Aliases for LSM5 Gene
- LSM5 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated 2 3 5
- U6 SnRNA-Associated Sm-Like Protein LSm5 3 4
- YER146W 2 3
- LSM5 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
- LSM5 U6 Small Nuclear RNA And MRNA Degradation Associated 3
- LSM5 Homolog, U6 Small Nuclear RNA Associated 3
- LSM5 5
External Ids for LSM5 Gene
Previous GeneCards Identifiers for LSM5 Gene
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
GeneCards Summary for LSM5 Gene
LSM5 (LSM5 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Diseases associated with LSM5 include Retinitis Pigmentosa. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding.
UniProtKB/Swiss-Prot Summary for LSM5 Gene
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).