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Aliases for LRRN3 Gene

Aliases for LRRN3 Gene

  • Leucine Rich Repeat Neuronal 3 2 3 5
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 5 2 3
  • Neuronal Leucine-Rich Repeat Protein 3 3 4
  • NLRR-3 3 4
  • Leucine-Rich Repeat Protein, Neuronal 3 3
  • Leucine-Rich Repeat Neuronal Protein 3 3
  • FIGLER5 3
  • NLRR3 3

External Ids for LRRN3 Gene

Previous GeneCards Identifiers for LRRN3 Gene

  • GC07P109215
  • GC07M109214
  • GC07P110277
  • GC07P110291
  • GC07P110325
  • GC07P110518
  • GC07P110731
  • GC07P105099

Summaries for LRRN3 Gene

GeneCards Summary for LRRN3 Gene

LRRN3 (Leucine Rich Repeat Neuronal 3) is a Protein Coding gene. An important paralog of this gene is LRRN1.

Gene Wiki entry for LRRN3 Gene

Additional gene information for LRRN3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN3 Gene

Genomics for LRRN3 Gene

GeneHancer (GH) Regulatory Elements for LRRN3 Gene

Promoters and enhancers for LRRN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J111090 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 655.2 +1.2 1246 3.1 PKNOX1 INSM2 FEZF1 ZNF2 ZNF213 ZNF366 ZSCAN5C RCOR1 RUNX3 EGR2 LRRN3 GC07M111109 IMMP2L
GH07J111009 Enhancer 1.1 FANTOM5 Ensembl ENCODE 33.9 -78.9 -78869 5.5 PKNOX1 JUN CEBPG BATF IRF4 FOSL2 ETV6 IKZF2 ZNF174 CEBPB LRRN3 IMMP2L PIR56888 GC07M111005 PIR51103
GH07J111081 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -8.0 -7975 3.2 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM LRRN3 PIR51103 IMMP2L
GH07J111113 Enhancer 1.2 FANTOM5 Ensembl ENCODE 19.2 +22.9 22895 0.6 LEF1 PKNOX1 ZBTB21 JUN INSM2 BATF RELA ZNF335 ZSCAN29 ATF7 LRRN3 GC07M111109 GC07P111351 IMMP2L
GH07J111137 Enhancer 1.3 FANTOM5 Ensembl ENCODE 16.1 +47.4 47418 2 PKNOX1 FEZF1 BATF IRF4 ATF7 RCOR1 ETV6 IKZF2 RUNX3 CREM LRRN3 GC07M111109 GC07P111351 IMMP2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRN3 gene promoter:
  • AREB6
  • POU2F1
  • POU2F1a
  • TBP
  • FOXD1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • AP-1

Genomic Locations for LRRN3 Gene

Genomic Locations for LRRN3 Gene
34,449 bases
Plus strand
34,449 bases
Plus strand

Genomic View for LRRN3 Gene

Genes around LRRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN3 Gene

Proteins for LRRN3 Gene

  • Protein details for LRRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat neuronal protein 3
    Protein Accession:
    Secondary Accessions:
    • O43377
    • Q6I9V8
    • Q8IYQ6

    Protein attributes for LRRN3 Gene

    708 amino acids
    Molecular mass:
    79424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN3 Gene

Post-translational modifications for LRRN3 Gene

  • Glycosylation at posLast=625625, isoforms=624, isoforms=608, isoforms=579, posLast=522522, isoforms=382, posLast=223223, isoforms=103, and isoforms=93
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN3 Gene

No data available for DME Specific Peptides for LRRN3 Gene

Domains & Families for LRRN3 Gene

Gene Families for LRRN3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LRRN3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRN3: view

No data available for UniProtKB/Swiss-Prot for LRRN3 Gene

Function for LRRN3 Gene

genes like me logo Genes that share phenotypes with LRRN3: view

Animal Models for LRRN3 Gene

MGI Knock Outs for LRRN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN3

miRNA for LRRN3 Gene

miRTarBase miRNAs that target LRRN3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRN3 Gene

Localization for LRRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN3 gene
Compartment Confidence
extracellular 4
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN3: view

Pathways & Interactions for LRRN3 Gene

SuperPathways for LRRN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 NOT axonogenesis IBA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with LRRN3: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN3 Gene

Drugs & Compounds for LRRN3 Gene

No Compound Related Data Available

Transcripts for LRRN3 Gene

mRNA/cDNA for LRRN3 Gene

Unigene Clusters for LRRN3 Gene

Leucine rich repeat neuronal 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: - -

Relevant External Links for LRRN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRN3 Gene

This gene is overexpressed in Adrenal Gland (x5.4) and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for LRRN3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRN3 Gene

Protein tissue co-expression partners for LRRN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRN3 Gene:


SOURCE GeneReport for Unigene cluster for LRRN3 Gene:


Evidence on tissue expression from TISSUES for LRRN3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with LRRN3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN3 Gene

Orthologs for LRRN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRN3 34 33
  • 99.62 (n)
(Canis familiaris)
Mammalia LRRN3 34 33
  • 92.51 (n)
(Bos Taurus)
Mammalia LRRN3 34 33
  • 91.62 (n)
(Monodelphis domestica)
Mammalia LRRN3 34
  • 87 (a)
(Mus musculus)
Mammalia Lrrn3 16 34 33
  • 86.75 (n)
(Rattus norvegicus)
Mammalia Lrrn3 33
  • 86.19 (n)
(Ornithorhynchus anatinus)
Mammalia LRRN3 34
  • 83 (a)
(Gallus gallus)
Aves LRRN3 34 33
  • 79.85 (n)
(Anolis carolinensis)
Reptilia LRRN3 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrn3 33
  • 71.97 (n)
(Danio rerio)
Actinopterygii LOC100535105 33
  • 62.45 (n)
LRRN3 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta caps 34
  • 24 (a)
trn 34 35
  • 23 (a)
CG14762 34
  • 21 (a)
Fili 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea lron-11 34
  • 21 (a)
Species where no ortholog for LRRN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRN3 Gene

Gene Tree for LRRN3 (if available)
Gene Tree for LRRN3 (if available)
Evolutionary constrained regions (ECRs) for LRRN3: view image

Paralogs for LRRN3 Gene

(3) SIMAP similar genes for LRRN3 Gene using alignment to 3 proteins:

  • A4D0T1_HUMAN
  • E7EW58_HUMAN
genes like me logo Genes that share paralogs with LRRN3: view

Variants for LRRN3 Gene

Sequence variations from dbSNP and Humsavar for LRRN3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000030769 -- 111,095,758(+) A/G intron_variant
rs1000099823 -- 111,107,746(+) T/C intron_variant
rs1000106734 -- 111,099,158(+) C/T intron_variant
rs1000378596 -- 111,094,164(+) A/G intron_variant
rs1000407892 -- 111,094,441(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN3 Gene

Variant ID Type Subtype PubMed ID
esv2759554 CNV loss 17122850
esv3614551 CNV loss 21293372
esv3614552 CNV loss 21293372
nsv1024477 CNV loss 25217958
nsv515693 CNV gain 19592680
nsv608080 CNV gain 21841781
nsv608154 CNV loss 21841781
nsv608155 CNV loss 21841781

Variation tolerance for LRRN3 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN3 Gene

Disorders for LRRN3 Gene

Additional Disease Information for LRRN3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN3 Gene

Publications for LRRN3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. (PMID: 11549284) Fukamachi K … Tsuda H (Biochemical and biophysical research communications 2001) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LRRN3 Gene

Sources for LRRN3 Gene

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