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Aliases for LRRIQ3 Gene

Aliases for LRRIQ3 Gene

  • Leucine Rich Repeats And IQ Motif Containing 3 2 3 5
  • Leucine-Rich Repeat-Containing Protein 44 3 4
  • Leucine Rich Repeat Containing 44 2 3
  • LRRC44 3 4
  • Leucine-Rich Repeat And IQ Domain-Containing Protein 3 3

External Ids for LRRIQ3 Gene

Previous HGNC Symbols for LRRIQ3 Gene

  • LRRC44

Previous GeneCards Identifiers for LRRIQ3 Gene

  • GC01M074265
  • GC01M074491
  • GC01M072626

Summaries for LRRIQ3 Gene

GeneCards Summary for LRRIQ3 Gene

LRRIQ3 (Leucine Rich Repeats And IQ Motif Containing 3) is a Protein Coding gene.

Additional gene information for LRRIQ3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRIQ3 Gene

Genomics for LRRIQ3 Gene

GeneHancer (GH) Regulatory Elements for LRRIQ3 Gene

Promoters and enhancers for LRRIQ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J074197 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 696 -0.2 -157 2.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 SP3 LRRIQ3 FPGT-TNNI3K FPGT TNNI3K
GH01J074199 Enhancer 0.6 ENCODE 650.7 -1.5 -1511 0.2 HDAC1 BHLHE40 MAX CEBPG MNT ATF4 IKZF1 SPI1 FPGT LRRIQ3 FPGT-TNNI3K TNNI3K
GH01J073979 Enhancer 0.2 ENCODE 5.8 +218.3 218273 0.5 LRRIQ3 TNNI3K GC01P074005 PIR50843
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRIQ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRIQ3 gene promoter:
  • STAT5A
  • GCNF-2
  • GCNF-1
  • GCNF
  • FOXL1
  • Pbx1a
  • RSRFC4
  • YY1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for LRRIQ3 Gene

Genomic Locations for LRRIQ3 Gene
chr1:74,026,015-74,198,201
(GRCh38/hg38)
Size:
172,187 bases
Orientation:
Minus strand
chr1:74,491,699-74,663,871
(GRCh37/hg19)
Size:
172,173 bases
Orientation:
Minus strand

Genomic View for LRRIQ3 Gene

Genes around LRRIQ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRIQ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRIQ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRIQ3 Gene

Proteins for LRRIQ3 Gene

  • Protein details for LRRIQ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVS8-LRIQ3_HUMAN
    Recommended name:
    Leucine-rich repeat and IQ domain-containing protein 3
    Protein Accession:
    A6PVS8
    Secondary Accessions:
    • A6PVS9
    • Q6P5P7
    • Q6ZMV4
    • Q8WUE0

    Protein attributes for LRRIQ3 Gene

    Size:
    624 amino acids
    Molecular mass:
    73675 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRIQ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRIQ3 Gene

Post-translational modifications for LRRIQ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRIQ3 Gene

Domains & Families for LRRIQ3 Gene

Gene Families for LRRIQ3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRIQ3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRIQ3: view

No data available for UniProtKB/Swiss-Prot for LRRIQ3 Gene

Function for LRRIQ3 Gene

Phenotypes From GWAS Catalog for LRRIQ3 Gene

Gene Ontology (GO) - Molecular Function for LRRIQ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LRRIQ3: view
genes like me logo Genes that share phenotypes with LRRIQ3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRIQ3 Gene

Localization for LRRIQ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRIQ3 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRIQ3 Gene

Pathways & Interactions for LRRIQ3 Gene

SuperPathways for LRRIQ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRIQ3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRIQ3 Gene

Drugs & Compounds for LRRIQ3 Gene

No Compound Related Data Available

Transcripts for LRRIQ3 Gene

mRNA/cDNA for LRRIQ3 Gene

Unigene Clusters for LRRIQ3 Gene

Leucine-rich repeats and IQ motif containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRIQ3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for LRRIQ3 Gene

GeneLoc Exon Structure for
LRRIQ3
ECgene alternative splicing isoforms for
LRRIQ3

Expression for LRRIQ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRIQ3 Gene

mRNA differential expression in normal tissues according to GTEx for LRRIQ3 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for LRRIQ3 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRIQ3 Gene



Protein tissue co-expression partners for LRRIQ3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRIQ3 Gene:

LRRIQ3

SOURCE GeneReport for Unigene cluster for LRRIQ3 Gene:

Hs.644625
genes like me logo Genes that share expression patterns with LRRIQ3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRIQ3 Gene

Orthologs for LRRIQ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRIQ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRIQ3 34 33
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRIQ3 34 33
  • 88.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRIQ3 34 33
  • 84.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrriq3 16 34 33
  • 72.77 (n)
rat
(Rattus norvegicus)
Mammalia Lrriq3 33
  • 71.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRIQ3 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRIQ3 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRIQ3 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrriq3 33
  • 51.39 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-267j14.7 33
  • 56.52 (n)
lrriq3 34
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for LRRIQ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRIQ3 Gene

ENSEMBL:
Gene Tree for LRRIQ3 (if available)
TreeFam:
Gene Tree for LRRIQ3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRIQ3: view image

Paralogs for LRRIQ3 Gene

No data available for Paralogs for LRRIQ3 Gene

Variants for LRRIQ3 Gene

Sequence variations from dbSNP and Humsavar for LRRIQ3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000036156 -- 74,182,200(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000053646 -- 74,101,640(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000060888 -- 74,124,461(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000064626 -- 74,038,458(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000086014 -- 74,079,735(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRIQ3 Gene

Variant ID Type Subtype PubMed ID
dgv28e214 CNV gain 21293372
esv3307830 CNV mobile element insertion 20981092
esv3360567 CNV insertion 20981092
esv3586446 CNV gain 21293372
esv3586451 CNV loss 21293372
esv3893723 CNV gain 25118596
nsv1002115 CNV gain 25217958
nsv1137772 CNV deletion 24896259
nsv1411 CNV deletion 18451855
nsv470717 CNV loss 18288195
nsv522147 CNV loss 19592680

Variation tolerance for LRRIQ3 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRIQ3 Gene

Human Gene Mutation Database (HGMD)
LRRIQ3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRIQ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRIQ3 Gene

Disorders for LRRIQ3 Gene

Additional Disease Information for LRRIQ3

No disorders were found for LRRIQ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRIQ3 Gene

Publications for LRRIQ3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for LRRIQ3 Gene

Sources for LRRIQ3 Gene

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