Aliases for LTC4S Gene
External Ids for LTC4S Gene
Previous GeneCards Identifiers for LTC4S Gene
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
GeneCards Summary for LTC4S Gene
LTC4S (Leukotriene C4 Synthase) is a Protein Coding gene. Diseases associated with LTC4S include Leukotriene C4 Synthase Deficiency and Asthma. Among its related pathways are Arachidonic acid metabolism and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include lipid binding and glutathione transferase activity. An important paralog of this gene is MGST2.
UniProtKB/Swiss-Prot Summary for LTC4S Gene
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).