Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are ... See more...

Aliases for LSM7 Gene

Aliases for LSM7 Gene

  • LSM7 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated 2 3 5
  • U6 SnRNA-Associated Sm-Like Protein LSm7 3 4
  • YNL147W 2 3
  • LSM7 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
  • LSM7 U6 Small Nuclear RNA And MRNA Degradation Associated 3
  • LSM7 Homolog, U6 Small Nuclear RNA Associated 3
  • LSM7 5

External Ids for LSM7 Gene

Previous GeneCards Identifiers for LSM7 Gene

  • GC19M002384
  • GC19M002261
  • GC19M002272
  • GC19M002092

Summaries for LSM7 Gene

Entrez Gene Summary for LSM7 Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

GeneCards Summary for LSM7 Gene

LSM7 (LSM7 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Diseases associated with LSM7 include Spermatogenic Failure 5. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include U6 snRNA binding. An important paralog of this gene is SNRPG.

UniProtKB/Swiss-Prot Summary for LSM7 Gene

  • Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Gene Wiki entry for LSM7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LSM7 Gene

Genomics for LSM7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LSM7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LSM7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LSM7

Top Transcription factor binding sites by QIAGEN in the LSM7 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • Sp1
  • STAT5A
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for LSM7 Gene

Genomic Locations for LSM7 Gene
chr19:2,321,520-2,328,630
(GRCh38/hg38)
Size:
7,111 bases
Orientation:
Minus strand
chr19:2,321,516-2,328,619
(GRCh37/hg19)
Size:
7,104 bases
Orientation:
Minus strand

Genomic View for LSM7 Gene

Genes around LSM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM7 Gene

Proteins for LSM7 Gene

  • Protein details for LSM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK45-LSM7_HUMAN
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm7
    Protein Accession:
    Q9UK45

    Protein attributes for LSM7 Gene

    Size:
    103 amino acids
    Molecular mass:
    11602 Da
    Quaternary structure:
    • Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166). Interacts with TACC1 (PubMed:12165861).

    Three dimensional structures from OCA and Proteopedia for LSM7 Gene

neXtProt entry for LSM7 Gene

Post-translational modifications for LSM7 Gene

  • Ubiquitination at Lys17 and Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for LSM7 Gene

No data available for DME Specific Peptides for LSM7 Gene

Domains & Families for LSM7 Gene

Gene Families for LSM7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LSM7 Gene

InterPro:
Blocks:
  • Small nuclear ribonucleoprotein (Sm protein)
  • Like-Sm ribonucleoprotein-related, core
ProtoNet:

Suggested Antigen Peptide Sequences for LSM7 Gene

GenScript: Design optimal peptide antigens:
  • U6 snRNA-associated Sm-like protein LSm7 (LSM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK45

UniProtKB/Swiss-Prot:

LSM7_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with LSM7: view

Function for LSM7 Gene

Molecular function for LSM7 Gene

UniProtKB/Swiss-Prot Function:
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Phenotypes From GWAS Catalog for LSM7 Gene

Gene Ontology (GO) - Molecular Function for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12165861
GO:0017070 U6 snRNA binding NAS 10523320
genes like me logo Genes that share ontologies with LSM7: view
genes like me logo Genes that share phenotypes with LSM7: view

Animal Model Products

CRISPR Products

miRNA for LSM7 Gene

miRTarBase miRNAs that target LSM7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LSM7 Gene

Localization for LSM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSM7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 26912367
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005688 U6 snRNP IBA 21873635
GO:0005689 U12-type spliceosomal complex IBA 21873635
genes like me logo Genes that share ontologies with LSM7: view

Pathways & Interactions for LSM7 Gene

genes like me logo Genes that share pathways with LSM7: view

Pathways by source for LSM7 Gene

Gene Ontology (GO) - Biological Process for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0000956 nuclear-transcribed mRNA catabolic process IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
genes like me logo Genes that share ontologies with LSM7: view

No data available for SIGNOR curated interactions for LSM7 Gene

Drugs & Compounds for LSM7 Gene

No Compound Related Data Available

Transcripts for LSM7 Gene

mRNA/cDNA for LSM7 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM7

Alternative Splicing Database (ASD) splice patterns (SP) for LSM7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for LSM7 Gene

GeneLoc Exon Structure for
LSM7

Expression for LSM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LSM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LSM7 Gene

This gene is overexpressed in Liver (24.7) and Peripheral blood mononuclear cells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LSM7 Gene



Protein tissue co-expression partners for LSM7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LSM7

SOURCE GeneReport for Unigene cluster for LSM7 Gene:

Hs.512610

Evidence on tissue expression from TISSUES for LSM7 Gene

  • Nervous system(2.7)
  • Skin(2.5)
  • Intestine(2.2)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Heart(2.1)
  • Muscle(2)
  • Liver(2)
  • Blood(2)
genes like me logo Genes that share expression patterns with LSM7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LSM7 Gene

Orthologs for LSM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSM7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LSM7 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LSM7 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm10146 31
  • 97 (a)
OneToMany
Lsm7 30 17 31
  • 87.06 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia LSM7 30 31
  • 91.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LSM7 30 31
  • 90.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lsm7 30
  • 85.76 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia LSM7 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LSM7 30 31
  • 77.99 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lsm7 30
  • 76.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii lsm7 30 31
  • 79.61 (n)
OneToOne
wufj64g01 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8944 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008122 30
  • 72.79 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta LSm7 30 31
  • 70.1 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea lsm-7 30 31
  • 56.33 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR053C 30
  • 61.96 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22881g 30
  • 51.69 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM7 30 31 33
  • 49.81 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G03870 30
  • 58.87 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0177700 30
  • 61.48 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lsm7 30
  • 52.08 (n)
Species where no ortholog for LSM7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LSM7 Gene

ENSEMBL:
Gene Tree for LSM7 (if available)
TreeFam:
Gene Tree for LSM7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LSM7: view image

Paralogs for LSM7 Gene

Paralogs for LSM7 Gene

(2) SIMAP similar genes for LSM7 Gene using alignment to 3 proteins:

  • LSM7_HUMAN
  • K7EML7_HUMAN
  • K7ENY5_HUMAN
genes like me logo Genes that share paralogs with LSM7: view

Variants for LSM7 Gene

Additional dbSNP identifiers (rs#s) for LSM7 Gene

Structural Variations from Database of Genomic Variants (DGV) for LSM7 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv3643422 CNV gain 21293372
nsv1160562 CNV deletion 26073780
nsv833707 CNV loss 17160897
nsv953944 CNV deletion 24416366

Additional Variant Information for LSM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSM7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for LSM7 Gene

Disorders for LSM7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LSM7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure 5
  • spgf5
- elite association - COSMIC cancer census association via MalaCards
Search LSM7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LSM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LSM7 Gene

Publications for LSM7 Gene

  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N … Birnbaum D (Oncogene 2002) 3 4 23
  2. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PMID: 10523320) Achsel T … Lührmann R (The EMBO journal 1999) 2 3 4
  3. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4
  4. Molecular architecture of the human U4/U6.U5 tri-snRNP. (PMID: 26912367) Agafonov DE … Stark H (Science (New York, N.Y.) 2016) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for LSM7 Gene

Sources for LSM7 Gene