Aliases for LRRIQ4 Gene

Aliases for LRRIQ4 Gene

  • Leucine Rich Repeats And IQ Motif Containing 4 2 3 5
  • LRRC64 2 3 4
  • Leucine-Rich Repeat And IQ Domain-Containing Protein 4 3 4
  • Leucine Rich Repeat Containing 64 2 3
  • Leucine-Rich Repeat-Containing Protein 64 4
  • LRRIQ4 5

External Ids for LRRIQ4 Gene

Previous GeneCards Identifiers for LRRIQ4 Gene

  • GC03P171023
  • GC03P169539
  • GC03P166909

Summaries for LRRIQ4 Gene

GeneCards Summary for LRRIQ4 Gene

LRRIQ4 (Leucine Rich Repeats And IQ Motif Containing 4) is a Protein Coding gene. Diseases associated with LRRIQ4 include Cardiomyopathy, Familial Restrictive, 3 and Retinitis Pigmentosa 38. An important paralog of this gene is SHOC2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRIQ4 Gene

Genomics for LRRIQ4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRIQ4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRIQ4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRIQ4

Top Transcription factor binding sites by QIAGEN in the LRRIQ4 gene promoter:
  • FOXO1
  • FOXO1a
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • HTF
  • Msx-1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for LRRIQ4 Gene

Latest Assembly
chr3:169,812,947-169,838,007
(GRCh38/hg38)
Size:
25,061 bases
Orientation:
Plus strand

Previous Assembly
chr3:169,539,679-169,555,561
(GRCh37/hg19 by Entrez Gene)
Size:
15,883 bases
Orientation:
Plus strand

chr3:169,539,710-169,555,563
(GRCh37/hg19 by Ensembl)
Size:
15,854 bases
Orientation:
Plus strand

Genomic View for LRRIQ4 Gene

Genes around LRRIQ4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRIQ4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRIQ4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRIQ4 Gene

Proteins for LRRIQ4 Gene

  • Protein details for LRRIQ4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIV6-LRIQ4_HUMAN
    Recommended name:
    Leucine-rich repeat and IQ domain-containing protein 4
    Protein Accession:
    A6NIV6

    Protein attributes for LRRIQ4 Gene

    Size:
    560 amino acids
    Molecular mass:
    63977 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRIQ4 Gene

Post-translational modifications for LRRIQ4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRIQ4 Gene

No data available for DME Specific Peptides for LRRIQ4 Gene

Domains & Families for LRRIQ4 Gene

Gene Families for LRRIQ4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LRRIQ4 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 64 (LRIQ4_HUMAN)
genes like me logo Genes that share domains with LRRIQ4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRIQ4 Gene

Function for LRRIQ4 Gene

Phenotypes From GWAS Catalog for LRRIQ4 Gene

Gene Ontology (GO) - Molecular Function for LRRIQ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRIQ4: view
genes like me logo Genes that share phenotypes with LRRIQ4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRIQ4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRIQ4 Gene

Localization for LRRIQ4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRIQ4 gene
Compartment Confidence
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRIQ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with LRRIQ4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRIQ4 Gene

Pathways & Interactions for LRRIQ4 Gene

PathCards logo

SuperPathways for LRRIQ4 Gene

No Data Available

Interacting Proteins for LRRIQ4 Gene

Gene Ontology (GO) - Biological Process for LRRIQ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with LRRIQ4: view

No data available for Pathways by source and SIGNOR curated interactions for LRRIQ4 Gene

Drugs & Compounds for LRRIQ4 Gene

No Compound Related Data Available

Transcripts for LRRIQ4 Gene

mRNA/cDNA for LRRIQ4 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRIQ4

Alternative Splicing Database (ASD) splice patterns (SP) for LRRIQ4 Gene

No ASD Table

Relevant External Links for LRRIQ4 Gene

GeneLoc Exon Structure for
LRRIQ4

Expression for LRRIQ4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRIQ4 Gene

mRNA differential expression in normal tissues according to GTEx for LRRIQ4 Gene

This gene is overexpressed in Testis (x28.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRIQ4

SOURCE GeneReport for Unigene cluster for LRRIQ4 Gene:

Hs.319484
genes like me logo Genes that share expression patterns with LRRIQ4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRIQ4 Gene

Orthologs for LRRIQ4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRIQ4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRIQ4 29 30
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRIQ4 29 30
  • 80.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRIQ4 29 30
  • 79.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrriq4 29 16 30
  • 75.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrriq4 29
  • 74.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia LRRIQ4 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRIQ4 29 30
  • 60.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRIQ4 30
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496663 29
  • 56.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii LRRIQ4 30
  • 13 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Sur-8 30
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea soc-2 30
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 42 (a)
OneToOne
Species where no ortholog for LRRIQ4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRRIQ4 Gene

ENSEMBL:
Gene Tree for LRRIQ4 (if available)
TreeFam:
Gene Tree for LRRIQ4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRIQ4: view image
Alliance of Genome Resources:
Additional Orthologs for LRRIQ4

Paralogs for LRRIQ4 Gene

(1) SIMAP similar genes for LRRIQ4 Gene using alignment to 1 proteins:

  • LRIQ4_HUMAN
genes like me logo Genes that share paralogs with LRRIQ4: view

Variants for LRRIQ4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRIQ4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs16854411 -- p.Lys159Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRIQ4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRIQ4 Gene

Variant ID Type Subtype PubMed ID
esv2422204 CNV deletion 17116639
nsv237474 CNV deletion 16902084
nsv460987 CNV loss 19166990
nsv592505 CNV loss 21841781
nsv7356 OTHER inversion 18451855

Variation tolerance for LRRIQ4 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.63; 78.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRIQ4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRIQ4
Leiden Open Variation Database (LOVD)
LRRIQ4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRIQ4 Gene

Disorders for LRRIQ4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRIQ4 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRIQ4

genes like me logo Genes that share disorders with LRRIQ4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRIQ4 Gene

Publications for LRRIQ4 Gene

  1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T … Xu J (Neurobiology of aging 2015) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3

Products for LRRIQ4 Gene

Sources for LRRIQ4 Gene