Aliases for LTB4R2 Gene

Aliases for LTB4R2 Gene

  • Leukotriene B4 Receptor 2 2 3 4 5
  • BLTR2 2 3 4
  • Seven Transmembrane Receptor BLTR2 3 4
  • Leukotriene B4 Receptor BLT2 3 4
  • LTB4 Receptor JULF2 3 4
  • LTB4-R 2 3 4
  • LTB4-R2 3 4
  • JULF2 2 3
  • BLT2 2 3
  • NOP9 2 3
  • KPG_004 3
  • LTB4R2 5
  • BLT2R 4

External Ids for LTB4R2 Gene

Previous GeneCards Identifiers for LTB4R2 Gene

  • GC14P022150
  • GC14P018565
  • GC14P022768
  • GC14P023838
  • GC14P023848
  • GC14P024778
  • GC14P004894
  • GC14P024306
  • GC14P024506
  • GC14P024633
  • GC14P024743
  • GC14P025025
  • GC14P024321
  • GC14P024413
  • GC14P025298
  • GC14P025589

Summaries for LTB4R2 Gene

GeneCards Summary for LTB4R2 Gene

LTB4R2 (Leukotriene B4 Receptor 2) is a Protein Coding gene. Diseases associated with LTB4R2 include Diffuse Pulmonary Fibrosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and leukotriene B4 receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot Summary for LTB4R2 Gene

  • Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Tocris Summary for LTB4R2 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for LTB4R2 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LTB4R2 Gene

Genomics for LTB4R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LTB4R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024309 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.4 +8.0 7996 8.6 BCLAF1 NCOR1 IKZF1 MYC ZNF600 SSRP1 JUND ZNF592 KLF9 CEBPA LTB4R CIDEB HSALNG0100126 LTB4R2 NGDN NYNRIN KHNYN SDR39U1 RNA5SP383 PABPN1
GH14J024306 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 250.7 +1.9 1852 2.5 ZNF654 IKZF1 SSRP1 KLF9 CEBPA ATF3 CHD4 YY1 MXD4 CTCF CIDEB HSALNG0100123 LTB4R2 NGDN RNA5SP383 KHNYN AP1G2-AS1 RNF31 ENSG00000259321 PABPN1
GH14J024303 Enhancer 0.2 ENCODE 250.7 -1.9 -1854 0.2 HSALNG0100122 LTB4R2 piR-49209 NOP9
GH14J024277 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.4 -27.0 -27022 3.1 CTCF SMC3 RFX5 EBF1 BHLHE40 SPI1 MYC PKNOX1 MAX POLR2A piR-47276 DHRS1 TINF2 NOP9 NEDD8 NEDD8-MDP1 LTB4R2 LTB4R CIDEB MDP1
GH14J024435 Enhancer 1 ENCODE dbSUPER 11 +131.4 131377 3.1 ZNF654 KLF9 POLR2A ZNF10 YY1 MXD4 CTCF REST TRIM22 MAFF HSALNG0100144 SDR39U1 ADCY4 LTB4R CIDEB NOP9 DHRS1 LTB4R2 NYNRIN ENSG00000258744
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTB4R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LTB4R2

Top Transcription factor binding sites by QIAGEN in the LTB4R2 gene promoter:
  • c-Ets-1
  • c-Myc
  • GATA-1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • Max
  • POU3F1
  • Roaz
  • YY1

Genomic Locations for LTB4R2 Gene

Latest Assembly
chr14:24,305,734-24,312,053
(GRCh38/hg38)
Size:
6,320 bases
Orientation:
Plus strand

Previous Assembly
chr14:24,779,346-24,781,244
(GRCh37/hg19 by Entrez Gene)
Size:
1,899 bases
Orientation:
Plus strand

chr14:24,774,940-24,781,259
(GRCh37/hg19 by Ensembl)
Size:
6,320 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr14(PATCHES):611,118-613,016 (+)

Genomic View for LTB4R2 Gene

Genes around LTB4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTB4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTB4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R2 Gene

Proteins for LTB4R2 Gene

  • Protein details for LTB4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC1-LT4R2_HUMAN
    Recommended name:
    Leukotriene B4 receptor 2
    Protein Accession:
    Q9NPC1
    Secondary Accessions:
    • Q5KU28
    • Q9NPE5

    Protein attributes for LTB4R2 Gene

    Size:
    358 amino acids
    Molecular mass:
    37942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF81261.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAP23200.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB96134.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LTB4R2 Gene

Post-translational modifications for LTB4R2 Gene

  • Glycosylation at Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R2 Gene

No data available for DME Specific Peptides for LTB4R2 Gene

Domains & Families for LTB4R2 Gene

Gene Families for LTB4R2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for LTB4R2 Gene

InterPro:
Blocks:
  • Leukotriene B4 receptor signature
  • Leukotriene B4 type 2 receptor signature

Suggested Antigen Peptide Sequences for LTB4R2 Gene

GenScript: Design optimal peptide antigens:
  • LTB4R2 protein (A1L156_HUMAN)
  • Seven transmembrane receptor BLTR2 (LT4R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPC1

UniProtKB/Swiss-Prot:

LT4R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R2: view

Function for LTB4R2 Gene

Molecular function for LTB4R2 Gene

UniProtKB/Swiss-Prot Function:
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Phenotypes From GWAS Catalog for LTB4R2 Gene

Gene Ontology (GO) - Molecular Function for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001632 leukotriene B4 receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004974 leukotriene receptor activity IEA,TAS 10889186
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with LTB4R2: view
genes like me logo Genes that share phenotypes with LTB4R2: view

Animal Models for LTB4R2 Gene

MGI Knock Outs for LTB4R2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTB4R2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTB4R2 Gene

Localization for LTB4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTB4R2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LTB4R2: view

Pathways & Interactions for LTB4R2 Gene

genes like me logo Genes that share pathways with LTB4R2: view

SIGNOR curated interactions for LTB4R2 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10889186
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007194 negative regulation of adenylate cyclase activity TAS 10889186
genes like me logo Genes that share ontologies with LTB4R2: view

Drugs & Compounds for LTB4R2 Gene

(19) Drugs for LTB4R2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zafirlukast Approved, Investigational Pharma 4
Cinalukast Experimental Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
Leukotriene B4 Investigational Pharma Target BLT1/BLT2 receptor agonist and potent chemotactic factor 0
CP-195543 Investigational Pharma Agonist, Partial agonist, Antagonist 0
Amelubant Investigational Pharma Target 0

(2) Additional Compounds for LTB4R2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]LTB4

(5) Tocris Compounds for LTB4R2 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(6) ApexBio Compounds for LTB4R2 Gene

Compound Action Cas Number
Cinalukast 128312-51-6
FPL 55712 40785-97-5
Leukotriene B4 71160-24-2
LY 255283 117690-79-6
SR 2640 hydrochloride 146662-42-2
Zafirlukast 107753-78-6
genes like me logo Genes that share compounds with LTB4R2: view

Drug products for research

Transcripts for LTB4R2 Gene

mRNA/cDNA for LTB4R2 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTB4R2

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R2 Gene

No ASD Table

Relevant External Links for LTB4R2 Gene

GeneLoc Exon Structure for
LTB4R2

Expression for LTB4R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTB4R2 Gene

Protein differential expression in normal tissues from HIPED for LTB4R2 Gene

This gene is overexpressed in Lung (57.0) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LTB4R2 Gene



Protein tissue co-expression partners for LTB4R2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LTB4R2

SOURCE GeneReport for Unigene cluster for LTB4R2 Gene:

Hs.642693

mRNA Expression by UniProt/SwissProt for LTB4R2 Gene:

Q9NPC1-LT4R2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for LTB4R2 Gene

  • Spleen(2.2)
  • Intestine(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with LTB4R2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LTB4R2 Gene

Orthologs for LTB4R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LTB4R2 29
  • 98.32 (n)
-- 30
  • 89 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 91 (a)
OneToMany
LTB4R2 29
  • 89.92 (n)
Dog
(Canis familiaris)
Mammalia LTB4R2 29
  • 89.82 (n)
Rat
(Rattus norvegicus)
Mammalia Ltb4r2 29
  • 86.05 (n)
Mouse
(Mus musculus)
Mammalia Ltb4r2 29 16 30
  • 85.96 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 79 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 39 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 40 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ltb4r2 29
  • 51.49 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101883256 29
  • 49.47 (n)
si:ch211-272h9.1 30
  • 32 (a)
ManyToMany
CR376803.1 30
  • 31 (a)
ManyToMany
si:ch211-272h9.2 30
  • 31 (a)
ManyToMany
Species where no ortholog for LTB4R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LTB4R2 Gene

ENSEMBL:
Gene Tree for LTB4R2 (if available)
TreeFam:
Gene Tree for LTB4R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTB4R2: view image
Alliance of Genome Resources:
Additional Orthologs for LTB4R2

Paralogs for LTB4R2 Gene

(6) SIMAP similar genes for LTB4R2 Gene using alignment to 4 proteins:

  • LT4R2_HUMAN
  • A1L156_HUMAN
  • E9PIC1_HUMAN
  • E9PNJ6_HUMAN
genes like me logo Genes that share paralogs with LTB4R2: view

Variants for LTB4R2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LTB4R2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs138224360 Benign: not provided 24,311,052(+) C/T
NM_019839.5(LTB4R2):c.388C>T (p.Pro130Ser)
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs1950503 Benign: not provided 24,311,228(+) C/T
NM_019839.5(LTB4R2):c.564C>T (p.Thr188=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs374257326 Benign: not provided 24,311,220(+) ACT/A
NM_019839.5(LTB4R2):c.557_558CT[1] (p.Leu187fs)
FRAMESHIFT_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LTB4R2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LTB4R2 Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV deletion 23128226
esv3633804 CNV loss 21293372
nsv564058 CNV loss 21841781
nsv564059 CNV loss 21841781
nsv564060 CNV loss 21841781

Variation tolerance for LTB4R2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 63.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTB4R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTB4R2
Leiden Open Variation Database (LOVD)
LTB4R2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTB4R2 Gene

Disorders for LTB4R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LTB4R2 Gene - From: COP

Disorder Aliases PubMed IDs
diffuse pulmonary fibrosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LTB4R2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LTB4R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTB4R2 Gene

Publications for LTB4R2 Gene

  1. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. (PMID: 11006272) Wang S … Laz T (The Journal of biological chemistry 2000) 2 3 4
  2. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PMID: 10934229) Kato K … Shimizu T (The Journal of experimental medicine 2000) 2 3 22
  3. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. (PMID: 20194723) Kim GY … Kim JH (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22
  4. Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. (PMID: 19748928) Choi JA … Kim JH (Carcinogenesis 2010) 3 22
  5. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. (PMID: 18852255) Sánchez-Galán E … Tuñón J (Cardiovascular research 2009) 3 22

Products for LTB4R2 Gene

Sources for LTB4R2 Gene