This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulatio... See more...

Aliases for LTF Gene

Aliases for LTF Gene

  • Lactotransferrin 2 3 4 5
  • Growth-Inhibiting Protein 12 3 4
  • Talalactoferrin 3 4
  • GIG12 3 4
  • HLF2 2 3
  • LF 3 4
  • Epididymis Luminal Protein 110 3
  • Neutrophil Lactoferrin 3
  • Lactoferricin 3
  • Lactoferroxin 3
  • Lactoferrin 4
  • EC 3.4.21.- 4
  • Kaliocin-1 3
  • EC 3.4.21 51
  • HEL110 3
  • LTF 5

External Ids for LTF Gene

Previous GeneCards Identifiers for LTF Gene

  • GC03M045718
  • GC03M046296
  • GC03M046438
  • GC03M046452
  • GC03M046477

Summaries for LTF Gene

Entrez Gene Summary for LTF Gene

  • This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for LTF Gene

LTF (Lactotransferrin) is a Protein Coding gene. Diseases associated with LTF include Mastitis and Keratoconjunctivitis Sicca. Among its related pathways are Response of Mtb to phagocytosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and heparin binding. An important paralog of this gene is TF.

UniProtKB/Swiss-Prot Summary for LTF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
  • Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.
  • Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.
  • Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.
  • Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.
  • The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
  • [Isoform DeltaLf]: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters.

Gene Wiki entry for LTF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LTF Gene

Genomics for LTF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LTF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J046483 Enhancer 0.8 Ensembl ENCODE 608.1 -0.6 -567 4.4 IKZF1 ZIC2 TCF12 POLR2A MYNN SPI1 TAL1 CREM TFAP4 SMARCA4 LTF lnc-LRRC2-1 KIF9 CCRL2 piR-36393-360 RTP3
GH03J046504 Promoter/Enhancer 0.7 EPDnew FANTOM5 600.4 -19.8 -19790 0.2 EBF1 BHLHE40 LTF TDGF1 MYL3 PTH1R CCRL2 CCR1 CCR5 RTP3 piR-40762
GH03J046465 Promoter 0.5 EPDnew 600.4 +20.1 20135 0.1 TBP EZH2 LTF lnc-LRRC2-2 lnc-LRRC2-1 CCRL2
GH03J046464 Promoter 0.5 EPDnew 600.4 +20.3 20309 0.1 TBP EZH2 LTF lnc-LRRC2-2 lnc-LRRC2-1 CCRL2
GH03J046556 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -72.8 -72770 3.8 ARHGAP35 GATAD2A CTCF REST IKZF1 NFKBIZ ZNF143 ZNF24 RAD21 IRF2 LRRC2-AS1 LRRC2 RTP3 LTF CCR2 TDGF1 lnc-LTF-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LTF

Top Transcription factor binding sites by QIAGEN in the LTF gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • STAT3
  • STAT5A

Genomic Locations for LTF Gene

Genomic Locations for LTF Gene
chr3:46,435,645-46,485,234
(GRCh38/hg38)
Size:
49,590 bases
Orientation:
Minus strand
chr3:46,477,136-46,526,724
(GRCh37/hg19)
Size:
49,589 bases
Orientation:
Minus strand

Genomic View for LTF Gene

Genes around LTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTF Gene

Proteins for LTF Gene

  • Protein details for LTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02788-TRFL_HUMAN
    Recommended name:
    Lactotransferrin
    Protein Accession:
    P02788
    Secondary Accessions:
    • A8K9U8
    • B2MV13
    • B7Z4X2
    • E7EQH5
    • O00756
    • Q16780
    • Q16785
    • Q16786
    • Q16789
    • Q5DSM0
    • Q8IU92
    • Q8IZH6
    • Q8TCD2
    • Q96KZ4
    • Q96KZ5
    • Q9H1Z3
    • Q9UCY5

    Protein attributes for LTF Gene

    Size:
    710 amino acids
    Molecular mass:
    78182 Da
    Quaternary structure:
    • Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1.
    Miscellaneous:
    • [Isoform DeltaLf]: Contains a phosphoserine at position 10 (alternate). Contains a O-linked (GlcNAc) serine at position 10 (alternate). O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates DeltaLf transcriptional activity, whereas phosphorylation activates it. Phosphorylation at Ser-10 also promotes proteasomal degradation.

    Three dimensional structures from OCA and Proteopedia for LTF Gene

    Alternative splice isoforms for LTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTF Gene

Selected DME Specific Peptides for LTF Gene

P02788:
  • RKPVTEA
  • LLCPDNT
  • GDVAFVK
  • VVWCAVG
  • YSGAFKCL
  • APNHAVVS
  • SSQEPYF
  • VLKGEADA
  • YYGYTGAFRCLAE
  • VPSHAVVARSV
  • GKKSCHT

Post-translational modifications for LTF Gene

  • [Isoform DeltaLf]: Phosphorylation at Ser-10 activates the transcriptional activity (PubMed:20404350). Phosphorylation at Ser-10 also promotes proteasomal degradation (PubMed:20404350). Alternatively can undergo O-GlcNAcylation at Ser-10 (PubMed:20404350).
  • [Isoform DeltaLf]: O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates the transcriptional activity (PubMed:20404350). Alternatively can undergo phosphorylation at Ser-10 (PubMed:20404350).
  • Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.
  • Glycosylation at Asn156, Asn497, and Asn642
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TRFL_HUMAN (320)

Antibody Products

Domains & Families for LTF Gene

Gene Families for LTF Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LTF Gene

Suggested Antigen Peptide Sequences for LTF Gene

GenScript: Design optimal peptide antigens:
  • Lactoferrin (B2MV13_HUMAN)
  • Truncated lactoferrin (B2MV14_HUMAN)
  • cDNA FLJ58679, highly similar to Lactotransferrin (EC 3.4.21.-) (B7Z4X2_HUMAN)
  • Growth-inhibiting protein 12 (Q5DSM0_HUMAN)
  • Talalactoferrin (TRFL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P02788

UniProtKB/Swiss-Prot:

TRFL_HUMAN :
  • Belongs to the transferrin family.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with LTF: view

Function for LTF Gene

Molecular function for LTF Gene

UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
UniProtKB/Swiss-Prot Function:
Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.
UniProtKB/Swiss-Prot Function:
Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.
UniProtKB/Swiss-Prot Function:
Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.
UniProtKB/Swiss-Prot Function:
Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.
UniProtKB/Swiss-Prot Function:
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
UniProtKB/Swiss-Prot Function:
[Isoform DeltaLf]: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters.
GENATLAS Biochemistry:
lactotransferrin,80kDa,iron binding protein present in milk and a variety of secretions derived from glandular epithelium cells,also expressed in secondary granules of neutrophils,involved in iron transport,storage and chelation,and host defense mechanisms

Enzyme Numbers (IUBMB) for LTF Gene

Phenotypes From GWAS Catalog for LTF Gene

Gene Ontology (GO) - Molecular Function for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IMP 15155221
GO:0003677 DNA binding IEA --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IDA 12788072
GO:0005506 iron ion binding IEA,IDA 12037568
genes like me logo Genes that share ontologies with LTF: view
genes like me logo Genes that share phenotypes with LTF: view

Animal Models for LTF Gene

MGI Knock Outs for LTF:
  • Ltf Ltf<tm1Omc>
  • Ltf Ltf<tm1.2Smoc>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTF

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTF Gene

Localization for LTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTF Gene

[Isoform 1]: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
[Isoform DeltaLf]: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTF gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 12788072
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,HDA 21630459
GO:0005737 cytoplasm IMP 25193851
genes like me logo Genes that share ontologies with LTF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LTF Gene

Pathways & Interactions for LTF Gene

genes like me logo Genes that share pathways with LTF: view

Pathways by source for LTF Gene

SIGNOR curated interactions for LTF Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001817 regulation of cytokine production IEA,IDA 20345905
GO:0001895 retina homeostasis HEP 23580065
GO:0002227 innate immune response in mucosa IDA 12037568
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LTF: view

Drugs & Compounds for LTF Gene

(89) Drugs for LTF Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1560
lauric acid Approved, Experimental Pharma Agonist, Target 0
Rose bengal Approved, Investigational Pharma Carrier, binder VGlut and vesicular monoamine transporter (VMAT) inhibitor, Potent VGlut and VMAT inhibitor; cell permeable 0
Nimesulide Approved, Investigational, Withdrawn Pharma Target Non-steroidal anti-inflammatory drug 13
parecoxib Approved Pharma Inhibitor, Inhibition, Target 48

(69) Additional Compounds for LTF Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • [co(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Carbonate
71-52-3, 463-79-6
genes like me logo Genes that share compounds with LTF: view

Transcripts for LTF Gene

mRNA/cDNA for LTF Gene

4 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTF

Alternative Splicing Database (ASD) splice patterns (SP) for LTF Gene

No ASD Table

Relevant External Links for LTF Gene

GeneLoc Exon Structure for
LTF

Expression for LTF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTF Gene

This gene is overexpressed in Minor Salivary Gland (x18.9), Whole Blood (x13.3), Kidney - Cortex (x6.1), and Breast - Mammary Tissue (x4.5).

Protein differential expression in normal tissues from HIPED for LTF Gene

This gene is overexpressed in Milk (36.8) and Neutrophil (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LTF Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LTF

SOURCE GeneReport for Unigene cluster for LTF Gene:

Hs.529517

mRNA Expression by UniProt/SwissProt for LTF Gene:

P02788-TRFL_HUMAN
Tissue specificity: High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.

Evidence on tissue expression from TISSUES for LTF Gene

  • Blood(5)
  • Bone marrow(4.7)
  • Lung(4.7)
  • Liver(4.6)
  • Spleen(4.6)
  • Eye(4.5)
  • Lymph node(4.5)
  • Stomach(4.1)
  • Nervous system(4)
  • Intestine(3.4)
  • Kidney(3.1)
  • Skin(2.6)
  • Heart(2.5)
  • Gall bladder(2.5)
  • Pancreas(2.3)
  • Saliva(2)
genes like me logo Genes that share expression patterns with LTF: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LTF Gene

Orthologs for LTF Gene

This gene was present in the common ancestor of animals.

Orthologs for LTF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LTF 30 31
  • 98.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LTF 30 31
  • 80.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LTF 30 31
  • 77.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ltf 30 17 31
  • 76.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ltf 30
  • 71.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 58 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TF 31
  • 51 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64306 30
Zebrafish
(Danio rerio)
Actinopterygii tfa 31
  • 41 (a)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tsf2 31
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4617 31
  • 29 (a)
ManyToMany
Species where no ortholog for LTF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LTF Gene

ENSEMBL:
Gene Tree for LTF (if available)
TreeFam:
Gene Tree for LTF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTF: view image

Paralogs for LTF Gene

Paralogs for LTF Gene

(2) SIMAP similar genes for LTF Gene using alignment to 6 proteins:

  • TRFL_HUMAN
  • B2MV14_HUMAN
  • C9J0S5_HUMAN
  • C9JCF5_HUMAN
  • E7EQB2_HUMAN
  • E7ER44_HUMAN
genes like me logo Genes that share paralogs with LTF: view

Variants for LTF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LTF Gene

TRFL_HUMAN-P02788
The sequence shown corresponds to the reference genome sequence and is likely to represent the minor allele, whereas most publications refer to the longer sequence containing variant Arg-22 ins. Insertion of the additional arginine in variant Arg-22 ins creates an N-terminal basic cluster of four arginines, all of which appear to be important for the full functionality of the protein, including bactericidal and antifungal activities as well as binding to glycosaminoglycans, pspA, LPS, lysozyme and DNA.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LTF Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
721972 Benign: not provided 46,445,350(-) C/A MISSENSE_VARIANT
731672 Benign: not provided 46,455,878(-) G/T SYNONYMOUS_VARIANT
738852 Likely Benign: not provided 46,441,477(-) C/G SYNONYMOUS_VARIANT
743969 Likely Benign: not provided 46,456,312(-) C/T SYNONYMOUS_VARIANT
746010 Likely Benign: not provided 46,443,509(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LTF Gene

Structural Variations from Database of Genomic Variants (DGV) for LTF Gene

Variant ID Type Subtype PubMed ID
esv2725234 CNV deletion 23290073
esv3367734 CNV duplication 20981092
nsv1013306 CNV gain 25217958
nsv1014624 CNV loss 25217958

Variation tolerance for LTF Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTF Gene

Human Gene Mutation Database (HGMD)
LTF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTF

SNP Genotyping and Copy Number Assay Products

Disorders for LTF Gene

MalaCards: The human disease database

(45) MalaCards diseases for LTF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mastitis
  • breast inflammation
keratoconjunctivitis sicca
  • kcs
oral candidiasis
  • candidiasis of mouth
sjogren syndrome
  • sicca syndrome
dental caries
  • dental caries extending into pulp
- elite association - COSMIC cancer census association via MalaCards
Search LTF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LTF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTF Gene

Publications for LTF Gene

  1. Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. (PMID: 18156281) Moreno-Navarrete JM … Fernández-Real JM (Clinical chemistry 2008) 3 23 41
  2. Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma. (PMID: 17476971) Yi HM … Ren CP (Oncology research 2006) 2 3 23
  3. Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. (PMID: 15687491) Japelj B … Jerala R (The Journal of biological chemistry 2005) 3 4 23
  4. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. (PMID: 15166119) Cornish J … Reid IR (Endocrinology 2004) 3 4 23
  5. Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane. (PMID: 12693969) Viejo-Díaz M … Fierro JF (Biochemistry. Biokhimiia 2003) 3 4 23

Products for LTF Gene

  • Addgene plasmids for LTF

Sources for LTF Gene