Aliases for LTA4H Gene
External Ids for LTA4H Gene
Previous GeneCards Identifiers for LTA4H Gene
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for LTA4H Gene
LTA4H (Leukotriene A4 Hydrolase) is a Protein Coding gene. Diseases associated with LTA4H include Tuberculous Meningitis and Intestinal Tuberculosis. Among its related pathways are Innate Immune System and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is RNPEP.
UniProtKB/Swiss-Prot Summary for LTA4H Gene
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Leukotriene A4 hydrolase, (LTA4 hydrolase, LTA4H) is a zinc-dependent epoxide hydrolase which hydrolyzes LTA4 to form LTB4 during leukotriene biosynthesis. The enzyme is the only member of the leukotriene biosynthetic pathway which is mainly cytoplasmic.