Aliases for LSP1 Gene
External Ids for LSP1 Gene
Previous GeneCards Identifiers for LSP1 Gene
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LSP1 Gene
LSP1 (Lymphocyte Specific Protein 1) is a Protein Coding gene. Diseases associated with LSP1 include Neutrophil Actin Dysfunction and Pyometritis. Among its related pathways are p38 signaling mediated by MAPKAP kinases and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and obsolete signal transducer activity. An important paralog of this gene is CALD1.
UniProtKB/Swiss-Prot Summary for LSP1 Gene
May play a role in mediating neutrophil activation and chemotaxis.