Aliases for LSM1 Gene
External Ids for LSM1 Gene
Previous GeneCards Identifiers for LSM1 Gene
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
GeneCards Summary for LSM1 Gene
LSM1 (LSM1 Homolog, MRNA Degradation Associated) is a Protein Coding gene. Diseases associated with LSM1 include Non-Functioning Pancreatic Endocrine Tumor and Oligohydramnios. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA cap binding. An important paralog of this gene is LSM8.
UniProtKB/Swiss-Prot Summary for LSM1 Gene
Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).