The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been impli... See more...

Aliases for LTC4S Gene

Aliases for LTC4S Gene

  • Leukotriene C4 Synthase 2 3 4 5
  • Glutathione S-Transferase LTC4 3 4
  • LTC4 Synthase 3 4
  • Leukotriene-C(4) Synthase 4
  • Leukotriene-C4 Synthase 4
  • EC 4.4.1.20 4
  • EC 2.5.1.- 4
  • MGC33147 2
  • LTC4S 5

External Ids for LTC4S Gene

Previous GeneCards Identifiers for LTC4S Gene

  • GC05P179333
  • GC05P180165
  • GC05P179285
  • GC05P179330
  • GC05P179153
  • GC05P179220
  • GC05P173947

Summaries for LTC4S Gene

Entrez Gene Summary for LTC4S Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

GeneCards Summary for LTC4S Gene

LTC4S (Leukotriene C4 Synthase) is a Protein Coding gene. Diseases associated with LTC4S include Leukotriene C4 Synthase Deficiency and Asthma. Among its related pathways are Arachidonic acid metabolism and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include lipid binding and glutathione transferase activity. An important paralog of this gene is MGST2.

UniProtKB/Swiss-Prot Summary for LTC4S Gene

  • Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).

Gene Wiki entry for LTC4S Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LTC4S Gene

Genomics for LTC4S Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LTC4S Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTC4S on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LTC4S

Top Transcription factor binding sites by QIAGEN in the LTC4S gene promoter:
  • C/EBPalpha
  • Sp1

Genomic Locations for LTC4S Gene

Latest Assembly
chr5:179,793,980-179,796,647
(GRCh38/hg38)
Size:
2,668 bases
Orientation:
Plus strand

Previous Assembly
chr5:179,220,987-179,223,648
(GRCh37/hg19 by Entrez Gene)
Size:
2,662 bases
Orientation:
Plus strand

chr5:179,220,981-179,223,648
(GRCh37/hg19 by Ensembl)
Size:
2,668 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr5(PATCHES):559,563-562,224 (+)

Genomic View for LTC4S Gene

Genes around LTC4S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTC4S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTC4S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTC4S Gene

Proteins for LTC4S Gene

  • Protein details for LTC4S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16873-LTC4S_HUMAN
    Recommended name:
    Leukotriene C4 synthase
    Protein Accession:
    Q16873
    Secondary Accessions:
    • Q8N6P0
    • Q9UC73
    • Q9UD18

    Protein attributes for LTC4S Gene

    Size:
    150 amino acids
    Molecular mass:
    16567 Da
    Quaternary structure:
    • Homotrimer (PubMed:17632548, PubMed:17632546). Interacts with ALOX5AP and ALOX5 (PubMed:19233132).

    Three dimensional structures from OCA and Proteopedia for LTC4S Gene

neXtProt entry for LTC4S Gene

Post-translational modifications for LTC4S Gene

  • Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LTC4S Gene

No data available for DME Specific Peptides for LTC4S Gene

Domains & Families for LTC4S Gene

Gene Families for LTC4S Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for LTC4S Gene

InterPro:
Blocks:
  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

Suggested Antigen Peptide Sequences for LTC4S Gene

GenScript: Design optimal peptide antigens:
  • Leukotriene-C(4) synthase (LTC4S_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16873

UniProtKB/Swiss-Prot:

LTC4S_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with LTC4S: view

Function for LTC4S Gene

Molecular function for LTC4S Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence={ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:27365393, ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:7937884, ECO:0000269|PubMed:9153254};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:53508, ChEBI:CHEBI:57925, ChEBI:CHEBI:131958, ChEBI:CHEBI:137407; Evidence={ECO:0000269|PubMed:27791009};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=70 uM for glutathione {ECO:0000269|PubMed:27365393}; KM=300 uM for glutathione {ECO:0000269|PubMed:23409838}; KM=30 uM for leukotriene A4 {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:27791009}; KM=70.5 uM for 13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid {ECO:0000269|PubMed:27791009}; KM=76 uM for leukotriene A4 {ECO:0000269|PubMed:27365393}; Vmax=70.5 mmol/min/mg enzyme with 13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid as substrate {ECO:0000269|PubMed:27791009}; Vmax=6.7 mmol/min/mg enzyme with leukotriene A4 as substrate {ECO:0000269|PubMed:27791009}; Note=kcat is 19 sec(-1) with glutathione as substrate (PubMed:27365393). kcat is 105 sec(-1) with leukotriene A4 as substrate (PubMed:27365393). {ECO:0000269|PubMed:27365393}; pH dependence: Optimum pH is 8. {ECO:0000269|PubMed:9153254};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by MK886.
GENATLAS Biochemistry:
leukotriene C4 synthase,microsomal,GST superfamily

Enzyme Numbers (IUBMB) for LTC4S Gene

Phenotypes From GWAS Catalog for LTC4S Gene

Gene Ontology (GO) - Molecular Function for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA 21873635
GO:0004464 leukotriene-C4 synthase activity TAS,IDA 8706658
GO:0004602 glutathione peroxidase activity IBA 21873635
GO:0005515 protein binding IPI 19233132
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with LTC4S: view
genes like me logo Genes that share phenotypes with LTC4S: view

Human Phenotype Ontology for LTC4S Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LTC4S Gene

MGI Knock Outs for LTC4S:

miRNA for LTC4S Gene

miRTarBase miRNAs that target LTC4S

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTC4S

No data available for Transcription Factor Targets and HOMER Transcription for LTC4S Gene

Localization for LTC4S Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTC4S Gene

Nucleus outer membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Nucleus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTC4S gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
extracellular 3
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005640 nuclear outer membrane IEA,IDA 12023288
GO:0005783 endoplasmic reticulum IEA,IDA 19233132
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with LTC4S: view

Pathways & Interactions for LTC4S Gene

genes like me logo Genes that share pathways with LTC4S: view

Pathways by source for LTC4S Gene

2 KEGG pathways for LTC4S Gene
1 Qiagen pathway for LTC4S Gene
  • all-trans-Retinoic Acid Signaling in Brain

UniProtKB/Swiss-Prot Q16873-LTC4S_HUMAN

  • Pathway: Lipid metabolism; leukotriene C4 biosynthesis.

Gene Ontology (GO) - Biological Process for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006691 leukotriene metabolic process IEA,TAS --
GO:0019370 leukotriene biosynthetic process IEA,IBA 21873635
GO:0019372 lipoxygenase pathway TAS --
GO:0042759 long-chain fatty acid biosynthetic process IDA,TAS --
genes like me logo Genes that share ontologies with LTC4S: view

No data available for SIGNOR curated interactions for LTC4S Gene

Drugs & Compounds for LTC4S Gene

(16) Drugs for LTC4S Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Aspirin Approved, Vet_approved Pharma 1600
Montelukast Approved Pharma 321
Azelastine Approved Pharma Target, inhibitor 47
Leukotriene C4 Experimental, Investigational Pharma 0

(13) Additional Compounds for LTC4S Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene A4
  • (5S,6S,7E,9E,11Z,14Z)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
  • 5(S)-5,6-Oxido-7,9-trans-11,14-cis-eicosatetraenoic acid
72059-45-1
genes like me logo Genes that share compounds with LTC4S: view

Transcripts for LTC4S Gene

mRNA/cDNA for LTC4S Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTC4S

Alternative Splicing Database (ASD) splice patterns (SP) for LTC4S Gene

No ASD Table

Relevant External Links for LTC4S Gene

GeneLoc Exon Structure for
LTC4S

Expression for LTC4S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTC4S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LTC4S Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.9), Gallbladder (13.4), Placenta (8.0), and Urinary Bladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LTC4S Gene



Protein tissue co-expression partners for LTC4S Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LTC4S

SOURCE GeneReport for Unigene cluster for LTC4S Gene:

Hs.706741

mRNA Expression by UniProt/SwissProt for LTC4S Gene:

Q16873-LTC4S_HUMAN
Tissue specificity: Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.

Evidence on tissue expression from TISSUES for LTC4S Gene

  • Blood(4.5)
  • Lung(4.4)
  • Bone marrow(4.3)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LTC4S Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • skull
genes like me logo Genes that share expression patterns with LTC4S: view

Primer products for research

No data available for mRNA differential expression in normal tissues for LTC4S Gene

Orthologs for LTC4S Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTC4S Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LTC4S 29 30
  • 99.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LTC4S 29 30
  • 92.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LTC4S 29 30
  • 89.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ltc4s 29 16 30
  • 89.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ltc4s 29
  • 88.89 (n)
Oppossum
(Monodelphis domestica)
Mammalia LTC4S 30
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC770619 29
  • 72.37 (n)
LTC4S 30
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LTC4S 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mgst2 29
  • 66.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii ltc4s 30
  • 54 (a)
OneToOne
Species where no ortholog for LTC4S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LTC4S Gene

ENSEMBL:
Gene Tree for LTC4S (if available)
TreeFam:
Gene Tree for LTC4S (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTC4S: view image
Alliance of Genome Resources:
Additional Orthologs for LTC4S

Paralogs for LTC4S Gene

Paralogs for LTC4S Gene

(2) SIMAP similar genes for LTC4S Gene using alignment to 3 proteins:

  • LTC4S_HUMAN
  • B5MCC3_HUMAN
  • D6RJA1_HUMAN
genes like me logo Genes that share paralogs with LTC4S: view

Variants for LTC4S Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LTC4S Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
1027771 Pathogenic: Leukotriene c4 synthase deficiency 179,795,857(+) G/A
NM_145867.2(LTC4S):c.229+1G>A
SPLICE_DONOR
1032473 Pathogenic: Leukotriene c4 synthase deficiency 179,796,023(+) G/T
NM_145867.2(LTC4S):c.311+1G>T
SPLICE_DONOR
rs200212829 Likely Benign: not provided 179,795,863(+) G/A
NM_145867.2(LTC4S):c.229+7G>A
INTRON
rs730012 Drug Response: aspirin response - Toxicity/ADR 179,793,637(+) A/C
NM_145867.1(LTC4S):c.-444A>C
rs75759006 Benign: not provided 179,794,104(+) G/A
NM_145867.2(LTC4S):c.24G>A (p.Leu8=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LTC4S Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LTC4S Gene

Variant ID Type Subtype PubMed ID
dgv10240n54 CNV loss 21841781
dgv10241n54 CNV loss 21841781
nsv1119059 CNV deletion 24896259
nsv469579 CNV loss 16826518
nsv518964 CNV loss 19592680
nsv600659 CNV loss 21841781
nsv600660 CNV loss 21841781
nsv600661 CNV loss 21841781
nsv823361 CNV loss 20364138

Variation tolerance for LTC4S Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTC4S Gene

Human Gene Mutation Database (HGMD)
LTC4S
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTC4S
Leiden Open Variation Database (LOVD)
LTC4S

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTC4S Gene

Disorders for LTC4S Gene

MalaCards: The human disease database

(9) MalaCards diseases for LTC4S Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
leukotriene c4 synthase deficiency
  • ltc4 synthase deficiency
asthma
  • asthma, susceptibility to
urticaria
angioedema
  • angioneurotic edema
henoch-schoenlein purpura
  • allergic purpura
- elite association - COSMIC cancer census association via MalaCards
Search LTC4S in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LTC4S_HUMAN
  • Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. {ECO:0000269 PubMed:10896305, ECO:0000269 PubMed:9820300}.

Additional Disease Information for LTC4S

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LTC4S: view

No data available for Genatlas for LTC4S Gene

Publications for LTC4S Gene

  1. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. (PMID: 17632546) Martinez Molina D … Nordlund P (Nature 2007) 3 4 22 25
  2. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PMID: 17632548) Ago H … Miyano M (Nature 2007) 3 4 22 25
  3. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. (PMID: 8052639) Lam BK … Austen KF (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22
  4. Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. (PMID: 19280718) Freiberg JJ … Nordestgaard BG (Journal of molecular and cellular cardiology 2009) 3 22 40
  5. The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. (PMID: 19862937) Sánchez-Borges M … Caraballo L (Journal of investigational allergology & clinical immunology 2009) 3 22 40

Products for LTC4S Gene

Sources for LTC4S Gene