Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are impo... See more...

Aliases for LSM14A Gene

Aliases for LSM14A Gene

  • LSM14A MRNA Processing Body Assembly Factor 2 3 5
  • RAP55A 2 3 4
  • RAP55 2 3 4
  • Family With Sequence Similarity 61, Member A 2 3
  • Putative Alpha-Synuclein-Binding Protein 3 4
  • RNA-Associated Protein 55A 3 4
  • RNA-Associated Protein 55 2 3
  • Protein LSM14 Homolog A 3 4
  • Protein SCD6 Homolog 3 4
  • AlphaSNBP 3 4
  • C19orf13 3 4
  • HRAP55A 3 4
  • FAM61A 3 4
  • HRAP55 3 4
  • LSM14A, MRNA Processing Body Assembly Factor 2
  • LSM14 Homolog A (SCD6, S. Cerevisiae) 2
  • Chromosome 19 Open Reading Frame 13 2
  • LSM14A, SCD6 Homolog A 3
  • LSM14 Homolog A 3
  • Protein FAM61A 4
  • DKFZP434D1335 2
  • LSM14A 5

External Ids for LSM14A Gene

Previous HGNC Symbols for LSM14A Gene

  • C19orf13
  • FAM61A

Previous GeneCards Identifiers for LSM14A Gene

  • GC19P039359
  • GC19P034663
  • GC19P031161

Summaries for LSM14A Gene

Entrez Gene Summary for LSM14A Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

GeneCards Summary for LSM14A Gene

LSM14A (LSM14A MRNA Processing Body Assembly Factor) is a Protein Coding gene. Diseases associated with LSM14A include Brugada Syndrome 5. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is LSM14B.

UniProtKB/Swiss-Prot Summary for LSM14A Gene

  • Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Additional gene information for LSM14A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LSM14A Gene

Genomics for LSM14A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LSM14A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LSM14A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LSM14A

Top Transcription factor binding sites by QIAGEN in the LSM14A gene promoter:
  • AML1a
  • FOXJ2 (long isoform)
  • HSF1 (long)
  • HSF1short
  • N-Myc
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • YY1

Genomic Locations for LSM14A Gene

Genomic Locations for LSM14A Gene
chr19:34,172,499-34,229,515
(GRCh38/hg38)
Size:
57,017 bases
Orientation:
Plus strand
chr19:34,663,352-34,720,420
(GRCh37/hg19)
Size:
57,069 bases
Orientation:
Plus strand

Genomic View for LSM14A Gene

Genes around LSM14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM14A Gene

Proteins for LSM14A Gene

  • Protein details for LSM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND56-LS14A_HUMAN
    Recommended name:
    Protein LSM14 homolog A
    Protein Accession:
    Q8ND56
    Secondary Accessions:
    • B4DTG6
    • Q76LX7
    • Q96AR3
    • Q96K73
    • Q96SN5
    • Q9UFR3

    Protein attributes for LSM14A Gene

    Size:
    463 amino acids
    Molecular mass:
    50530 Da
    Quaternary structure:
    • Component of a ribonucleoprotein (RNP) complex. Interacts with DDX6 (PubMed:31422817).
    SequenceCaution:
    • Sequence=BAB55066.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LSM14A Gene

    Alternative splice isoforms for LSM14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSM14A Gene

Post-translational modifications for LSM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for LSM14A

No data available for DME Specific Peptides for LSM14A Gene

Domains & Families for LSM14A Gene

Gene Families for LSM14A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LSM14A Gene

Suggested Antigen Peptide Sequences for LSM14A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54754, highly similar to Protein FAM61A (B4DTG6_HUMAN)
  • RNA-associated protein 55A (LS14A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8ND56

UniProtKB/Swiss-Prot:

LS14A_HUMAN :
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
  • Belongs to the LSM14 family.
Domain:
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
Family:
  • Belongs to the LSM14 family.
genes like me logo Genes that share domains with LSM14A: view

Function for LSM14A Gene

Molecular function for LSM14A Gene

UniProtKB/Swiss-Prot Function:
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Phenotypes From GWAS Catalog for LSM14A Gene

Gene Ontology (GO) - Molecular Function for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003725 double-stranded RNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0003729 mRNA binding IBA 21873635
genes like me logo Genes that share ontologies with LSM14A: view
genes like me logo Genes that share phenotypes with LSM14A: view

Animal Models for LSM14A Gene

MGI Knock Outs for LSM14A:
  • Lsm14a Lsm14a<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for LSM14A Gene

miRTarBase miRNAs that target LSM14A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM14A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSM14A Gene

Localization for LSM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM14A Gene

Cytoplasm, P-body. Cytoplasm, Stress granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSM14A gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 16484376
GO:0005737 cytoplasm IEA,IDA 16484376
GO:0005829 cytosol IDA --
GO:0010494 cytoplasmic stress granule IEA,IDA 16484376
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with LSM14A: view

Pathways & Interactions for LSM14A Gene

PathCards logo

SuperPathways for LSM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0033962 cytoplasmic mRNA processing body assembly IMP 17074753
GO:0034063 stress granule assembly IBA 21873635
GO:0039529 RIG-I signaling pathway IEA --
genes like me logo Genes that share ontologies with LSM14A: view

No data available for Pathways by source and SIGNOR curated interactions for LSM14A Gene

Drugs & Compounds for LSM14A Gene

No Compound Related Data Available

Transcripts for LSM14A Gene

mRNA/cDNA for LSM14A Gene

20 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LSM14A

Alternative Splicing Database (ASD) splice patterns (SP) for LSM14A Gene

No ASD Table

Relevant External Links for LSM14A Gene

GeneLoc Exon Structure for
LSM14A

Expression for LSM14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LSM14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LSM14A Gene

This gene is overexpressed in Pancreas (11.0), CD8 Tcells (10.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LSM14A Gene



Protein tissue co-expression partners for LSM14A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LSM14A

SOURCE GeneReport for Unigene cluster for LSM14A Gene:

Hs.744009

Evidence on tissue expression from TISSUES for LSM14A Gene

  • Blood(4.2)
  • Nervous system(4.2)
  • Liver(4.2)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with LSM14A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LSM14A Gene

Orthologs for LSM14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LSM14A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LSM14A 30 31
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LSM14A 30 31
  • 94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LSM14A 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LSM14A 30 31
  • 93.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LSM14A 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Lsm14a 30 17 31
  • 90.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lsm14a 30
  • 90.5 (n)
Chicken
(Gallus gallus)
Aves LSM14A 30 31
  • 84.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LSM14A 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lsm14a 30
  • 76.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53350 30
Zebrafish
(Danio rerio)
Actinopterygii lsm14ab 31
  • 68 (a)
OneToMany
lsm14aa 30 31
  • 65.48 (n)
OneToMany
wufa10g11 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2043 30
Fruit Fly
(Drosophila melanogaster)
Insecta tral 31
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea car-1 31
  • 44 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCD6 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10167 31
  • 43 (a)
OneToMany
Species where no ortholog for LSM14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LSM14A Gene

ENSEMBL:
Gene Tree for LSM14A (if available)
TreeFam:
Gene Tree for LSM14A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LSM14A: view image

Paralogs for LSM14A Gene

Paralogs for LSM14A Gene

(1) SIMAP similar genes for LSM14A Gene using alignment to 4 proteins:

  • LS14A_HUMAN
  • B4DTG6_HUMAN
  • I3L4Q1_HUMAN
  • K7EMZ9_HUMAN
genes like me logo Genes that share paralogs with LSM14A: view

Variants for LSM14A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LSM14A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2274896 - p.Arg448Gln
rs36006556 - p.Arg238Gln

Additional dbSNP identifiers (rs#s) for LSM14A Gene

Structural Variations from Database of Genomic Variants (DGV) for LSM14A Gene

Variant ID Type Subtype PubMed ID
dgv3515n100 CNV gain 25217958
nsv2467 CNV insertion 18451855
nsv474170 CNV novel sequence insertion 20440878
nsv509737 CNV insertion 20534489
nsv963038 CNV duplication 23825009

Variation tolerance for LSM14A Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LSM14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSM14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM14A Gene

Disorders for LSM14A Gene

MalaCards: The human disease database

(1) MalaCards diseases for LSM14A Gene - From: DISEASES

Disorder Aliases PubMed IDs
brugada syndrome 5
  • brgda5
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LSM14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LSM14A Gene

Publications for LSM14A Gene

  1. Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation. (PMID: 31422817) Balak C … Piton A (American journal of human genetics 2019) 3 4
  2. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. (PMID: 22745163) Li Y … Shu HB (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3
  3. RAP55: insights into an evolutionarily conserved protein family. (PMID: 18723115) Marnef A … Ladomery MR (The international journal of biochemistry & cell biology 2009) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. (PMID: 17074753) Tanaka KJ … Tsujimoto M (The Journal of biological chemistry 2006) 3 4

Products for LSM14A Gene

Sources for LSM14A Gene