Aliases for LRRFIP2 Gene
External Ids for LRRFIP2 Gene
Previous GeneCards Identifiers for LRRFIP2 Gene
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
GeneCards Summary for LRRFIP2 Gene
LRRFIP2 (LRR Binding FLII Interacting Protein 2) is a Protein Coding gene. Diseases associated with LRRFIP2 include Lynch Syndrome and Muir-Torre Syndrome. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and LRR domain binding. An important paralog of this gene is LRRFIP1.
UniProtKB/Swiss-Prot Summary for LRRFIP2 Gene
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.