Aliases for LSM6 Gene
- LSM6 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated 2 3 5
- LSM6 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
- LSM6 U6 Small Nuclear RNA And MRNA Degradation Associated 3
- LSM6 Homolog, U6 Small Nuclear RNA Associated 3
- U6 SnRNA-Associated Sm-Like Protein LSm6 3
- Sm Protein F 3
- YDR378C 3
External Ids for LSM6 Gene
Previous GeneCards Identifiers for LSM6 Gene
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
GeneCards Summary for LSM6 Gene
LSM6 (LSM6 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Deadenylation-dependent mRNA decay. An important paralog of this gene is SNRPF.
UniProtKB/Swiss-Prot for LSM6 Gene
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5-to-3 mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).