This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and... See more...

Aliases for LUC7L3 Gene

Aliases for LUC7L3 Gene

  • LUC7 Like 3 Pre-MRNA Splicing Factor 2 3 5
  • CREAP-1 2 3 4
  • CROP 2 3 4
  • Cisplatin Resistance-Associated-Overexpressed Protein 3 4
  • Okadaic Acid-Inducible Phosphoprotein OA48-18 3 4
  • CAMP Regulatory Element-Associated Protein 1 3 4
  • CRE-Associated Protein 1 3 4
  • Luc7-Like Protein 3 3 4
  • OA48-18 2 3
  • HLuc7A 2 3
  • LUC7A 2 3
  • CRA 2 3
  • Cisplatin Resistance Associated Overexpressed Protein 2
  • LUC7-Like 3 Pre-MRNA Splicing Factor 2
  • LUC7-Like 3 (S. Cerevisiae) 2
  • CRE-Associated Protein 2
  • LUC7-Like 3 3
  • FLJ11063 2
  • LUC7L3 5
  • CREAP1 4
  • Luc7A 4
  • O48 4

External Ids for LUC7L3 Gene

Previous GeneCards Identifiers for LUC7L3 Gene

  • GC17P046153
  • GC17P048796
  • GC17P044164

Summaries for LUC7L3 Gene

Entrez Gene Summary for LUC7L3 Gene

  • This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for LUC7L3 Gene

LUC7L3 (LUC7 Like 3 Pre-MRNA Splicing Factor) is a Protein Coding gene. Diseases associated with LUC7L3 include Type 1 Diabetes Mellitus 4. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is LUC7L2.

UniProtKB/Swiss-Prot Summary for LUC7L3 Gene

  • Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.

Gene Wiki entry for LUC7L3 Gene

Additional gene information for LUC7L3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LUC7L3 Gene

Genomics for LUC7L3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LUC7L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050718 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 614.3 +1.3 1336 4.6 SP1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 NFKBIZ ZNF692 POLR2A NFRKB LUC7L3 ENSG00000278963 lnc-ANKRD40-4 MBTD1 ENSG00000262837 UTP18 ANKRD40 FAM117A ENSG00000204584 KAT7
GH17J051152 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 60.7 +434.2 434236 3.2 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 PRDM10 NME1 HSALNG0117364 NME1-NME2 MBTD1 LUC7L3 UTP18 EME1 COL1A1 ENSG00000250286 CACNA1G-AS1
GH17J049758 Promoter/Enhancer 2.4 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 53.1 -957.6 -957584 6.4 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 ZNF512 LEF1 IKZF1 NFKBIZ FAM117A LUC7L3 ENSG00000262837 UBE2Z ENSG00000204584 SPOP SLC35B1 ITGA3 ENSG00000230532 COL1A1
GH17J050860 Promoter/Enhancer 2.8 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 40.5 +145.6 145578 8.5 ZNF221 RNF2 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TOB1-AS1 TOB1 MBTD1 LUC7L3 UTP18 ENSG00000247011 ENSG00000251665 COL1A1 WFIKKN2 EME1
GH17J050046 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.4 -662.5 -662532 21.5 CREB1 ZBTB33 PRDM10 ZNF629 IKZF1 CTCF ZNF692 TARDBP ZHX2 JUND ITGA3 PICART1 ENSG00000262837 LUC7L3 FAM117A ENSG00000204584 PDK2 ENSG00000250282 ENSG00000250286 COL1A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LUC7L3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LUC7L3

Genomic Locations for LUC7L3 Gene

Genomic Locations for LUC7L3 Gene
chr17:50,719,565-50,756,219
(GRCh38/hg38)
Size:
36,655 bases
Orientation:
Plus strand
chr17:48,796,905-48,833,574
(GRCh37/hg19)
Size:
36,670 bases
Orientation:
Plus strand

Genomic View for LUC7L3 Gene

Genes around LUC7L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L3 Gene

Proteins for LUC7L3 Gene

  • Protein details for LUC7L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95232-LC7L3_HUMAN
    Recommended name:
    Luc7-like protein 3
    Protein Accession:
    O95232
    Secondary Accessions:
    • B3KN54
    • D3DTY1
    • Q6PHR9
    • Q9NUY0
    • Q9P2S7

    Protein attributes for LUC7L3 Gene

    Size:
    432 amino acids
    Molecular mass:
    51466 Da
    Quaternary structure:
    • May interact with SFRS1 and form homodimers (PubMed:12565863). Interacts with JMJD6 (PubMed:19574390). Interacts with RBM25 (PubMed:18663000). Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186). Interacts with RRP1B (PubMed:23604122).
    SequenceCaution:
    • Sequence=AAC79807.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for LUC7L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L3 Gene

Post-translational modifications for LUC7L3 Gene

No data available for DME Specific Peptides for LUC7L3 Gene

Domains & Families for LUC7L3 Gene

Gene Families for LUC7L3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LUC7L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LUC7L3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59548, highly similar to Cisplatin resistance-associated overexpressed protein (B4DJ96_HUMAN)
  • cAMP regulatory element-associated protein 1 (LC7L3_HUMAN)
  • CROP protein (Q6PKC2_HUMAN)
  • CROP protein (Q86Y74_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95232

UniProtKB/Swiss-Prot:

LC7L3_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L3: view

Function for LUC7L3 Gene

Molecular function for LUC7L3 Gene

UniProtKB/Swiss-Prot Function:
Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.

Phenotypes From GWAS Catalog for LUC7L3 Gene

Gene Ontology (GO) - Molecular Function for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IEA,IMP 10631324
GO:0005515 protein binding IPI 15798186
genes like me logo Genes that share ontologies with LUC7L3: view
genes like me logo Genes that share phenotypes with LUC7L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L3 Gene

Localization for LUC7L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L3 Gene

Nucleus speckle. Note=The subnuclear localization is affected by cisplatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12565863
GO:0005654 nucleoplasm IDA --
GO:0005685 U1 snRNP IEA,IBA 21873635
GO:0016607 nuclear speck IDA --
GO:0071004 U2-type prespliceosome IBA 21873635
genes like me logo Genes that share ontologies with LUC7L3: view

Pathways & Interactions for LUC7L3 Gene

PathCards logo

SuperPathways for LUC7L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA,IBA 21873635
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IMP 10631324
genes like me logo Genes that share ontologies with LUC7L3: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L3 Gene

Drugs & Compounds for LUC7L3 Gene

(2) Drugs for LUC7L3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with LUC7L3: view

Transcripts for LUC7L3 Gene

mRNA/cDNA for LUC7L3 Gene

3 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L3

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3:
SP4: - - -
SP5:
SP6: - -

Relevant External Links for LUC7L3 Gene

GeneLoc Exon Structure for
LUC7L3

Expression for LUC7L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LUC7L3 Gene

Protein differential expression in normal tissues from HIPED for LUC7L3 Gene

This gene is overexpressed in Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LUC7L3 Gene



Protein tissue co-expression partners for LUC7L3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LUC7L3

SOURCE GeneReport for Unigene cluster for LUC7L3 Gene:

Hs.130293

mRNA Expression by UniProt/SwissProt for LUC7L3 Gene:

O95232-LC7L3_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.

Evidence on tissue expression from TISSUES for LUC7L3 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Pancreas(3.3)
  • Lung(3)
  • Kidney(2.9)
  • Heart(2.8)
  • Skin(2.7)
  • Muscle(2.7)
  • Intestine(2.6)
  • Lymph node(2.3)
  • Spleen(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with LUC7L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUC7L3 Gene

Orthologs for LUC7L3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LUC7L3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LUC7L3 30 31
  • 99.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LUC7L3 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LUC7L3 30 31
  • 94.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LUC7L3 30 31
  • 94.29 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Luc7l3 30 17 31
  • 92.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Luc7l3 30
  • 91.94 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia LUC7L3 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LUC7L3 30 31
  • 85.34 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LUC7L3 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia luc7l3 30
  • 76.02 (n)
Str.1675 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68481 30
Zebrafish
(Danio rerio)
Actinopterygii luc7l3 31
  • 68 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG3198 31
  • 32 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C50D2.8 31
  • 33 (a)
OneToMany
Y119D3B.12 31
  • 29 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 31
  • 25 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G51410 30
  • 49.64 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0456400 30
  • 51.7 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3010 30
Species where no ortholog for LUC7L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LUC7L3 Gene

ENSEMBL:
Gene Tree for LUC7L3 (if available)
TreeFam:
Gene Tree for LUC7L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LUC7L3: view image

Paralogs for LUC7L3 Gene

Paralogs for LUC7L3 Gene

(5) SIMAP similar genes for LUC7L3 Gene using alignment to 14 proteins:

  • LC7L3_HUMAN
  • B4DJ96_HUMAN
  • C9JL41_HUMAN
  • D6RDI2_HUMAN
  • D6RHH0_HUMAN
  • E7EN55_HUMAN
  • H0YA81_HUMAN
  • H0YAR4_HUMAN
  • H0YAX1_HUMAN
  • H0YAY6_HUMAN
  • H0YBV7_HUMAN
  • H7C5U7_HUMAN
  • J3KPP4_HUMAN
  • U3KQT3_HUMAN

Pseudogenes.org Pseudogenes for LUC7L3 Gene

genes like me logo Genes that share paralogs with LUC7L3: view

Variants for LUC7L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LUC7L3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
774521 Benign: not provided 50,741,141(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LUC7L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LUC7L3 Gene

Variant ID Type Subtype PubMed ID
dgv42n68 CNV loss 17160897
esv2448711 CNV deletion 19546169
esv2615229 CNV deletion 19546169
nsv507843 OTHER sequence alteration 20534489

Variation tolerance for LUC7L3 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LUC7L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUC7L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L3 Gene

Disorders for LUC7L3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LUC7L3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 4
  • diabetes mellitus, insulin-dependent, 4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LUC7L3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LUC7L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LUC7L3 Gene

Publications for LUC7L3 Gene

  1. CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. (PMID: 10631324) Nishii Y … Ueda K (FEBS letters 2000) 2 3 4 23
  2. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. (PMID: 12565863) Umehara H … Ueda K (Biochemical and biophysical research communications 2003) 2 3 4
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41
  4. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby CJ … Böttger A (Science (New York, N.Y.) 2009) 3 4
  5. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. (PMID: 18663000) Zhou A … Huang SC (Molecular and cellular biology 2008) 3 4

Products for LUC7L3 Gene

  • Signalway Proteins for LUC7L3

Sources for LUC7L3 Gene