The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2... See more...

Aliases for LSS Gene

Aliases for LSS Gene

  • Lanosterol Synthase 2 3 4 5
  • OSC 2 3 4
  • Lanosterol Synthase (2,3-Oxidosqualene-Lanosterol Cyclase) 2 3
  • Oxidosqualene--Lanosterol Cyclase 3 4
  • EC 5.4.99.7 4 51
  • HOSC 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • 2,3-Epoxysqualene--Lanosterol Cyclase 4
  • 2,3-Epoxysqualene-Lanosterol Cyclase 3
  • Oxidosqualene-Lanosterol Cyclase 2
  • EC 5.4.99 51
  • CTRCT44 3
  • HYPT14 3
  • APMR4 3
  • LSS 5

External Ids for LSS Gene

Previous GeneCards Identifiers for LSS Gene

  • GC21M044116
  • GC21M046464
  • GC21M046465
  • GC21M046432
  • GC21M047608
  • GC21M032990
  • GC21M046189
  • GC21M046639
  • GC21M046849
  • GC21M046630
  • GC21M047163
  • GC21M046196

Summaries for LSS Gene

Entrez Gene Summary for LSS Gene

  • The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

GeneCards Summary for LSS Gene

LSS (Lanosterol Synthase) is a Protein Coding gene. Diseases associated with LSS include Cataract 44 and Hypotrichosis 14. Among its related pathways are cholesterol biosynthesis III (via desmosterol) and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Gene Ontology (GO) annotations related to this gene include intramolecular transferase activity and lanosterol synthase activity.

UniProtKB/Swiss-Prot Summary for LSS Gene

  • Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:7639730, PubMed:26200341). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341).

Tocris Summary for LSS Gene

Gene Wiki entry for LSS Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LSS Gene

Genomics for LSS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LSS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LSS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LSS

Top Transcription factor binding sites by QIAGEN in the LSS gene promoter:
  • Brachyury
  • p53
  • Pax-3

Genomic Locations for LSS Gene

Genomic Locations for LSS Gene
chr21:46,188,141-46,228,824
(GRCh38/hg38)
Size:
40,684 bases
Orientation:
Minus strand
chr21:47,608,055-47,648,738
(GRCh37/hg19)
Size:
40,684 bases
Orientation:
Minus strand

Genomic View for LSS Gene

Genes around LSS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSS Gene

Proteins for LSS Gene

  • Protein details for LSS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48449-LSS_HUMAN
    Recommended name:
    Lanosterol synthase
    Protein Accession:
    P48449
    Secondary Accessions:
    • B4DJZ9
    • D3DSN0
    • E9PEI9
    • G5E9Q9
    • Q8IYL6
    • Q9UEZ1

    Protein attributes for LSS Gene

    Size:
    732 amino acids
    Molecular mass:
    83309 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LSS Gene

    Alternative splice isoforms for LSS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSS Gene

Selected DME Specific Peptides for LSS Gene

P48449:
  • PDYQKYYR
  • DCTAEALK
  • LHKKGGAV
  • DGGFATYE
  • NTLFPEMWL
  • GDYGGPLFLLP
  • PLVQSLRQELY
  • EVFGDIMI
  • YRNIFPIWALG
  • KSTVFGTALNYV
  • VYLPMSY
  • LQAEDGHW
  • GSQIWDT
  • DGSWEGSWGVCFTYG

Post-translational modifications for LSS Gene

  • Ubiquitination at Lys61, Lys148, Lys318, Lys331, Lys340, Lys432, Lys439, Lys470, Lys506, Lys680, and Lys698
  • Modification sites at PhosphoSitePlus

Domains & Families for LSS Gene

Gene Families for LSS Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for LSS Gene

InterPro:
Blocks:
  • Prenyltransferase/squalene oxidase
  • Terpene synthase
ProtoNet:

Suggested Antigen Peptide Sequences for LSS Gene

GenScript: Design optimal peptide antigens:
  • Oxidosqualene--lanosterol cyclase (ERG7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48449

UniProtKB/Swiss-Prot:

LSS_HUMAN :
  • Belongs to the terpene cyclase/mutase family.
Family:
  • Belongs to the terpene cyclase/mutase family.
genes like me logo Genes that share domains with LSS: view

Function for LSS Gene

Molecular function for LSS Gene

UniProtKB/Swiss-Prot Function:
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:7639730, PubMed:26200341). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(S)-2,3-epoxysqualene = lanosterol; Xref=Rhea:RHEA:14621, ChEBI:CHEBI:15441, ChEBI:CHEBI:16521; EC=5.4.99.7; Evidence={ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:26200341, ECO:0000269|PubMed:7639730};.
GENATLAS Biochemistry:
lanosterol synthase catalyzing cyclization of squalene-2,3-epoxide to lanosterol (cholesterol biosynthesis),not involved in holoprosencephaly (HPE1)

Enzyme Numbers (IUBMB) for LSS Gene

Phenotypes From GWAS Catalog for LSS Gene

Gene Ontology (GO) - Molecular Function for LSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000250 lanosterol synthase activity TAS --
GO:0016853 isomerase activity IEA --
GO:0016866 intramolecular transferase activity IEA --
GO:0042300 beta-amyrin synthase activity IEA --
genes like me logo Genes that share ontologies with LSS: view
genes like me logo Genes that share phenotypes with LSS: view

Human Phenotype Ontology for LSS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LSS Gene

MGI Knock Outs for LSS:
  • Lss Lss<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSS

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for LSS Gene

Localization for LSS Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSS Gene

Endoplasmic reticulum membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSS gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005811 lipid droplet IBA,IDA 14741744
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with LSS: view

Pathways & Interactions for LSS Gene

genes like me logo Genes that share pathways with LSS: view

UniProtKB/Swiss-Prot P48449-LSS_HUMAN

  • Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.

Gene Ontology (GO) - Biological Process for LSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IMP 26200341
GO:0006695 cholesterol biosynthetic process IMP,TAS --
GO:0016104 triterpenoid biosynthetic process IEA --
GO:0031647 regulation of protein stability IMP 26200341
genes like me logo Genes that share ontologies with LSS: view

No data available for SIGNOR curated interactions for LSS Gene

Drugs & Compounds for LSS Gene

(16) Drugs for LSS Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lanosterin Experimental Pharma Target 0
R048-8071 Experimental Pharma Target 0
COMPOUND 1 [CID 44270471] Pharma 0
COMPOUND 1 [PMID: 22533316] Pharma 0
COMPOUND 10 [PMID: 22533316] Pharma 0

(7) Additional Compounds for LSS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3S)-2,3-epoxy-2,3-dihydrosqualene
  • (S)-Squalene-2,3-epoxide
  • Squalene 2,3-epoxide
  • Squalene 2,3-oxide
(S)-2,3-Epoxysqualene
  • (3S)-2,3-Dihydro-2,3-epoxysqualene
  • (3S)-2,3-Epoxy-2,3-dihydrosqualene
  • (S)-2,3-Dihydro-2,3-epoxysqualene
  • (S)-2,3-Epoxy-2,3-dihydrosqualene
  • (S)-2,3-Oxidosqualene
54910-48-4
genes like me logo Genes that share compounds with LSS: view

Transcripts for LSS Gene

mRNA/cDNA for LSS Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSS

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSS Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - -
SP2: -
SP3: - - -
SP4: - - -
SP5:
SP6: - - -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:

Relevant External Links for LSS Gene

GeneLoc Exon Structure for
LSS

Expression for LSS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LSS Gene

Protein differential expression in normal tissues from HIPED for LSS Gene

This gene is overexpressed in Fetal Liver (9.6) and Milk (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LSS Gene



Protein tissue co-expression partners for LSS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LSS

SOURCE GeneReport for Unigene cluster for LSS Gene:

Hs.596543

mRNA Expression by UniProt/SwissProt for LSS Gene:

P48449-LSS_HUMAN
Tissue specificity: Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.

Evidence on tissue expression from TISSUES for LSS Gene

  • Nervous system(5)
  • Liver(4.6)
  • Eye(4.5)
  • Lung(3.6)
  • Skin(3.2)
  • Blood(2.6)
  • Muscle(2.6)
  • Heart(2.5)
  • Intestine(2.4)
  • Kidney(2.3)
  • Lymph node(2.2)
  • Stomach(2.2)
  • Pancreas(2.1)
  • Adrenal gland(2.1)
  • Bone(2.1)
  • Thyroid gland(2.1)
  • Bone marrow(2)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LSS Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with LSS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LSS Gene

Orthologs for LSS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LSS 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LSS 30 31
  • 86.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LSS 30 31
  • 85.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lss 30 17 31
  • 83.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lss 30
  • 82.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia LSS 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LSS 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LSS 30 31
  • 72.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LSS 31
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lss 30
  • 69.19 (n)
Str.15698 30
Zebrafish
(Danio rerio)
Actinopterygii lss 30 31
  • 70.73 (n)
OneToOne
wufj45h02 30
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR351W 30
  • 48.84 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG7 30 31 33
  • 47.71 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10175g 30
  • 46.26 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CAS1 30
  • 51.92 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1230 30
Rice
(Oryza sativa)
Liliopsida Os02g0139700 30
  • 53.12 (n)
Os.2342 30
Wheat
(Triticum aestivum)
Liliopsida Ta.9982 30
Corn
(Zea mays)
Liliopsida Zm.5697 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU01119 30
  • 52.79 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes erg7 30
  • 48.16 (n)
Species where no ortholog for LSS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Worm (Caenorhabditis elegans)

Evolution for LSS Gene

ENSEMBL:
Gene Tree for LSS (if available)
TreeFam:
Gene Tree for LSS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LSS: view image

Paralogs for LSS Gene

No data available for Paralogs for LSS Gene

Variants for LSS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LSS Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
668540 Likely Benign: not provided 46,191,885(-) G/A MISSENSE_VARIANT
677172 Benign: not provided 46,219,578(-) C/G GENIC_UPSTREAM_TRANSCRIPT_VARIANT,INTRON_VARIANT
677173 Benign: not provided 46,215,799(-) G/A INTRON_VARIANT
677174 Benign: not provided 46,215,713(-) C/G SYNONYMOUS_VARIANT
677175 Benign: not provided 46,194,555(-) A/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LSS Gene

Structural Variations from Database of Genomic Variants (DGV) for LSS Gene

Variant ID Type Subtype PubMed ID
esv1986816 CNV deletion 18987734
esv2338420 CNV deletion 18987734
esv2587417 CNV deletion 19546169
esv2668812 CNV deletion 23128226
esv2723906 CNV deletion 23290073
esv2723907 CNV deletion 23290073
esv29868 CNV loss 19812545
esv3647164 CNV loss 21293372
nsv1060978 CNV gain 25217958
nsv1061087 CNV loss 25217958
nsv1062031 CNV gain 25217958
nsv1072611 CNV deletion 25765185
nsv1148428 CNV duplication 26484159
nsv3546 CNV insertion 18451855
nsv470910 CNV gain 18288195
nsv509804 CNV insertion 20534489
nsv519904 CNV loss 19592680

Variation tolerance for LSS Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LSS Gene

Human Gene Mutation Database (HGMD)
LSS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSS Gene

Disorders for LSS Gene

MalaCards: The human disease database

(22) MalaCards diseases for LSS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cataract 44
  • ctrct44
hypotrichosis 14
  • hypt14
alopecia-mental retardation syndrome 4
  • apmr4
alopecia-intellectual disability syndrome
  • alopecia-mental retardation syndrome 1
hypotrichosis simplex
  • hhs
- elite association - COSMIC cancer census association via MalaCards
Search LSS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LSS_HUMAN
  • Cataract 44 (CTRCT44) [MIM:616509]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:26200341}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypotrichosis 14 (HYPT14) [MIM:618275]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT14 is an autosomal recessive form characterized by sparse to absent lanugo-like scalp hair, sparse and brittle eyebrows, and sparse eyelashes and body hair. {ECO:0000269 PubMed:30401459}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LSS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LSS: view

No data available for Genatlas for LSS Gene

Publications for LSS Gene

  1. The human lanosterol synthase gene maps to chromosome 21q22.3. (PMID: 8655142) Young M … Antonarakis SE (Human genetics 1996) 2 3 4 23
  2. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library. (PMID: 7639730) Baker CH … Corey EJ (Biochemical and biophysical research communications 1995) 2 3 4 23
  3. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. (PMID: 15525992) Thoma R … Ruf A (Nature 2004) 3 4 23
  4. The monotopic membrane protein human oxidosqualene cyclase is active as monomer. (PMID: 14766201) Ruf A … Thoma R (Biochemical and biophysical research communications 2004) 3 4 23
  5. Structure of the human Lanosterol synthase gene and its analysis as a candidate for holoprosencephaly (HPE1). (PMID: 10598817) Roessler E … Antonarakis SE (Human genetics 1999) 3 4 23

Products for LSS Gene

  • Signalway Proteins for LSS

Sources for LSS Gene