Aliases for LSM2 Gene
External Ids for LSM2 Gene
Previous HGNC Symbols for LSM2 Gene
Previous GeneCards Identifiers for LSM2 Gene
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
GeneCards Summary for LSM2 Gene
LSM2 (LSM2 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Diseases associated with LSM2 include Mixed Connective Tissue Disease and Spinal Muscular Atrophy. Among its related pathways are Deadenylation-dependent mRNA decay and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include Ral GTPase binding.
UniProtKB/Swiss-Prot Summary for LSM2 Gene
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).