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Aliases for LRRN4CL Gene

Aliases for LRRN4CL Gene

  • LRRN4 C-Terminal Like 2 3 5

External Ids for LRRN4CL Gene

Previous GeneCards Identifiers for LRRN4CL Gene

  • GC11M062211
  • GC11M062454
  • GC11M058782
  • GC11M062456
  • GC11M062470
  • GC11M062476
  • GC11M062488

Summaries for LRRN4CL Gene

GeneCards Summary for LRRN4CL Gene

LRRN4CL (LRRN4 C-Terminal Like) is a Protein Coding gene. An important paralog of this gene is LRRN4.

Additional gene information for LRRN4CL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN4CL Gene

Genomics for LRRN4CL Gene

GeneHancer (GH) Regulatory Elements for LRRN4CL Gene

Promoters and enhancers for LRRN4CL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I062687 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.3 289 4 ZBTB21 KLF17 GLIS2 ZBTB48 POLR2A PATZ1 FOS ZNF600 KLF8 EZH2 LRRN4CL TTC9C GANAB UBXN1 BSCL2 HNRNPUL2-BSCL2
GH11I062838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 46 -150.9 -150947 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR74 GC11M062842 RNU2-2P NXF1 CSKMT INTS5 UBXN1 MTA2 SNHG1 GANAB
GH11I061960 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.8 +721.0 720975 16.4 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 FTH1 GC11M061968 GC11M061969 GC11M061970 LOC399900 NXF1 INTS5 LOC105369332 CPSF7 UBXN1
GH11I061916 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 +771.3 771342 4.3 HDGF PKNOX1 CLOCK SMAD1 SIN3A ZBTB7B SP3 REST ZNF592 SMARCA4 RAB3IL1 CSKMT CPSF7 TUT1 TAF6L WDR74 GANAB SNHG1 FADS3 BEST1
GH11I062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -165.9 -165938 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNHG1 SLC3A2 ENSG00000278527 GC11M062911 GC11M062919 GC11M062920 GC11M062923 GC11M062925 GC11M062930 SNORD25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRN4CL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRN4CL gene promoter:

Genomic Locations for LRRN4CL Gene

Genomic Locations for LRRN4CL Gene
chr11:62,686,402-62,689,899
(GRCh38/hg38)
Size:
3,498 bases
Orientation:
Minus strand
chr11:62,453,874-62,457,371
(GRCh37/hg19)

Genomic View for LRRN4CL Gene

Genes around LRRN4CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN4CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN4CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN4CL Gene

Proteins for LRRN4CL Gene

  • Protein details for LRRN4CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND94-LRN4L_HUMAN
    Recommended name:
    LRRN4 C-terminal-like protein
    Protein Accession:
    Q8ND94
    Secondary Accessions:
    • A8K5L9

    Protein attributes for LRRN4CL Gene

    Size:
    238 amino acids
    Molecular mass:
    25262 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN4CL Gene

Post-translational modifications for LRRN4CL Gene

Other Protein References for LRRN4CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN4CL Gene

Domains & Families for LRRN4CL Gene

Gene Families for LRRN4CL Gene

Protein Domains for LRRN4CL Gene

Suggested Antigen Peptide Sequences for LRRN4CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRN4CL: view

No data available for UniProtKB/Swiss-Prot for LRRN4CL Gene

Function for LRRN4CL Gene

Phenotypes From GWAS Catalog for LRRN4CL Gene

Phenotypes for LRRN4CL Gene

GenomeRNAi human phenotypes for LRRN4CL:
genes like me logo Genes that share phenotypes with LRRN4CL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRN4CL Gene

Localization for LRRN4CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN4CL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN4CL gene
Compartment Confidence
plasma membrane 3
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRN4CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN4CL: view

Pathways & Interactions for LRRN4CL Gene

SuperPathways for LRRN4CL Gene

No Data Available

Interacting Proteins for LRRN4CL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325808%0d%0a9606.ENSP00000358739%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: Q8ND94-LRN4L_HUMAN ENSP00000325808 for LRRN4CL Gene via IID STRING

Gene Ontology (GO) - Biological Process for LRRN4CL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRN4CL Gene

Drugs & Compounds for LRRN4CL Gene

No Compound Related Data Available

Transcripts for LRRN4CL Gene

mRNA/cDNA for LRRN4CL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN4CL Gene

LRRN4 C-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN4CL Gene

No ASD Table

Relevant External Links for LRRN4CL Gene

GeneLoc Exon Structure for
LRRN4CL
ECgene alternative splicing isoforms for
LRRN4CL

Expression for LRRN4CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRN4CL Gene

Protein differential expression in normal tissues from HIPED for LRRN4CL Gene

This gene is overexpressed in Cerebral cortex (25.7), Uterus (12.5), Ovary (9.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRN4CL Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRN4CL Gene:

LRRN4CL

SOURCE GeneReport for Unigene cluster for LRRN4CL Gene:

Hs.427449

Evidence on tissue expression from TISSUES for LRRN4CL Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with LRRN4CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN4CL Gene

Orthologs for LRRN4CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRN4CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRN4CL 34 33
  • 99.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRN4CL 34 33
  • 80.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRN4CL 33 34
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Lrrn4cl 16 34 33
  • 72.27 (n)
rat
(Rattus norvegicus)
Mammalia Lrrn4cl 33
  • 71.09 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRN4CL 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN4CL 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN4CL 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494823 33
  • 51.44 (n)
zebrafish
(Danio rerio)
Actinopterygii FP245511.1 34
  • 26 (a)
ManyToMany
CU984579.1 34
  • 25 (a)
ManyToMany
Species where no ortholog for LRRN4CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRN4CL Gene

ENSEMBL:
Gene Tree for LRRN4CL (if available)
TreeFam:
Gene Tree for LRRN4CL (if available)

Paralogs for LRRN4CL Gene

Paralogs for LRRN4CL Gene

genes like me logo Genes that share paralogs with LRRN4CL: view

Variants for LRRN4CL Gene

Sequence variations from dbSNP and Humsavar for LRRN4CL Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1057516190 likely-pathogenic, Familial partial lipodystrophy 3 62,690,439(-) G/T upstream_transcript_variant
rs1060503382 uncertain-significance, Charcot-Marie-Tooth disease, type 2 62,690,402(-) C/A upstream_transcript_variant
rs137852974 pathogenic, Congenital generalized lipodystrophy type 2 62,691,132(-) G/A upstream_transcript_variant
rs140676897 uncertain-significance, likely-benign, not specified, Charcot-Marie-Tooth disease, type 2 62,691,116(-) G/A upstream_transcript_variant
rs141377075 uncertain-significance, Hereditary spastic paraplegia, Charcot-Marie-Tooth disease, type 2 62,691,390(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN4CL Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for LRRN4CL Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRN4CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRN4CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN4CL Gene

Disorders for LRRN4CL Gene

Additional Disease Information for LRRN4CL

No disorders were found for LRRN4CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN4CL Gene

Publications for LRRN4CL Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for LRRN4CL Gene

Sources for LRRN4CL Gene

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