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This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
LSM4 (LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. An important paralog of this gene is SNRPD3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA,IEA | 21873635 |
GO:0005515 | protein binding | IPI | 15231747 |
GO:0017070 | U6 snRNA binding | IBA | 21873635 |
GO:0042731 | PH domain binding | IDA | 15905169 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IBA | 21873635 |
GO:0005634 | nucleus | IDA,IEA | 26912367 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005681 | spliceosomal complex | IEA | -- |
GO:0005688 | U6 snRNP | TAS,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
2 | Deadenylation-dependent mRNA decay |
.46
|
|
3 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000387 | spliceosomal snRNP assembly | IBA | 21873635 |
GO:0000398 | mRNA splicing, via spliceosome | TAS,IEA | -- |
GO:0000956 | nuclear-transcribed mRNA catabolic process | IEA | -- |
GO:0006396 | RNA processing | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LSM4 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | LSM4 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | LSM4 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | LSM4 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | LSM4 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Lsm4 32 |
|
||
mouse (Mus musculus) |
Mammalia | Lsm4 17 33 32 |
|
||
chicken (Gallus gallus) |
Aves | LSM4 33 32 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | lsm4 32 |
|
||
MGC76085 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3329 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | lsm4 33 32 |
|
OneToOne | |
zgc73057 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4425 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG17768 33 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | lsm-4 33 |
|
OneToOne | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LSM4 33 |
|
OneToOne | |
corn (Zea mays) |
Liliopsida | Zm.3350 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os.197 32 |
|
||
barley (Hordeum vulgare) |
Liliopsida | Hv.3996 32 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.3949 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000029179 | -- | 18,308,693(-) | G/A | intron_variant | |
rs1000201773 | -- | 18,306,632(-) | A/C/G | 3_prime_UTR_variant | |
rs1000260355 | -- | 18,324,369(-) | T/C | upstream_transcript_variant | |
rs1000365262 | -- | 18,315,878(-) | G/A | intron_variant | |
rs1000378967 | -- | 18,317,970(-) | G/A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3643836 | CNV | loss | 21293372 |
nsv952420 | CNV | deletion | 24416366 |
No disorders were found for LSM4 Gene.