The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmon... See more...

Aliases for LTA4H Gene

Aliases for LTA4H Gene

  • Leukotriene A4 Hydrolase 2 3 5
  • Tripeptide Aminopeptidase LTA4H 3 4
  • Leukotriene A-4 Hydrolase 3 4
  • LTA-4 Hydrolase 3 4
  • Testicular Secretory Protein Li 27 3
  • Leukotriene A(4) Hydrolase 4
  • EC 3.4.11.4 4
  • EC 3.3.2.6 4
  • LTA4H 5
  • LTA4 4

External Ids for LTA4H Gene

Previous GeneCards Identifiers for LTA4H Gene

  • GC12M095829
  • GC12M096758
  • GC12M096327
  • GC12M094897
  • GC12M093456
  • GC12M096394

Summaries for LTA4H Gene

Entrez Gene Summary for LTA4H Gene

  • The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for LTA4H Gene

LTA4H (Leukotriene A4 Hydrolase) is a Protein Coding gene. Diseases associated with LTA4H include Tuberculous Meningitis and Intestinal Tuberculosis. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is RNPEP.

UniProtKB/Swiss-Prot Summary for LTA4H Gene

  • Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).

Tocris Summary for LTA4H Gene

  • Leukotriene A4 hydrolase, (LTA4 hydrolase, LTA4H) is a zinc-dependent epoxide hydrolase which hydrolyzes LTA4 to form LTB4 during leukotriene biosynthesis. The enzyme is the only member of the leukotriene biosynthetic pathway which is mainly cytoplasmic.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LTA4H Gene

Genomics for LTA4H Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LTA4H Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LTA4H on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LTA4H

Top Transcription factor binding sites by QIAGEN in the LTA4H gene promoter:
  • AML1a
  • COUP
  • COUP-TF
  • HFH-1
  • HOXA3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for LTA4H Gene

Latest Assembly
chr12:96,000,753-96,043,520
(GRCh38/hg38)
Size:
42,768 bases
Orientation:
Minus strand

Previous Assembly
chr12:96,394,531-96,437,298
(GRCh37/hg19 by Entrez Gene)
Size:
42,768 bases
Orientation:
Minus strand

chr12:96,394,606-96,437,298
(GRCh37/hg19 by Ensembl)
Size:
42,693 bases
Orientation:
Minus strand

Genomic View for LTA4H Gene

Genes around LTA4H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTA4H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTA4H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTA4H Gene

Proteins for LTA4H Gene

  • Protein details for LTA4H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09960-LKHA4_HUMAN
    Recommended name:
    Leukotriene A-4 hydrolase
    Protein Accession:
    P09960
    Secondary Accessions:
    • B4DNQ9
    • F8VV40
    • Q6IAT6
    • Q9UCT7

    Protein attributes for LTA4H Gene

    Size:
    611 amino acids
    Molecular mass:
    69285 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LTA4H Gene

    Alternative splice isoforms for LTA4H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTA4H Gene

Post-translational modifications for LTA4H Gene

  • Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity.
  • Ubiquitination at Lys20, Lys64, Lys73, Lys58, Lys83, Lys127, Lys225, Lys355, Lys414, Lys418, Lys480, Lys493, Lys557, Lys573, Lys580, and Lys593
  • Modification sites at PhosphoSitePlus

Antibodies for research

No data available for DME Specific Peptides for LTA4H Gene

Domains & Families for LTA4H Gene

Gene Families for LTA4H Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LTA4H Gene

Suggested Antigen Peptide Sequences for LTA4H Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51712, moderately similar to Leukotriene A-4 hydrolase (EC 3.3.2.6) (B4DEH5_HUMAN)
  • Leukotriene A(4) hydrolase (LKHA4_HUMAN)
  • LTA4H protein (Q49AK0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09960

UniProtKB/Swiss-Prot:

LKHA4_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with LTA4H: view

Function for LTA4H Gene

Molecular function for LTA4H Gene

UniProtKB/Swiss-Prot Function:
Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + leukotriene A4 = leukotriene B4; Xref=Rhea:RHEA:22324, ChEBI:CHEBI:15377, ChEBI:CHEBI:57461, ChEBI:CHEBI:57463; EC=3.3.2.6; Evidence={ECO:0000269|PubMed:11675384, ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:24591641, ECO:0000269|PubMed:6490615, ECO:0000269|PubMed:7667299, ECO:0000269|PubMed:9395533};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1; Xref=Rhea:RHEA:50272, ChEBI:CHEBI:15377, ChEBI:CHEBI:91000, ChEBI:CHEBI:132219; Evidence={ECO:0000269|PubMed:21206090};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1; Xref=Rhea:RHEA:51988, ChEBI:CHEBI:15377, ChEBI:CHEBI:134661, ChEBI:CHEBI:136057; Evidence={ECO:0000269|PubMed:21206090};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of the N-terminal residue from a tripeptide.; EC=3.4.11.4; Evidence={ECO:0000269|PubMed:11675384, ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:24591641, ECO:0000269|PubMed:9395533};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.29 mM for Pro-Gly-Pro {ECO:0000269|PubMed:20813919};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by bestatin (PubMed:11175901). The epoxide hydrolase activity is restrained by suicide inactivation that involves binding of LTA4 to Tyr-379 (PubMed:7667299). 4-(4-benzylphenyl)thiazol-2-amine (ARM1) selectively inhibits the epoxide hydrolase activity (PubMed:24591641).
GENATLAS Biochemistry:
leukotriene A4 hydrolase,highly expressed in spleen,lung,small intestine

Enzyme Numbers (IUBMB) for LTA4H Gene

Phenotypes From GWAS Catalog for LTA4H Gene

Gene Ontology (GO) - Molecular Function for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004177 aminopeptidase activity IBA,IDA 9774412
GO:0004301 epoxide hydrolase activity IBA,TAS 11154734
GO:0004463 leukotriene-A4 hydrolase activity IBA,IDA 9774412
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with LTA4H: view
genes like me logo Genes that share phenotypes with LTA4H: view

Animal Models for LTA4H Gene

MGI Knock Outs for LTA4H:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTA4H

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTA4H Gene

Localization for LTA4H Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTA4H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTA4H gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LTA4H: view

Pathways & Interactions for LTA4H Gene

genes like me logo Genes that share pathways with LTA4H: view

Pathways by source for LTA4H Gene

UniProtKB/Swiss-Prot P09960-LKHA4_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 biosynthesis.

Gene Ontology (GO) - Biological Process for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0019370 leukotriene biosynthetic process IBA,IMP 11675384
GO:0042759 long-chain fatty acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with LTA4H: view

No data available for SIGNOR curated interactions for LTA4H Gene

Drugs & Compounds for LTA4H Gene

(48) Drugs for LTA4H Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Captopril Approved Pharma Target, inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 55
Dexamethasone Approved, Investigational, Vet_approved Pharma Anti-inflammatory glucocorticoid 3149
Montelukast Approved Pharma 321
Dexamethasone acetate Approved, Investigational, Vet_approved Pharma 3149
Water Approved Pharma 0

(13) Additional Compounds for LTA4H Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-Keto-tetrahydro-leukotriene B4
  • 12-Keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
Leukotriene A4
  • (5S,6S,7E,9E,11Z,14Z)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
  • 5(S)-5,6-Oxido-7,9-trans-11,14-cis-eicosatetraenoic acid
72059-45-1

(1) Tocris Compounds for LTA4H Gene

Compound Action Cas Number
SC 57461A Selective inhibitor of LTA4 hydrolase 423169-68-0

(2) ApexBio Compounds for LTA4H Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
SC 57461A LTA4 hydrolase inhibitor,potent and selective 423169-68-0
genes like me logo Genes that share compounds with LTA4H: view

Drug products for research

Transcripts for LTA4H Gene

mRNA/cDNA for LTA4H Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LTA4H

Alternative Splicing Database (ASD) splice patterns (SP) for LTA4H Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LTA4H Gene

GeneLoc Exon Structure for
LTA4H

Expression for LTA4H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTA4H Gene

mRNA differential expression in normal tissues according to GTEx for LTA4H Gene

This gene is overexpressed in Whole Blood (x8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LTA4H Gene



Protein tissue co-expression partners for LTA4H Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LTA4H

SOURCE GeneReport for Unigene cluster for LTA4H Gene:

Hs.524648

mRNA Expression by UniProt/SwissProt for LTA4H Gene:

P09960-LKHA4_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

Evidence on tissue expression from TISSUES for LTA4H Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Liver(4.6)
  • Eye(4.5)
  • Kidney(3.9)
  • Intestine(3.5)
  • Blood(3.4)
  • Heart(2.8)
  • Spleen(2.8)
  • Skin(2.7)
  • Muscle(2.6)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.2)
  • Pancreas(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with LTA4H: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LTA4H Gene

Orthologs for LTA4H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LTA4H Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LTA4H 29 30
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LTA4H 29 30
  • 90.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LTA4H 29 30
  • 90.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lta4h 29 16 30
  • 87.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lta4h 29
  • 86.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia LTA4H 30
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LTA4H 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LTA4H 29 30
  • 74.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LTA4H 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lta4h 29
  • 68.37 (n)
Zebrafish
(Danio rerio)
Actinopterygii lta4h 29 30
  • 64.92 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009907 29
  • 54.17 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10602 29 30 31
  • 51.29 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ZC416.6 29 30 31
  • 53.14 (n)
OneToMany
C42C1.11 30
  • 45 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP2 29 30 32
  • 49.48 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03883g 29
  • 48.53 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G13520 29
  • 46.71 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0819100 29
  • 46.1 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.27066 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 50 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1322.05c 29
  • 49.1 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06732 29
  • 48.17 (n)
Species where no ortholog for LTA4H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LTA4H Gene

ENSEMBL:
Gene Tree for LTA4H (if available)
TreeFam:
Gene Tree for LTA4H (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LTA4H: view image
Alliance of Genome Resources:
Additional Orthologs for LTA4H

Paralogs for LTA4H Gene

Paralogs for LTA4H Gene

(2) SIMAP similar genes for LTA4H Gene using alignment to 3 proteins:

  • LKHA4_HUMAN
  • B4DEH5_HUMAN
  • Q49AK0_HUMAN
genes like me logo Genes that share paralogs with LTA4H: view

Variants for LTA4H Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LTA4H Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs114493880 Benign: not provided 96,029,046(-) C/G
NM_000895.3(LTA4H):c.290+9G>C
INTRON
rs143721623 Likely Benign: not provided 96,029,065(-) C/T
NM_000895.3(LTA4H):c.280G>A (p.Ala94Thr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs147001898 Benign: not provided 96,014,985(-) C/T
NM_000895.3(LTA4H):c.1074G>A (p.Gly358=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs149942316 Benign: not provided 96,018,811(-) A/G
NM_000895.3(LTA4H):c.804T>C (p.Tyr268=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs2228061 Benign: not provided 96,013,217(-) G/A
NM_000895.3(LTA4H):c.1350C>T (p.Tyr450=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LTA4H Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LTA4H Gene

Variant ID Type Subtype PubMed ID
esv3630445 CNV gain 21293372
esv3630446 CNV loss 21293372
nsv523292 CNV gain 19592680
nsv7234 OTHER inversion 18451855

Variation tolerance for LTA4H Gene

Residual Variation Intolerance Score: 9.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LTA4H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTA4H
Leiden Open Variation Database (LOVD)
LTA4H

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTA4H Gene

Disorders for LTA4H Gene

MalaCards: The human disease database

(10) MalaCards diseases for LTA4H Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tuberculous meningitis
  • tb meningitis
intestinal tuberculosis
  • tuberculosis of intestine
arthrogryposis, distal, type 1a
  • da1a
lymph node tuberculosis
  • king's evil
meningitis
- elite association - COSMIC cancer census association via MalaCards
Search LTA4H in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LTA4H

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LTA4H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTA4H Gene

Publications for LTA4H Gene

  1. Cloning and characterization of the human leukotriene A4 hydrolase gene. (PMID: 7628486) Mancini JA … Evans JF (European journal of biochemistry 1995) 2 3 4 22
  2. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. (PMID: 20067482) Via M … Genetics of Asthma in Latino Americans (GALA) Study (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010) 3 22 40
  3. Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene. (PMID: 19622707) Zhao J … Vaccarino V (Psychosomatic medicine 2009) 3 22 40
  4. Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. (PMID: 19130089) Crosslin DR … Hauser ER (Human genetics 2009) 3 22 40
  5. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira KG … Weiss ST (Pharmacogenetics and genomics 2009) 3 22 40

Products for LTA4H Gene

Sources for LTA4H Gene