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Aliases for LTB4R Gene

Aliases for LTB4R Gene

  • Leukotriene B4 Receptor 2 3 5
  • Chemoattractant Receptor-Like 1 3 4
  • P2Y Purinoceptor 7 3 4
  • LTB4-R 1 3 4
  • LTB4-R1 3 4
  • CMKRL1 3 4
  • GPR16 3 4
  • P2RY7 3 4
  • BLT1 3 4
  • BLTR 3 4
  • P2Y7 3 4
  • Purinergic Receptor P2Y, G-Protein Coupled, 7 3
  • G Protein-Coupled Receptor 16 3
  • G-Protein Coupled Receptor 16 4
  • Chemokine Receptor-Like 1 3
  • Leukotriene B4 Receptor 1 3
  • LTB4R1 3
  • LTBR1 3
  • BLT 4

External Ids for LTB4R Gene

Previous HGNC Symbols for LTB4R Gene

  • P2RY7
  • GPR16
  • CMKRL1

Previous GeneCards Identifiers for LTB4R Gene

  • GC14P022154
  • GC14P018569
  • GC14P022770
  • GC14P022772
  • GC14P023852
  • GC14P023842
  • GC14P024780
  • GC14P004895

Summaries for LTB4R Gene

GeneCards Summary for LTB4R Gene

LTB4R (Leukotriene B4 Receptor) is a Protein Coding gene. Diseases associated with LTB4R include Specific Language Impairment and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2.

UniProtKB/Swiss-Prot for LTB4R Gene

  • Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Tocris Summary for LTB4R Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for LTB4R Gene

Additional gene information for LTB4R Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTB4R Gene

Genomics for LTB4R Gene

GeneHancer (GH) Regulatory Elements for LTB4R Gene

Promoters and enhancers for LTB4R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024309 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 672.6 +2.3 2280 8.6 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS PAF1 CIDEB LTB4R LTB4R2 KHNYN RNA5SP383 NGDN TM9SF1 RNF31 TINF2 NYNRIN
GH14J024298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.2 -11.6 -11634 2.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 E2F8 ZNF143 FOS DHRS1 NOP9 LTB4R KHNYN RNA5SP383 TINF2 RNF31 TM9SF1 CIDEB TSSK4
GH14J024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 15.4 -38.6 -38624 5.4 MLX ZFP64 DMAP1 IRF4 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 RABGGTA LOC102725044 IPO4 TSSK4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
GH14J024306 Promoter/Enhancer 1.5 EPDnew ENCODE 20.7 -3.9 -3864 2.5 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 CIDEB LTB4R2 DHRS1 LTB4R KHNYN RNA5SP383 TINF2 RNF31 TM9SF1 TSSK4
GH14J024364 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +56.6 56556 6.1 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A DMAP1 YBX1 ZNF2 ZBTB7B NFATC4 KHNYN ADCY4 SDR39U1 RNA5SP383 RIPK3 RNF31 TINF2 TM9SF1 CIDEB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTB4R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LTB4R gene promoter:
  • HNF-4alpha1
  • c-Ets-1
  • GR
  • GR-alpha
  • PPAR-alpha
  • Roaz

Genomic Locations for LTB4R Gene

Genomic Locations for LTB4R Gene
chr14:24,311,450-24,318,036
(GRCh38/hg38)
Size:
6,587 bases
Orientation:
Plus strand
chr14:24,780,656-24,787,242
(GRCh37/hg19)
Size:
6,587 bases
Orientation:
Plus strand

Genomic View for LTB4R Gene

Genes around LTB4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTB4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTB4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R Gene

Proteins for LTB4R Gene

  • Protein details for LTB4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15722-LT4R1_HUMAN
    Recommended name:
    Leukotriene B4 receptor 1
    Protein Accession:
    Q15722
    Secondary Accessions:
    • Q13305
    • Q53XV5
    • Q92641
    • Q9BSU5

    Protein attributes for LTB4R Gene

    Size:
    352 amino acids
    Molecular mass:
    37557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB16747.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LTB4R Gene

Post-translational modifications for LTB4R Gene

  • Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
  • Glycosylation at posLast=164164 and posLast=22
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R Gene

No data available for DME Specific Peptides for LTB4R Gene

Domains & Families for LTB4R Gene

Gene Families for LTB4R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for LTB4R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15722

UniProtKB/Swiss-Prot:

LT4R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R: view

Function for LTB4R Gene

Molecular function for LTB4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
GENATLAS Biochemistry:
leukotriene B4 (LTB4) receptor,43kDa,G protein coupled receptor superfamily,expressed in leukocytes and several tissues of the immune system,involved in the regulation of the inflammatory system

Phenotypes From GWAS Catalog for LTB4R Gene

Gene Ontology (GO) - Molecular Function for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 8702478
GO:0001631 cysteinyl leukotriene receptor activity IBA --
GO:0001632 leukotriene B4 receptor activity IEA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LTB4R: view
genes like me logo Genes that share phenotypes with LTB4R: view

Animal Models for LTB4R Gene

MGI Knock Outs for LTB4R:

Animal Model Products

  • Taconic Biosciences Mouse Models for LTB4R

Clone Products

  • Addgene plasmids for LTB4R
  • R&D Systems cDNA Clones for LTB4R (Leukotriene B4 R1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LTB4R Gene

Localization for LTB4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTB4R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9177352
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with LTB4R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LTB4R Gene

Pathways & Interactions for LTB4R Gene

genes like me logo Genes that share pathways with LTB4R: view

Gene Ontology (GO) - Biological Process for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 8702478
GO:0006954 inflammatory response TAS,IEA --
GO:0006955 immune response TAS 9177352
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with LTB4R: view

No data available for SIGNOR curated interactions for LTB4R Gene

Drugs & Compounds for LTB4R Gene

(33) Drugs for LTB4R Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cinalukast Approved Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
calcium Approved Nutra 0
Morniflumate Approved Pharma Target, antagonist 0
Zafirlukast Approved, Investigational Pharma Antagonist 3
Leukotriene B4 Investigational Pharma Target BLT1/BLT2 receptor agonist and potent chemotactic factor 0

(12) Additional Compounds for LTB4R Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]LTB4
Full agonist, Agonist

(5) Tocris Compounds for LTB4R Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2
genes like me logo Genes that share compounds with LTB4R: view

Transcripts for LTB4R Gene

mRNA/cDNA for LTB4R Gene

Unigene Clusters for LTB4R Gene

Leukotriene B4 receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for LTB4R
  • R&D Systems cDNA Clones for LTB4R (Leukotriene B4 R1)

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R Gene

No ASD Table

Relevant External Links for LTB4R Gene

GeneLoc Exon Structure for
LTB4R
ECgene alternative splicing isoforms for
LTB4R

Expression for LTB4R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LTB4R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTB4R Gene

This gene is overexpressed in Whole Blood (x10.8), Skin - Not Sun Exposed (Suprapubic) (x6.5), Esophagus - Mucosa (x5.5), and Skin - Sun Exposed (Lower leg) (x5.3).

Protein differential expression in normal tissues from HIPED for LTB4R Gene

This gene is overexpressed in Monocytes (57.3) and Neutrophil (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LTB4R Gene



Protein tissue co-expression partners for LTB4R Gene

NURSA nuclear receptor signaling pathways regulating expression of LTB4R Gene:

LTB4R

SOURCE GeneReport for Unigene cluster for LTB4R Gene:

Hs.567248

mRNA Expression by UniProt/SwissProt for LTB4R Gene:

Q15722-LT4R1_HUMAN
Tissue specificity: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Evidence on tissue expression from TISSUES for LTB4R Gene

  • Lung(4.5)
  • Blood(2.6)
  • Bone marrow(2.5)
  • Skin(2.4)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with LTB4R: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LTB4R Gene

Orthologs for LTB4R Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTB4R 34 33
  • 99.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LTB4R 34 33
  • 84.15 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltb4r 33
  • 82.65 (n)
mouse
(Mus musculus)
Mammalia Ltb4r1 16 34 33
  • 81.23 (n)
dog
(Canis familiaris)
Mammalia LTB4R 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LTB4R 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTB4R 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia LTB4R 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ltb4r 33
  • 52.82 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329657 33
  • 55.37 (n)
si:ch211-272h9.2 34
  • 36 (a)
ManyToMany
si:ch211-272h9.1 34
  • 36 (a)
ManyToMany
Species where no ortholog for LTB4R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTB4R Gene

ENSEMBL:
Gene Tree for LTB4R (if available)
TreeFam:
Gene Tree for LTB4R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTB4R: view image

Paralogs for LTB4R Gene

Paralogs for LTB4R Gene

(16) SIMAP similar genes for LTB4R Gene using alignment to 3 proteins:

  • LT4R1_HUMAN
  • G3V244_HUMAN
  • G3V4Q5_HUMAN
genes like me logo Genes that share paralogs with LTB4R: view

Variants for LTB4R Gene

Sequence variations from dbSNP and Humsavar for LTB4R Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000251068 -- 24,314,478(+) C/T 5_prime_UTR_variant, intron_variant
rs1000657788 -- 24,313,263(+) G/A 5_prime_UTR_variant, intron_variant
rs1001512399 -- 24,310,053(+) C/T upstream_transcript_variant
rs1001777583 -- 24,312,013(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002362910 -- 24,317,153(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for LTB4R Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV deletion 23128226
esv3633804 CNV loss 21293372
nsv564058 CNV loss 21841781
nsv564059 CNV loss 21841781
nsv564060 CNV loss 21841781

Variation tolerance for LTB4R Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTB4R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTB4R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTB4R Gene

Disorders for LTB4R Gene

MalaCards: The human disease database

(2) MalaCards diseases for LTB4R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
specific language impairment
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search LTB4R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LTB4R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LTB4R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTB4R Gene

Publications for LTB4R Gene

  1. Cloning of cDNA encoding a putative chemoattractant receptor. (PMID: 8921391) Owman C … Lolait SJ (Genomics 1996) 2 3 4 22 58
  2. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. (PMID: 8702478) Akbar GK … Kunapuli SP (The Journal of biological chemistry 1996) 2 3 4 22 58
  3. Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. (PMID: 12077128) Gaudreau R … Rola-Pleszczynski M (The Journal of biological chemistry 2002) 3 4 22 58
  4. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PMID: 10934229) Kato K … Shimizu T (The Journal of experimental medicine 2000) 3 4 22 58
  5. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. (PMID: 9177352) Yokomizo T … Shimizu T (Nature 1997) 3 4 22 58

Products for LTB4R Gene

Sources for LTB4R Gene

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