The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alter... See more...

Aliases for LRRN2 Gene

Aliases for LRRN2 Gene

  • Leucine Rich Repeat Neuronal 2 2 3 5
  • GAC1 2 3 4
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domain 7 2 3
  • Glioma Amplified On Chromosome 1 Protein 3 4
  • Leucine-Rich Repeat Neuronal Protein 2 3 4
  • Leucine-Rich Repeat Neuronal Protein 5 3 4
  • Leucine Rich And Ankyrin Repeats 1 2 3
  • Leucine Rich Repeat Neuronal 5 2 3
  • FIGLER7 2 3
  • LRANK1 2 3
  • LRRN5 3 4
  • LRRN2 5

External Ids for LRRN2 Gene

Previous HGNC Symbols for LRRN2 Gene

  • LRRN5

Previous GeneCards Identifiers for LRRN2 Gene

  • GC00U911621
  • GC01M202853
  • GC01M175751

Summaries for LRRN2 Gene

Entrez Gene Summary for LRRN2 Gene

  • The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRN2 Gene

LRRN2 (Leucine Rich Repeat Neuronal 2) is a Protein Coding gene. An important paralog of this gene is LRRN1.

Gene Wiki entry for LRRN2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRN2 Gene

Genomics for LRRN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRN2

Top Transcription factor binding sites by QIAGEN in the LRRN2 gene promoter:
  • E47
  • GCNF
  • GCNF-1
  • Hand1
  • HNF-4alpha1
  • Lmo2

Genomic Locations for LRRN2 Gene

Latest Assembly
chr1:204,617,170-204,685,836
(GRCh38/hg38)
Size:
68,667 bases
Orientation:
Minus strand

Previous Assembly
chr1:204,586,298-204,654,866
(GRCh37/hg19 by Entrez Gene)
Size:
68,569 bases
Orientation:
Minus strand

chr1:204,586,298-204,654,861
(GRCh37/hg19 by Ensembl)
Size:
68,564 bases
Orientation:
Minus strand

Genomic View for LRRN2 Gene

Genes around LRRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN2 Gene

Proteins for LRRN2 Gene

  • Protein details for LRRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75325-LRRN2_HUMAN
    Recommended name:
    Leucine-rich repeat neuronal protein 2
    Protein Accession:
    O75325
    Secondary Accessions:
    • B2R624
    • Q5T0Y0
    • Q6UXM0
    • Q8N182

    Protein attributes for LRRN2 Gene

    Size:
    713 amino acids
    Molecular mass:
    78859 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN2 Gene

Post-translational modifications for LRRN2 Gene

  • Glycosylation at Asn94, Asn381, Asn555, and Asn583
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN2 Gene

No data available for DME Specific Peptides for LRRN2 Gene

Domains & Families for LRRN2 Gene

Gene Families for LRRN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRN2 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin I-set
  • Cysteine-rich flanking region, N-terminal
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for LRRN2 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat neuronal protein 5 (LRRN2_HUMAN)
genes like me logo Genes that share domains with LRRN2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRN2 Gene

Function for LRRN2 Gene

Phenotypes From GWAS Catalog for LRRN2 Gene

Gene Ontology (GO) - Molecular Function for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0038023 signaling receptor activity TAS 9662332
genes like me logo Genes that share ontologies with LRRN2: view
genes like me logo Genes that share phenotypes with LRRN2: view

Animal Models for LRRN2 Gene

MGI Knock Outs for LRRN2:

Animal Models for research

  • Taconic Biosciences Mouse Models for LRRN2

miRNA for LRRN2 Gene

miRTarBase miRNAs that target LRRN2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRN2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRN2 Gene

Localization for LRRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN2 gene
Compartment Confidence
plasma membrane 3
extracellular 3
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IBA 21873635
genes like me logo Genes that share ontologies with LRRN2: view

Pathways & Interactions for LRRN2 Gene

PathCards logo

SuperPathways for LRRN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9662332
GO:0007165 signal transduction TAS 9662332
genes like me logo Genes that share ontologies with LRRN2: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN2 Gene

Drugs & Compounds for LRRN2 Gene

No Compound Related Data Available

Transcripts for LRRN2 Gene

mRNA/cDNA for LRRN2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRN2

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for LRRN2 Gene

GeneLoc Exon Structure for
LRRN2

Expression for LRRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRN2

SOURCE GeneReport for Unigene cluster for LRRN2 Gene:

Hs.26312

mRNA Expression by UniProt/SwissProt for LRRN2 Gene:

O75325-LRRN2_HUMAN
Tissue specificity: Overamplified in malignant gliomas.

Evidence on tissue expression from TISSUES for LRRN2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LRRN2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN2 Gene

Orthologs for LRRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRN2 30 31
  • 99.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRN2 30 31
  • 90.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrrn2 30 17 31
  • 87.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrn2 30
  • 87.08 (n)
Cow
(Bos Taurus)
Mammalia LRRN5 31
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRN2 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRN2 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRN2 30 31
  • 71.45 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRN2 31
  • 66 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100150431 30
  • 60.17 (n)
LRRN2 31
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011378 30
  • 49.26 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta trn 30 31
  • 44.29 (n)
ManyToMany
caps 31
  • 25 (a)
ManyToMany
CG14762 31
  • 22 (a)
ManyToMany
Fili 31
  • 21 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea lron-11 31
  • 23 (a)
OneToMany
Species where no ortholog for LRRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for LRRN2 Gene

ENSEMBL:
Gene Tree for LRRN2 (if available)
TreeFam:
Gene Tree for LRRN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRN2: view image

Paralogs for LRRN2 Gene

(2) SIMAP similar genes for LRRN2 Gene using alignment to 1 proteins:

  • LRRN2_HUMAN
genes like me logo Genes that share paralogs with LRRN2: view

Variants for LRRN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRN2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs201376768 Benign: not provided 204,619,306(-) G/A
NM_201630.2(LRRN2):c.687C>T (p.Ser229=)
SYNONYMOUS
rs11588857 - p.Pro692Ser
rs34771052 - p.Val659Ala
rs36012907 - p.Ala19Thr
rs3747631 - p.Leu518Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRN2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRN2 Gene

Variant ID Type Subtype PubMed ID
esv3328620 CNV insertion 20981092
esv3336117 CNV insertion 20981092
esv3588622 CNV gain 21293372
nsv4154 CNV insertion 18451855

Variation tolerance for LRRN2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.36; 94.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRN2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN2 Gene

Disorders for LRRN2 Gene

Additional Disease Information for LRRN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for LRRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN2 Gene

Publications for LRRN2 Gene

  1. GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. (PMID: 9662332) Almeida A … Hanash S (Oncogene 1998) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for LRRN2 Gene

Sources for LRRN2 Gene