Aliases for LTBP2 Gene
External Ids for LTBP2 Gene
Previous HGNC Symbols for LTBP2 Gene
Previous GeneCards Identifiers for LTBP2 Gene
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
GeneCards Summary for LTBP2 Gene
LTBP2 (Latent Transforming Growth Factor Beta Binding Protein 2) is a Protein Coding gene. Diseases associated with LTBP2 include Weill-Marchesani Syndrome 3 and Microspherophakia And/Or Megalocornea, With Ectopia Lentis And With Or Without Secondary Glaucoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and growth factor binding. An important paralog of this gene is LTBP1.
UniProtKB/Swiss-Prot Summary for LTBP2 Gene
May play an integral structural role in elastic-fiber architectural organization and/or assembly.