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Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
LSM6 (LSM6 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. An important paralog of this gene is SNRPF.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15231747 |
GO:0046982 | protein heterodimerization activity | IDA | 12515382 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 26912367 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005681 | spliceosomal complex | IEA | -- |
GO:0005688 | U6 snRNP | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
2 | Deadenylation-dependent mRNA decay |
.46
|
|
3 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006364 | rRNA processing | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0006402 | mRNA catabolic process | IDA | 12515382 |
GO:0008033 | tRNA processing | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | - | - | |||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LSM6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LSM6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LSM6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lsm6 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LSM6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lsm6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | LSM6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LSM6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lsm6 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lsm6 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005314 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9344 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | lsm-6 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMX3 31 |
|
OneToMany | |
LSM6 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G59810 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.2690 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0388900 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1789 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | lsm6 30 |
|
No disorders were found for LSM6 Gene.