Aliases for LTO1 Gene

Aliases for LTO1 Gene

  • LTO1 Maturation Factor Of ABCE1 2 3 5
  • Tumor-Amplified And Overexpressed Sequence 1 3 4
  • Oral Cancer Overexpressed Protein 1-A 2 3
  • Oral Cancer-Overexpressed Protein 1 3 4
  • LTO1, ABCE1 Maturation Factor 2 3
  • Oral Cancer Overexpressed 1 2 3
  • Protein LTO1 Homolog 3 4
  • ORAOV1 3 4
  • TAOS1 3 4
  • CIAB1 3

External Ids for LTO1 Gene

Previous HGNC Symbols for LTO1 Gene

  • ORAOV1

Summaries for LTO1 Gene

GeneCards Summary for LTO1 Gene

LTO1 (LTO1 Maturation Factor Of ABCE1) is a Protein Coding gene. Diseases associated with LTO1 include Oral Cancer.

UniProtKB/Swiss-Prot Summary for LTO1 Gene

  • The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).

Additional gene information for LTO1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LTO1 Gene

Genomics for LTO1 Gene

GeneHancer (GH) Regulatory Elements for LTO1 Gene

Promoters and enhancers for LTO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTO1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LTO1 Gene

Genomic Locations for LTO1 Gene
chr11:69,653,076-69,675,416
(GRCh38/hg38)
Size:
22,341 bases
Orientation:
Minus strand
chr11:69,467,844-69,490,184
(GRCh37/hg19)
Size:
22,341 bases
Orientation:
Minus strand

Genomic View for LTO1 Gene

Genes around LTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTO1 Gene

Proteins for LTO1 Gene

  • Protein details for LTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV07-LTO1_HUMAN
    Recommended name:
    Protein LTO1 homolog
    Protein Accession:
    Q8WV07
    Secondary Accessions:
    • B2R4R2
    • Q8NFK0

    Protein attributes for LTO1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15354 Da
    Quaternary structure:
    • Forms a complex with YAE1 (PubMed:23318452). Interacts with PYCR1 and PYCR2 (PubMed:24930674).
    Miscellaneous:
    • Amplified and overexpressed in oral cancer cells.

neXtProt entry for LTO1 Gene

Post-translational modifications for LTO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LTO1 Gene

Domains & Families for LTO1 Gene

Gene Families for LTO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LTO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LTO1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58145, highly similar to Oral cancer overexpressed protein 1 (B4DFA5_HUMAN)
  • Tumor-amplified and overexpressed sequence 1 (ORAV1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WV07

UniProtKB/Swiss-Prot:

LTO1_HUMAN :
  • Belongs to the LTO1 family.
Family:
  • Belongs to the LTO1 family.
genes like me logo Genes that share domains with LTO1: view

Function for LTO1 Gene

Molecular function for LTO1 Gene

UniProtKB/Swiss-Prot Function:
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).

Phenotypes From GWAS Catalog for LTO1 Gene

Gene Ontology (GO) - Molecular Function for LTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24930674
genes like me logo Genes that share ontologies with LTO1: view
genes like me logo Genes that share phenotypes with LTO1: view

Animal Model Products

CRISPR Products

miRNA for LTO1 Gene

miRTarBase miRNAs that target LTO1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LTO1 Gene

Localization for LTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTO1 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with LTO1: view

Pathways & Interactions for LTO1 Gene

PathCards logo

SuperPathways for LTO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IBA 21873635
GO:0006413 translational initiation IMP 23318452
GO:0042273 ribosomal large subunit biogenesis IMP 23318452
GO:0106035 protein maturation by [4Fe-4S] cluster transfer IDA 26182403
genes like me logo Genes that share ontologies with LTO1: view

No data available for Pathways by source and SIGNOR curated interactions for LTO1 Gene

Drugs & Compounds for LTO1 Gene

No Compound Related Data Available

Transcripts for LTO1 Gene

mRNA/cDNA for LTO1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTO1 Gene

No ASD Table

Relevant External Links for LTO1 Gene

GeneLoc Exon Structure for
LTO1
ECgene alternative splicing isoforms for
LTO1

Expression for LTO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of LTO1 Gene:

LTO1

mRNA Expression by UniProt/SwissProt for LTO1 Gene:

Q8WV07-LTO1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.

Evidence on tissue expression from TISSUES for LTO1 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with LTO1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LTO1 Gene

Orthologs for LTO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORAOV1 33 32
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ORAOV1 33 32
  • 86.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ORAOV1 33 32
  • 85.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Oraov1 33 32
  • 77.13 (n)
OneToOne
LTO1 17
rat
(Rattus norvegicus)
Mammalia Oraov1 32
  • 76.31 (n)
oppossum
(Monodelphis domestica)
Mammalia ORAOV1 33
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORAOV1 33
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORAOV1 33 32
  • 69.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORAOV1 33
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oraov1 32
  • 63.26 (n)
zebrafish
(Danio rerio)
Actinopterygii oraov1 33 32
  • 64.44 (n)
OneToOne
Species where no ortholog for LTO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTO1 Gene

ENSEMBL:
Gene Tree for LTO1 (if available)
TreeFam:
Gene Tree for LTO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTO1: view image

Paralogs for LTO1 Gene

Pseudogenes.org Pseudogenes for LTO1 Gene

genes like me logo Genes that share paralogs with LTO1: view

No data available for Paralogs for LTO1 Gene

Variants for LTO1 Gene

Sequence variations from dbSNP and Humsavar for LTO1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000343924 -- 69,674,364(-) G/A intron_variant
rs1000375301 -- 69,674,632(-) G/A intron_variant
rs1000493325 -- 69,668,129(-) C/T intron_variant
rs1000858545 -- 69,669,745(-) G/A intron_variant
rs1000993565 -- 69,665,242(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LTO1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
esv3626752 CNV loss 21293372
nsv825973 CNV gain 20364138
nsv825974 CNV gain 20364138

Variation tolerance for LTO1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTO1 Gene

Disorders for LTO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LTO1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • lip and oral cavity carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search LTO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LTO1

genes like me logo Genes that share disorders with LTO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTO1 Gene

Publications for LTO1 Gene

  1. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. (PMID: 12172009) Huang X … Godfrey TE (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 23 56
  2. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. (PMID: 23318452) Zhai C … Panaretou B (Oncogene 2014) 2 3 4 56
  3. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. (PMID: 26182403) Paul VD … Lill R (eLife 2015) 3 4 56
  4. Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. (PMID: 24930674) Togashi Y … Nishio K (Oncotarget 2014) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for LTO1 Gene

Sources for LTO1 Gene