Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LUC7L3 Gene

Aliases for LUC7L3 Gene

  • LUC7 Like 3 Pre-MRNA Splicing Factor 2 3 5
  • Cisplatin Resistance-Associated-Overexpressed Protein 3 4
  • Okadaic Acid-Inducible Phosphoprotein OA48-18 3 4
  • CAMP Regulatory Element-Associated Protein 1 3 4
  • CRE-Associated Protein 1 3 4
  • CREAP-1 3 4
  • CROP 3 4
  • Cisplatin Resistance Associated Overexpressed Protein 2
  • LUC7-Like 3 Pre-MRNA Splicing Factor 2
  • LUC7-Like 3 (S. Cerevisiae) 2
  • CRE-Associated Protein 2
  • Luc7-Like Protein 3 3
  • LUC7-Like 3 3
  • OA48-18 3
  • HLuc7A 3
  • CREAP1 4
  • LUC7A 3
  • Luc7A 4
  • CRA 3
  • O48 4

External Ids for LUC7L3 Gene

Previous GeneCards Identifiers for LUC7L3 Gene

  • GC17P046153
  • GC17P048796
  • GC17P044164

Summaries for LUC7L3 Gene

Entrez Gene Summary for LUC7L3 Gene

  • This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for LUC7L3 Gene

LUC7L3 (LUC7 Like 3 Pre-MRNA Splicing Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is LUC7L2.

UniProtKB/Swiss-Prot for LUC7L3 Gene

  • Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.

Gene Wiki entry for LUC7L3 Gene

Additional gene information for LUC7L3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L3 Gene

Genomics for LUC7L3 Gene

GeneHancer (GH) Regulatory Elements for LUC7L3 Gene

Promoters and enhancers for LUC7L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050718 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 664.4 +1.0 993 3.3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 LUC7L3 ENSG00000278963 MBTD1 ENSG00000262837 UTP18 ANKRD40 FAM117A FLJ45513 KAT7 TAC4
GH17J049758 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 69.9 -957.6 -957595 6.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B FAM117A ENSG00000262837 UBE2Z LUC7L3 FLJ45513 SPOP COL1A1 TAC4 SLC35B1 ITGA3
GH17J051152 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 69.3 +434.1 434135 2.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NME1 NME1-NME2 MBTD1 LUC7L3 UTP18 COL1A1 EME1 NME2 LOC105371824 CACNA1G-AS1
GH17J050860 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 40.5 +145.6 145599 8.5 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TOB1-AS1 TOB1 MBTD1 LUC7L3 ENSG00000249870 ENSG00000206824 LINC02071 ENSG00000249658 ENSG00000251665 ENSG00000247011
GH17J050262 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40.2 -450.4 -450364 13.4 HDGF PKNOX1 SIN3A ZBTB7B ZNF143 ZNF263 MCM3 SP3 MXD4 REST TMEM92 MBTD1 ENSG00000262837 LUC7L3 FAM117A COL1A1 LOC105371824 MYCBPAP SPATA20 UTP18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LUC7L3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LUC7L3 Gene

Genomic Locations for LUC7L3 Gene
36,670 bases
Plus strand
36,670 bases
Plus strand

Genomic View for LUC7L3 Gene

Genes around LUC7L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L3 Gene

Proteins for LUC7L3 Gene

  • Protein details for LUC7L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Luc7-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B3KN54
    • D3DTY1
    • Q6PHR9
    • Q9NUY0
    • Q9P2S7

    Protein attributes for LUC7L3 Gene

    432 amino acids
    Molecular mass:
    51466 Da
    Quaternary structure:
    • May interact with SFRS1 and form homodimers (PubMed:12565863). Interacts with JMJD6 (PubMed:19574390). Interacts with RBM25 (PubMed:18663000). Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186). Interacts with RRP1B (PubMed:23604122).
    • Sequence=AAC79807.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L3 Gene


neXtProt entry for LUC7L3 Gene

Post-translational modifications for LUC7L3 Gene

No data available for DME Specific Peptides for LUC7L3 Gene

Domains & Families for LUC7L3 Gene

Gene Families for LUC7L3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LUC7L3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Luc7 family.
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L3: view

Function for LUC7L3 Gene

Molecular function for LUC7L3 Gene

UniProtKB/Swiss-Prot Function:
Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.

Phenotypes From GWAS Catalog for LUC7L3 Gene

Gene Ontology (GO) - Molecular Function for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IEA,IMP 10631324
GO:0005515 protein binding IPI 15324660
genes like me logo Genes that share ontologies with LUC7L3: view
genes like me logo Genes that share phenotypes with LUC7L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L3 Gene

Localization for LUC7L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L3 Gene

Nucleus speckle. Note=The subnuclear localization is affected by cisplatin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L3 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12565863
GO:0005654 nucleoplasm IDA --
GO:0005685 U1 snRNP IBA,IEA --
GO:0016607 nuclear speck IDA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L3: view

Pathways & Interactions for LUC7L3 Gene

SuperPathways for LUC7L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IBA,IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IMP 10631324
genes like me logo Genes that share ontologies with LUC7L3: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L3 Gene

Drugs & Compounds for LUC7L3 Gene

(2) Drugs for LUC7L3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with LUC7L3: view

Transcripts for LUC7L3 Gene

Unigene Clusters for LUC7L3 Gene

LUC7-like 3 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP2: -
SP4: - - -
SP6: - -

Relevant External Links for LUC7L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUC7L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LUC7L3 Gene

Protein differential expression in normal tissues from HIPED for LUC7L3 Gene

This gene is overexpressed in Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LUC7L3 Gene

Protein tissue co-expression partners for LUC7L3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LUC7L3 Gene:


SOURCE GeneReport for Unigene cluster for LUC7L3 Gene:


mRNA Expression by UniProt/SwissProt for LUC7L3 Gene:

Tissue specificity: Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.

Evidence on tissue expression from TISSUES for LUC7L3 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Pancreas(3.3)
  • Lung(3)
  • Kidney(2.5)
  • Spleen(2.2)
  • Heart(2)
  • Lymph node(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with LUC7L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUC7L3 Gene

Orthologs for LUC7L3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LUC7L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LUC7L3 34 33
  • 99.77 (n)
(Monodelphis domestica)
Mammalia LUC7L3 34
  • 98 (a)
(Canis familiaris)
Mammalia LUC7L3 34 33
  • 94.83 (n)
(Bos Taurus)
Mammalia LUC7L3 34 33
  • 94.29 (n)
(Mus musculus)
Mammalia Luc7l3 16 34 33
  • 92.8 (n)
(Rattus norvegicus)
Mammalia Luc7l3 33
  • 91.94 (n)
(Ornithorhynchus anatinus)
Mammalia LUC7L3 34
  • 86 (a)
(Gallus gallus)
Aves LUC7L3 34 33
  • 85.34 (n)
(Anolis carolinensis)
Reptilia LUC7L3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l3 33
  • 76.02 (n)
Str.1675 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68481 33
(Danio rerio)
Actinopterygii luc7l3 34
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3198 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea C50D2.8 34
  • 33 (a)
Y119D3B.12 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51410 33
  • 49.64 (n)
(Oryza sativa)
Liliopsida Os07g0456400 33
  • 51.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Cin.3010 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3010 33
Species where no ortholog for LUC7L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L3 Gene

Gene Tree for LUC7L3 (if available)
Gene Tree for LUC7L3 (if available)
Evolutionary constrained regions (ECRs) for LUC7L3: view image

Paralogs for LUC7L3 Gene

Paralogs for LUC7L3 Gene

(5) SIMAP similar genes for LUC7L3 Gene using alignment to 14 proteins:

  • B4DJ96_HUMAN
  • C9JL41_HUMAN
  • E7EN55_HUMAN
  • H0YA81_HUMAN
  • H7C5U7_HUMAN
  • U3KQT3_HUMAN Pseudogenes for LUC7L3 Gene

genes like me logo Genes that share paralogs with LUC7L3: view

Variants for LUC7L3 Gene

Sequence variations from dbSNP and Humsavar for LUC7L3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000057385 -- 50,750,450(+) T/C intron_variant
rs1000118320 -- 50,743,281(+) C/T intron_variant
rs1000189913 -- 50,749,439(+) G/A intron_variant
rs1000274387 -- 50,718,196(+) A/G upstream_transcript_variant
rs1000352274 -- 50,723,928(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L3 Gene

Variant ID Type Subtype PubMed ID
dgv42n68 CNV loss 17160897
esv2448711 CNV deletion 19546169
esv2615229 CNV deletion 19546169
nsv507843 OTHER sequence alteration 20534489

Variation tolerance for LUC7L3 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LUC7L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L3 Gene

Disorders for LUC7L3 Gene

Additional Disease Information for LUC7L3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LUC7L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L3 Gene

Publications for LUC7L3 Gene

  1. CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. (PMID: 10631324) Nishii Y … Ueda K (FEBS letters 2000) 2 3 4 22 58
  2. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. (PMID: 12565863) Umehara H … Ueda K (Biochemical and biophysical research communications 2003) 2 3 4 58
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  4. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby CJ … Böttger A (Science (New York, N.Y.) 2009) 3 4 58
  5. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. (PMID: 18663000) Zhou A … Huang SC (Molecular and cellular biology 2008) 3 4 58

Products for LUC7L3 Gene

Sources for LUC7L3 Gene

Loading form....