:

  • LURA1_HUMAN
genes like me logo Genes that share paralogs with LURAP1: view

Variants for LURAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LURAP1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs62620990 Benign: not specified 46,220,120(+) A/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for LURAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LURAP1 Gene

Variant ID Type Subtype PubMed ID
esv1137837 CNV insertion 17803354
esv2761743 CNV gain 21179565
esv3306122 CNV mobile element insertion 20981092
esv3326121 CNV insertion 20981092
nsv470711 CNV gain 18288195

Variation tolerance for LURAP1 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LURAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LURAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LURAP1 Gene

Disorders for LURAP1 Gene

Additional Disease Information for LURAP1

No disorders were found for LURAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LURAP1 Gene

Publications for LURAP1 Gene

  1. Chromosome 1 open reading frame 190 promotes activation of NF-κB canonical pathway and resistance of dendritic cells to tumor-associated inhibition in vitro. (PMID: 21048106) Jing Z … Yang R (Journal of immunology (Baltimore, Md. : 1950) 2010) 2 3 4 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for LURAP1 Gene

Sources for LURAP1 Gene