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Aliases for LSM8 Gene

Aliases for LSM8 Gene

  • LSM8 Homolog, U6 Small Nuclear RNA Associated 2 3 3 5
  • LSM8 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
  • N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit 3
  • U6 SnRNA-Associated Sm-Like Protein LSm8 3
  • LSM8 U6 Small Nuclear RNA Associated 3
  • MAK31-Like Protein 3
  • NAA38 3

External Ids for LSM8 Gene

Previous GeneCards Identifiers for LSM8 Gene

  • GC07P116302
  • GC07P117364
  • GC07P117378
  • GC07P117418
  • GC07P117611
  • GC07P117825

Summaries for LSM8 Gene

Entrez Gene Summary for LSM8 Gene

  • This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

GeneCards Summary for LSM8 Gene

LSM8 (LSM8 Homolog, U6 Small Nuclear RNA Associated) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include U6 snRNA 3-end binding.

UniProtKB/Swiss-Prot for LSM8 Gene

  • Binds specifically to the 3-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.

Gene Wiki entry for LSM8 Gene

Additional gene information for LSM8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM8 Gene

Genomics for LSM8 Gene

GeneHancer (GH) Regulatory Elements for LSM8 Gene

Promoters and enhancers for LSM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J118182 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 683.9 +0.3 260 3.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LSM8 LOC105375470 LOC105375467 LOC100130680 ANKRD7
GH07J118214 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 29 +30.6 30569 1.2 HIC1 ZNF335 ZNF157 POLR2A PATZ1 PRDM10 ZNF600 ZBTB20 SRF ZNF202 ANKRD7 LSM8
GH07J117871 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 14.6 -311.2 -311233 2.7 SIN3A ZNF2 ZNF121 GLIS2 KLF13 SP3 MCM5 CBX8 GLIS1 PRDM4 CTTNBP2 LSM8 LOC105375469
GH07J117773 Enhancer 0.9 Ensembl dbSUPER 30.1 -410.1 -410131 1 HDGF SMAD1 BMI1 MCM2 IRF4 ZNF316 ATF7 ETV6 IKZF2 RUNX3 LSM8 CTTNBP2 CAPZA2 CFTR LOC105375469
GH07J118311 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16.8 +127.6 127643 1.2 MEIS2 PKNOX1 JUN CEBPG BATF POLR2A SCRT2 ATF7 TRIM24 ETV6 LSM8 ANKRD7 LOC102724495 LOC105375471
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LSM8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LSM8 gene promoter:
  • c-Myb
  • Cart-1
  • POU2F1a
  • POU2F1
  • AML1a
  • S8
  • Nkx6-1
  • POU2F1b
  • POU2F1c

Genomic Locations for LSM8 Gene

Genomic Locations for LSM8 Gene
chr7:118,184,032-118,204,039
(GRCh38/hg38)
Size:
20,008 bases
Orientation:
Plus strand
chr7:117,824,086-117,844,093
(GRCh37/hg19)
Size:
20,008 bases
Orientation:
Plus strand

Genomic View for LSM8 Gene

Genes around LSM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM8 Gene

Proteins for LSM8 Gene

  • Protein details for LSM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95777-LSM8_HUMAN
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm8
    Protein Accession:
    O95777

    Protein attributes for LSM8 Gene

    Size:
    96 amino acids
    Molecular mass:
    10403 Da
    Quaternary structure:
    • LSm subunits form a heteromer with a doughnut shape.

    Three dimensional structures from OCA and Proteopedia for LSM8 Gene

neXtProt entry for LSM8 Gene

Post-translational modifications for LSM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSM8 Gene

No data available for DME Specific Peptides for LSM8 Gene

Domains & Families for LSM8 Gene

Gene Families for LSM8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LSM8 Gene

Graphical View of Domain Structure for InterPro Entry

O95777

UniProtKB/Swiss-Prot:

LSM8_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with LSM8: view

Function for LSM8 Gene

Molecular function for LSM8 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to the 3-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.

Gene Ontology (GO) - Molecular Function for LSM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 14667819
GO:0017070 U6 snRNA binding NAS 10523320
genes like me logo Genes that share ontologies with LSM8: view
genes like me logo Genes that share phenotypes with LSM8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LSM8 Gene

Localization for LSM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM8 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LSM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005688 U6 snRNP IEA,IBA --
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA,IEA --
genes like me logo Genes that share ontologies with LSM8: view

No data available for Subcellular locations from COMPARTMENTS for LSM8 Gene

Pathways & Interactions for LSM8 Gene

genes like me logo Genes that share pathways with LSM8: view

Pathways by source for LSM8 Gene

Gene Ontology (GO) - Biological Process for LSM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0016070 RNA metabolic process IBA --
genes like me logo Genes that share ontologies with LSM8: view

No data available for SIGNOR curated interactions for LSM8 Gene

Drugs & Compounds for LSM8 Gene

No Compound Related Data Available

Transcripts for LSM8 Gene

mRNA/cDNA for LSM8 Gene

(1) REFSEQ mRNAs :
(189) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSM8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for LSM8 Gene

GeneLoc Exon Structure for
LSM8
ECgene alternative splicing isoforms for
LSM8

Expression for LSM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LSM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LSM8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Nasal epithelium (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LSM8 Gene



Protein tissue co-expression partners for LSM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LSM8 Gene:

LSM8
genes like me logo Genes that share expression patterns with LSM8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LSM8 Gene

Orthologs for LSM8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSM8 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Naa38 34
  • 100 (a)
OneToOne
Lsm8 16 33
  • 87.5 (n)
chimpanzee
(Pan troglodytes)
Mammalia NAA38 34
  • 100 (a)
OneToOne
LSM8 33
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA38 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA38 34
  • 96 (a)
OneToOne
LOC100685900 33
  • 92.01 (n)
cow
(Bos Taurus)
Mammalia NAA38 34 33
  • 93.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm8 33
  • 86.81 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA38 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAA38 34
  • 95 (a)
OneToOne
LSM8 33
  • 85.76 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm8 33
  • 84.72 (n)
zebrafish
(Danio rerio)
Actinopterygii lsm8 34 33
  • 76.04 (n)
OneToOne
Dr.17055 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13915 33
fruit fly
(Drosophila melanogaster)
Insecta CG2021 34 33
  • 60.99 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011837 33
  • 56.74 (n)
worm
(Caenorhabditis elegans)
Secernentea lsm-8 34 33
  • 53.55 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM8 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65700 33
  • 61.05 (n)
rice
(Oryza sativa)
Liliopsida Os05g0594900 33
  • 59.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4849 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4849 33
Species where no ortholog for LSM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM8 Gene

ENSEMBL:
Gene Tree for LSM8 (if available)
TreeFam:
Gene Tree for LSM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LSM8: view image

Paralogs for LSM8 Gene

(6) SIMAP similar genes for LSM8 Gene using alignment to 2 proteins:

  • LSM8_HUMAN
  • A4D0W0_HUMAN
genes like me logo Genes that share paralogs with LSM8: view

No data available for Paralogs for LSM8 Gene

Variants for LSM8 Gene

Sequence variations from dbSNP and Humsavar for LSM8 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000164092 -- 118,190,534(+) T/C intron_variant
rs1000217694 -- 118,190,259(+) G/A intron_variant
rs1000218936 -- 118,193,904(+) A/C 3_prime_UTR_variant
rs1000300075 -- 118,195,465(+) G/T 3_prime_UTR_variant
rs1000355276 -- 118,195,742(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for LSM8 Gene

Variant ID Type Subtype PubMed ID
nsv5920 CNV insertion 18451855
nsv608259 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Additional Variant Information for LSM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSM8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LSM8 Gene

Disorders for LSM8 Gene

Additional Disease Information for LSM8

No disorders were found for LSM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSM8 Gene

Publications for LSM8 Gene

  1. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PMID: 10523320) Achsel T … Lührmann R (The EMBO journal 1999) 2 3 4 58
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LSM8 Gene

Sources for LSM8 Gene

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