Free for academic non-profit institutions. Other users need a Commercial license
Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
LTN1 (Listerin E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 21903422 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0043023 | ribosomal large subunit binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IBA | 21873635 |
GO:1990112 | RQC complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0051865 | protein autoubiquitination | IEA | -- |
GO:0072344 | rescue of stalled ribosome | IBA | 21873635 |
GO:1990116 | ribosome-associated ubiquitin-dependent protein catabolic process | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LTN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LTN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LTN1 30 |
|
||
RNF160 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Ltn1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ltn1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LTN1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LTN1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LTN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ltn1 30 |
|
||
Str.7225 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-175g6.5 30 |
|
||
LTN1 31 |
|
OneToOne | |||
Dr.13250 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | l(3)76BDr 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y54E10A.11 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RKR1 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.543 30 |
|
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708013 | Likely Benign: not provided | 28,958,490(-) | T/C | SYNONYMOUS_VARIANT | |
744096 | Likely Benign: not provided | 28,971,391(-) | C/T | SYNONYMOUS_VARIANT | |
771781 | Benign: not provided | 28,966,992(-) | G/A | MISSENSE_VARIANT | |
785670 | Benign: not provided | 28,967,105(-) | T/G | MISSENSE_VARIANT | |
rs16983580 | - | p.Ala500Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3893402 | CNV | gain | 25118596 |
esv993752 | CNV | loss | 20482838 |
No disorders were found for LTN1 Gene.