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This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov ... See more...
Aliases for LSM4 Gene
Aliases for LSM4 Gene
- LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated 2 3 5
- U6 SnRNA-Associated Sm-Like Protein LSm4 3 4
- Glycine-Rich Protein 3 4
- GRP 3 4
- LSM4 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
- LSM4 U6 Small Nuclear RNA And MRNA Degradation Associated 3
- LSM4 Homolog, U6 Small Nuclear RNA Associated 3
- YER112W 3
External Ids for LSM4 Gene
- HGNC: 17259
- Entrez Gene: 25804
- Ensembl: ENSG00000130520
- OMIM: 607284
- UniProtKB: Q9Y4Z0
Previous GeneCards Identifiers for LSM4 Gene
- GC19M018911
- GC19M018809
- GC19M018262
- GC19M018278
- GC19M018417
- GC19M017981
Summaries for LSM4 Gene
-
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for LSM4 Gene
LSM4 (LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. An important paralog of this gene is SNRPD3.
UniProtKB/Swiss-Prot Summary for LSM4 Gene
-
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LSM4 Gene
Genomics for LSM4 Gene
GeneHancer (GH) Regulatory Elements for LSM4 Gene
Promoters and enhancers for LSM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LSM4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LSM4 gene promoter:
-
- CBF-A
- CBF-B
- CP1A
- GATA-1
- NF-Y
- NF-YA
- NF-YB
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for LSM4 Gene
Genomic Locations for LSM4 Gene
- chr19:18,306,230-18,323,274
- (GRCh38/hg38)
- Size:
- 17,045 bases
- Orientation:
- Minus strand
- chr19:18,417,040-18,434,084
- (GRCh37/hg19)
- Size:
- 17,045 bases
- Orientation:
- Minus strand
Genomic View for LSM4 Gene
Genes around LSM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.1 by HGNC
- 19p13.11 by Entrez Gene
- 19p13.11 by Ensembl
LSM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LSM4 Gene
Proteins for LSM4 Gene
-
Protein details for LSM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4Z0-LSM4_HUMAN
- Recommended name:
- U6 snRNA-associated Sm-like protein LSm4
- Protein Accession:
- Q9Y4Z0
Protein attributes for LSM4 Gene
- Size:
- 139 amino acids
- Molecular mass:
- 15350 Da
- Quaternary structure:
-
- Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166).
Protein Expression for LSM4 Gene
Post-translational modifications for LSM4 Gene
Other Protein References for LSM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-LSM4 Antibody
- Creative Diagnostics Anti-LSM4 monoclonal antibody, clone 9B20, Anti-LSM4 monoclonal antibody, and Anti-LSM4 (aa 1-139) polyclonal antibody
- Novus Biologicals Antibodies for LSM4
-
Abcam antibodies for LSM4
- Invitrogen Antibodies for LSM4 (AFLGC-LSM4)
Protein Products
- G Biosciences Human GRP/LSM4, Lyophilized
- Atlas Antibodies PrEST Antigen LSM4
-
OriGene Purified Proteins for LSM4
- Search Origene for MassSpec and Protein Over-expression Lysates for LSM4
- Origene Custom Protein Services for LSM4
- ProSpec Recombinant Proteins for LSM4
-
ProSci Proteins for LSM4
-
Abcam proteins for LSM4
No data available for DME Specific Peptides for LSM4 Gene
Domains & Families for LSM4 Gene
Gene Families for LSM4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for LSM4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LSM4 Gene
- GenScript: Design optimal peptide antigens:
-
- Glycine-rich protein (LSM4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y4Z0- Family:
-
- Belongs to the snRNP Sm proteins family.
Function for LSM4 Gene
Molecular function for LSM4 Gene
- UniProtKB/Swiss-Prot Function:
- Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Phenotypes From GWAS Catalog for LSM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA,IEA | 21873635 |
| GO:0005515 | protein binding | IPI | 15231747 |
| GO:0017070 | U6 snRNA binding | IBA | 21873635 |
| GO:0042731 | PH domain binding | IDA | 15905169 |
Phenotypes for LSM4 Gene
- MGI mutant phenotypes for LSM4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LSM4:
-
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Increased homologous recombination repair frequency
- Decreased viability
- no effect
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- FOXO1 nuclear localization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for LSM4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LSM4
- genomics-online: gRNA clones - Search for available LSM4 gRNA products
- Overview of 127 available LSM4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for LSM4 - Select products 50% OFF >
- * LSM4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LSM4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for LSM4
miRNA for LSM4 Gene
- miRTarBase miRNAs that target LSM4
-
- hsa-mir-769-5p (MIRT039176)
- hsa-mir-423-3p (MIRT042595)
- hsa-mir-874-3p (MIRT572298)
- hsa-mir-6882-3p (MIRT572299)
- hsa-mir-146b-3p (MIRT572300)
- hsa-mir-6799-3p (MIRT572301)
- hsa-mir-3173-5p (MIRT572302)
- hsa-mir-7153-5p (MIRT572303)
- hsa-mir-7976 (MIRT572304)
- hsa-mir-146b-5p (MIRT572305)
- hsa-mir-146a-5p (MIRT572306)
- hsa-mir-589-5p (MIRT572307)
- hsa-mir-18a-3p (MIRT572308)
- hsa-mir-4251 (MIRT572309)
- hsa-mir-4324 (MIRT572310)
- hsa-mir-4319 (MIRT572311)
- hsa-mir-125b-5p (MIRT572312)
- hsa-mir-125a-5p (MIRT572313)
- hsa-mir-3158-3p (MIRT765085)
- hsa-mir-421 (MIRT767936)
- hsa-mir-4297 (MIRT768473)
- hsa-mir-4721 (MIRT771448)
- hsa-mir-488-3p (MIRT772682)
- hsa-mir-505-3p (MIRT773094)
- hsa-mir-532-5p (MIRT773936)
- hsa-mir-5581-5p (MIRT774704)
- hsa-mir-5586-5p (MIRT774787)
- hsa-mir-6512-3p (MIRT776916)
- hsa-mir-6720-5p (MIRT777762)
- hsa-mir-676-5p (MIRT778550)
- hsa-mir-6849-3p (MIRT780302)
- hsa-mir-7159-5p (MIRT781575)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LSM4
- Browse OriGene Inhibitory RNA Products For LSM4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM4
- genomics-online: shRNA clones - Search for available LSM4 shRNA products
- Overview of 127 available LSM4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LSM4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LSM4
- genomics-online: cdna clones - Search for available LSM4 CDNA products
- Overview of 127 available LSM4 gene related products
- orf clones - Search for available LSM4 ORF products
- Overview of 127 available LSM4 gene related products
- Applied Biological Materials (abm): Clones for LSM4 - Select products 50% OFF >
- * LSM4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LSM4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LSM4 Gene
Localization for LSM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LSM4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IBA | 21873635 |
| GO:0005634 | nucleus | IDA,IEA | 26912367 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005688 | U6 snRNP | TAS,IBA | 21873635 |
Pathways & Interactions for LSM4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
| 2 | Deadenylation-dependent mRNA decay |
.46
|
|
| 3 | Gene Expression |
.48
|
|
Pathways by source for LSM4 Gene
6 Reactome pathways for LSM4 Gene
2 KEGG pathways for LSM4 Gene
Interacting Proteins for LSM4 Gene
Selected Interacting proteins:
Q9Y4Z0-LSM4_HUMAN
ENSP00000469468
for LSM4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LSM4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000387 | spliceosomal snRNP assembly | IBA | 21873635 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS,IEA | -- |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | IEA | -- |
| GO:0006396 | RNA processing | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
No data available for SIGNOR curated interactions for LSM4 Gene
Drugs & Compounds for LSM4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
Transcripts for LSM4 Gene
mRNA/cDNA for LSM4 Gene
- (2) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (633) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000593829 1908 bps (ENST00000593829.5)
- ENST00000252816 986 bps (ENST00000252816.10)
- ENST00000600289 1113 bps (ENST00000600289.6)
- ENST00000594828 807 bps (ENST00000594828.7)
- ENST00000597776 446 bps (ENST00000597776.1)
CRISPR Products
-
OriGene CRISPR knockouts for LSM4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LSM4
- genomics-online: gRNA clones - Search for available LSM4 gRNA products
- Overview of 127 available LSM4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for LSM4 - Select products 50% OFF >
- * LSM4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LSM4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for LSM4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LSM4
- Browse OriGene Inhibitory RNA Products For LSM4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM4
- genomics-online: shRNA clones - Search for available LSM4 shRNA products
- Overview of 127 available LSM4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LSM4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LSM4
- genomics-online: cdna clones - Search for available LSM4 CDNA products
- Overview of 127 available LSM4 gene related products
- orf clones - Search for available LSM4 ORF products
- Overview of 127 available LSM4 gene related products
- Applied Biological Materials (abm): Clones for LSM4 - Select products 50% OFF >
- * LSM4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LSM4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: |
Expression for LSM4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Saliva (8.5) and Peripheral blood mononuclear cells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LSM4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LSM4 Gene:
LSM4SOURCE GeneReport for Unigene cluster for LSM4 Gene:
Hs.515255Evidence on tissue expression from TISSUES for LSM4 Gene
- Lung(4.8)
- Nervous system(4.8)
- Liver(4.3)
- Pancreas(3.1)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for LSM4
-
OriGene qPCR primer pairs and template standards for LSM4
- genomics-online: primer clones - Search for available LSM4 Primer products
- Overview of 127 available LSM4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LSM4 Gene
Orthologs for LSM4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LSM4 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LSM4 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LSM4 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LSM4 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LSM4 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lsm4 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Lsm4 17 33 32 |
|
||
| chicken (Gallus gallus) |
Aves | LSM4 33 32 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lsm4 32 |
|
||
| MGC76085 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3329 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lsm4 33 32 |
|
OneToOne | |
| zgc73057 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4425 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17768 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | lsm-4 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LSM4 33 |
|
OneToOne | |
| corn (Zea mays) |
Liliopsida | Zm.3350 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.197 32 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3996 32 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.3949 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
- Species where no ortholog for LSM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for LSM4 Gene
- ENSEMBL:
- Gene Tree for LSM4 (if available)
- TreeFam:
- Gene Tree for LSM4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LSM4: view image
Paralogs for LSM4 Gene
Variants for LSM4 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029179 | -- | 18,308,693(-) | G/A | intron_variant | |
| rs1000201773 | -- | 18,306,632(-) | A/C/G | 3_prime_UTR_variant | |
| rs1000260355 | -- | 18,324,369(-) | T/C | upstream_transcript_variant | |
| rs1000365262 | -- | 18,315,878(-) | G/A | intron_variant | |
| rs1000378967 | -- | 18,317,970(-) | G/A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3643836 | CNV | loss | 21293372 |
| nsv952420 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.26;
25.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LSM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LSM4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM4 Gene
Disorders for LSM4 Gene
Additional Disease Information for LSM4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for LSM4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSM4 Gene
Publications for LSM4 Gene
- Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PMID: 10369684) Salgado-Garrido J … Séraphin B (The EMBO journal 1999) 2 3 4 56
- A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PMID: 10523320) Achsel T … Lührmann R (The EMBO journal 1999) 2 3 4 56
- Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4 56
- Molecular architecture of the human U4/U6.U5 tri-snRNP. (PMID: 26912367) Agafonov DE … Stark H (Science (New York, N.Y.) 2016) 3 4 56
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 43 56
ExternalLinks
Products for LSM4 Gene
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for LSM4
- Browse OriGene Inhibitory RNA Products For LSM4
- OriGene qPCR primer pairs for LSM4
- OriGene qPCR primer pairs and template standards for LSM4
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- Abcam proteins for LSM4
- Find your target
- Browse Primary Antibodies
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- antibodies-online: Show 14 available LSM4 Antibodies ranked by validation data
- Compare Top LSM4 Antibodies
- antibodies-online: Search results for available LSM4 related products ranked by validation data
- antibodies-online: Show 15 available LSM4 Proteins ranked by validation data
- Compare Top LSM4 Proteins
- genomics-online: cdna clones - Search for available LSM4 CDNA products
- Overview of 127 available LSM4 gene related products
- orf clones - Search for available LSM4 ORF products
- Overview of 127 available LSM4 gene related products
- genomics-online: gRNA clones - Search for available LSM4 gRNA products
- Overview of 127 available LSM4 gene related products
- genomics-online: primer clones - Search for available LSM4 Primer products
- Overview of 127 available LSM4 gene related products
- genomics-online: shRNA clones - Search for available LSM4 shRNA products
- Overview of 127 available LSM4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LSM4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LSM4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LSM4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM4
Sources for LSM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource